-
1
-
-
0035282458
-
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
-
10.1038/35065138, 11242054
-
Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 2001, 410:120-124. 10.1038/35065138, 11242054.
-
(2001)
Nature
, vol.410
, pp. 120-124
-
-
Bannister, A.J.1
Zegerman, P.2
Partridge, J.F.3
Miska, E.A.4
Thomas, J.O.5
Allshire, R.C.6
Kouzarides, T.7
-
2
-
-
0035282573
-
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
-
10.1038/35065132, 11242053
-
Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001, 410:116-120. 10.1038/35065132, 11242053.
-
(2001)
Nature
, vol.410
, pp. 116-120
-
-
Lachner, M.1
O'Carroll, D.2
Rea, S.3
Mechtler, K.4
Jenuwein, T.5
-
3
-
-
56149098200
-
Linking Heterochromatin protein 1 (HP1) to cancer progression.
-
10.1016/j.mrfmmm.2008.09.007, 2637788, 18926834
-
Dialynas GK, Vitalini MW, Wallrath LL. Linking Heterochromatin protein 1 (HP1) to cancer progression. Mutat Res 2008, 647:13-20. 10.1016/j.mrfmmm.2008.09.007, 2637788, 18926834.
-
(2008)
Mutat Res
, vol.647
, pp. 13-20
-
-
Dialynas, G.K.1
Vitalini, M.W.2
Wallrath, L.L.3
-
4
-
-
16644385308
-
Kinetochore and heterochromatin domains of the fission yeast centromere.
-
Pidoux AL, Allshire RC. Kinetochore and heterochromatin domains of the fission yeast centromere. Chromosome Res 2004, 12:521-534.
-
(2004)
Chromosome Res
, vol.12
, pp. 521-534
-
-
Pidoux, A.L.1
Allshire, R.C.2
-
5
-
-
34047231261
-
High-resolution mapping reveals links of HP1 with active and inactive chromatin components.
-
10.1371/journal.pgen.0030038, 1808074, 17335352
-
de Wit E, Greil F, van Steensel B. High-resolution mapping reveals links of HP1 with active and inactive chromatin components. PLoS Genet 2007, 3:e38. 10.1371/journal.pgen.0030038, 1808074, 17335352.
-
(2007)
PLoS Genet
, vol.3
-
-
de Wit, E.1
Greil, F.2
van Steensel, B.3
-
6
-
-
0037059081
-
Does heterochromatin protein 1 always follow code?
-
139909, 12151603
-
Li Y, Kirschmann DA, Wallrath LL. Does heterochromatin protein 1 always follow code?. Proc Natl Acad Sci USA 2002, 99(Suppl 4):16462-16469. 139909, 12151603.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.SUPPL. 4
, pp. 16462-16469
-
-
Li, Y.1
Kirschmann, D.A.2
Wallrath, L.L.3
-
7
-
-
33644850958
-
Heterochromatin protein 1: don't judge the book by its cover!
-
10.1016/j.gde.2006.02.013, 16503133
-
Hediger F, Gasser SM. Heterochromatin protein 1: don't judge the book by its cover!. Curr Opin Genet Dev 2006, 16:143-150. 10.1016/j.gde.2006.02.013, 16503133.
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 143-150
-
-
Hediger, F.1
Gasser, S.M.2
-
8
-
-
56849114113
-
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.
-
10.1016/j.molcel.2008.11.008, 2642969, 19061644
-
Lin CH, Li B, Swanson S, Zhang Y, Florens L, Washburn MP, Abmayr SM, Workman JL. Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol Cell 2008, 32:696-706. 10.1016/j.molcel.2008.11.008, 2642969, 19061644.
-
(2008)
Mol Cell
, vol.32
, pp. 696-706
-
-
Lin, C.H.1
Li, B.2
Swanson, S.3
Zhang, Y.4
Florens, L.5
Washburn, M.P.6
Abmayr, S.M.7
Workman, J.L.8
-
9
-
-
55749105905
-
Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression.
-
10.1101/gad.481408, 2577788, 18981478
-
Font-Burgada J, Rossell D, Auer H, Azorin F. Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression. Genes Dev 2008, 22:3007-3023. 10.1101/gad.481408, 2577788, 18981478.
-
(2008)
Genes Dev
, vol.22
, pp. 3007-3023
-
-
Font-Burgada, J.1
Rossell, D.2
Auer, H.3
Azorin, F.4
-
10
-
-
73449102588
-
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila.
-
10.1371/journal.pgen.1000670, 2743825, 19798443
-
Piacentini L, Fanti L, Negri R, Del Vescovo V, Fatica A, Altieri F, Pimpinelli S. Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. PLoS Genet 2009, 5:e1000670. 10.1371/journal.pgen.1000670, 2743825, 19798443.
-
(2009)
PLoS Genet
, vol.5
-
-
Piacentini, L.1
Fanti, L.2
Negri, R.3
Del Vescovo, V.4
Fatica, A.5
Altieri, F.6
Pimpinelli, S.7
-
11
-
-
77957662160
-
Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II.
-
Kwon SH, Florens L, Swanson SK, Washburn MP, Abmayr SM, Workman JL. Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. Genes Dev 24:2133-2145.
-
Genes Dev
, vol.24
, pp. 2133-2145
-
-
Kwon, S.H.1
Florens, L.2
Swanson, S.K.3
Washburn, M.P.4
Abmayr, S.M.5
Workman, J.L.6
-
12
-
-
0037052539
-
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
-
10.1126/science.1069861, 12004135
-
Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 2002, 296:1132-1136. 10.1126/science.1069861, 12004135.
-
(2002)
Science
, vol.296
, pp. 1132-1136
-
-
Ogawa, H.1
Ishiguro, K.2
Gaubatz, S.3
Livingston, D.M.4
Nakatani, Y.5
-
13
-
-
23044431656
-
Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin.
-
10.1016/j.molcel.2005.06.011, 16061184
-
Vakoc CR, Mandat SA, Olenchock BA, Blobel GA. Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell 2005, 19:381-391. 10.1016/j.molcel.2005.06.011, 16061184.
-
(2005)
Mol Cell
, vol.19
, pp. 381-391
-
-
Vakoc, C.R.1
Mandat, S.A.2
Olenchock, B.A.3
Blobel, G.A.4
-
14
-
-
79952364016
-
Histone H3 lysine 9 trimethylation and HP1 gamma favor inclusion of alternative exons.
