Angiotensin II induces insulin resistance independent of changes in interstitial insulin

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 5 40-5, 1999, Pages

  Richey, Joyce M ^a   Ader, Marilyn ^a   Moore, Donna ^a   Bergman, Richard N ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Blood flow; Endogenous glucose production; Euglycemic hyperinsulinemia; Lymph insulin

Indexed keywords

ANGIOTENSIN; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCONEOGENESIS; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HEMODYNAMICS; HYPERINSULINEMIA; INSULIN RESISTANCE; INTERSTITIAL FLUID; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032760296     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.5.e920     Document Type: Article

References (37)

1. Ader, M., I. D. Hope, R. A. Poulin, Y. J. Yang, and R. N. Bergman. Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues. Diabetes 41: 241-253, 1992.
2. Allison, S. P., P. J. Tomlin, and M. J. Chamberlain. Some effects of anesthesia and surgery on carbohydrate and fat metabolism. Br. J. Anaesth. 41: 588-592, 1987.
3. Andersen, L., B. Dinesen, P. N. Jorgensen, F. Poulsen, and M. E. Roder. Enzyme immunoassay for intact human insulin in serum or plasma. Clin. Chem. 39: 578-582, 1993.
4. Baron, A. D., G. Brechtel-Hook, A. Johnson, and D. Hardin. Skeletal muscle flow: a possible link between insulin resistance and blood pressure. Hypertension 21: 129-135, 1993.
5. Baron, A. D., and G. Brechtel. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E61-E67, 1993.
6. Bradley, D. C., G. M. Steil, and R. N. Bergman. Quantitation of measurement error with optimal segments: basis for adaptive time course smoothing. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E902-E911, 1993.
7. Buchanan, T. A., H. Thawani, W. Kades, J. G. Modrall, F. A. Weaver, C. Laurel, R. Poppiti, A. Xiang, and W. Hsueh. Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism. J. Clin. Invest. 92: 720-726, 1993.
8. DeBono, E., G. D. Lee, R. Mottram, and G. W. Pickering. The action of angiotensin of man. Clin. Sci. (Colch.) 25: 123-157, 1963.
9. Diebert, D. C., and R. DeFronzo. Epinephrine-induced insulin resistance in man. J. Clin. Invest. 65: 717-721, 1980.
10. Doursout, M. F., J. E. Chelly, C. J. Hartley, J. Szilagyi, J. L. Montastruc, and J. P. Buckley. Regional blood flows and cardiac function changes induced by angiotensin II in conscious dogs. J. Pharmacol. Exp. Ther. 246: 591-596, 1988.
11. Dzau, V. Atherosclerosis and hypertension: mechanisms and interrelationships. J. Cardiovasc. Pharmacol. 15, Suppl. 5: S59-S64, 1990.
12. Ferrannini, E., R. Buzzigoli, R. Bonadonna, M. A. Giorico, M. Olegini, L. Graziadei, R. Pedrinelli, L. Brandi, and S. Bevilacqua. Insulin resistance in essential hypertension. N. Engl. J. Med. 317: 350-357, 1987.
13. Finegood D. T., and R. N. Bergman. Optimal segments: a method for smoothing tracer data to calculate metabolic fluxes. Am. J. Physiol. 244 (Endocrinol. Metab. 7): E472-E479, 1983.
14. Finegood, D. T., R. N. Bergman, and M. Vranic. Estimation of endogenous glucose production during hyperinsulinemic euglycemic glucose clamps: comparison of unlabeled and labeled exogenous glucose infusates. Diabetes 36: 914-924, 1987.
15. Grega, G. J., and S. W. Adamski. Patterns of constriction produced by vasoactive agents. Federation Proc. 46: 270-275, 1983.
16. Jamerson, K. A., S. D. Nesbitt, J. V. Amerena, E. Grant, and S. Julius. Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects. Hypertension 27: 854-858, 1996.
