Formation mechanism and structure of a guanine - Uracil DNA intrastrand cross-link

Chemical Research in Toxicology

Volumn 24, Issue 12, 2011, Pages 2189-2199

  Churchill, Cassandra D M ^a   Eriksson, Leif A ^b   Wetmore, Stacey D ^a  

^a UNIVERSITY OF LETHBRIDGE   (Canada)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DINUCLEOTIDE; GUANINE; HYDROGEN; URACIL;

ARTICLE; CYTOTOXICITY; DENSITY FUNCTIONAL THEORY; DNA CROSS LINKING; DNA HELIX; DNA STRUCTURE; HUMAN; IONIZING RADIATION; MOLECULAR DYNAMICS; PHOSPHORESCENCE; ULTRAVIOLET IRRADIATION;

ANTINEOPLASTIC AGENTS; DNA; GUANINE; KINETICS; MOLECULAR DYNAMICS SIMULATION; THERMODYNAMICS; ULTRAVIOLET RAYS; URACIL;

EID: 84055218884     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx2003239     Document Type: Article

References (90)

1. Georgakilas, A. G. (2011) From Chemistry of DNA Damage to Repair and Biological Significance. Comprehending the Future Mutat. Res., Fundam. Mol. Mech. Mutagen. 711, 1-2
2. Rajski, S. R. and Williams, R. M. (1998) DNA Cross-Linking Agents As Antitumor Drugs Chem. Rev. 98, 2723-2796
3. Siddik, Z. H. (2003) Cisplatin: Mode of Cytotoxic Action and Molecular Basis of Resistance Oncogene 22, 7265-7279 (Pubitemid 37487159)
4. Jung, Y. and Lippard, S. J. (2007) Direct Cellular Responses to Platinum-Induced DNA Damage Chem. Rev. 107, 1387-1407 (Pubitemid 46864967)
5. Djordjevic, B. and Szybalski, W. (1960) Genetics of Human Cell Lines: III. Incorporation of 5-Bromo- and 5-Iododeoxyuridine into the Deoxyribononucleic Acid of Human Cells and Its Effect on Radiation Sensitivity J. Exp. Med. 112, 509-531
6. Szybalski, W. (1974) X-ray Sensitization by Halopyrimidines Cancer Chemother. Rep. 1 (58) 539-557
7. Kinsella, T. J., Mitchell, J. B., Russo, A., Morstyn, G., and Glatstein, E. (1984) The Use of Halogenated Thymidine Analogues As Clinical Radiosensitizers: Rationalle, Current Status, And Future Prospects: Non-Hypoxic Cell Sensitizers Int. J. Radiat. Oncol., Biol., Phys. 10, 1399-1406 (Pubitemid 14029902)
8. Greer, S., Schwade, J., and Marion, H. S. (1995) Five-Chloro- deoxycytidine and Biomodulators of Its Metabolism Result in Fifty to Eighty Percent Cures of Advanced EMT-6 Tumors When Used with Fractionated Radiation Int. J. Radiat. Oncol., Biol., Phys. 32, 1059-1069
9. Greer, S., Alvarez, M., Mas, M., Wozniak, C., Arnold, D., Knapinska, A., Norris, C., Burk, R., Aller, A., and Dauphinée, M. (2001) Five-Chlorodeoxycytidine, a Tumor-Selective Enzyme-Driven Radiosensitizer, Effectively Controls Five Advanced Human Tumors in Nude Mice Int. J. Radiat. Oncol., Biol., Phys. 51, 791-806
10. Prados, M. D., Seiferheld, W., Sandler, H. M., Buckner, J. C., Phillips, T., Schultz, C., Urtasun, R., Davis, R., Gutin, P., Cascino, T. L., Greenberg, H. S., and Curran, W. J. (2004) Phase III Randomized Study of Radiotherapy Plus Procarbazine, Lomustine, and Vincristine with or without BUdR for Treatment of Anaplastic Astrocytoma: Final Report of RTOG 9404 Int. J. Radiat. Oncol. 58, 1147-1152 (Pubitemid 38314798)
11. von Sonntag, C. (2006) Free-Radical-Induced DNA Damage and Its Repair, Springer-Verlag, Berlin, Germany.