-
10.1038/nsmb.1995, 21358630
-
Saint-Andre V, Batsche E, Rachez C, Muchardt C. Histone H3 lysine 9 trimethylation and HP1 gamma favor inclusion of alternative exons. Nat Struct Mol Biol 2011, 18:337-U127. 10.1038/nsmb.1995, 21358630.
-
(2011)
Nat Struct Mol Biol
, vol.18
-
-
Saint-Andre, V.1
Batsche, E.2
Rachez, C.3
Muchardt, C.4
-
15
-
-
0028947197
-
Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos.
-
Kellum R, Alberts BM. Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos. J Cell Sci 1995, 108:1419-1431.
-
(1995)
J Cell Sci
, vol.108
, pp. 1419-1431
-
-
Kellum, R.1
Alberts, B.M.2
-
16
-
-
28444497751
-
Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription.
-
10.1038/ng1662, 16258543
-
Liu LP, Ni JQ, Shi YD, Oakeley EJ, Sun FL. Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Nat Genet 2005, 37:1361-1366. 10.1038/ng1662, 16258543.
-
(2005)
Nat Genet
, vol.37
, pp. 1361-1366
-
-
Liu, L.P.1
Ni, J.Q.2
Shi, Y.D.3
Oakeley, E.J.4
Sun, F.L.5
-
17
-
-
34548799689
-
MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation.
-
10.1093/nar/gkm599, 2018631, 17698499
-
Agarwal N, Hardt T, Brero A, Nowak D, Rothbauer U, Becker A, Leonhardt H, Cardoso MC. MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation. Nucleic Acids Res 2007, 35:5402-5408. 10.1093/nar/gkm599, 2018631, 17698499.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 5402-5408
-
-
Agarwal, N.1
Hardt, T.2
Brero, A.3
Nowak, D.4
Rothbauer, U.5
Becker, A.6
Leonhardt, H.7
Cardoso, M.C.8
-
18
-
-
58249120513
-
Heterochromatin protein 1gamma epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers.
-
10.2353/ajpath.2009.080148, 2631343, 19056850
-
Takanashi M, Oikawa K, Fujita K, Kudo M, Kinoshita M, Kuroda M. Heterochromatin protein 1gamma epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers. Am J Pathol 2009, 174:309-316. 10.2353/ajpath.2009.080148, 2631343, 19056850.
-
(2009)
Am J Pathol
, vol.174
, pp. 309-316
-
-
Takanashi, M.1
Oikawa, K.2
Fujita, K.3
Kudo, M.4
Kinoshita, M.5
Kuroda, M.6
-
19
-
-
34547731900
-
Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation.
-
10.1111/j.1432-0436.2007.00166.x, 17381543
-
Cammas F, Janoshazi A, Lerouge T, Losson R. Dynamic and selective interactions of the transcriptional corepressor TIF1 beta with the heterochromatin protein HP1 isotypes during cell differentiation. Differentiation 2007, 75:627-637. 10.1111/j.1432-0436.2007.00166.x, 17381543.
-
(2007)
Differentiation
, vol.75
, pp. 627-637
-
-
Cammas, F.1
Janoshazi, A.2
Lerouge, T.3
Losson, R.4
-
20
-
-
34547751335
-
HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation.
-
10.1038/sj.emboj.7601789, 1949014, 17627279
-
Panteleeva I, Boutillier S, See V, Spiller DG, Rouaux C, Almouzni G, Bailly D, Maison C, Lai HC, Loeffler JP, Boutillier AL. HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation. EMBO J 2007, 26:3616-3628. 10.1038/sj.emboj.7601789, 1949014, 17627279.
-
(2007)
EMBO J
, vol.26
, pp. 3616-3628
-
-
Panteleeva, I.1
Boutillier, S.2
See, V.3
Spiller, D.G.4
Rouaux, C.5
Almouzni, G.6
Bailly, D.7
Maison, C.8
Lai, H.C.9
Loeffler, J.P.10
Boutillier, A.L.11
-
21
-
-
35648992959
-
Variant-specific patterns and humoral regulation of HP1 proteins in human cells and tissues.
-
10.1242/jcs.012955, 17855381
-
Ritou E, Bai M, Georgatos SD. Variant-specific patterns and humoral regulation of HP1 proteins in human cells and tissues. J Cell Sci 2007, 120:3425-3435. 10.1242/jcs.012955, 17855381.
-
(2007)
J Cell Sci
, vol.120
, pp. 3425-3435
-
-
Ritou, E.1
Bai, M.2
Georgatos, S.D.3
-
22
-
-
0036204113
-
A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development.
-
10.1093/embo-reports/kvf051, 1084015, 11850401
-
Couteau F, Guerry F, Muller F, Palladino F. A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development. EMBO Rep 2002, 3:235-241. 10.1093/embo-reports/kvf051, 1084015, 11850401.
-
(2002)
EMBO Rep
, vol.3
, pp. 235-241
-
-
Couteau, F.1
Guerry, F.2
Muller, F.3
Palladino, F.4
-
23
-
-
33748440342
-
The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.
-
10.1016/j.ydbio.2006.04.474, 16890929
-
Coustham V, Bedet C, Monier K, Schott S, Karali M, Palladino F. The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development. Dev Biol 2006, 297:308-322. 10.1016/j.ydbio.2006.04.474, 16890929.
-
(2006)
Dev Biol
, vol.297
, pp. 308-322
-
-
Coustham, V.1
Bedet, C.2
Monier, K.3
Schott, S.4
Karali, M.5
Palladino, F.6
-
24
-
-
33748782790
-
Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.
-
10.1016/j.ydbio.2006.06.039, 16905130
-
Schott S, Coustham V, Simonet T, Bedet C, Palladino F. Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development. Dev Biol 2006, 298:176-187. 10.1016/j.ydbio.2006.06.039, 16905130.
-
(2006)
Dev Biol
, vol.298
, pp. 176-187
-
-
Schott, S.1
Coustham, V.2
Simonet, T.3
Bedet, C.4
Palladino, F.5
-
25
-
-
80755136621
-
Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.
-
Yuen KW, Nabeshima K, Oegema K, Desai A. Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos. Curr Biol 2011, 211:1800-1807.
