Distinct roles of Gαq Gα11 and Purkinje cell signaling and motor behavior

Journal of Neuroscience

Volumn 24, Issue 22, 2004, Pages 5119-5130

  Hartmann, J ^a   Blum, R ^a   Kovalchuk, Y ^a   Adelsberger, H ^a   Kuner, R ^b   Durand, G M ^a   Miyata, M ^c   Kano, M ^d   Offermanns, S ^b   Konnerth, Arthur ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

Calcium Ca imaging; G protein; Knock out; mGluR; Motor control; Patch clamp; Purkinje cell; RT PCR; Synaptic plasticity

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 METHYL (CARBOXYCYCLOPROPYL)GLYCINE; CALCIUM ION; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; UNCLASSIFIED DRUG; CALCIUM; FLUORESCENT DYE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; PROTEIN SUBUNIT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CEREBELLUM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; KNOCKOUT MOUSE; MOTOR CONTROL; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIORITY JOURNAL; PURKINJE CELL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CALCIUM SIGNALING; CELL STRAIN COS1; CERCOPITHECUS; CYTOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENETICS; LONG TERM DEPRESSION; METABOLISM; MOTOR ACTIVITY; MOUSE MUTANT; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

ANIMALS; BEHAVIOR, ANIMAL; CALCIUM; CALCIUM SIGNALING; CERCOPITHECUS AETHIOPS; CEREBELLUM; COS CELLS; EXCITATORY POSTSYNAPTIC POTENTIALS; FLUORESCENT DYES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; LONG-TERM DEPRESSION (PHYSIOLOGY); MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURONAL PLASTICITY; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PURKINJE CELLS; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 3042586651     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4193-03.2004     Document Type: Article

References (48)

