Recognition and incision of γ-radiation-induced cross-linked guanine-thymine tandem lesion G[8,5-Me]T by UvrABC nuclease

Chemical Research in Toxicology

Volumn 18, Issue 9, 2005, Pages 1339-1346

  Yang, Zhengguan ^a   Colis, Laureen C ^b   Basu, Ashis K ^b   Zou, Yue ^a  

^a East Tennessee State University   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DNA; EXCISION REPAIR PROTEIN UVRA; EXCISION REPAIR PROTEIN UVRB; EXCISION REPAIR PROTEIN UVRC; GUANINE DERIVATIVE; NUCLEASE; PYRIMIDINE DERIVATIVE; PYRIMIDINONE DERIVATIVE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARCINOGENICITY; CATALYSIS; COMPLEX FORMATION; COVALENT BOND; DNA DAMAGE; DNA STRAND; ENZYME ANALYSIS; ESCHERICHIA COLI; EXCISION REPAIR; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN CROSS LINKING; RADIATION INJURY; ULTRAVIOLET RADIATION;

BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; ENDODEOXYRIBONUCLEASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GAMMA RAYS; GUANINE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; SUBSTRATE SPECIFICITY; THYMINE;

ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA;

EID: 25444460601     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050147+     Document Type: Article

References (31)