12. Cecchini, S., Girouard, S., Huels, M. A., Sanche, L., and Hunting, D. J. (2005) Interstrand Cross-Links: A New Type of γ-Ray Damage in Bromodeoxyuridine-Substituted DNA Biochemistry 44, 1932-1940 (Pubitemid 40223622)
13. Cecchini, S., Masson, C., La Madeleine, C., Huels, M. A., Sanche, L., Wagner, J. R., and Hunting, D. J. (2005) Interstrand Cross-Link Induction by UV Radiation in Bromodeoxyuridine-Substituted DNA: Dependence on DNA Conformation Biochemistry 44, 16957-16966 (Pubitemid 43007224)
14. Wojcik, A., Bochenek, A., Lankoff, A., Lisowska, H., Padjas, A., Szumiel, I., von Sonntag, C., and Obe, G. (2006) DNA Interstrand Crosslinks are Induced in Cells Prelabelled with 5-Bromo-2′-Deoxyuridine and Exposed to UVC Radiation J. Photochem. Photobiol., B 84, 15-20 (Pubitemid 43869408)
15. Zeng, Y. and Wang, Y. (2006) Sequence-Dependent Formation of Intrastrand Crosslink Products from the UVB Irradiation of Duplex DNA Containing a 5-Bromo-2′-Deoxyuridine or 5-Bromo-2′-Deoxycytidine Nucleic Acids Res. 34, 6521-6529 (Pubitemid 46017947)
16. Dextraze, M.-E., Wagner, J. R., and Hunting, D. J. (2007) 5-Bromodeoxyuridine Radiosensitization: Conformation-Dependent DNA Damage Biochemistry 46, 9089-9097 (Pubitemid 47237383)
17. Zeng, Y. and Wang, Y. (2007) UVB-Induced Formation of Intrastrand Cross-Link Products of DNA in MCF-7 Cells Treated with 5-Bromo-2′- Deoxyuridine Biochemistry 46, 8189-8195 (Pubitemid 47051655)
18. Dextraze, M.-E., Cecchini, S., Bergeron, F., Girouard, S., Turcotte, K., Wagner, J. R., and Hunting, D. J. (2009) Reaching for the Other Side: Generating Sequence-Dependent Interstrand Cross-Links with 5-Bromodeoxyuridine and γ-rays Biochemistry 48, 2005-2011
19. Dextraze, M. E., Gantchev, T., Girouard, S., and Hunting, D. (2010) DNA Interstrand Cross-links Induced by Ionizing Radiation: An Unsung Lesion Mutat. Res., Rev. Mutat. Res. 704, 101-107
20. Lin, G., Zhang, J., Zeng, Y., Luo, H., and Wang, Y. (2010) Conformation-Dependent Formation of the G[8-5]U Intrastrand Cross-Link in 5-Bromouracil-Containing G-Quadruplex DNA Induced by UVA Irradiation Biochemistry 49, 2346-2350
21. Krasin, F. and Hutchinson, F. (1978) Double-Strand Breaks from Single Photochemical Events in DNA Containing 5-Bromouracil Biophys. J. 24, 645-656 (Pubitemid 9067600)
22. Cornforth, M. N. and Bedford, J. S. (1987) A Quantitative Comparison of Potentially Lethal Damage Repair and the Rejoining of Interphase Chromosome Breaks in Low Passage Normal Human Fibroblasts Radiat. Res. 111, 385-405 (Pubitemid 17144554)
23. Iliakis, G., Kurtzman, S., Pantelias, G., and Okayasu, R. (1989) Mechanism of Radiosensitization by Halogenated Pyrimidines: Effect of BrdU on Radiation Induction of DNA and Chromosome Damage and Its Correlation with Cell Killing Radiat. Res. 119, 286-304 (Pubitemid 19208559)
24. Sugiyama, H., Tsutsumi, Y., and Saito, I. (1990) Highly Sequence-Selective Photoreaction of 5-Bromouracil-Containing Deoxy-hexanucleotides J. Am. Chem. Soc. 112, 6720-6721 (Pubitemid 20303354)