-
(2011)
Curr Biol
, vol.211
, pp. 1800-1807
-
-
Yuen, K.W.1
Nabeshima, K.2
Oegema, K.3
Desai, A.4
-
26
-
-
62449305379
-
HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.
-
2644966, 19064713
-
Schott S, Ramos F, Coustham V, Palladino F. HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells. Genetics 2009, 181:797-801. 2644966, 19064713.
-
(2009)
Genetics
, vol.181
, pp. 797-801
-
-
Schott, S.1
Ramos, F.2
Coustham, V.3
Palladino, F.4
-
27
-
-
67649491263
-
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
-
10.1038/nature08106, 2716045, 19506556
-
Curran SP, Wu X, Riedel CG, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 2009, 459:1079-1084. 10.1038/nature08106, 2716045, 19506556.
-
(2009)
Nature
, vol.459
, pp. 1079-1084
-
-
Curran, S.P.1
Wu, X.2
Riedel, C.G.3
Ruvkun, G.4
-
28
-
-
79955158646
-
SynMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival.
-
10.1242/dev.059501, 21343362
-
Petrella LN, Wang W, Spike CA, Rechtsteiner A, Reinke V, Strome S. synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival. Development 2011, 138:1069-1079. 10.1242/dev.059501, 21343362.
-
(2011)
Development
, vol.138
, pp. 1069-1079
-
-
Petrella, L.N.1
Wang, W.2
Spike, C.A.3
Rechtsteiner, A.4
Reinke, V.5
Strome, S.6
-
29
-
-
84857922665
-
ModENCODE
-
modENCODE. , http://www.modENCODE.org
-
-
-
-
30
-
-
50049116926
-
C. elegans dauer formation and the molecular basis of plasticity.
-
10.1101/gad.1701508, 2735354, 18708575
-
Fielenbach N, Antebi A. C. elegans dauer formation and the molecular basis of plasticity. Genes Dev 2008, 22:2149-2165. 10.1101/gad.1701508, 2735354, 18708575.
-
(2008)
Genes Dev
, vol.22
, pp. 2149-2165
-
-
Fielenbach, N.1
Antebi, A.2
-
31
-
-
14644392176
-
Role of Drosophila HP1 in euchromatic gene expression.
-
10.1002/dvdy.20310, 15704177
-
Cryderman DE, Grade SK, Li Y, Fanti L, Pimpinelli S, Wallrath LL. Role of Drosophila HP1 in euchromatic gene expression. Dev Dyn 2005, 232:767-774. 10.1002/dvdy.20310, 15704177.
-
(2005)
Dev Dyn
, vol.232
, pp. 767-774
-
-
Cryderman, D.E.1
Grade, S.K.2
Li, Y.3
Fanti, L.4
Pimpinelli, S.5
Wallrath, L.L.6
-
32
-
-
77957739239
-
Positive regulation of euchromatic gene expression by HP1.
-
Piacentini L, Pimpinelli S. Positive regulation of euchromatic gene expression by HP1. Fly (Austin) 2010, 4:299-301.
-
(2010)
Fly (Austin)
, vol.4
, pp. 299-301
-
-
Piacentini, L.1
Pimpinelli, S.2
-
33
-
-
23144462374
-
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.
-
10.1038/nature04010, 16049496
-
Wang D, Kennedy S, Conte D, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 2005, 436:593-597. 10.1038/nature04010, 16049496.
-
(2005)
Nature
, vol.436
, pp. 593-597
-
-
Wang, D.1
Kennedy, S.2
Conte, D.3
Kim, J.K.4
Gabel, H.W.5
Kamath, R.S.6
Mello, C.C.7
Ruvkun, G.8
-
34
-
-
17044417320
-
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences.
-
10.1101/gad.332305, 1074315, 15774721
-
Robert VJ, Sijen T, van Wolfswinkel J, Plasterk RH. Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev 2005, 19:782-787. 10.1101/gad.332305, 1074315, 15774721.
-
(2005)
Genes Dev
, vol.19
, pp. 782-787
-
-
Robert, V.J.1
Sijen, T.2
van Wolfswinkel, J.3
Plasterk, R.H.4
-
35
-
-
0035860551
-
A gene expression map for Caenorhabditis elegans.
-
10.1126/science.1061603, 11557892
-
Kim SK, Lund J, Kiraly M, Duke K, Jiang M, Stuart JM, Eizinger A, Wylie BN, Davidson GS. A gene expression map for Caenorhabditis elegans. Science 2001, 293:2087-2092. 10.1126/science.1061603, 11557892.
-
(2001)
Science
, vol.293
, pp. 2087-2092
-
-
Kim, S.K.1
Lund, J.2
Kiraly, M.3
Duke, K.4
Jiang, M.5
Stuart, J.M.6
Eizinger, A.7
Wylie, B.N.8
Davidson, G.S.9
-
36
-
-
44349122537
-
HP1: a functionally multifaceted protein.
-
10.1016/j.gde.2008.01.009, 18329871
-
Fanti L, Pimpinelli S. HP1: a functionally multifaceted protein. Curr Opin Genet Dev 2008, 18:169-174. 10.1016/j.gde.2008.01.009, 18329871.
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 169-174
-
-
Fanti, L.1
Pimpinelli, S.2
-
37
-
-
0036333386
-
X-chromosome silencing in the germline of C. elegans.
-
Kelly WG, Schaner CE, Dernburg AF, Lee MH, Kim SK, Villeneuve AM, Reinke V. X-chromosome silencing in the germline of C. elegans. Development 2002, 129:479-492.
-
(2002)
Development
, vol.129
, pp. 479-492
-
-
Kelly, W.G.1
Schaner, C.E.2
Dernburg, A.F.3
Lee, M.H.4
Kim, S.K.5
Villeneuve, A.M.6
Reinke, V.7
-
38
-
-
76749160352
-
Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.
-
Bessler JB, Andersen EC, Villeneuve AM. Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line. PLoS Genet 6:e1000830.
-
PLoS Genet
, vol.6
-
-
Bessler, J.B.1
Andersen, E.C.2
Villeneuve, A.M.3
-
39
-
-
8844225983
-
Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans.
-
10.1186/1471-213X-4-11, 524168, 15380030
-
Liu T, Zimmerman KK, Patterson GI. Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans. BMC Dev Biol 2004, 4:11. 10.1186/1471-213X-4-11, 524168, 15380030.