1. Friedberg, E. C., Walker, G. C., and Siede, W. (1995) DNA Repair and Mutagenesis, ASM Press, Washington DC.
2. Huttermann, J., Kuhnlein, W., and Téoule, R. (1978) Effects of Ionizing Radiation on DNA. Physical, Chemical, and Biological Aspects, Springer-Verlag, Berlin.
3. Goodhead, D. T. (1994) Initial events in the cellular effects of ionizing radiation: Clustered damage in DNA. Int. J. Radiat. Biol. 65, 7-17.
4. Box, H. C., Patrzyc, H. B., Dawidzik, J. B., Wallace, J. C., Freund, H. G., Iijima, H., and Budzinski, E. E. (2000) Double base lesions in DNA X-irradiated in the presence or absence of oxygen. Radiat. Res. 153, 442-446.
5. Gu, C., and Wang, Y. (2004) LC-MS/MS Identification and yeast polymerase η bypass of a novel γ-irradiation-induced intrastrand cross-link lesion G[8-5]C. Biochemistry 43, 6745-6750.
6. Zhang, Q., and Wang, Y. (2003) Independent generation of 5-(2′-deoxycytidinyl)methyl radical and the formation of a novel cross-link lesion between 5-methylcytosine and guanine. J. Am. Chem. Soc. 125, 12795-12802.
7. Zhang, Q., and Wang, Y. (2004) Independent generation of the 5-hydroxy-5,6-dihydrothymidin-6-yl radical and its reactivity in dinucleoside monophosphates. J. Am. Chem. Soc. 126, 13287-13297.
8. Zhang, Q., and Wang, Y. (2005) Generation of 5-(2′-deoxycytidyl)- methyl radical and the formation of intrastrand cross-link lesions in oligodeoxyribonucleotides. Nucleic Acids Res. 33, 1593-1603.
9. Box, H. C., Dawidzik, J. B., and Budzinski, E. E. (2001) Free radical-induced double lesions in DNA. Free Radical Biol. Med. 31, 856-868.
10. Hazra, T., Izumi, T., Row, Y. W., and Mitra, S. (2003) The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications. Carcinogenesis 24, 155-157.
11. Brooks, P. J., Wise, D. S., Berry, D. A., Kosmoski, J. V., Smerdon, M. J., Somers, R. L., Mackie, H., Spoonde, A. Y., Ackerman, E. J., Coleman, K., Tarone, R. E., and Robbins, J. H. (2000) The oxidative DNA lesion 8,5′-(S)-cyclo-2′-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells. J. Biol. Chem. 275, 22355-22362.
12. Zou, Y., and Van Houten, B. (1999) Strand opening by the UvrA2B complex allows dynamic recognition of DNA damage. EMBO J. 18, 4889-4901.
13. Zou, Y., Luo, C., and Geacintov, N. E. (2001) Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair. Biochemistry 40, 2923-2931.
14. Theis, K., Chen, P. J., Skorvaga, M., Vna Houten, B., and Kisker, C. (1999) Crystal structure of UvrB, a DNA helicase adapted for nucleotide excision repair. EMBO J. 18, 6899-6907.
15. Skorvaga, M., Theis, K., Mandavilli, B. S., Kisker, C., and Van Houten, B. (2002) The beta-hairpin motif of UvrB is essential for DNA binding, damage processing, and UvrC-mediated incisions. J. Biol. Chem. 277, 1553-1559.
16. Van Houten, B., Eisen, J. A., and Hanawalt, P. C. (2002) A cut above: Discovery of an alternative excision repair pathway in bacteria. Proc. Natl. Acad. Sci. U.S.A. 99, 2581-2583.
17. Svoboda, D. L., Smith, C. A., Taylor, J.-S. A., and Sancar, A. (1993) Effect of sequence, adduct type, and opposing lesions on the binding and repair of ultraviolet photodamage by DNA photolyase and (A)BC excinuclease. J. Biol. Chem. 268, 10694-10700.
18. 2 positions of adjacent guanines. Biochemistry 41, 3109-3118.
19. Luo, C., Krishnasamy, R., Basu, A. K., and Zou, Y. (2000) Recognition and incision of site-specifically modified C8 guanine adducts formed by 2-aminofluorene, N-acetyl-2-aminofluorene and 1-nitropyrene by UvrABC nuclease. Nucleic Acids Res. 28, 3719-3724.
20. Liu, Y., Yang, Z., Utzat, C. D., Liu, Y., Geacintov, N. E., Basu, A. K., and Zou, Y. (2005) Interactions of human replication protein A with single-stranded DNA adducts. Biochem. J. 385, 519-526.
21. Zou, Y., Ma, H., Minko, I. G., Shell, S. M., Yang, Z., Qu, Y., Xu, Y., Geacintov, N. E., and Lloyd, R. S. (2004) DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair. Biochemistry 43, 4196-4205.
22. Romieu, A., Bellon, S., Gasparutto, D., and Cadet, J. (2000) Synthesis and UV photolysis of oligodeoxynucleotides that contain 5-(phenylthiomethyl)- 2′-deoxyuridine: A specific photolabile precursor of 5-(2′- deoxyuridilyl)methyl radical. Org. Lett. 2, 1085-1088.
23. Bellon, S., Ravanat, J.-L., Gasparutto, D., and Cadet, J. (2002) Cross-linked thymine-purine base tandem lesions: Synthesis, characterization, and measurement in γ-irradiated isolated DNA Chem. Res. Toxicol. 15, 598-606.
24. Zou, Y., Shell, S. M., Utzat, C. D., Luo, C, Yang, Z., Geacintov, N. E., and Basu, A. K. (2003)Effects of DNA adduct structure and sequence context on strand opening of repair intermediates and incision by UvrABC nuclease. Biochemistry 42, 12654-12661.
25. Delagoutte, E., Bertrand-Burggraf, E., Dunand, J., and Fuchs, R. P. P. (1997) Sequence-dependent modulation of nucleotide excision repair: The efficiency of the incision reaction is inversely correlated with the stability of the pre-incision UvrB-DNA complex. J. Mol. Biol. 266, 703-710.
26. Van Houten, B. (1990) Nucleotide excision repair in Escherichia coli. Microbiol. Rev. 54, 18-51.
27. Van Houten, B., and Snowden, A. (1993) Mechanism of action of the Escherichia coli UvrABC nuclease: Clues to the damage recognition problem. Bioessays 15, 51-59.
28. Gordienko, I., and Rupp, W. D. (1998) A specific 3′ exonuclease activity of UvrABC. EMBO J. 17, 626-633.
29. Moolenaar, G. F., Bazuine, M., van Knippenberg, I. C., Visse, R., and Goosen, N. (1998) Characterization of the Escherichia coli damage-independent UvrBC endonuclease activity. J. Biol. Chem. 273, 34896-34903.
30. Taylor, J.-S., Garrett, D. S., and Wang, M. J. (1988) Models for the solution state structure of the (6-4) photoproduct of thymidylyl- (3′→5′)-thymidine derived via a distance- and angle-constrained conformation search procedure. Biopolymers 27, 1571-1593.
31. 5(6-4) pyrimidone photoproducts. Implications on the design of new biologically relevant analogues. J. Org. Chem. 67, 9140-9145.