Five-chlorodeoxycytidine, a tumor-selective enzyme-driven radiosensitizer, effectively controls five advanced human tumors in nude mice

International Journal of Radiation Oncology Biology Physics

Volumn 51, Issue 3, 2001, Pages 791-806

  Greer, Sheldon ^a,b,c   Alvarez, Marcy ^c   Mas, Marisol ^c   Wozniak, Chandra ^a   Arnold, David ^b   Knapinska, Anna ^c   Norris, Christina ^c   Burk, Ronald ^d   Aller, Alex ^c   Dauphinée, Michael ^c  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c NOVA SOUTHEASTERN UNIVERSITY   (United States)

^d Veterinary Radiology Services of South Florida   (United States)

Author keywords

5 chloro 2 deoxycytidine; Brain; Human tumors of the prostate; Lung and breast; Radiation therapy; Radiosensitization

Indexed keywords

DRUG PRODUCTS; ENZYMES; HISTOLOGY; IRRADIATION; MODULATORS; TISSUE; TUMORS; X RAYS;

HUMAN TUMORS;

ONCOLOGY;

5 CHLORODEOXYCYTIDINE; ASPARTATE CARBAMOYLTRANSFERASE; BROXURIDINE; CHLORIDE; CLOXURIDINE; CYTIDINE DEAMINASE; DEOXYCYTIDINE KINASE; DEOXYCYTIDINE PHOSPHATE DEAMINASE; DNA; FLUCYTOSINE DEOXYRIBOSIDE; IDOXURIDINE; SPARFOSIC ACID; TETRAHYDROURIDINE; THYMIDYLATE SYNTHASE; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOM; BREAST TUMOR; CANCER INHIBITION; CERVICAL SPINAL CORD; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; FRACTIONATION; GLIOBLASTOMA; HEAD AND NECK TUMOR; HISTOLOGY; HUMAN; HUMAN CELL; INHIBITION KINETICS; IRRADIATION; LUNG TUMOR; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROSTATE TUMOR; RADIATION DOSE; RADIOSENSITIZATION; TISSUE INJURY; TREATMENT OUTCOME; TUMOR CELL LINE; TUMOR GROWTH; X RAY;

ANIMALS; BREAST NEOPLASMS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DCMP DEAMINASE; DEOXYCYTIDINE; DEOXYCYTIDINE KINASE; FEMALE; GLIOBLASTOMA; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASMS; PROSTATIC NEOPLASMS; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; SPINAL CORD; TETRAHYDROURIDINE;

EID: 0035501336     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(01)01706-0     Document Type: Article

References (54)

