Quantum dots in cancer therapy

Expert Opinion on Drug Delivery

Volumn 9, Issue 1, 2012, Pages 47-58

  Luo, Guopei ^a   Long, Jiang ^a   Zhang, Bo ^b   Liu, Chen ^b   Ji, Shunrong ^b   Xu, Jin ^b   Yu, Xianjun ^b   Ni, Quanxing ^b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Cancer; Molecular imaging; Nanoparticles; Nanotechnology; Quantum dots; Therapy

Indexed keywords

BIOLOGICAL MARKER; DOXORUBICIN; EVANS BLUE; MACROGOL; MERCAPTAMINE; MOLECULAR MARKER; NANOPARTICLE; PHOTOSENSITIZING AGENT; QUANTUM DOT; THIOGLYCOLIC ACID;

CANCER CELL; CANCER DIAGNOSIS; CANCER SURGERY; CANCER THERAPY; CLINICAL PRACTICE; COVALENT BOND; DRUG COATING; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG TARGETING; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMAGING SYSTEM; MEDICINE; MOLECULARLY TARGETED THERAPY; NANOTECHNOLOGY; PERSONALIZED MEDICINE; PHOTODYNAMIC THERAPY; PROGNOSIS; REVIEW; SENTINEL LYMPH NODE;

ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; MOLECULAR IMAGING; NANOMEDICINE; NEOPLASMS; QUANTUM DOTS; TUMOR MARKERS, BIOLOGICAL;

EID: 84255171266     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2012.638624     Document Type: Review

References (114)

