Advances in characterization of neuroprotective peptide, humanin

Current Medicinal Chemistry

Volumn 18, Issue 36, 2011, Pages 5554-5563

  Arakawa, T ^a   Hirano, A ^b   Shiraki, K ^b   Niikura, T ^c   Kita, Y ^d  

^a ALLIANCE PROTEIN LABORATORIES   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c SIMON FRASER UNIVERSITY   (Canada)

^d KEIO UNIVERSITY   (Japan)

Author keywords

Aggregation; Disordered structure; Humanin; Liposome; Neuroprotection; sheet

Indexed keywords

HUMANIN; LIPOSOME; NEUROPROTECTIVE AGENT; ZINC;

ARTICLE; BETA SHEET; BINDING KINETICS; CELL AGGREGATION; CIRCULAR DICHROISM; INCUBATION TEMPERATURE; METAL BINDING; MOLECULAR STABILITY; MUTATION RATE; NEUROPROTECTION; PROTEIN BINDING; PROTEIN STRUCTURE; SCANNING ELECTRON MICROSCOPY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TEMPERATURE SENSE;

EID: 84055189716     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711798347261     Document Type: Article

References (69)

1. Monien, B.H.; Apostolova, L.G.; Bitan, G. Early diagnostics and therapeutics for Alzheimer's disease-how early can we get there? Expert Rev Neurother, 2006, 6(9), 1293-1306. (Pubitemid 44580952)
2. Davies, P.; Maloney, A.J. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet, 1976, 2(8000), 1403. (Pubitemid 8004505)
3. Evans, D.A.; Funkenstein, H.H.; Albert, M.S.; Scherr, P.A.; Cook, N.R.; Chown, M.J.; Hebert, L.E.; Hennekens, C.H.; Taylor, J.O. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. Jama, 1989, 262(18), 2551-2556.
4. Thomsen, T.; Kewitz, H. Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo. Life Sci, 1990, 46(21), 1553-1558. (Pubitemid 20177958)
5. Sugimoto, H. Structure-activity relationship of acetylcholinesterase inhibitors: donepezil hydrochloride for treatment of Alzheimer's disease. Pure Appl. Chem., 1999, 71, 2031-2037.
6. Aisen, P.S. Amyloid-based therapeutics: findings translated into novel treatments. CNS Spectr, 2008, 13(10 Suppl 16), 36-38.
7. Schnabel, J. Amyloid: little proteins, big clues. Nature, 2011, 475(7355), S12-14.
8. Palmer, A.M. Neuroprotective therapeutics for Alzheimer's disease: progress and prospects. Trends Pharmacol Sci, 2011, 32(3), 141-147.
9. Hashimoto, Y.; Niikura, T.; Tajima, H.; Yasukawa, T.; Sudo, H.; Ito, Y.; Kita, Y.; Kawasumi, M.; Kouyama, K.; Doyu, M.; Sobue, G.; Koide, T.; Tsuji, S.; Lang, J.; Kurokawa, K.; Nishimoto, I. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A, 2001, 98(11), 6336-6341. (Pubitemid 32488239)
10. Hashimoto, Y.; Ito, Y.; Niikura, T.; Shao, Z.; Hata, M.; Oyama, F.; Nishimoto, I. Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein. Biochem Biophys Res Commun, 2001, 283(2), 460-468. (Pubitemid 32924714)
11. Hashimoto, Y.; Niikura, T.; Ito, Y.; Sudo, H.; Hata, M.; Arakawa, E.; Abe, Y.; Kita, Y.; Nishimoto, I. Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. J Neurosci, 2001, 21(23), 9235-9245. (Pubitemid 33096867)
12. Mamiya, T.; Ukai, M. [Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo. Br J Pharmacol, 2001, 134(8), 1597-1599. (Pubitemid 34038091)
13. Kariya, S.; Takahashi, N.; Ooba, N.; Kawahara, M.; Nakayama, H.; Ueno, S. Humanin inhibits cell death of serum-deprived PC12h cells. Neuroreport, 2002, 13(6), 903-907. (Pubitemid 34492924)
14. Niikura, T. Humanin, a potential peptide for neuroprotective therapy against Alzheimer's disease. Expert Opinion on Drug Discovery, 2007, 2, 1273-1282. (Pubitemid 47496484)
15. Corsaro, A.; Thellung, S.; Villa, V.; Principe, D.R.; Paludi, D.; Arena, S.; Millo, E.; Schettini, D.; Damonte, G.; Aceto, A.; Schettini, G.; Florio, T. Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation. Ann N Y Acad Sci, 2003, 1010, 610-622. (Pubitemid 38265055)