25. Morris, S. M. (1991) The Genetic Toxicology of 5-Bromodeoxyuridine in Mammalian Cells Mutat. Res. 258, 161-188 (Pubitemid 121007626)
26. Cook, G. P. and Greenberg, M. M. (1996) A Novel Mechanism for the Formation of Direct Strand Breaks upon Anaerobic Photolysis of Duplex DNA Containing 5-Bromodeoxyuridine J. Am. Chem. Soc. 118, 10025-10030 (Pubitemid 26375186)
27. Freese, A., O'Rourke, D., Judy, K., and O'Connor, M. J. (1994) The Application of 5-Bromodeoxyuridine in the Management of CNS Tumors J. Neuro-Oncol. 20, 81-95 (Pubitemid 24299478)
28. Robertson, J. M., Sondak, V. K., Weiss, S. A., Sussman, J. J., Chang, A. E., and Lawrence, T. S. (1995) Preoperative Radiation Therapy and Iododeoxyuridine for Large Retroperitoneal Sarcomas Int. J. Radiat. Oncol., Biol., Phys. 31, 87-92
29. Johnstone, P. A. S., Laskin, W. B., DeLuca, A. M., Barnes, M., Kinsella, T. J., and Sindelar, W. F. (1996) Tumors in Dogs Exposed to Experimental Intraoperative Radiotherapy Int. J. Radiat. Oncol., Biol., Phys. 34, 853-857 (Pubitemid 26089223)
30. Urtasun, R. C., Kinsella, T. J., Farnan, N., DelRowe, J. D., Lester, S. G., and Fulton, D. S. (1996) Survival Improvement in Anaplastic Astrocytoma, Combining External Radiation with Halogenated Pyrimidines: Final Report of RTOG 86-12, Phase I-II Study Int. J. Radiat. Oncol., Biol., Phys. 36, 1163-1167
31. Schulz, C. A., Mehta, M. P., Robins, H. I., Badie, B., Arzoomanian, R., Simon, K., Alberti, D., Feierabend, C., Kunugi, K. A., Wilding, G., and Kinsella, T. J. (1997) 9 Continuous 28 Day Iododeoxyuridine (IUdR) Infusion and Hyperfractionated Accelerated Radiotherapy (HART) for Malignant Glioma: A Phase I Clinical and Thymidine Replacement Study Int. J. Radiat. Oncol., Biol., Phys. 39, 139-139
32. Ding, H. and Greenberg, M. M. (2010) DNA Damage and Interstrand Cross-Link Formation upon Irradiation of Aryl Iodide C-Nucleotide Analogues J. Org. Chem. 75, 535-544
33. Li, Y., Owusu, A., and Lehnert, S. (2004) Treatment of Intracranial Rat Glioma Model with Implant of Radiosensitizer and Biomodulator Drug Combined with External Beam Radiotherapy Int. J. Radiat. Oncol., Biol., Phys. 58, 519-527 (Pubitemid 38142479)
34. Hazra, S., Ort, S., Konrad, M., and Lavie, A. (2010) Structural and Kinetic Characterization of Human Deoxycytidine Kinase Variants Able To Phosphorylate 5-Substituted Deoxycytidine and Thymidine Analogues Biochemistry 49, 6784-6790
35. Gulston, M., de Lara, C., Jenner, T., Davis, E., and O'Neill, P. (2004) Processing of Clustered DNA Damage Generates Additional Double-Strand Breaks in Mammalian Cells Post-Irradiation Nucleic Acids Res. 32, 1602-1609 (Pubitemid 38854757)
36. Harrison, L., Hatahet, Z., and Wallace, S. S. (1999) In Vitro Repair of Synthetic Ionizing Radiation-Induced Multiply Damaged DNA Sites J. Mol. Biol. 290, 667-684 (Pubitemid 29355700)
