Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues

Biochemistry

Volumn 49, Issue 31, 2010, Pages 6784-6790

  Hazra, Saugata ^a   Ort, Stephan ^b   Konrad, Manfred ^b   Lavie, Arnon ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CANCER CELLS; CYTIDINE; DEOXYNUCLEOSIDES; DNA SYNTHESISS; HYDROPHOBIC RESIDUES; KINETIC CHARACTERIZATION; METHYL GROUP; NUCLEOSIDE ANALOGUES; STERIC FACTOR; STRUCTURAL DATA; SUICIDE GENE THERAPY; THYMINE BASE; WILD TYPES;

BIOMOLECULES; GENE THERAPY; GENETIC ENGINEERING; HYDROCARBONS; PHOSPHORYLATION; STRUCTURAL ANALYSIS;

CRYSTAL STRUCTURE;

ALANINE; ARGININE; ASPARTIC ACID; CYTIDINE; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; NUCLEOSIDE; THYMIDINE;

ARTICLE; CANCER CELL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME KINETICS; HUMAN; HYDROPHOBICITY; MUTAGENESIS; MUTATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; STEREOCHEMISTRY; SUICIDE GENE THERAPY;

AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; HUMANS; KINETICS; PHOSPHORYLATION; SUBSTRATE SPECIFICITY; THYMIDINE;

EID: 77955261224     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100839e     Document Type: Article

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