1. Studies on ultraviolet irradiation of Escherichia coli containing 5-bromouracil in its DNA
2. Genetics of human cell lines. III. Incorporation of 5-bromo and 5-iododeoxyuridine into the deoxyribonucleic acid of human cells and its effects on radiation sensitivity
3. Enhancement of X-ray sensitivity of E-coli by 5-bromouracil
4. Intra-arterial 5-bromodeoxyuridine and X-ray therapy
5. Pharmacology and Phase I/II study of continuous intravenous infusions of iododeoxyuridine and hyperfractionated radiotherapy in patients with glioblastoma multiforme
6. Initial analysis of NCOG 6G82-1: Bromodeoxyuridine (BUdR) during irradiation followed by CCNU, procarbazine and vincristine (PCV) chemotherapy for malignant gliomas
7. Evaluation of bromodeoxyuridine in glioblastoma multiforme: A Northern California Cancer Center Phase II study
8. Halogenated pyrimidines as radiosensitizers for high-grade glioma: Revisited
9. Measurement of thymidine replacement in patients with high grade gliomas, head and neck tumors, and high grade sarcomas after continuous intravenous infusions of 5-iododeoxyuridine
10. Long-term follow-up on National Cancer Institute Phase I/II study of glioblastoma multiforme treated with iododeoxyuridine and hyperfractionated irradiation
11. National Cancer Institute (Phase II) study of high-grade glioma treated with accelerated hyperfractionated radiation and iododeoxyuridine: Results in anaplastic astrocytoma
12. Preoperative radiation therapy and iododeoxyuridine for large retroperitoneal sarcoma
13. Survival improvement in anaplastic astrocytoma, combining external radiation with halogenated pyrimidines: Final report of RTOG 86-12, Phase I-II study
14. A Phase I study of intra-arterial iododeoxyuridine in patients with colorectal liver metastases
15. Selective incorporation of iododeoxyuridine into DNA of hepatic metastases versus normal human liver
16. Incorporation of 5-bromo-2′-deoxyuridine into colorectal liver metastases and liver in patients receiving a 7-day hepatic arterial infusion
17. Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation
18. Fluorodeoxyuridine-mediated modulation of iododeoxyuridine incorporation and radiosensitization in human colon cancer cells in vitro and in vivo
19. Preclinical evaluation of 5-iodo-2-pyrimidinone-2′-deoxyribose as a prodrug for 5-iodo-2′-deoxyuridine-mediated radiosensitization in mouse and human tissues
20. Deoxycytidine kinase. I. Distribution in normal and neoplastic tissues and interrelationships of deoxycytidine and 1-β-D-arabinofuranosylcytosine phosphorylation
21. Increase in liver and kidney deoxycytidine kinase activity linked to neoplastic transformation
22. Distribution of kinase and deaminase of 1-β-D-arabinofuranosylcytosine in tissues of man and mouse
23. Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine
24. Inhibition of difluorodeoxycytidine of deoxycytidine kinase activity and inhibition by DFDC
25. Regulation of deoxycytidine kinase activity and inhibition by DFDC
26. Mammalian deoxyribonucleoside kinases
27. Deoxycytidylate deaminase in normal and neoplastic human tissue
28. Activities of various enzymes of pyrimidine nucleoside and DNA synthesis in normal and neoplastic human tissues
29. Deoxycytidylate deaminase activity in lymphoproliferative disorders
30. Deoxycytidylate deaminase activity in non-stimulated and phytohemagglutinin-stimulated human lymphocytes and in leukemic cells
31. A novel model of a metastatic human breast tumour xenograft line
32. Herpes simplex virus type 2-induced pyrimidine nucleoside kinase: Enzymatic basis for the selective antiherpetic effect of 5-halogenated analogs of deoxycytidine
33. Flow cytometric analysis of two incorporated halogenated thymidine analogs and DNA in mouse mammary tumor grown in vivo
34. Radiation, pool size, and incorporation studies in mice with 5-chloro-2′-deoxycytidine
35. 5-Chlorodeoxycytidine, a radiosensitizer effective against RIF-1 and Lewis lung carcinoma, is also effective against a DMBA-induced mammary adenocarcinoma and the EMT-6 tumor in BALB/c mice
36. Nucleotide interconversions. X. Deoxyribo- and ribonucleoside 5′-phosphate synthesis via a phosphotransferase reaction in chick embryo extracts
37. Incorporation of 5-substituted analogs of deoxycytidine into DNA of herpes simplex virus-infected or -transformed cells without deamination to the thymidine analog
38. Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity
39. Phosphorylation of 5-halogenated deoxycytidine analogs by deoxycytidine kinase
40. Preclinical toxicologic evaluation of tetrahydrouridine (NSC-112907) in beagle dogs and rhesus monkeys
41. Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA and target-directed therapy
42. The effect of inhibition of cytidine deaminase by tetrahydrouridine on the utilization of deoxycytidine and 5-bromodeoxycytidine for DNA synthesis
43. Thymidylate synthetase catalyzed dehalogenation of 5-bromo- and 5-iodo-2′-deoxyuridylate
44. 5-Benzylacyclouridine and benzyloxybenzyl-acyclouridine, potent inhibitors of uridine phosphorylase
45. Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro
46. Thymidylate synthetase: A target enzyme in cancer chemotherapy
47. The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine
48. Biochemical mechanisms by which reutilization of DNA 5-methylcytosine is prevented in human cells
49. Induction of a deoxycytidineless state in cultured mammalian cells by bromodeoxyuridine
50. DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells
51. Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2′-deoxyuridylates. Preliminary quantitative structure-activity relationship
52. Radio-induced changes in nucleotide metabolism of two colon cancer cell lines with different radiosensitivities
53. Deoxycytidine transport in the central nervous system