1. Alivisatos P. The use of nanocrystals in biological detection. Nat Biotechnol 2004;22:47-52 (Pubitemid 38057955)
2. Michalet X, Pinaud FF, Bentolila LA, et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005;307:538-44 (Pubitemid 40165671)
3. Chan WC, Maxwell DJ, Gao X, et al. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 2002;13:40-6 (Pubitemid 34146546)
4. Alivisatos A. Semiconductor clusters, nanocrystals, and quantum dots. Science 1996;271:933-7 (Pubitemid 126554899)
5. Zrazhevskiy P, Gao X. Multifunctional Quantum Dots for Personalized Medicine. Nano Today 2009;4:414-28
6. Nune SK, Gunda P, Thallapally PK, et al. Nanoparticles for biomedical imaging. Expert Opin Drug Deliv 2009;6:1175-94
7. Medintz IL, Uyeda HT, Goldman ER, et al. Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater 2005;4:435-46 (Pubitemid 40774047)
8. Pietryga JM, Schaller RD, Werder D, et al. Pushing the band gap envelope: mid-infrared emitting colloidal PbSe quantum dots. J Am Chem Soc 2004;126:11752-3 (Pubitemid 39298299)
9. Singhal S, Nie S, Wang MD. Nanotechnology applications in surgical oncology. Annu Rev Med 2010;61:359-73
10. Gao X, Cui Y, Levenson RM, et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004;22:969-76 (Pubitemid 39014473)
11. Weissleder R, Kelly K, Sun EY, et al. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol 2005;23:1418-23 (Pubitemid 41679395)
12. Smith AM, Duan H, Mohs AM, et al. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Deliv Rev 2008;60:1226-40
13. Goldman ER, Balighian ED, Mattoussi H, et al. Avidin: a natural bridge for quantum dot-antibody conjugates. J Am Chem Soc 2002;124:6378-82 (Pubitemid 34579391)
14. Xiao Y, Gao X. Use of IgY antibodies and semiconductor nanocrystal detection in cancer biomarker quantitation. Biomark Med 2011;4:227-39
15. Wagner MK, Li F, Li J, et al. Use of quantum dots in the development of assays for cancer biomarkers. Anal Bioanal Chem 2010;397:3213-24
16. Lee J, Choi Y, Kim K, et al. Characterization and cancer cell specific binding properties of anti-EGFR antibody conjugated quantum dots. Bioconjug Chem 2010;21:940-6
17. Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005;353:1659-72 (Pubitemid 41464705)
18. Wu X, Liu H, Liu J, et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 2003;21:41-6 (Pubitemid 36055825)
19. Gao J, Chen K, Miao Z, et al. Affibody-based nanoprobes for HER2-expressing cell and tumor imaging. Biomaterials 2011;32:2141-8
20. Chen C, Sun SR, Gong YP, et al. Quantum dots-based molecular classification of breast cancer by quantitative spectroanalysis of hormone receptors and HER2. Biomaterials 2011;32:7592-9
21. Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008;26:2442-9
22. Nida DL, Rahman MS, Carlson KD, et al. Fluorescent nanocrystals for use in early cervical cancer detection. Gynecol Oncol 2005;99:S89-94 (Pubitemid 41774342)
23. Jung KH, Choe YS, Paik JY, et al. 99 mTc-Hydrazinonicotinamide epidermal growth factor-polyethylene glycol-quantum dot imaging allows quantification of breast cancer epidermal growth factor receptor expression and monitors receptor downregulation in response to cetuximab therapy. J Nucl Med 2011;52:1457-64
24. Neves AA, Brindle KM. Assessing responses to cancer therapy using molecular imaging. Biochim Biophys Acta 2006;1766:242-61
25. Morgan NY, English S, Chen W, et al. Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots. Acad Radiol 2005;12:313-23 (Pubitemid 40353762)
26. Torne A, Puig-Tintore LM. The use of sentinel lymph nodes in gynaecological malignancies. Curr Opin Obstet Gynecol 2004;16:57-64 (Pubitemid 38241543)
27. Newman EA, Newman LA. Lymphatic mapping techniques and sentinel lymph node biopsy in breast cancer. Surg Clin North Am 2007;87:353-64 (Pubitemid 46693953)
28. Peley G, Sinkovics I, Liszkay G, et al. The role of intraoperative gamma-probe-guided sentinel lymph node biopsy in the treatment of malignant melanoma and breast cancer. Orv Hetil 1999;140:2331-8