37. Sutherland, B. M., Bennett, P. V., Sidorkina, O., and Laval, J. (2000) Clustered Damages and Total Lesions Induced in DNA by Ionizing Radiation: Oxidized Bases and Strand Breaks Biochemistry 39, 8026-8031 (Pubitemid 30452377)
38. Hwang, J. T., Tallman, K. A., and Greenberg, M. M. (1999) The Reactivity of the 2-Deoxyribonolactone Lesion in Single-Stranded DNA and its Implication in Reaction Mechanisms of DNA Damage and Repair Nucleic Acids Res. 27, 3805-3810 (Pubitemid 29454428)
39. Roupioz, Y., Lhomme, J., and Kotera, M. (2002) Chemistry of the 2-Deoxyribonolactone Lesion in Oligonucleotides: Cleavage Kinetics and Products Analysis J. Am. Chem. Soc. 124, 9129-9135 (Pubitemid 34847674)
40. Kroeger, K. M., Jiang, Y. L., Kow, Y. W., Goodman, M. F., and Greenberg, M. M. (2004) Mutagenic Effects of 2-Deoxyribonolactone in Escherichia coli. An Abasic Lesion That Disobeys the A-Rule Biochemistry 43, 6723-6733 (Pubitemid 38697571)
41. Zheng, Y. and Sheppard, T. L. (2004) Half-Life and DNA Strand Scission Products of 2-Deoxyribonolactone Oxidative DNA Damage Lesions Chem. Res. Toxicol. 17, 197-207 (Pubitemid 38252499)
42. Schyman, P., Eriksson, L. A., and Laaksonen, A. (2009) Hydrogen Abstraction from Deoxyribose by a Neighboring 3′-Uracil Peroxyl Radical J. Phys. Chem. B 113, 6574-6578
43. Schyman, P., Zhang, R. B., Eriksson, L. A., and Laaksonen, A. (2007) Hydrogen Abstraction from Deoxyribose by a Neighbouring Uracil-5-yl Radical Phys. Chem. Chem. Phys. 9, 5975-5979
44. BrUT-3′ Sequence in Duplex DNA: Efficent Generation of Uracil-5-yl Radical by Charge Transfer J. Am. Chem. Soc. 129, 8163-8168 (Pubitemid 47035129)
45. Bellon, S., Ravanat, J.-L., Gasparutto, D., and Cadet, J. (2002) Cross-Linked Thymine-Purine Base Tandem Lesions: Synthesis, Characterization, and Measurement in γ-Irradiated Isolated DNA Chem. Res. Toxicol. 15, 598-606 (Pubitemid 34326942)
46. Gu, C. and Wang, Y. (2004) LC-MS/MS Identification and Yeast Polymerase n Bypass of a Novel γ-Irradiation-Induced Intrastrand Cross-Link Lesion G[8-5]C Biochemistry 43, 6745-6750 (Pubitemid 38697573)
47. Zhang, Q. B. and Wang, Y. S. (2005) Generation of 5-(2 ′-Deoxycytidyl)methyl Radical and the Formation of Intrastrand Cross-link Lesions in Oligodeoxyribonucleotides Nucleic Acids Res. 33, 1593-1603
48. Bellon, S., Gasparutto, D., Saint-Pierre, C., and Cadet, J. (2006) Guanine-Thymine Intrastrand Cross-Linked Lesion Containing Oligonucleotides: From Chemical Synthesis to in Vitro Enzymatic Replication Org. Biomol. Chem. 4, 3831-3837 (Pubitemid 44536097)
49. Jiang, Y., Hong, H., Cao, H., and Wang, Y. (2007) In Vivo Formation and in Vitro Replication of a Guanine-Thymine Intrastrand Cross-Link Lesion Biochemistry 46, 12757-12763 (Pubitemid 350064224)
50. Gu, C., Zhang, Q., Yang, Z., Wang, Y., Zou, Y., and Wang, Y. (2006) Recognition and Incision of Oxidative Intrastrand Cross-Link Lesions by UvrABC Nuclease Biochemistry 45, 10739-10746 (Pubitemid 44320489)