1. 2+ signal transduction. J Biol Chem 267:13361-13368.
2. Aiba A, Kano M, Chen C, Stanton ME, Fox GD, Herrup K, Zwingman TA, Tonegawa S (1994) Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79:377-388.
3. Barski JJ, Hartmann J, Rose CR, Hoebeek F, Mörl K, Noll-Hussong M, De Zeeuw CI, Konnerth A, Meyer M (2003) Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. J Neurosci 23:3469-3477.
4. Batchelor AM, Madge DJ, Garthwaite J (1994) Synaptic activation of metabotropic glutamate receptors in the parallel fibre-Purkinje cell pathway in rat cerebellar slices. Neuroscience 63:911-915.
5. Canepari M, Ogden D (2003) Evidence for protein tyrosine phosphatase, tyrosine kinase, and G-protein regulation of the parallel fiber metabotropic slow EPSC of rat cerebellar Purkinje neurons. J Neurosci 23:4066-4071.
6. Canepari M, Papageorgiou G, Corrie JE, Watkins C, Ogden D (2001) The conductance underlying the parallel fibre slow EPSP in rat cerebellar Purkinje neurones studied with photolytic release of L-glutamate. J Physiol (Lond) 533:765-772.
7. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
8. Conquet F, Bashir ZI, Davies CH, Daniel H, Ferraguti F, Bordi F, Franz-Bacon K, Reggiani A, Matarese V, Conde F, Collingridge GL, Crépel F (1994) Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372:237-243.
9. Crepel F, Daniel H, Hemart N, Jaillard D (1991) Effects of ACPD and AP3 on parallel-fibre-mediated EPSPs of Purkinje cells in cerebellar slices in vitro. Exp Brain Res 86:402-406.
10. 2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons. Nature 373:155-158.
11. Feil R, Hartmann J, Luo C, Wolfsgruber W, Schilling K, Feil S, Barski JJ, Meyer M, Konnerth A, De Zeeuw CI, Hofmann F (2003) Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. J Cell Biol 163:295-302.
12. Finch EA, Augustine GJ (1998) Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Nature 396:753-756.
13. Fitzjohn SM, Palmer MJ, May JE, Neeson A, Morris SA, Collingridge GL (2001) A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro. J Physiol (Lond) 537:421-430.
14. 2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones. J Physiol (Lond) 491:757-772.
15. 11α. Activation of purified phospholipase C isozymes by Gα subunits. J Biol Chem 268:14367-14375.
16. Heuss C, Scanziani M, Gähwiler BH, Gerber U (1999) G-protein-independent signaling mediated by metabotropic glutamate receptors. Nat Neurosci 2:1070-1077.
17. Hirono M, Konishi S, Yoshioka T (1998) Phospholipase C-independent group I metabotropic glutamate receptor- mediated inward current in mouse Purkinje cells. Biochem Biophys Res Commun 251:753-758.
18. Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A (2000) mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science 288:1832-1835.
19. Inoue T, Kato K, Kohda K, Mikoshiba K (1998) Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar Purkinje neurons. J Neurosci 18:5366-5373.
20. Ito M (2001) Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol Rev 81:1143-1195.
21. Kano M, Garaschuk O, Verkhratsky A, Konnerth A (1995) Ryanodine-receptor-mediated intracellular calcium release in rat cerebellar Purkinje neurons. J Physiol (Lond) 487:1-16.
22. 2+ release in rat cerebellar Purkinje neurones. J Physiol (Lond) 487:343-358.
23. Kim SJ, Kim YS, Yuan JP, Petralia RS, Worley PF, Linden DJ (2003) Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature 426:285-291.
24. Konnerth A, Llano I, Armstrong CM (1990) Synaptic currents in cerebellar Purkinje cells. Proc Natl Acad Sci USA 87:2662-2665.
25. Lambolez B, Audinat E, Bochet P, Crepel F, Rossier J (1992) AMPA receptor subunits expressed by single Purkinje cells. Neuron 9:247-258.
26. Liss B, Franz O, Sewing S, Bruns R, Neuhoff H, Roeper J (2001) Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. EMBO J 20:5715-5724.
27. 11α in the adult rat brain. Neuroscience 51:311-316.
28. Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S (1991) Sequence and expression of a metabotropic glutamate receptor. Nature 349:760-765.
29. 11 secures the induction of long-term potentiation in the hippocampal area CA1. J Neurosci 22:8379-8390.
30. Miyata M, Finch EA, Khiroug L, Hashimoto K, Hayasaka S, Oda SI, Inouye M, Takagishi Y, Augustine GJ, Kano M (2000) Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 28:233-244.
31. 16 couple a wide variety of receptors to phospholipase C. J Biol Chem 270:15175-15180.
32. 11 are concurrently activated by bombesin and vasopressin in Swiss 3T3 cells. FEBS Lett 349:201-204.
33. q. Proc Natl Acad Sci USA 94:14089-14094.
34. 2+ channels in motoneurons of the rat facial nucleus. J Neurosci 18:9573-9584.
35. Rasmussen R (2001) Quantification on the LightCycler. In: Rapid-cycle real-time PCR. Methods and applications (Meurer S, Wittwer C, Nakawara K, eds), pp 21-34. Berlin: Springer.
36. Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C*. Annu Rev Biochem 70:281-312.
37. Rose CR, Konnerth A (2001) Stores not just for storage: intracellular calcium release and synaptic plasticity. Neuron 31:519-522.
38. 11α knockout mice. Endocrinology 139:2710-2717.
39. Sugiyama T, Hirono M, Suzuki K, Nakamura Y, Aiba A, Nakamura K, Nakao K, Katsuki M, Yoshioka T (1999) Localization of phospholipase Cβ isozymes in the mouse cerebellum. Biochem Biophys Res Commun 265:473-478.
40. Takechi H, Eilers J, Konnerth A (1998) A new class of synaptic response involving calcium release in dendritic spines. Nature 396:757-760.
41. 11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Eur J Neurosci 12:781-792.
42. q class of G proteins stimulate phosphoinositide phospholipase C-β 1 activity. FEBS Lett 286:214-216.
43. Tempia F, Miniaci MC, Anchisi D, Strata P (1998) Postsynaptic current mediated by metabotropic glutamate receptors in cerebellar Purkinje cells. J Neurophysiol 80:520-528.
44. 2+ signals in cerebellar Purkinje cells. NeuroReport 2:759-762.
45. q class of G proteins. J Biol Chem 266:11409-11412.
46. q class: expression in murine tissues and in stromal and hematopoietic cell lines. Proc Natl Acad Sci USA 88:10049-10053.
47. q family. J Biol Chem 267:25798-25802.
48. 14. Am J Physiol 276:G271-G279.