-
(2004)
BMC Dev Biol
, vol.4
, pp. 11
-
-
Liu, T.1
Zimmerman, K.K.2
Patterson, G.I.3
-
40
-
-
38449105152
-
Dauer.
-
Hu PJ. Dauer. WormBook 2007, 1-19.
-
(2007)
WormBook
, pp. 1-19
-
-
Hu, P.J.1
-
41
-
-
0038406208
-
Global analysis of dauer gene expression in Caenorhabditis elegans.
-
10.1242/dev.00363, 12620986
-
Wang J, Kim SK. Global analysis of dauer gene expression in Caenorhabditis elegans. Development 2003, 130:1621-1634. 10.1242/dev.00363, 12620986.
-
(2003)
Development
, vol.130
, pp. 1621-1634
-
-
Wang, J.1
Kim, S.K.2
-
42
-
-
10844246408
-
Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
-
10.1534/genetics.104.027953, 1448789, 15579684
-
Novelli J, Ahmed S, Hodgkin J. Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target. Genetics 2004, 168:1259-1273. 10.1534/genetics.104.027953, 1448789, 15579684.
-
(2004)
Genetics
, vol.168
, pp. 1259-1273
-
-
Novelli, J.1
Ahmed, S.2
Hodgkin, J.3
-
43
-
-
77149138820
-
Characterization of the astacin family of metalloproteases in C. elegans.
-
Park JO, Pan J, Mohrlen F, Schupp M, Johnsen R, Baillie DL, Zapf R, Moerman DG, Hutter H. Characterization of the astacin family of metalloproteases in C. elegans. BMC Dev Biol 10:14.
-
BMC Dev Biol
, vol.10
, pp. 14
-
-
Park, J.O.1
Pan, J.2
Mohrlen, F.3
Schupp, M.4
Johnsen, R.5
Baillie, D.L.6
Zapf, R.7
Moerman, D.G.8
Hutter, H.9
-
44
-
-
67249115310
-
Secretion of Hedgehog-related peptides and WNT during Caenorhabditis elegans development.
-
Kolotuev I, Apaydin A, Labouesse M. Secretion of Hedgehog-related peptides and WNT during Caenorhabditis elegans development. Traffic 2009, 10:803-810.
-
(2009)
Traffic
, vol.10
, pp. 803-810
-
-
Kolotuev, I.1
Apaydin, A.2
Labouesse, M.3
-
45
-
-
25844502073
-
The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans.
-
10.1101/gr.3935405, 1240083, 16204193
-
Zugasti O, Rajan J, Kuwabara PE. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Genome Res 2005, 15:1402-1410. 10.1101/gr.3935405, 1240083, 16204193.
-
(2005)
Genome Res
, vol.15
, pp. 1402-1410
-
-
Zugasti, O.1
Rajan, J.2
Kuwabara, P.E.3
-
46
-
-
38449099388
-
Homologs of the Hh signalling network in C. elegans.
-
Burglin TR, Kuwabara PE. Homologs of the Hh signalling network in C. elegans. WormBook 2006, 1-14.
-
(2006)
WormBook
, pp. 1-14
-
-
Burglin, T.R.1
Kuwabara, P.E.2
-
48
-
-
58349085789
-
Molecular time-course and the metabolic basis of entry into dauer in Caenorhabditis elegans.
-
10.1371/journal.pone.0004162, 2612749, 19129915
-
Jeong PY, Kwon MS, Joo HJ, Paik YK. Molecular time-course and the metabolic basis of entry into dauer in Caenorhabditis elegans. PLoS One 2009, 4:e4162. 10.1371/journal.pone.0004162, 2612749, 19129915.
-
(2009)
PLoS One
, vol.4
-
-
Jeong, P.Y.1
Kwon, M.S.2
Joo, H.J.3
Paik, Y.K.4
-
49
-
-
84857913522
-
Dauer Metabolic Database
-
Dauer Metabolic Database. , http://dauerdb.org
-
-
-
-
50
-
-
0019496482
-
Interacting genes in nematode dauer larva formation.
-
10.1038/290668a0, 7219552
-
Riddle DL, Swanson MM, Albert PS. Interacting genes in nematode dauer larva formation. Nature 1981, 290:668-671. 10.1038/290668a0, 7219552.
-
(1981)
Nature
, vol.290
, pp. 668-671
-
-
Riddle, D.L.1
Swanson, M.M.2
Albert, P.S.3
-
51
-
-
0037466652
-
DAF-16 target genes that control C. elegans life-span and metabolism.
-
10.1126/science.1083614, 12690206
-
Lee SS, Kennedy S, Tolonen AC, Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science 2003, 300:644-647. 10.1126/science.1083614, 12690206.
-
(2003)
Science
, vol.300
, pp. 644-647
-
-
Lee, S.S.1
Kennedy, S.2
Tolonen, A.C.3
Ruvkun, G.4
-
52
-
-
0019434720
-
Critical periods in the development of the Caenorhabditis elegans dauer larva.
-
10.1016/0012-1606(81)90367-5, 7250500
-
Swanson MM, Riddle DL. Critical periods in the development of the Caenorhabditis elegans dauer larva. Dev Biol 1981, 84:27-40. 10.1016/0012-1606(81)90367-5, 7250500.
-
(1981)
Dev Biol
, vol.84
, pp. 27-40
-
-
Swanson, M.M.1
Riddle, D.L.2
-
53
-
-
0033576579
-
Regulation of lifespan by sensory perception in Caenorhabditis elegans.
-
10.1038/45544, 10617200
-
Apfeld J, Kenyon C. Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 1999, 402:804-809. 10.1038/45544, 10617200.
-
(1999)
Nature
, vol.402
, pp. 804-809
-
-
Apfeld, J.1
Kenyon, C.2
-
54
-
-
0034613164
-
Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
-
10.1126/science.290.5489.147, 11021802
-
Wolkow CA, Kimura KD, Lee MS, Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 2000, 290:147-150. 10.1126/science.290.5489.147, 11021802.
-
(2000)
Science
, vol.290
, pp. 147-150
-
-
Wolkow, C.A.1
Kimura, K.D.2
Lee, M.S.3
Ruvkun, G.4
-
55
-
-
0345447590
-
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan.