51. Colis, L. C., Raychaudhury, P., and Basu, A. K. (2008) Mutational Specificity of γ-Radiation-Induced Guanine-Thymine and Thymine-Guanine Intrastrand Cross-Links in Mammalian Cells and Translesion Synthesis Past the Guanine-Thymine Lesion by Human DNA Polymerase? Biochemistry 47, 8070-8079
52. Gu, C. and Wang, Y. (2005) Thermodynamic and in Vitro Replication Studies of an Intrastrand G[8-5]C Cross-Link Lesion Biochemistry 44, 8883-8889 (Pubitemid 40840454)
53. Hong, H., Cao, H., and Wang, Y. (2007) Formation and Genotoxicity of a Guanine-Cytosine Intrastrand Cross-link Lesion in Vivo Nucleic Acids Res. 35, 7118-7127
54. Raychaudhury, P. and Basu, A. K. (2011) Genetic Requirement for Mutagenesis of the G[8,5-Me]T Cross-Link in Escherichia coli: DNA Polymerases IV and V Compete for Error-Prone Bypass Biochemistry 50, 2330-2338
55. Zhao, Y. and Truhlar, D. G. (2008) The M06 Suite of Density Functionals for Main Group Thermochemistry, Thermochemical Kinetics, Noncovalent Interactions, Excited States, and Transition Elements: Two New Functionals and Systematic Testing of Four M06-class Functionals and 12 Other Functionals Theor. Chem. Acc. 120, 215-241
56. Scalmani, G. and Frisch, M. J. (2010) Continuous Surface Charge Polarizable Continuum Models of Solvation. I. General Formalism J. Chem. Phys. 132, 114110
57. Churchill, C. D. M. and Wetmore, S. D. (2011) Developing a Computational Model That Accurately Reproduces the Structural Features of a Dinucleoside Monophosphate Unit Within B-DNA Phys. Chem. Chem. Phys. 13, 16373-16383
58. Rutledge, L. R. and Wetmore, S. D. (2010) The Assessment of Density Functionals for DNA-Protein Stacked and T-Shaped Complexes Can. J. Chem. 88, 815-830
59. Merrick, J. P., Moran, D., and Radom, L. (2007) An Evaluation of Harmonic Vibrational Frequency Scale Factors J. Phys. Chem. A 111, 11683-11700 (Pubitemid 350197612)
60. Marenich, A. V., Cramer, C. J., and Truhlar, D. G. (2009) Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions J. Phys. Chem. B 113, 6378-6396
61. Frisch, M. J., Trucks, G. W., Schlegel, H. B., Scuseria, G. E., Robb, M. A., Cheeseman, J. R., Scalmani, G., Barone, V., Mennucci, B., Petersson, G. A., Nakatsuji, H., Caricato, M., Li, X., Hratchian, H. P., Izmaylov, A. F., Bloino, J., Zheng, G., Sonnenberg, J. L., Hada, M., Ehara, M., Toyota, K., Fukuda, R., Hasegawa, J., Ishida, M., Nakajima, T., Honda, Y., Kitao, O., Nakai, H., Vreven, T., Jr. , Peralta, J. E., Ogliaro, F., Bearpark, M., Heyd, J. J., Brothers, E., Kudin, K. N., Staroverov, V. N., Kobayashi, R., Normand, J., Raghavachari, K., Rendell, A., Burant, J. C., Iyengar, S. S., Tomasi, J., Cossi, M., Rega, N., Millam, J. M., Klene, M., Knox, M. E., Cross, J. B., Bakken, V., Adamo, C., Jaramillo, J., Gomperts, R., Stratmann, R. E., Yazyev, O., Austin, A. J., Cammi, R., Pomelli, C., Ochterski, J. W., Martin, R. L., Morokuma, K., Zakrzewski, V. G., Voth, G. A., Salvador, P., Dannenberg, J. J., Dapprich, S., Daniels, A. D., Farkas, O., Foresman, J. B., Ortiz, J. V., Cioslowski, J., and Fox, D. J. (2009) Gaussian 09, Gaussian, Inc., Wallingford, CT.