29. Soltesz EG, Kim S, Kim SW, et al. Sentinel lymph node mapping of the gastrointestinal tract by using invisible light. Ann Surg Oncol 2006;13:386-96 (Pubitemid 43255923)
30. Kim S, Lim YT, Soltesz EG, et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat Biotechnol 2004;22:93-7 (Pubitemid 38057962)
31. Parungo CP, Ohnishi S, Kim SW, et al. Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg 2005;129:844-50 (Pubitemid 40487887)
32. Soltesz EG, Kim S, Laurence RG, et al. Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann Thorac Surg 2005;79:269-77; discussion-77. (Pubitemid 40037484)
33. Ballou B, Ernst LA, Andreko S, et al. Sentinel lymph node imaging using quantum dots in mouse tumor models. Bioconjug Chem 2007;18:389-96 (Pubitemid 46493509)
34. Jain R, Dandekar P, Patravale V. Diagnostic nanocarriers for sentinel lymph node imaging. J Control Release 2009;138:90-102
35. Pons T, Pic E, Lequeux N, et al. Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity. ACS Nano 2010;4:2531-8
36. Hama Y, Koyama Y, Urano Y, et al. Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity. Breast Cancer Res Treat 2007;103:23-8 (Pubitemid 46653262)
37. Knapp DW, Adams LG, Degrand AM, et al. Sentinel lymph node mapping of invasive urinary bladder cancer in animal models using invisible light. Eur Urol 2007;52:1700-8
38. Wang Y, Chen L. Quantum dots, lighting up the research and development of nanomedicine. Nanomedicine 2011;7:385-402
39. Frangioni JV, Kim SW, Ohnishi S, et al. Sentinel lymph node mapping with type-II quantum dots. Methods Mol Biol 2007;374:147-59 (Pubitemid 350183405)
40. Yezhelyev MV, Qi L, ORegan RM, et al. Proton-sponge coated quantum dots for siRNA delivery and intracellular imaging. J Am Chem Soc 2008;130:9006-12 (Pubitemid 352000838)
41. Buchler MW, Werner J, Weitz J. R0 in pancreatic cancer surgery: surgery, pathology, biology, or definition matters? Ann Surg 2010;251:1011-12
42. Arndt-Jovin DJ, Kantelhardt SR, Caarls W, et al. Tumor-targeted quantum dots can help surgeons find tumor boundaries. IEEE Trans Nanobioscience 2009;8:65-71
43. Trehin R, Figueiredo JL, Pittet MJ, et al. Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia 2006;8:302-11
44. Marchal F, Pic E, Pons T, et al. Quantum dots in oncological surgery: the future for surgical margin status. Bull Cancer 2008;95:1149-53
45. Cai W, Shin DW, Chen K, et al. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett 2006;6:669-76
46. Wang J, Yong WH, Sun Y, et al. Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis. J Biomed Opt 2007;12:044021
47. Kantelhardt SR, Caarls W, de Vries AH, et al. Specific visualization of glioma cells in living low-grade tumor tissue. PLoS ONE 2010;5:e11323
48. Yong KT, Roy I, Swihart MT, et al. Multifunctional nanoparticles as biocompatible targeted probes for human cancer diagnosis and therapy. J Mater Chem 2009;19:4655-72
49. Wang Y, Chen L. Quantum dots, lighting up the research and development of nanomedicine. Nanomedicine 2011;7:385-402
50. Bagalkot V, Zhang L, Levy-Nissenbaum E, et al. Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett 2007;7:3065-70 (Pubitemid 350132931)
51. Zhao MX, Li JM, Du L, et al. Targeted cellular uptake and siRNA silencing by quantum-dot nanoparticles coated with beta-cyclodextrin coupled to amino acids. Chemistry (Easton) 2011;17:5171-9
52. Lidke DS, Nagy P, Heintzmann R, et al. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nat Biotechnol 2004;22:198-203 (Pubitemid 38160535)
53. Kim KS, Hur W, Park SJ, et al. Bioimaging for targeted delivery of hyaluronic acid derivatives to the livers in cirrhotic mice using quantum dots. ACS Nano 2010;4:3005-14
54. Derfus AM, Chen AA, Min DH, et al. Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem 2007;18:1391-6 (Pubitemid 47464045)
55. Dahan M, Levi S, Luccardini C, et al. Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 2003;302:442-5 (Pubitemid 37296269)
56. Chen AA, Derfus AM, Khetani SR, et al. Quantum dots to monitor RNAi delivery and improve gene silencing. Nucleic Acids Res 2005;33:e190 (Pubitemid 43125090)