-
10.1016/S0092-8674(03)00889-4, 14622602
-
Libina N, Berman JR, Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 2003, 115:489-502. 10.1016/S0092-8674(03)00889-4, 14622602.
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
56
-
-
34548190256
-
Endocrine regulation of ageing.
-
10.1038/nrm2234, 17684529
-
Russell SJ, Kahn CR. Endocrine regulation of ageing. Nat Rev Mol Cell Biol 2007, 8:681-691. 10.1038/nrm2234, 17684529.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 681-691
-
-
Russell, S.J.1
Kahn, C.R.2
-
57
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
-
10.1038/nature01789, 12845331
-
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003, 424:277-283. 10.1038/nature01789, 12845331.
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
58
-
-
47549100826
-
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.
-
10.1016/j.cell.2008.05.044, 18662544
-
Budovskaya YV, Wu K, Southworth LK, Jiang M, Tedesco P, Johnson TE, Kim SK. An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 2008, 134:291-303. 10.1016/j.cell.2008.05.044, 18662544.
-
(2008)
Cell
, vol.134
, pp. 291-303
-
-
Budovskaya, Y.V.1
Wu, K.2
Southworth, L.K.3
Jiang, M.4
Tedesco, P.5
Johnson, T.E.6
Kim, S.K.7
-
59
-
-
41849128523
-
The FoxO code.
-
10.1038/onc.2008.21, 18391970
-
Calnan DR, Brunet A. The FoxO code. Oncogene 2008, 27:2276-2288. 10.1038/onc.2008.21, 18391970.
-
(2008)
Oncogene
, vol.27
, pp. 2276-2288
-
-
Calnan, D.R.1
Brunet, A.2
-
60
-
-
0035846604
-
Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.
-
10.1016/S0960-9822(01)00594-2, 11747825
-
Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 2001, 11:1975-1980. 10.1016/S0960-9822(01)00594-2, 11747825.
-
(2001)
Curr Biol
, vol.11
, pp. 1975-1980
-
-
Henderson, S.T.1
Johnson, T.E.2
-
61
-
-
61449184625
-
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
-
10.1371/journal.pgen.1000361, 2628729, 19197346
-
Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 2009, 5:e1000361. 10.1371/journal.pgen.1000361, 2628729, 19197346.
-
(2009)
PLoS Genet
, vol.5
-
-
Van Raamsdonk, J.M.1
Hekimi, S.2
-
62
-
-
2442565649
-
Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans.
-
10.1074/jbc.M313119200, 14982934
-
Fujii M, Matsumoto Y, Tanaka N, Miki K, Suzuki T, Ishii N, Ayusawa D. Mutations in chemosensory cilia cause resistance to paraquat in nematode Caenorhabditis elegans. J Biol Chem 2004, 279:20277-20282. 10.1074/jbc.M313119200, 14982934.
-
(2004)
J Biol Chem
, vol.279
, pp. 20277-20282
-
-
Fujii, M.1
Matsumoto, Y.2
Tanaka, N.3
Miki, K.4
Suzuki, T.5
Ishii, N.6
Ayusawa, D.7
-
63
-
-
33644750381
-
SMK-1, an essential regulator of DAF-16-mediated longevity.
-
10.1016/j.cell.2005.12.042, 16530049
-
Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A. SMK-1, an essential regulator of DAF-16-mediated longevity. Cell 2006, 124:1039-1053. 10.1016/j.cell.2005.12.042, 16530049.
-
(2006)
Cell
, vol.124
, pp. 1039-1053
-
-
Wolff, S.1
Ma, H.2
Burch, D.3
Maciel, G.A.4
Hunter, T.5
Dillin, A.6
-
64
-
-
54749095200
-
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.
-
10.1371/journal.pbio.0060233, 2553839, 18828672
-
Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee SS. Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol 2008, 6:e233. 10.1371/journal.pbio.0060233, 2553839, 18828672.
-
(2008)
PLoS Biol
, vol.6
-
-
Li, J.1
Ebata, A.2
Dong, Y.3
Rizki, G.4
Iwata, T.5
Lee, S.S.6
-
65
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor.
-
10.1126/science.1083701, 12750521
-
Hsu AL, Murphy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 2003, 300:1142-1145. 10.1126/science.1083701, 12750521.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
66
-
-
0041507039
-
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals.
-
10.1046/j.1474-9728.2003.00045.x, 12882326
-
Walker GA, Lithgow GJ. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell 2003, 2:131-139. 10.1046/j.1474-9728.2003.00045.x, 12882326.
-
(2003)
Aging Cell
, vol.2
, pp. 131-139
-
-
Walker, G.A.1
Lithgow, G.J.2
-
67
-
-
38449111466
-
Gene expression changes associated with aging in C. elegans.
-
Melov S, Golden TR. Gene expression changes associated with aging in C. elegans. WormBook 2007, 1-12.
-
(2007)
WormBook
, pp. 1-12
-
-
Melov, S.1
Golden, T.R.2
-
68
-
-
0037942739
-
Extended longevity in mice lacking the insulin receptor in adipose tissue.
-
10.1126/science.1078223, 12543978
-
Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003, 299:572-574. 10.1126/science.1078223, 12543978.
-
(2003)
Science
, vol.299
, pp. 572-574
-
-
Bluher, M.1
Kahn, B.B.2
Kahn, C.R.3
-
69
-
-
3142749712
-
Long-lived Drosophila with overexpressed dFOXO in adult fat body.
-
10.1126/science.1098219, 15192154
-
Giannakou ME, Goss M, Junger MA, Hafen E, Leevers SJ, Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004, 305:361. 10.1126/science.1098219, 15192154.
-
(2004)
Science
, vol.305
, pp. 361
-
-
Giannakou, M.E.1
Goss, M.2
Junger, M.A.3
Hafen, E.4
Leevers, S.J.5
Partridge, L.6
-
70
-
-
2942563805
-
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body.
-
10.1038/nature02549, 15175753
-
Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004, 429:562-566. 10.1038/nature02549, 15175753.
-
(2004)
Nature
, vol.429
, pp. 562-566
-
-
Hwangbo, D.S.1
Gershman, B.2
Tu, M.P.3
Palmer, M.4
Tatar, M.5
-
71
-
-
55849101681
-
Fat metabolism links germline stem cells and longevity in C. elegans.