62. Krieger, E., Darden, T., Nabuurs, S. B., Finkelstein, A., and Vriend, G. (2004) Making Optimal use of Empirical Energy Functions: Force-Field Parameterization in Crystal Space Proteins: Struct., Funct., Bioinf. 57, 678-683 (Pubitemid 39626989)
63. Case, D. A., Darden, T. A., Cheatham, T. E., III., Simmerling, C. L., Wang, J., Duke, R. E., Luo, R., Walker, R. C., Zhang, W., Merz, K. M., Roberts, B., Wang, B., Hayik, S., Roitberg, A., Seabra, G., Kolossvai, I., Wong, K. F., Paesani, F., Vanicek, J., Liu, J., Wu, X., Brozell, S. R., Steinbrecher, T., Gohlke, H., Cai, Q., Ye, X., Wang, J., Hsieh, M.-J., Cui, G., Roe, D. R., Mathews, D. H., Seetin, M. G., Sagui, C., Babin, V., Luchko, T., Gusarov, S., Kovalenko, A., and Kollman, P. A. (2010) AMBER 11, University of California, San Francisco, CA.
64. Cheatham, T. E., III and Case, D. A. (2006) Using Amber to Simulate DNA and RNA, in Computational Studies of RNA and DNA (Sponer, J. and Lankas, F., Eds.) pp 45-72, Springer, Dordrecht, The Netherlands.
65. Duan, Y., Wu, C., Chowdhury, S., Lee, M. C., Xiong, G. M., Zhang, W., Yang, R., Cieplak, P., Luo, R., Lee, T., Caldwell, J., Wang, J. M., and Kollman, P. (2003) A Point-Charge Force Field for Molecular Mechanics Simulations of Proteins Based on Condensed-Phase Quantum Mechanical Calculations J. Comput. Chem. 24, 1999-2012
66. Wang, J. M., Wolf, R. M., Caldwell, J. W., Kollman, P. A., and Case, D. A. (2004) Development and Testing of a General Amber Force Field J. Comput. Chem. 25, 1157-1174
67. Lavery, R., Moakher, M., Maddocks, J. H., Petkeviciute, D., and Zakrzewska, K. (2009) Conformational Analysis of Nucleic Acids Revisited: Curves+ Nucleic Acids Res. 37, 5917-5929
68. Storoniak, P., Rak, J., Polska, K., and Blancafort, L. (2011) Local Excitation of the 5-Bromouracil Chromophore in DNA. Computational and UV Spectroscopic Studies J. Phys. Chem. B 115, 4532-4537
69. Kobyecka, M., Migani, A., Asturiol, D., Rak, J., and Blancafort, L. (2009) Benign Decay vs. Photolysis in the Photophysics and Photochemistry of 5-Bromouracil. A Computational Study J. Phys. Chem. A 113, 5489-5495
70. Wang, C. R., Hu, A., and Lu, Q. B. (2006) Direct Observation of the Transition State of Ultrafast Electron Transfer Reaction of a Radiosensitizing Drug Bromodeoxyuridine J. Chem. Phys. 124, 241102
71. Wang, C.-R. and Lu, Q.-B. (2007) Real-Time Observation of a Molecular Reaction Mechanism of Aqueous 5-Halo-2′-Deoxyuridines under UV/Ionizing Radiation Angew. Chem., Int. Ed. 46, 6316-6320 (Pubitemid 47329425)
72. Tashiro, R., Nakamura, K., and Sugiyama, H. (2008) Photoreaction of Iodouracil in DNA Duplex; C-I Bond is Cleaved via Two Different Pathways 'Homolysis and Heterolysis' Tetrahedron Lett. 49, 428-431 (Pubitemid 50013010)