57. Stroh M, Zimmer JP, Duda DG, et al. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med 2005;11:678-82 (Pubitemid 40868310)
58. Tan WB, Jiang S, Zhang Y. Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. Biomaterials 2007;28:1565-71 (Pubitemid 46039833)
59. Hong H, Zhang Y, Cai W. In vivo imaging of RNA interference. J Nucl Med 2010;51:169-72
60. Stryer L. Fluorescence energy transfer as a spectroscopic ruler. Annu Rev Biochem 1978;47:819-46
61. Kang WJ, Ko MH, Lee DS, et al. Bioimaging of geographically adjacent proteins in a single cell by quantum dot-based fluorescent resonance energy transfer. Proteomics Clin Appl 2009;3:1383-8
62. Medintz IL, Mattoussi H. Quantum dot-based resonance energy transfer and its growing application in biology. Phys Chem Chem Phys 2009;11:17-45
63. Kagan CR, Murray CB, Bawendi MG. Long-range resonance transfer of electronic excitations in close-packed CdSe quantum-dot solids. Phys Rev B 1996;54:8633-43
64. Dong H, Gao W, Yan F, et al. Fluorescence resonance energy transfer between quantum dots and graphene oxide for sensing biomolecules. Anal Chem 2010;82:5511-17
65. Medintz IL, Clapp AR, Mattoussi H, et al. Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat Mater 2003;2:630-8
66. Medintz IL, Konnert JH, Clapp AR, et al. A fluorescence resonance energy transfer-derived structure of a quantum dot-protein bioconjugate nanoassembly. Proc Natl Acad Sci USA 2004;101:9612-17 (Pubitemid 38869284)
67. Oh E, Hong MY, Lee D, et al. Inhibition assay of biomolecules based on fluorescence resonance energy transfer (FRET) between quantum dots and gold nanoparticles. J Am Chem Soc 2005;127:3270-1 (Pubitemid 40365254)
68. Ghadiali JE, Cohen BE, Stevens MM. Protein kinase-actuated resonance energy transfer in quantum dot-peptide conjugates. ACS Nano 2010;4:4915-19
69. Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst 1998;90:889-905 (Pubitemid 28304157)
70. Morris RL, Azizuddin K, Lam M, et al. Fluorescence resonance energy transfer reveals a binding site of a photosensitizer for photodynamic therapy. Cancer Res 2003;63:5194-7 (Pubitemid 37139826)
71. Almeida RD, Manadas BJ, Carvalho AP, et al. Intracellular signaling mechanisms in photodynamic therapy. Biochim Biophys Acta 2004;1704:59-86 (Pubitemid 39195350)
72. Samia AC, Chen X, Burda C. Semiconductor quantum dots for photodynamic therapy. J Am Chem Soc 2003;125:15736-7 (Pubitemid 37553678)
73. Morosini V, Bastogne T, Frochot C, et al. Quantum dot-folic acid conjugates as potential photosensitizers in photodynamic therapy of cancer. Photochem Photobiol Sci 2011;10:842-51
74. Chatterjee DK, Fong LS, Zhang Y. Nanoparticles in photodynamic therapy: an emerging paradigm. Adv Drug Deliv Rev 2008;60:1627-37
75. Chan IS, Ginsburg GS. Personalized medicine: progress and promise. Annu rev genomics hum genet. 2011. [Epub ahead of print]
76. Smith MQ, Staley CA, Kooby DA, et al. Multiplexed fluorescence imaging of tumor biomarkers in gene expression and protein levels for personalized and predictive medicine. Curr Mol Med 2009;9:1017-23
77. Tainsky MA. Genomic and proteomic biomarkers for cancer: a multitude of opportunities. Biochim Biophys Acta 2009;1796:176-93
78. Chan WC, Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998;281:2016-18 (Pubitemid 28475486)
79. Phan JH, Moffitt RA, Stokes TH, et al. Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment. Trends Biotechnol 2009;27:350-8
80. Liu J, Lau SK, Varma VA, et al. Molecular mapping of tumor heterogeneity on clinical tissue specimens with multiplexed quantum dots. ACS Nano 2010;4:2755-65
81. Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92 (Pubitemid 32222155)
82. Chen C, Xia HS, Gong YP, et al. The quantitative detection of total HER2 load by quantum dots and the identification of a new subtype of breast cancer with different 5-year prognosis. Biomaterials 2010;31:8818-25
83. Liu XL, Peng CW, Chen C, et al. Quantum dots-based double-color imaging of HER2 positive breast cancer invasion. Biochem Biophys Res Commun 2011;409:577-82