16. Guo, B.; Zhai, D.; Cabezas, E.; Welsh, K.; Nouraini, S.; Satterthwait, A.C.; Reed, J.C. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature, 2003, 423(6938), 456-461. (Pubitemid 36626999)
17. Ikonen, M.; Liu, B.; Hashimoto, Y.; Ma, L.; Lee, K.W.; Niikura, T.; Nishimoto, I.; Cohen, P. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A, 2003, 100(22), 13042-13047. (Pubitemid 37340022)
18. Jung, S.S.; Van Nostrand, W.E. Humanin rescues human cerebrovascular smooth muscle cells from Abeta-induced toxicity. J Neurochem, 2003, 84(2), 266-272. (Pubitemid 36182268)
19. Kariya, S.; Hirano, M.; Furiya, Y.; Sugie, K.; Ueno, S. Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent. Acta Neuropathol, 2005, 109(4), 367-372. (Pubitemid 40637308)
20. Tajima, H.; Kawasumi, M.; Chiba, T.; Yamada, M.; Yamashita, K.; Nawa, M.; Kita, Y.; Kouyama, K.; Aiso, S.; Matsuoka, M.; Niikura, T.; Nishimoto, I. A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice. J Neurosci Res, 2005, 79(5), 714-723. (Pubitemid 40476451)
21. Xu, X.; Chua, C.C.; Gao, J.; Chua, K.W.; Wang, H.; Hamdy, R.C.; Chua, B.H. Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res, 2008, 1227, 12-18.
22. Muzumdar, R.H.; Huffman, D.M.; Atzmon, G.; Buettner, C.; Cobb, L.J.; Fishman, S.; Budagov, T.; Cui, L.; Einstein, F.H.; Poduval, A.; Hwang, D.; Barzilai, N.; Cohen, P. Humanin: a novel central regulator of peripheral insulin action. PLoS One, 2009, 4(7), e6334.
23. Hoang, P.T.; Park, P.; Cobb, L.J.; Paharkova-Vatchkova, V.; Hakimi, M.; Cohen, P.; Lee, K.W. The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism: clinical and experimental, 2010, 59(3), 343-349.
24. Niikura, T.; Sidahmed, E.; Hirata-Fukae, C.; Aisen, P.S.; Matsuoka, Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS One, 2011, 6(1), e16259.
25. Oh, Y.K.; Bachar, A.R.; Zacharias, D.G.; Kim, S.G.; Wan, J.; Cobb, L.J.; Lerman, L.O.; Cohen, P.; Lerman, A. Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis, 2011.
26. Xu, X.; Chua, C.C.; Gao, J.; Hamdy, R.C.; Chua, B.H. Humanin is a novel neuroprotective agent against stroke. Stroke, 2006, 37(10), 2613-2619. (Pubitemid 44454687)
27. Bodzioch, M.; Lapicka-Bodzioch, K.; Zapala, B.; Kamysz, W.; Kiec-Wilk, B.; Dembinska-Kiec, A. Evidence for potential functionality of nuclearlyencoded humanin isoforms. Genomics, 2009, 94(4), 247-256.
28. Caricasole, A.; Bruno, V.; Cappuccio, I.; Melchiorri, D.; Copani, A.; Nicoletti, F. A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity. FASEB J, 2002, 16(10), 1331-1333.
29. Tajima, H.; Niikura, T.; Hashimoto, Y.; Ito, Y.; Kita, Y.; Terashita, K.; Yamazaki, K.; Koto, A.; Aiso, S.; Nishimoto, I. Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Neurosci Lett, 2002, 324(3), 227-231. (Pubitemid 34493875)
30. Colon, E.; Strand, M.L.; Carlsson-Skwirut, C.; Wahlgren, A.; Svechnikov, K.V.; Cohen, P.; Soder, O. Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis. J Cell Physiol, 2006, 208(2), 373-385. (Pubitemid 43993428)
31. Niikura, T.; Hashimoto, Y.; Tajima, H.; Ishizaka, M.; Yamagishi, Y.; Kawasumi, M.; Nawa, M.; Terashita, K.; Aiso, S.; Nishimoto, I. A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Eur J Neurosci, 2003, 17(6), 1150-1158. (Pubitemid 36459769)
32. Rossini, L.; Hashimoto, Y.; Suzuki, H.; Kurita, M.; Gianfriddo, M.; Scali, C.; Roncarati, R.; Franceschini, D.; Pollio, G.; Trabalzini, L.; Terstappen, G.C.; Matsuoka, M.; Caricasole, A. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin. FASEB J, 2011, 25(6), 1983-2000.
