Active form of neuroprotective humanin, HN, and inactive analog, S7A-HN, are monomeric and disordered in aqueous phosphate solution at pH 6.0; no correlation of solution structure with activity

Protein and Peptide Letters

Volumn 16, Issue 2, 2009, Pages 132-137

  Arisaka, Fumio ^a   Arakawa, Tsutomu ^b   Niikura, Takako ^c   Kita, Yoshiko ^d  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b ALLIANCE PROTEIN LABORATORIES   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KEIO UNIVERSITY   (Japan)

Author keywords

Aggregation; Disordered structure; Humanin; Inactive humanin; Neuroprotection

Indexed keywords

HUMANIN; NEUROPROTECTIVE AGENT; PHOSPHATE; SIGNAL PEPTIDE;

ANIMAL; ARTICLE; CELL SURVIVAL; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECT; MOUSE; NERVE CELL; PH; PROTEIN MULTIMERIZATION; STRUCTURE ACTIVITY RELATION; ULTRACENTRIFUGATION;

ANIMALS; CELL SURVIVAL; CIRCULAR DICHROISM; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHATES; PROTEIN MULTIMERIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; ULTRACENTRIFUGATION;

EID: 63449089439     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986609787316225     Document Type: Article

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