84. Jain KK. Role of nanobiotechnology in developing personalized medicine for cancer. Technol Cancer Res Treat 2005;4:645-50 (Pubitemid 43083348)
85. Nurunnabi M, Cho KJ, Choi JS, et al. Targeted near-IR QDs-loaded micelles for cancer therapy and imaging. Biomaterials 2010;31:5436-44
86. Chen K, Li ZB, Wang H, et al. Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots. Eur J Nucl Med Mol Imaging 2008;35:2235-44
87. Han M, Gao X, Su JZ, et al. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat Biotechnol 2001;19:631-5 (Pubitemid 32625432)
88. Pan J, Liu Y, Feng SS. Multifunctional nanoparticles of biodegradable copolymer blend for cancer diagnosis and treatment. Nanomedicine (Lond) 2010;5:347-60
89. Gindy ME, Prudhomme RK. Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin Drug Deliv 2009;6:865-78
90. Al-Jamal WT, Al-Jamal KT, Bomans PH, et al. Functionalizedquantum- dot-liposome hybrids as multimodal nanoparticles for cancer. Small 2008;4:1406-15
91. Choi HS, Liu W, Liu F, et al. Design considerations for tumour-targeted nanoparticles. Nat Nanotechnol 2010;5:42-7
92. Zhao F, Zhao Y, Liu Y, et al. Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small 2011;7:1322-37
93. Hardman R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ Health Perspect 2006;114:165-72 (Pubitemid 43193634)
94. Choi HS, Liu W, Misra P, et al. Renal clearance of quantum dots. Nat Biotechnol 2007;25:1165-70 (Pubitemid 47538116)
95. Almeida JP, Chen AL, Foster A, et al. In vivo biodistribution of nanoparticles. Nanomedicine (Lond) 2011;6:815-35
96. Zhao F, Zhao Y, Liu Y, et al. Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small 2011;7:1322-37
97. Chibli H, Carlini L, Park S, et al. Cytotoxicity of InP/ZnS quantum dots related to reactive oxygen species generation. Nanoscale 2011;3:2552-9
98. Lee J, Lilly GD, Doty RC, et al. In vitro toxicity testing of nanoparticles in 3D cell culture. Small 2009;5:1213-21
99. Li S, Wang Y, Wang H, et al. MicroRNAs as participants in cytotoxicity of CdTe quantum dots in NIH/3T3 cells. Biomaterials 2011;32:3807-14
100. Lovric J, Bazzi HS, Cuie Y, et al. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med 2005;83:377-85 (Pubitemid 41201802)
101. Kirchner C, Liedl T, Kudera S, et al. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 2005;5:331-8 (Pubitemid 40308295)
102. Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004;4:11-18 (Pubitemid 38167855)
103. Dubertret B, Skourides P, Norris DJ, et al. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 2002;298:1759-62 (Pubitemid 35404113)
104. Hoshino A, Hanaki K, Suzuki K, et al. Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochem Biophys Res Commun 2004;314:46-53 (Pubitemid 38058367)
105. Jaiswal JK, Mattoussi H, Mauro JM, et al. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat Biotechnol 2003;21:47-51 (Pubitemid 36055826)
106. Larson DR, Zipfel WR, Williams RM, et al. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 2003;300:1434-6 (Pubitemid 36638163)
107. Mattheakis LC, Dias JM, Choi YJ, et al. Optical coding of mammalian cells using semiconductor quantum dots. Anal Biochem 2004;327:200-8 (Pubitemid 38402188)
108. Voura EB, Jaiswal JK, Mattoussi H, et al. Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat Med 2004;10:993-8 (Pubitemid 39273742)
109. Chan WH, Shiao NH, Lu PZ. CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals. Toxicol Lett 2006;167:191-200
110. Bentzen EL, Tomlinson ID, Mason J, et al. Surface modification to reduce nonspecific binding of quantum dots in live cell assays. Bioconjug Chem 2005;16:1488-94 (Pubitemid 41681516)
111. Romoser A, Ritter D, Majitha R, et al. Mitigation of quantum dot cytotoxicity by microencapsulation. PLoS ONE 2011;6:e22079
112. Rosenthal SJ, Chang JC, Kovtun O, et al. Biocompatible quantum dots for biological applications. Chem Biol 2011;18:10-24
113. Cristofanilli M, Hayes DF, Budd GT, et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 2005;23:1420-30
114. Smith AM, Nie S. Chemical analysis and cellular imaging with quantum dots. Analyst 2004;129:672-7 (Pubitemid 39120509)