33. Hashimoto, Y.; Suzuki, H.; Aiso, S.; Niikura, T.; Nishimoto, I.; Matsuoka, M. Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection. Life Sci, 2005, 77(24), 3092-3104. (Pubitemid 41423745)
34. Harada, M.; Habata, Y.; Hosoya, M.; Nishi, K.; Fujii, R.; Kobayashi, M.; Hinuma, S. N-Formylated humanin activates both formyl peptide receptorlike 1 and 2. Biochem Biophys Res Commun, 2004, 324(1), 255-261. (Pubitemid 39311487)
35. Ying, G.; Iribarren, P.; Zhou, Y.; Gong, W.; Zhang, N.; Yu, Z.X.; Le, Y.; Cui, Y.; Wang, J.M. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J Immunol, 2004, 172(11), 7078-7085. (Pubitemid 38669150)
36. Hashimoto, Y.; Kurita, M.; Aiso, S.; Nishimoto, I.; Matsuoka, M. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. Mol Biol Cell, 2009, 20(12), 2864-2873.
37. Wang, D.; Li, H.; Yuan, H.; Zheng, M.; Bai, C.; Chen, L.; Pei, X. Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase. Apoptosis, 2005, 10(5), 963-971. (Pubitemid 41285576)
38. Zhai, D.; Luciano, F.; Zhu, X.; Guo, B.; Satterthwait, A.C.; Reed, J.C. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J Biol Chem, 2005, 280(16), 15815-15824. (Pubitemid 40616702)
39. Luciano, F.; Zhai, D.; Zhu, X.; Bailly-Maitre, B.; Ricci, J.E.; Satterthwait, A.C.; Reed, J.C. Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. J Biol Chem, 2005, 280(16), 15825-15835. (Pubitemid 40616703)
40. Zou, P.; Ding, Y.; Sha, Y.; Hu, B.; Nie, S. Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Abeta(1-40). Peptides, 2003, 24(5), 679-685. (Pubitemid 36929997)
41. Armas, A.; Sonois, V.; Mothes, E.; Mazarguil, H.; Faller, P. Zinc(II) binds to the neuroprotective peptide humanin. J Inorg Biochem, 2006, 100(10), 1672-1678. (Pubitemid 44332529)
42. Arakawa, T.; Kita, Y.; Niikura, T. A rescue factor for Alzheimer's diseases: discovery, activity, structure, and mechanism. Curr Med Chem, 2008, 15(21), 2086-2098.
43. Arakawa, T.; Niikura, T.; Tajima, H.; Kita, Y. The secondary structure analysis of a potent Ser14Gly analog of antiAlzheimer peptide, Humanin, by circular dichroism. J Pept Sci, 2006, 12(10), 639-642. (Pubitemid 44574892)
44. Arisaka, F.; Arakawa, T.; Niikura, T.; Kita, Y. Active form of neuroprotective Humanin, HN, and inactive analog, S7A-HN, are monomeric and disordered in aqueous phosphate solution at pH 6.0; No correlation of solution structure with activity. Protein Pept Lett, 2009, 16(2), 132-137.
45. Kita, Y.; Niikura, T.; Arisaka, F.; Arakawa, T. The complex structure transition of Humanin peptides by sodium dodecylsulfate and trifluoroethanol. Protein Pept Lett, 2008, 15(5), 510-515. (Pubitemid 351872471)
46. Arakawa, T.; Niikura, T.; Kita, Y. The biological activity of Humanin analogs correlates with structure stabilities in solution. Int J Biol Macromol, 2011, 49(1), 93-97.
47. Hirano, A.; Shiraki, K.; Niikura, T.; Arakawa, T.; Kita, Y. Structure changes of natively disordered Humanin in the presence of lipid. Int J Biol Macromol, 2010, 46(3), 375-379.
48. Hirano, A.; Shiraki, K.; Niikura, T.; Arakawa, T.; Kita, Y. Structure of three Humanin peptides with different activities upon interaction with liposome. Int J Biol Macromol, 2011, 48(2), 360-363.
49. Arisaka, F.; Niikura, T.; Arakawa, T.; Kita, Y. The structure analysis of Humanin analog, AGA-(C8R)HNG17, by circular dichroism and sedimentation equilibrium: Comparison with the parent molecule. Int J Biol Macromol, 2008, 43(2), 88-93.
50. Hirano, A.; Shiraki, K.; Niikura, T.; Arakawa, T.; Kita, Y. Structure of three Humanin peptides with different activities upon interaction with liposome. Int J Biol Macromol, 2011, 48(2), 360-363.
