Activation of extracellular-regulated kinase by 5-hydroxytryptamine2A receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 2, 2002, Pages 746-752

  Quinn, John C ^a   Johnson Farley, Nadine N ^a   Yoon, Jiyoung ^a   Cowen, Daniel S ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 3,5 DI TERT BUTYL 4 HYDROXYBENZYLIDENEMALONONITRILE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 1 TERT BUTYL 3 (1' NAPHTHYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CALCIUM; CALMODULIN; CALMODULIN INHIBITOR; GENISTEIN; IONOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; N (4 AMINOBUTYL) 5 CHLORO 2 NAPSYLAMIDE; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SEROTONIN; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN; CHELATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EXTRACELLULAR CALCIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BENZYLAMINES; CALMODULIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYME INHIBITORS; MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SULFONAMIDES; TYRPHOSTINS;

EID: 0036827963     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.038083     Document Type: Article

References (41)

1. 2s regulating NF-κB activation in response to tumor necrosis factor-a and interleukin-10. J Biol Chem 276:35344-35351.
2. Avdi NJ, Nick JA, Whitlock BB, Billstrom MA, Henson PM, Johnson GL, and Worthen SG (2001) Tumor necrosis factor-α activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases to apoptosis. J Biol Chem 276:2189-2199.
3. Berg KA, Maayani S, Goldfarb J, Scaramellini C, Leff P, and Clarke WP (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus. Mol Pharmacol 54:94-104.
4. 2+ or protein kinase C in α-1A adrenergic receptor activation of mitogen-activated protein kinase pathways in transfected PC12 cells. Mol Pharmacol 55:296-303.
5. Cammarota M, Bevilaqua LRM, Dunkley PR, and Rostas JAP (2001) Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser 133 through an ERK1/2-dependent mechanism. J Neurochem 79:1122-1128.
6. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T, and Hidaka H (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265:5267-5272.
7. Denton RM and Tavare JM (1995) Does mitogen-activated-protein kinase have a role in insulin action? Eur J Biochem 227:597-611.
8. Egea J, Espinet C, and Comella JX (1998) Calmodulin modulates mitogen-activated protein kinase activation in response to membrane depolarization in PC12 cells. J Neurochem 70:2554-2564.
9. Egea J, Espinet C, and Comella JX (1999) Calcium influx activates the extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells. J Biol Chem 274:75-85.
10. Encinas M, Iglesias M, Llecha N, and Comella JX (1999) Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neurogenesis of the neuroblastoma cell line SH-SY5Y. J Neurochem 73:1409-1421.
11. Erhardt P, Schremser EJ, and Cooper GM (1999) B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol Cell Biol 19:5308-5315.
12. Esteve L, Lutz P, Thiriet N, Revel M, Aunis D, and Zwiller J (2001) Cyclic GMP-dependent protein kinase potentiates serotonin-induced Egr-1 binding activity in PC12 cells. Cell Signal 13:25-432.
13. 2 receptors in P11 cells. Mol Pharmacol 43:726-733.
14. Fuortes M, Melchior M, Han H, Lyon GJ, and Nathan C (1999) Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest 104:327-335.
15. 2 involvement in the mechanism of action of hallucinogenic agents. Life Sci 35:2505-2511.
16. 2 generation in rat renal mesangial cells. Am J Physiol Renal Physiol 278:F650-F658.
17. Grewal SS, Horgan AM, York RD, Withers GS, and Banker GA (2000) Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase. J Biol Chem 275:3722-3728.
18. Gschwendt M, Dieterich S, Rennecke J, Kittstein W, Mueller HJ, and Johannes FJ (1996) Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes. FEBS Lett 392:77-80.
19. 1 muscarinic acetylcholine receptors to the activation of ERK1/2. J Biol Chem 276:25568-25581.
20. 3 receptors in rodents. J Neurochem 75:240-247.
21. Hershenson MB, Chao T-SO, Abe MK, Gomes I, Kelleher MD, Sloway J, and Rosner MR (1995) Histamine antagonizes serotonin and growth factor induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells. J Biol Chem 270:19908-19913.
22. Hetman M, Kanning K, Cavanaugh JE, and Xia Z (1999) Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem 274:22569-22580.
23. Humblot N, Esteve L, Burgun C, Aunis D, and Zwiller J (1997) 5-Hydroxytryptamine induces TIS8/egr-1 and c-fos expression in PC12 cells. Involvement of tyrosine protein phosphorylation. Eur J Neurosci 9:84-92.
24. 2 receptors in human platelets via a mechanism involving protein kinase C. J Pharmacol Exp Ther 255:305-311.
25. 2A antagonist with a favorable CNS safety profile. J Pharmacol Exp Ther 277:968-981.
26. Kennett GA, Wood MD, Bright F, Cilia J, Piper DC, Cager T, Thomas D, Baxter GS, Forbes IT, Ham P, and Blackburn TP (1996) In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. Br J Pharmacol 117:427-434.
27. Mann JJ, Arango V, Marzuk PM, Theccanat S, and Reis DJ (1989) Evidence for the 5-HT hypothesis of suicide. A review of post-mortem studies. Br J Psychol 8:7-14.
28. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, and Schachter C (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö6976. J Biol Chem 268:9194-9197.
29. i values. J Pharmacol Exp Ther 251:238-246.
30. Nakayama H, Numakawa T, Ikeuchi T, and Hatanaka H (2001) Nicotin-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12 cells. J Neurochem 79:489-498.
31. Pang LO, Saweda T, Decker SJ, and Saltiel AR (1995) Inhibition of MAP kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 270:13585-13599.
32. Pazos A, Cortes R, and Palacios JM (1985) Quantitative autoradiaographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 346:231-249.
33. 2 receptor. EMBO (Eur Mol Biol Organ) J 7:4135-4140.
34. 2 receptors coupled to phospholipase C in rat aorta: Modulation of phosphoinositide turnover by phorbol ester. J Pharmacol Exp Ther 238:480-485.
35. Roth BL, Willins DL, Kristiansen K, and Kroeze WK (1999) Activation is hallucinogenic and antagonism is therapeutic: Role of 5-HT2A receptors in atypical antipsychotics drug actions. Neuroscientist 5:254-262.
36. Standeart ML, Galloway L, Karnam P, Bandyopadhyay G, Moscat J, and Farese RV (1997) Protein kinase Cς as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. J Biol Chem 272:30075-30082.
37. 2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells. Biochem Biophys Res Commun 181:968-975.
38. 2+/calmodulin-dependent kinase II. J Biol Chem 265:4315-4320.
39. Watts Sw, Yeum CH, Campbell G, and Webb RC (1996) Serotonin stimulates protein tyrosyl phosphorylation and vascular contraction via tyrosine kinase. J Vasc Res 33:288-298.
40. Wooten MW, Zhou G, Wooten MC, and Seibenhener ML (1997) Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: Association of atypical ς-PKC with the nuclear matrix. J Neurosci Res 49:393-403.
41. Zang MR, Muller HJ, Kielbassa K, Marks F, and Gschwendt M (1994) Partial Purification of a type eta protein kinase C from murine brain; separation from other protein kinase C isoenzymes and characterization. Biochem J 304:641-647.