Humanin rescues human cerebrovascular smooth muscle cells from Aβ-induced toxicity

Journal of Neurochemistry

Volumn 84, Issue 2, 2003, Pages 266-272

  Jung, Sonia S ^a   Van Nostrand, William E ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Amyloid beta precursor protein; Amyloid beta protein; Cell death; Human cerebrovascular smooth muscle cells; Novel rescue factor

Indexed keywords

ALPHA ACTIN; AMYLOID BETA PROTEIN; BRAIN PROTEIN; HUMANIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD VESSEL; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL SURFACE; CELL VIABILITY; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; CULTURE MEDIUM; FIBER; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SMOOTH MUSCLE FIBER;

ACTINS; ADULT; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; CELL DEATH; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CEREBROVASCULAR CIRCULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MENINGES; MUSCLE, SMOOTH, VASCULAR; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037262465     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01524.x     Document Type: Article

References (22)

1. Barger S. W., Horster D., Furukawa K., Goodman Y., Krieglstein J. and Mattson M. P. (1995) Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. Proc. Natl Acad. Sci. USA 9, 9328-9332.
2. Brenneman D. E. and Gozes I. (1996) A femtomolar-acting neuroprotective peptide. J. Clin. Invest. 97, 2299-2307.
3. Brenneman D. E., Hauser J., Neale E., Rubinraut S., Fridkin M., Davidson A. and Gozes I. (1998) Activity-dependent neurotrophic factor: structure-activity relationships of femtomolar-acting peptides. J. Pharmacol. Exp. Ther. 285, 619-627.
4. Davis J., Cribbs D. H., Cotman C. W. and Van Nostrand W. E. (1999) Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells. Amyloid 6, 157-164.
5. Davis-Salinas J., Saporito-Irwin S. M., Cotman C. W. and Van Nostrand W. E. (1995) Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J. Neurochem. 65, 931-934.
6. Dore S., Kar S. and Quirion R. (1997) Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid-and human amylin-induced toxicity. Proc. Natl Acad. Sci. USA 94, 4772-4777.
7. Glazner G. W., Boland A., Dresse A. E., Brenneman D. E., Gozes I. and Mattson M. P. (1999) Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death. J. Neurochem. 73, 2341-2347.
8. Hashimoto Y., Niikura T., Yuko I. and Nishimoto I. (2000) Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein. J. Biol. Chem. 275, 34541-34551.
9. Hashimoto Y., Ito Y., Niikura T., Shao Z., Hata M., Oyama F. and Nishimoto I. (2001a) Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein. Biochem. Biophys. Res. Commun. 283, 460-468.
10. Hashimoto Y., Niikura T., Tajima H., Yasukawa T., Sudo H., Ito Y., Kita Y., Kawasumi M., Kouyama K., Doyu M., Sobue G., Koide T., Tsuji S., Lang J., Kurokawa K. and Nishimoto I. (2001b) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc. Natl Acad. Sci. USA 98, 6336-6341.
11. Hashimoto Y., Niikura T., Ito Y., Sudo H., Hata M., Arakawa E., Abe Y., Kita Y. and Nishimoto I. (2002) Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. J. Neurosci. 21, 9235-9245.
12. Jung S. S. and Van Nostrand W. E. (2002) Aβ does not induce oxidative stress in human cerebrovascular smooth muscle cells. Neuroreport 13, 1-4.
13. Kariya S., Takahashi N., Ooba N., Kawahara M., Nakayama H. and Ueno S. (2002) Humanin inhibits cell death of serum-deprived PC12h cells. Neuroreport 13, 903-907.
14. Kawai M., Kalaria R. N., Cras P., Siedlak S. L., Velasco M. E., Shelton E. R., Chan H. W., Greenberg B. D. and Perry G. (1993) Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res. 623, 142-146.
15. Kayalar C., Ord R., Testa M. P., Zhong L.-T. and Bredesen D. E. (1996) Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition. Proc. Natl Acad. Sci. USA 93, 2234-2238.
16. Mark R. J., Keller J. N., Kruman I. and Mattson M. P. (1997) Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons. Brain Res. 756, 205-214.
17. Mashima T., Naito N., Fujita N., Noguchi K. and Tsuruo T. (1995) Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis. Biochem. Biophys. Res. Commun. 217, 1185-1192.
18. Melchor J. P. and Van Nostrand W. E. (2000) Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells. J. Biol. Chem. 275, 9782-9791.
19. Rozemuller A. J., Roos R. A., Bots G. T., Kamphorst W., Eikelenboom P. and Van Nostrand W. E. (1993) Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease. Am. J. Pathol. 142, 1449-1457.
20. Van Nostrand W. E., Melchor J. P. and Ruffini L. (1998) Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells. J. Neurochem. 70, 216-223.
21. Van Nostrand W. E., Rozemuller A. J., Chung R., Cotman C. W. and Saporito-Irwin S. M. (1994) Amyloid beta-protein precursor in cultured leptomeningeal smooth muscle cells. Amyloid 1, 1-7.
22. Vinters H. V. (1987) Cerebral amyloid angiopathy. A critical review. Stroke 18, 311-324.