In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites

Journal of Molecular Biology

Volumn 290, Issue 3, 1999, Pages 667-684

  Harrison, Lynn ^a   Hatahet, Zafer ^a   Wallace, Susan S ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

8 Oxoguanine; Base excision repair; In vitro DNA repair; Ionizing radiation DNA damage; Multiply damaged sites

Indexed keywords

DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; FORMAMIDE DERIVATIVE; PHOSPHATE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PYRIMIDINE; SINGLE STRANDED DNA;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ESCHERICHIA COLI; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; RADIATION MUTAGENESIS;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0032788298     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2892     Document Type: Article

References (35)

1. Ahnstrom G., Bryant P. E. DNA double-strand breaks generated by the repair of X-ray damage in Chines hamster cells. Int. J. Radiat. Biol. 41:1982;671-676.
2. Bailly V., Verly W. G., O'Connor T. R., Laval J. Mechanism of DNA strand nicking at apurinic/apyrimidinic sites by Escherichia coli[formamidopyrimidine] DNA glycoslyase. Biochem. J. 262:1989;581-589.
3. Bhagwat M., Gerlt J. A. 3′- and 5′-strand cleavage reactions catalyzed by the Fpg protein from Escherichia coli occur via successive beta- and delta-elimination mechanisms, respectively. Biochemistry. 35:1996;659-665.
4. Bonura T., Smith K. C., Kaplan H. S. Enzymatic induction of DNA double-strand breaks in gamma-irradiated E. coli K-12. Proc. Natl Acad. Sci. USA. 72:1975;4265-4269.
5. Brenner D. J., Ward J. F. Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int. J. Radiat. Biol. 61:1992;737-748.
6. Castaing B., Boiteux S., Zelwer C. DNA containing a chemically reduced apurinic site is a high affinity ligand for the E. coli formamidopyrimidine-DNA glycosylase. Nucl. Acids Res. 20:1992;389-394.
7. Castaing B., Geiger A., Seliger H., Nehls P., Laval J., Zelwer C., Boiteux S. Cleavage and binding of a DNA fragment containing a single 8-oxoguanine by wild type and mutant FPG proteins. Nucl. Acids Res. 21:1993;2899-2905.
8. Chaudhry M. A., Weinfeld M. The action of Escherichia coli endonuclease III on multiply damaged sites in DNA. J. Mol. Biol. 249:1995a;914-922.
9. Chaudhry M. A., Weinfeld M. Induction of double-strand breaks by S1 nuclease, mung bean nuclease and nuclease P1 in DNA containing abasic sites and nicks. Nucl. Acids Res. 23:1995b;3805-3809.
10. Chaudhry M. A., Weinfeld M. Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA. J. Biol. Chem. 272:1997;15650-15655.
11. Cooper P. K., Nouspikel T., Clarkson S. G., Leadon S. A. Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Science. 275:1997;990-993.
12. Demple B., Harrison L. Repair of oxidative damage to DNA: enzymology and biology. Annu. Rev. Biochem. 63:1994;915-948.
13. Dianov G., Lindahl T. Reconstitution of the DNA base excision-repair pathway. Curr. Biol. 4:1994;1069-1076.
14. Dianov G. L., Timchenko T. V., Sinitsina O. I., Kuzminov A. V., Medvedev O. A., Salganik R. I. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol. Gen. Genet. 225:1991;448-452.
15. Dugle D. L., Gillespie C. J., Chapman J. D. DNA strand breaks, repair, and survival in X-irradiated mammalian cells. Proc. Natl Acad. Sci. USA. 73:1976;809-812.
16. Goodhead D. T. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int. J. Radiat. Biol. 61:1994;7-17.
17. Goodhead D. T., Thacker J., Cox R. Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. Int. J. Radiat. Biol. 63:1993;543-556.
18. Harrison L., Skorvaga M., Cunningham R. P., Hendry J. H., Margison G. P. Transfection of the Escherichia coli nth into radiosensitive Chinese hamster cells: effects on sensitivity to radiation, hydrogen peroxide, and bleomycin sulfate. Radiat. Res. 132:1992;30-39.
19. Harrison L., Hatahet Z., Purmal A. A., Wallace S. S. Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII. Nucl. Acids Res. 26:1998;932-941.
20. Hatahet Z., Kow Y. W., Purmal A. A., Cunningham R. P., Wallace S. S. New substrates for old enzymes. 5-Hydroxy-2′-deoxycytidine and 5-hydroxy-2′-deoxyuridine are substrates forEscherichia coli endonuclease III and formamidopyrimidine DNA N -glycosylase, while 5-hydroxy-2′-deoxyuridine is a substrate for uracil DNA N -glycosylase. J. Biol. Chem. 269:1994a;18814-18820.
21. Hatahet Z., Purmal A. A., Wallace S. S. Wallace S. S., Van Houten B., Kow Y. W. DNA Damage Effects on DNA Structure and Protein Recognition. 1994b;346-348.
22. Henner W. D., Rodriguez L. O., Hecht S. M., Haseltine W. A. γ-Ray induced deoxyribonucleic acid strand breaks. J. Biol. Chem. 258:1983;711-713.
23. Jiang D., Hatahet Z., Melamede R. J., Kow Y. W., Wallace S. S. Characterization of Escerichia coli endonuclease VIII. J. Biol. Chem. 272:1997;32230-32239.
24. Klett R. P., Cerami A., Reich E. Exonuclease VI, a new nuclease activity associated with E. coli DNA polymerase. Proc. Natl Acad. Sci. USA. 60:1968;943-950.
25. Kubota Y., Nash R. A., Klungland A., Schar P., Barnes D. E., Lindahl T. Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. EMBO J. 15:1996;6662-6670.
26. Leadon S. A., Cooper P. K. Preferential repair of ionizing radiation-induced damage in the transcribed strand of an active human gene is defective in Cockayne syndrome. Proc. Natl Acad. Sci. USA. 90:1993;10499-10503.
27. Melamede R. J., Hatahet Z., Kow Y. W., Ide H., Wallace S. S. Isolation and characterization of endonuclease VIII from Escherichia coli. Biochemistry. 33:1994;1255-1264.
28. O'Connor T. R., Laval J. Physical association of the 2,6-diamino-4-hydroxy-5-(N -methyl) formamidopyrimidine-DNA glycosylase ofEscherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc. Natl Acad. Sci. USA. 86:1989;5222-5226.
29. Shibutani S., Takeshita M., Grollman A. P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature. 349:1991;431-434.
30. Tchou J., Kasia H., Shibutani S., Chung M. H., Laval J., Grollman A. P., Nishimura S. 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc. Natl Acad. Sci. USA. 88:1991;4690-4694.
31. Tchou J., Michaels M. L., Miller J. H., Grollman A. P. Function of the zinc finger in Escherichia coli Fpg protein. J. Biol. Chem. 268:1993;26738-26744.
32. Wallace S. S. Oxidative damage to DNA and its repair. Scandalios J. Oxidative Stress and the Molecular Biology of Antioxidant Defenses. 1997;49-90 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
33. Ward J. F. DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog. Nucl. Acid Res. Mol. Biol. 35:1988;95-125.
34. Ward J. F. Radiation mutagenesis: the initial DNA lesions responsible. Radiat. Res. 142:1995;362-368.
35. Ward J. F., Evans J. W., Limoli C. L., Calabro-Jones P. M. Radiation and hydrogen peroxide induced free radical damage to DNA. Cancer. 55:1987;105-112.