Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway

Endocrinology

Volumn 153, Issue 1, 2012, Pages 56-68

  Li, Qinkai ^a   Hosaka, Toshio ^b,c   Shikama, Yosuke ^a   Bando, Yukiko ^a   Kosugi, Chisato ^a   Kataoka, Nanako ^a   Nakaya, Yutaka ^b   Funaki, Makoto ^a  

^a TOKUSHIMA UNIVERSITY HOSPITAL   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SERINE; SEROTONIN; THROMBIN; TYROSINE;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MALE; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL LINE; CELLS, CULTURED; ENDOTHELIN-1; GLUCOSE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE; MUSCLE FIBERS, SKELETAL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEROTONIN; SIGNAL TRANSDUCTION; THROMBIN; TOR SERINE-THREONINE KINASES; TRANSCRIPTIONAL ACTIVATION;

EID: 84455185285     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1418     Document Type: Article

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