-
10.1126/science.1162011, 2760269, 18988854
-
Wang MC, O'Rourke EJ, Ruvkun G. Fat metabolism links germline stem cells and longevity in C. elegans. Science 2008, 322:957-960. 10.1126/science.1162011, 2760269, 18988854.
-
(2008)
Science
, vol.322
, pp. 957-960
-
-
Wang, M.C.1
O'Rourke, E.J.2
Ruvkun, G.3
-
72
-
-
0037237117
-
C elegans: a model for exploring the genetics of fat storage.
-
10.1016/S1534-5807(02)00411-2, 12530969
-
McKay RM, McKay JP, Avery L, Graff JM. C elegans: a model for exploring the genetics of fat storage. Dev Cell 2003, 4:131-142. 10.1016/S1534-5807(02)00411-2, 12530969.
-
(2003)
Dev Cell
, vol.4
, pp. 131-142
-
-
McKay, R.M.1
McKay, J.P.2
Avery, L.3
Graff, J.M.4
-
73
-
-
70350365111
-
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.
-
10.1016/j.cmet.2009.10.002, 2921818, 19883620
-
O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G. C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab 2009, 10:430-435. 10.1016/j.cmet.2009.10.002, 2921818, 19883620.
-
(2009)
Cell Metab
, vol.10
, pp. 430-435
-
-
O'Rourke, E.J.1
Soukas, A.A.2
Carr, C.E.3
Ruvkun, G.4
-
74
-
-
0033801428
-
A procedure for fractionation of sphingolipid classes by solid-phase extraction on aminopropyl cartridges.
-
Bodennec J, Koul O, Aguado I, Brichon G, Zwingelstein G, Portoukalian J. A procedure for fractionation of sphingolipid classes by solid-phase extraction on aminopropyl cartridges. J Lipid Res 2000, 41:1524-1531.
-
(2000)
J Lipid Res
, vol.41
, pp. 1524-1531
-
-
Bodennec, J.1
Koul, O.2
Aguado, I.3
Brichon, G.4
Zwingelstein, G.5
Portoukalian, J.6
-
75
-
-
38549152194
-
Principles of bioactive lipid signalling: lessons from sphingolipids.
-
10.1038/nrm2329, 18216770
-
Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008, 9:139-150. 10.1038/nrm2329, 18216770.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
76
-
-
74449088292
-
A cellular memory of developmental history generates phenotypic diversity in C. elegans.
-
10.1016/j.cub.2009.11.035, 2990539, 20079644
-
Hall SE, Beverly M, Russ C, Nusbaum C, Sengupta P. A cellular memory of developmental history generates phenotypic diversity in C. elegans. Curr Biol 2010, 20:149-155. 10.1016/j.cub.2009.11.035, 2990539, 20079644.
-
(2010)
Curr Biol
, vol.20
, pp. 149-155
-
-
Hall, S.E.1
Beverly, M.2
Russ, C.3
Nusbaum, C.4
Sengupta, P.5
-
77
-
-
0026419552
-
Control of larval development by chemosensory neurons in Caenorhabditis elegans.
-
10.1126/science.2006412, 2006412
-
Bargmann CI, Horvitz HR. Control of larval development by chemosensory neurons in Caenorhabditis elegans. Science 1991, 251:1243-1246. 10.1126/science.2006412, 2006412.
-
(1991)
Science
, vol.251
, pp. 1243-1246
-
-
Bargmann, C.I.1
Horvitz, H.R.2
-
78
-
-
0023902842
-
Mutants of Caenorhabditis elegans that form dauer-like larvae.
-
10.1016/0012-1606(88)90138-8, 3350212
-
Albert PS, Riddle DL. Mutants of Caenorhabditis elegans that form dauer-like larvae. Dev Biol 1988, 126:270-293. 10.1016/0012-1606(88)90138-8, 3350212.
-
(1988)
Dev Biol
, vol.126
, pp. 270-293
-
-
Albert, P.S.1
Riddle, D.L.2
-
79
-
-
22344443522
-
A systematic RNAi screen for longevity genes in C. elegans.
-
10.1101/gad.1308205, 1172061, 15998808
-
Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS. A systematic RNAi screen for longevity genes in C. elegans. Genes Dev 2005, 19:1544-1555. 10.1101/gad.1308205, 1172061, 15998808.
-
(2005)
Genes Dev
, vol.19
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
Liu, W.4
Odell, I.5
Ruvkun, G.6
Lee, S.S.7
-
80
-
-
77954660029
-
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.
-
10.1038/nature09195, 3075006, 20555324
-
Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature 2010, 466:383-387. 10.1038/nature09195, 3075006, 20555324.
-
(2010)
Nature
, vol.466
, pp. 383-387
-
-
Greer, E.L.1
Maures, T.J.2
Hauswirth, A.G.3
Green, E.M.4
Leeman, D.S.5
Maro, G.S.6
Han, S.7
Banko, M.R.8
Gozani, O.9
Brunet, A.10
-
81
-
-
23844503747
-
Drosophila longevity is not affected by heterochromatin-mediated gene silencing.
-
10.1111/j.1474-9726.2005.00143.x, 15659213
-
Frankel S, Rogina B. Drosophila longevity is not affected by heterochromatin-mediated gene silencing. Aging Cell 2005, 4:53-56. 10.1111/j.1474-9726.2005.00143.x, 15659213.
-
(2005)
Aging Cell
, vol.4
, pp. 53-56
-
-
Frankel, S.1
Rogina, B.2
-
82
-
-
78249276176
-
Chromatin remodeling in the aging genome of Drosophila.
-
10.1111/j.1474-9726.2010.00624.x, 2980570, 20961390
-
Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, Neretti N, Helfand SL. Chromatin remodeling in the aging genome of Drosophila. Aging Cell 2010, 9:971-978. 10.1111/j.1474-9726.2010.00624.x, 2980570, 20961390.
-
(2010)
Aging Cell
, vol.9
, pp. 971-978
-
-
Wood, J.G.1
Hillenmeyer, S.2
Lawrence, C.3
Chang, C.4
Hosier, S.5
Lightfoot, W.6
Mukherjee, E.7
Jiang, N.8
Schorl, C.9
Brodsky, A.S.10
Neretti, N.11
Helfand, S.L.12
-
83
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging.
