Gα q/11 signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization

Pain

Volumn 153, Issue 1, 2012, Pages 184-196

  Tappe Theodor, Anke ^a   Constantin, Cristina E ^b   Tegeder, Irmgard ^c   Lechner, Stefan G ^d   Langeslag, Michiel ^b   Lepcynzsky, Peter ^a   Wirotanseng, Richard I ^a   Kurejova, Martina ^a   Agarwal, Nitin ^a   Nagy, Gergely ^e   Todd, Andrew ^e   Wettschureck, Nina ^a   Offermanns, Stefan ^a   Kress, Michaela ^b   Lewin, Gary R ^d   Kuner, Rohini ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

G protein coupled receptor; Knock out mice; Nociceptor; Pain; TTX resistant sodium channels

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; POTASSIUM ION; SODIUM ION; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE TARGETING; HYPERALGESIA; INFLAMMATION; MALE; MOUSE; NERVE INJURY; NEUROMODULATION; NEUROPATHIC PAIN; NOCICEPTION; NOCICEPTIVE RECEPTOR; NOCICEPTIVE STIMULATION; NONHUMAN; PAIN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; REGULATORY MECHANISM; SENSITIZATION; SIGNAL TRANSDUCTION; SODIUM CURRENT;

ANIMALS; CELLS, CULTURED; GANGLIA, SPINAL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HYPERALGESIA; MICE; MICE, KNOCKOUT; NEURONS; NOCICEPTION; NOCICEPTORS; PAIN MEASUREMENT; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TYPE C PHOSPHOLIPASES;

EID: 84155163842     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.10.014     Document Type: Article

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