73. Saenger, W. (1984) Principles of Nucleic Acid Structure, Springer-Verlag New York Inc., New York, NY.
74. Zhang, R. B. and Eriksson, L. A. (2006) A Triplet Mechanism for the Formation of Cyclobutane Pyrimidine Dimers in UV-Irradiated DNA J. Phys. Chem. B 110, 7556-7562
75. Xerri, B., Morell, C., Grand, A., Cadet, J., Cimino, P., and Barone, V. (2006) Radiation-Induced Formation of DNA Intrastrand Crosslinks Between Thymine and Adenine Bases: a Theoretical Approach Org. Biomol. Chem. 4, 3986-3992 (Pubitemid 44600671)
76. Labet, V., Morell, C., Grand, A., Cadet, J., Cimino, P., and Barone, V. (2008) Formation of Cross-Linked Adducts Between Guanine and Thymine Mediated by Hydroxyl Radical and One-electron Oxidation: a Theoretical Study Org. Biomol. Chem. 6, 3300-3305
77. Chou, S.-H. and Chin, K.-H. (2001) Solution Structure of a DNA Double Helix Incorporating Four Consecutive Non-Watson-Crick Base-pairs J. Mol. Biol. 312, 769-781 (Pubitemid 33116740)
78. Vaya, I., Gustavsson, T., Miannay, F.-A., Douki, T., and Markovitsi, D. (2010) Fluorescence of Natural DNA: From the Femtosecond to the Nanosecond Time Scales J. Am. Chem. Soc. 132, 11834-11835
79. Yashchuk, V., Kudrya, V., Losytskyy, M., Suga, H., and Ohul'chanskyy, T. (2006) The Nature of the Electronic Excitations Capturing Centres in the DNA J. Mol. Liq. 127, 79-83 (Pubitemid 44279132)
80. 2/Ascorbate Chem. Res. Toxicol. 19, 614-621 (Pubitemid 43800977)
81. Sims, G. E. and Kim, S. H. (2003) Global Mapping of Nucleic Acid Conformational Space: Dinucleoside Monophosphate Conformations and Transition Pathways Among Conformational Classes Nucleic Acids Res. 31, 5607-5616 (Pubitemid 37441932)
82. Svozil, D., Kalina, J., Omelka, M., and Schneider, B. (2008) DNA Conformations and Their Sequence Preferences Nucleic Acids Res. 36, 3690-3706 (Pubitemid 351917531)
83. Yang, Z., Colis, L. C., Basu, A. K., and Zou, Y. (2005) Recognition and Incision of γ-Radiation-Induced Cross-Linked Guanine-Thymine Tandem Lesion G[8,5-Me]T by UvrABC Nuclease Chem. Res. Toxicol. 18, 1339-1346 (Pubitemid 41361707)
84. Stivers, J. T. (2008) Extrahelical Damaged Base Recognition by DNA Glycosylase Enzymes Chem.-Eur. J. 14, 786-793 (Pubitemid 351196759)
85. Berdis, A. J. (2008) DNA Polymerases as Therapeutic Targets Biochemistry 47, 8253-8260
86. Lange, S. S., Takata, K.-I., and Wood, R. D. (2011) DNA Polymerases and Cancer Nat. Rev. Cancer 11, 96-110
87. Stehlikova, K., Kostrhunova, H., Kasparkova, J., and Brabec, V. (2002) DNA Bending and Unwinding due to the major 1,2-GG Intrastrand Cross-link Formed by Antitumor Cis-diamminedichloroplatinum(II) are Flanking-Base Independent Nucleic Acids Res. 30, 2894-2898 (Pubitemid 34778149)
88. Rink, S. M. and Hopkins, P. B. (1995) A Mechlorethamine-Induced DNA Interstrand Cross-link Bends Duplex DNA Biochemistry 34, 1439-1445
89. Rink, S. M., Lipman, R., Alley, S. C., Hopkins, P. B., and Tomasz, M. (1996) Bending of DNA by the Mitomycin C-Induced, GpG Intrastrand Cross-Link Chem. Res. Toxicol. 9, 382-389 (Pubitemid 26079978)
90. Rohs, R., Jin, X., West, S. M., Joshi, R., Honig, B., and Mann, R. S. (2010) Origins of Specificity in Protein-DNA Recognition Annu. Rev. Biochem. 79, 233-269