-
10.1126/science.1127168, 1855250, 16645051
-
Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006, 312:1059-1063. 10.1126/science.1127168, 1855250, 16645051.
-
(2006)
Science
, vol.312
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
84
-
-
7244238167
-
Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance.
-
10.1074/jbc.M406207200, 15308663
-
McElwee JJ, Schuster E, Blanc E, Thomas JH, Gems D. Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J Biol Chem 2004, 279:44533-44543. 10.1074/jbc.M406207200, 15308663.
-
(2004)
J Biol Chem
, vol.279
, pp. 44533-44543
-
-
McElwee, J.J.1
Schuster, E.2
Blanc, E.3
Thomas, J.H.4
Gems, D.5
-
85
-
-
21144460742
-
Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.
-
10.1101/gr.3274805, 1088289, 15837805
-
Halaschek-Wiener J, Khattra JS, McKay S, Pouzyrev A, Stott JM, Yang GS, Holt RA, Jones SJ, Marra MA, Brooks-Wilson AR, Riddle DL. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. Genome Res 2005, 15:603-615. 10.1101/gr.3274805, 1088289, 15837805.
-
(2005)
Genome Res
, vol.15
, pp. 603-615
-
-
Halaschek-Wiener, J.1
Khattra, J.S.2
McKay, S.3
Pouzyrev, A.4
Stott, J.M.5
Yang, G.S.6
Holt, R.A.7
Jones, S.J.8
Marra, M.A.9
Brooks-Wilson, A.R.10
Riddle, D.L.11
-
86
-
-
70350441907
-
The role of sirtuins in the control of metabolic homeostasis.
-
Yu J, Auwerx J. The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci 2009, 1173(Suppl 1):E10-19.
-
(2009)
Ann N Y Acad Sci
, vol.1173
, Issue.SUPPL. 1
-
-
Yu, J.1
Auwerx, J.2
-
87
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
-
10.1038/35065638, 11242085
-
Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 2001, 410:227-230. 10.1038/35065638, 11242085.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
88
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
-
10.1073/pnas.0404184101, 528752, 15520384
-
Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 2004, 101:15998-16003. 10.1073/pnas.0404184101, 528752, 15520384.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
89
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
-
10.1038/nature02789, 15254550
-
Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004, 430:686-689. 10.1038/nature02789, 15254550.
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
Helfand, S.L.5
Tatar, M.6
Sinclair, D.7
-
90
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.
-
10.1016/j.cmet.2009.02.006, 2668535, 19356714
-
Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 2009, 9:327-338. 10.1016/j.cmet.2009.02.006, 2668535, 19356714.
-
(2009)
Cell Metab
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
Schug, T.T.2
Xu, Q.3
Surapureddi, S.4
Guo, X.5
Li, X.6
-
91
-
-
77954488637
-
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
-
10.1101/gad.1901210, 2895199, 20595232
-
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Naar AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 2010, 24:1403-1417. 10.1101/gad.1901210, 2895199, 20595232.
-
(2010)
Genes Dev
, vol.24
, pp. 1403-1417
-
-
Walker, A.K.1
Yang, F.2
Jiang, K.3
Ji, J.Y.4
Watts, J.L.5
Purushotham, A.6
Boss, O.7
Hirsch, M.L.8
Ribich, S.9
Smith, J.J.10
Israelian, K.11
Westphal, C.H.12
Rodgers, J.T.13
Shioda, T.14
Elson, S.L.15
Mulligan, P.16
Najafi-Shoushtari, H.17
Black, J.C.18
Thakur, J.K.19
Kadyk, L.C.20
Whetstine, J.R.21
Mostoslavsky, R.22
Puigserver, P.23
Li, X.24
Dyson, N.J.25
Hart, A.C.26
Naar, A.M.27
more..
-
92
-
-
0037648395
-
Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin.
-
10.1083/jcb.200303012, 2199350, 12756231
-
Piacentini L, Fanti L, Berloco M, Perrini B, Pimpinelli S. Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J Cell Biol 2003, 161:707-714. 10.1083/jcb.200303012, 2199350, 12756231.
-
(2003)
J Cell Biol
, vol.161
, pp. 707-714
-
-
Piacentini, L.1
Fanti, L.2
Berloco, M.3
Perrini, B.4
Pimpinelli, S.5
-
93
-
-
0037688120
-
The emerging role for sphingolipids in the eukaryotic heat shock response.
-
10.1007/s00018-003-2239-0, 12785717
-
Jenkins GM. The emerging role for sphingolipids in the eukaryotic heat shock response. Cell Mol Life Sci 2003, 60:701-710. 10.1007/s00018-003-2239-0, 12785717.
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 701-710
-
-
Jenkins, G.M.1
-
94
-
-
0035880016
-
Sphingomyelin and ceramide as regulators of development and lifespan.
-
10.1016/S0047-6374(01)00246-9, 11348657
-
Cutler RG, Mattson MP. Sphingomyelin and ceramide as regulators of development and lifespan. Mech Ageing Dev 2001, 122:895-908. 10.1016/S0047-6374(01)00246-9, 11348657.
-
(2001)
Mech Ageing Dev
, vol.122
, pp. 895-908
-
-
Cutler, R.G.1
Mattson, M.P.2
-
95
-
-
70350676840
-
Increase in sphingolipid catabolic enzyme activity during aging.
-
10.1038/aps.2009.136, 19749786
-
Sacket SJ, Chung HY, Okajima F, Im DS. Increase in sphingolipid catabolic enzyme activity during aging. Acta Pharmacol Sin 2009, 30:1454-1461. 10.1038/aps.2009.136, 19749786.
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 1454-1461
-
-
Sacket, S.J.1
Chung, H.Y.2
Okajima, F.3
Im, D.S.4
-
96
-
-
0028214311
-
Cloning and characterization of LAG1, a longevity-assurance gene in yeast.
-
D'Mello NP, Childress AM, Franklin DS, Kale SP, Pinswasdi C, Jazwinski SM. Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J Biol Chem 1994, 269:15451-15459.
-
(1994)
J Biol Chem
, vol.269
, pp. 15451-15459
-
-
D'Mello, N.P.1
Childress, A.M.2
Franklin, D.S.3
Kale, S.P.4
Pinswasdi, C.5
Jazwinski, S.M.6
-
97
-
-
3242673409
-
Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity.