51. Benaki, D.; Zikos, C.; Evangelou, A.; Livaniou, E.; Vlassi, M.; Mikros, E.; Pelecanou, M. Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity. Biochem Biophys Res Commun, 2005, 329(1), 152-160. (Pubitemid 40255434)
52. Benaki, D.; Zikos, C.; Evangelou, A.; Livaniou, E.; Vlassi, M.; Mikros, E.; Pelecanou, M. Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease. Biochem Biophys Res Commun, 2006, 349(2), 634-642. (Pubitemid 44363058)
53. Deschamps, J.R.; George, C.; Flippen-Anderson, J.L. Structural studies of opioid peptides: a review of recent progress in x-ray diffraction studies. Biopolymers, 1996, 40(1), 121-139.
54. Kaiser, E.T.; Kezdy, F.J. Secondary structures of proteins and peptides in amphiphilic environments. (A review). Proc Natl Acad Sci U S A, 1983, 80(4), 1137-1143. (Pubitemid 13135810)
55. Schwyzer, R. Peptide-membrane interactions and a new principle in quantitative structure-activity relationships. Biopolymers, 1991, 31(6), 785-792.
56. Schwyzer, R. 100 years lock-and-key concept: are peptide keys shaped and guided to their receptors by the target cell membrane? Biopolymers, 1995, 37(1), 5-16.
57. Pistolesi, S.; Rossini, L.; Ferro, E.; Basosi, R.; Trabalzini, L.; Pogni, R. Humanin structural versatility and interaction with model cerebral cortex membranes. Biochemistry, 2009, 48(22), 5026-5033.
58. Yamagishi, Y.; Hashimoto, Y.; Niikura, T.; Nishimoto, I. Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults. Peptides, 2003, 24(4), 585-595. (Pubitemid 36829348)
59. Ying, G.; Iribarren, P.; Zhou, Y.; Gong, W.; Zhang, N.; Yu, Z.X.; Le, Y.; Cui, Y.; Wang, J.M. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J immunol, 2004, 172(11), 7078-7085. (Pubitemid 38669150)
60. Le, Y.; Gong, W.; Tiffany, H.L.; Tumanov, A.; Nedospasov, S.; Shen, W.; Dunlop, N.M.; Gao, J.L.; Murphy, P.M.; Oppenheim, J.J.; Wang, J.M. Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1. J Neurosci, 2001, 21(2), RC123.
61. Harada, M.; Habata, Y.; Hosoya, M.; Nishi, K.; Fujii, R.; Kobayashi, M.; Hinuma, S. N-Formylated humanin activates both formyl peptide receptorlike 1 and 2. Biochem Biophys Res Commun, 2004, 324(1), 255-261. (Pubitemid 39311487)
62. Tashima, Y.; Oe, R.; Lee, S.; Sugihara, G.; Chambers, E.J.; Takahashi, M.; Yamada, T. The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids. J Biol Chem, 2004, 279(17), 17587-17595. (Pubitemid 38560523)
63. Wank, S.A. G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family. Am J Physiol, 1998, 274(4 Pt 1), G607-613.
64. Ohki-Hamazaki, H. Neuromedin B. Progress in neurobiology, 2000, 62(3), 297-312. (Pubitemid 30326778)
65. Blomqvist, A.G.; Herzog, H. Y-receptor subtypes-how many more? Trends Neurosci, 1997, 20(7), 294-298.
66. Sankararamakrishnan, R. Recognition of GPCRs by peptide ligands and membrane compartments theory: structural studies of endogenous peptide hormones in membrane environment. Bioscience reports, 2006, 26(2), 131-158. (Pubitemid 43958797)
67. Chalifour, R.J.; McLaughlin, R.W.; Lavoie, L.; Morissette, C.; Tremblay, N.; Boule, M.; Sarazin, P.; Stea, D.; Lacombe, D.; Tremblay, P.; Gervais, F. Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide. J Biol Chem, 2003, 278(37), 34874-34881. (Pubitemid 37102246)
68. Zheng, J.; Liu, C.; Sawaya, M.R.; Vadla, B.; Khan, S.; Woods, R.J.; Eisenberg, D.; Goux, W.J.; Nowick, J.S. Macrocyclic beta-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc, 2011, 133(9), 3144-3157.
69. Sponne, I.; Fifre, A.; Koziel, V.; Kriem, B.; Oster, T.; Pillot, T. Humanin rescues cortical neurons from prion-peptide-induced apoptosis. Mol Cell Neurosci, 2004, 25(1), 95-102. (Pubitemid 38220867)