Gα(i2) but not Gα(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes

Circulation Research

Volumn 87, Issue 10, 2000, Pages 903-909

  Nagata, Kohzo ^a   Ye, Chianping ^c   Jain, Mohit ^a   Milstone, David S ^c   Liao, Ronglih ^a   Mortensen, Richard M ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Contractility; Gi proteins; Intracellular calcium; Muscarinic receptor; Myocyte

Indexed keywords

CARBACHOL; CHOLINERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; MUSCARINIC M2 RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM; CALCIUM CHANNEL L TYPE; GNAI2 PROTEIN, MOUSE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CHOLINERGIC SYSTEM; EMBRYO; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE; MEMBRANE CURRENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE TARGETING; GENETICS; HEART CONTRACTION; HEART MUSCLE; HEART MUSCLE CONDUCTION SYSTEM; INTRACELLULAR FLUID; METABOLISM; MOUSE MUTANT;

ADRENERGIC BETA-AGONISTS; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARBACHOL; CELLS, CULTURED; GENE TARGETING; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HETEROTRIMERIC GTP-BINDING PROTEINS; INTRACELLULAR FLUID; ISOPROTERENOL; MICE; MICE, KNOCKOUT; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PROTO-ONCOGENE PROTEINS; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION;

EID: 0034634090     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.10.903     Document Type: Article

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