17. Julius, S. Hemodynamic and neurohumoral evidence of multifaceted pathophysiology in human hypertension. J. Cardiovasc. Pharmacol. 15, Suppl. 5: S53-S58, 1990.
18. Laakso, M., S. V. Edelman, G. Brechtel, and A. D. Baron. Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow. Am. J. Physiol. 263 (Endocrinol. Metab. 26): E199-E204, 1992.
19. Lithell, H. O., T. Pollare, and C. Berne. Insulin sensitivity in newly detected hypertensive patients: influence of captopril and other antihypertensive agents on insulin sensitivity and related biological parameters. J. Cardiovasc. Pharmacol. 15: S46-S52, 1990.
20. Lithell, H. O. L. Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism. Diabetes Care 14: 203-209, 1991.
21. Morris, A. D., J. R. Petrie, J. M. C. Anderson, and R. Donnelly. Effects of angiotensin II on insulin sensitivity: a placebo-controlled study. Clin. Sci. (Colch.) 85: 431-436, 1993.
22. Motwani, J. G., and A. D. Struthers. Dose-response study of the redistribution of intravascular volume by angiotensin II in man. Clin. Sci. (Colch.) 82: 397-405, 1992.
23. Nosadini, R., P. Fioretto, R. Trevisan, and G. Crepaldi. Insulin-dependent diabetes mellitus and hypertension. Diabetes Care 14: 210-219, 1991.
24. Osborn, E. C., L. M. Fearn, R. J. Francis, J. C. Mackenzie, and J. Wilson. Receptors for angiotensins I and II: their relevance to renal hemodynamics, blood pressure control and hind-limb blood flow. Med. Hypotheses 36: 6-16, 1991.
25. Pacini, G., and R. N. Bergman. Pacberg: an adaptive program for controlling the blood sugar. Comput. Programs Biomed. 16: 13-20, 1983.
26. Pollare, T., H. Lithell, and C. Berne. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 39: 167-174, 1990.
27. Poulin, R. A., G. M. Steil, D. M. Moore, M. Ader, and R. N. Bergman. Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes 43: 180-190, 1994.
28. Rao, R. H. Effects of angiotensin II on insulin sensitivity and fasting glucose metabolism in rats. Am. J. Hypertens. 7: 655-660, 1994.
29. Richey, J. M., R. A. Poulin, T. A. Buchanan, E. Galperin, D. M. Moore, and R. N. Bergman. Acute hyperinsulinemia does not alter blood pressure in baroreceptor deactivated dogs. Am. J. Hypertens. 12: 405-413, 1999.
30. Rosen, O. M. After insulin binds. Science 237: 1452-1458, 1987.
31. Salvetti, A., C. Brogi, V. DiLegge, and G. P. Bernini. The inter-relationship between insulin resistance and hypertension. Drugs 46: 149-159, 1993.
32. Shitrit, A., and W. Fuchs. Hyperinsulinemia: a link between hypertension, obesity, and glucose intolerance. J. Clin. Invest. 75: 809-817, 1985.
33. Somogyi, M. Determination of blood sugar. J. Biol. Chem. 160: 69-73, 1945.
34. Stokland, O., M. Molaug, J. Thorvaldson, and A. Ilebekk. Angiotensin II infusion during B-adrenergic stimulation by isoproterenol. Effects on hepatic, splenic and cardiac blood volumes and on the magnitude and distribution of cardiac ouptut in the dog. Acta Physiol. Scand. 127: 387-394, 1986.
35. Townsend, R. R., and D. J. DiPette. Pressor doses of angiotensin II increase insulin-mediated glucose uptake in normotensive men. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E362-E366, 1993.
36. Widgren, B. R., V. Urbanavicius, J. Wikstrand, S. Attvall, and B. Persson. Low-dose angiotensin II increases glucose disposal rate during euglycemic hyperinsulinemia. Am. J. Hypertens. 6: 892-895, 1993.
37. Yang, Y. J., I. D. Hope, M. Ader, and R. N. Bergman. Insulin transport across capillaries is rate limiting for insulin action in dogs. J. Clin. Invest. 84: 1620-1628, 1989.