-
10.1016/j.exger.2004.03.026, 15236759
-
Jiang JC, Kirchman PA, Allen M, Jazwinski SM. Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity. Exp Gerontol 2004, 39:999-1009. 10.1016/j.exger.2004.03.026, 15236759.
-
(2004)
Exp Gerontol
, vol.39
, pp. 999-1009
-
-
Jiang, J.C.1
Kirchman, P.A.2
Allen, M.3
Jazwinski, S.M.4
-
98
-
-
41949097891
-
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging.
-
10.1371/journal.pgen.1000027, 2265412, 18369446
-
van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterk RH, Nollen EA. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet 2008, 4:e1000027. 10.1371/journal.pgen.1000027, 2265412, 18369446.
-
(2008)
PLoS Genet
, vol.4
-
-
van Ham, T.J.1
Thijssen, K.L.2
Breitling, R.3
Hofstra, R.M.4
Plasterk, R.H.5
Nollen, E.A.6
-
99
-
-
84857916642
-
Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1.
-
Tedesco P, Jiang J, Wang J, Jazwinski SM, Johnson TE. Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1. Age (Dordr) 2008, 30:43-52.
-
(2008)
Age (Dordr)
, vol.30
, pp. 43-52
-
-
Tedesco, P.1
Jiang, J.2
Wang, J.3
Jazwinski, S.M.4
Johnson, T.E.5
-
100
-
-
65249102170
-
Protection of C. elegans from anoxia by HYL-2 ceramide synthase.
-
10.1126/science.1168532, 19372430
-
Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mulhauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC. Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Science 2009, 324:381-384. 10.1126/science.1168532, 19372430.
-
(2009)
Science
, vol.324
, pp. 381-384
-
-
Menuz, V.1
Howell, K.S.2
Gentina, S.3
Epstein, S.4
Riezman, I.5
Fornallaz-Mulhauser, M.6
Hengartner, M.O.7
Gomez, M.8
Riezman, H.9
Martinou, J.C.10
-
101
-
-
0016063911
-
The Genetics of Caenorhabditis elegans.
-
1213120, 4366476
-
Brenner S. The Genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94. 1213120, 4366476.
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
Brenner, S.1
-
102
-
-
34047118042
-
Overlapping probabilities of top ranking gene lists, hypergeometric distribution, and stringency of gene selection criterion.
-
Fury W, Batliwalla F, Gregersen PK, Li W. Overlapping probabilities of top ranking gene lists, hypergeometric distribution, and stringency of gene selection criterion. Conf Proc IEEE Eng Med Biol Soc 2006, 1:5531-5534.
-
(2006)
Conf Proc IEEE Eng Med Biol Soc
, vol.1
, pp. 5531-5534
-
-
Fury, W.1
Batliwalla, F.2
Gregersen, P.K.3
Li, W.4
-
103
-
-
0026431968
-
Spatial control of gut-specific gene expression during Caenorhabditis elegans development.
-
10.1126/science.2020855, 2020855
-
Aamodt EJ, Chung MA, McGhee JD. Spatial control of gut-specific gene expression during Caenorhabditis elegans development. Science 1991, 252:579-582. 10.1126/science.2020855, 2020855.
-
(1991)
Science
, vol.252
, pp. 579-582
-
-
Aamodt, E.J.1
Chung, M.A.2
McGhee, J.D.3
-
104
-
-
53749097353
-
A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.
-
10.1371/journal.pone.0003354, 2556085, 18836529
-
Masse I, Molin L, Mouchiroud L, Vanhems P, Palladino F, Billaud M, Solari F. A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. PLoS One 2008, 3:e3354. 10.1371/journal.pone.0003354, 2556085, 18836529.
-
(2008)
PLoS One
, vol.3
-
-
Masse, I.1
Molin, L.2
Mouchiroud, L.3
Vanhems, P.4
Palladino, F.5
Billaud, M.6
Solari, F.7
-
105
-
-
61349098460
-
Differential chromatin marking of introns and expressed exons by H3K36me3.
-
10.1038/ng.322, 2648722, 19182803
-
Kolasinska-Zwierz P, Down T, Latorre I, Liu T, Liu XS, Ahringer J. Differential chromatin marking of introns and expressed exons by H3K36me3. Nat Genet 2009, 41:376-381. 10.1038/ng.322, 2648722, 19182803.
-
(2009)
Nat Genet
, vol.41
, pp. 376-381
-
-
Kolasinska-Zwierz, P.1
Down, T.2
Latorre, I.3
Liu, T.4
Liu, X.S.5
Ahringer, J.6
-
106
-
-
70449158340
-
A simple method for the isolation and purification of total lipides from animal tissues.
-
Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
-
(1957)
J Biol Chem
, vol.226
, pp. 497-509
-
-
Folch, J.1
Lees, M.2
Sloane Stanley, G.H.3
-
107
-
-
0027268170
-
Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans.
-
1205579, 8375650
-
Thomas JH, Birnby DA, Vowels JJ. Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans. Genetics 1993, 134:1105-1117. 1205579, 8375650.
-
(1993)
Genetics
, vol.134
, pp. 1105-1117
-
-
Thomas, J.H.1
Birnby, D.A.2
Vowels, J.J.3
-
108
-
-
17344395368
-
Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.
-
1461134, 10880475
-
Melendez A, Greenwald I. Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif. Genetics 2000, 155:1127-1137. 1461134, 10880475.
-
(2000)
Genetics
, vol.155
, pp. 1127-1137
-
-
Melendez, A.1
Greenwald, I.2
-
109
-
-
77950920142
-
The spatial dynamics of tissue-specific promoters during C. elegans development.
-
10.1101/gad.559610, 2854392, 20395364
-
Meister P, Towbin BD, Pike BL, Ponti A, Gasser SM. The spatial dynamics of tissue-specific promoters during C. elegans development. Genes Dev 2010, 24:766-782. 10.1101/gad.559610, 2854392, 20395364.
-
(2010)
Genes Dev
, vol.24
, pp. 766-782
-
-
Meister, P.1
Towbin, B.D.2
Pike, B.L.3
Ponti, A.4
Gasser, S.M.5
-
110
-
-
84857912575
-
DAVID
-
DAVID. , http://david.abcc.ncifcrf.gov/
-
-
-
|