Is it the method or the process - Separating the causes of low recovery

Drug Development and Industrial Pharmacy

Volumn 30, Issue 8, 2004, Pages 891-899

  Cory, Wendy ^a   Field, Kelly ^a   Wu Linhares, Dan ^a  

^a PFIZER INC   (United States)

Author keywords

Croscarmellose sodium; Drug excipient interactions; Microcrystalline cellulose; Segregation

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; CROSCARMELLOSE SODIUM; EXCIPIENT; MANNITOL; MICROCRYSTALLINE CELLULOSE;

ARTICLE; DRUG FORMULATION; EXTRACTION; PROCESS DEVELOPMENT; SCALE UP; SEGREGATION ANALYSIS; SEPARATION TECHNIQUE; TABLET FORMULATION; TABLET MANUFACTURE;

ADSORPTION; CARBOXYMETHYLCELLULOSE; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG EVALUATION, PRECLINICAL; DRUG INCOMPATIBILITY; EXCIPIENTS; HYDROCHLORIC ACID; HYDROGEN-ION CONCENTRATION; MANNITOL; PIPERIDINES; POWDERS; SOLVENTS; TABLETS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 5444239252     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-200034588     Document Type: Article

References (15)

1. Chien, Y.W.; Van Nostrand, P.; Hurwitz, A.R.; Shami, E.G. Drug-disintegrant interactions: binding of oxymorphone derivatives. J. Pharm. Sci. 1981, 70, 709-710.
2. Hollenbeck, R.G.; Mitrevej, K.T.; Fan, A.C. Estimation of the extent of drug-excipient interactions involving croscarmellose sodium. J. Pharm. Sci. 1983, 72, 325-327.
3. Senderoff, R.I.; Mahjour, M.; Radebaugh, G.W. Characterization of adsorption behavior by solid dosage form excipients in formulation develop-ment. Int. J. Pharm. 1992, 83, 65-72.
4. Al-Nimry, S.S.; Assaf, S.M.; Jalal, I.M.; Najib, N.M. Adsorption of ketotifen onto some pharmaceutical excipients. Int. J. Pharm. 1997, 149, 115-121.
5. Hollenbeck, R.G. Bioavailability of phenylpropanolamine HCl from tablet dosage forms containing croscarmellose sodium. Int. J. Pharm. 1988, 47, 89-93.
6. Ghannam, M.M.; Gautam, J.; Restaino, F.A. Devazipide (MK-329) adsorption on microcrystalline cellulose. Drug Dev. Ind. Pharm. 1992, 18, 973-996.
7. Okada, S.; Nakahara, H.; Isaka, H. Adsorption of drugs on microcrystalline cellulose suspended in aqueous solutions. Chem. Pharm. Bull. 1987, 35, 761-768.
8. Steele, D.F.; Edge, S.; Tobyn, M.J.; Moreton, R.C.; Staniforth, J.N. Adsorption of an arnine drug onto microcrystalline cellulose and silicified microcrystalline cellulose samples. Drug Dev. Ind. Pharm. 2003, 29, 475-487.
9. El-Samaligy, M.S.; El-Mahrouk, G.M.; El-Kirsh, T.A. Adsorption-desorption effect of microcrystalline cellulose on amipicillin and amoxycillin. Int. J. Pharm. 1986, 31, 137-144.
10. Qtaitat, M.A.; Zughul, M.B.; Badwan, A.A. Bromhexine hydrochloride adsorption by some solid excipients used in the formulation of tablets. Drug Dev. Ind. Pharm. 1988, 14, 415-429.
11. Prescott, J.K.; Carson, J.W. Analyzing and overcoming industrial blending and segregation problems. Solid Mech. Appl. 2000, 81, 89-101.
12. Williams, J.C. The segregation of particulate materials. A review. Powder Technol. 1976, 75, 245-251.
13. Poux, M.; Fayolle, P.; Bertrand, J.; Bridoux, D.; Bousquet, J. Powder mixing, some practical rules applied to agitated systems. Powder Technol. 1991, 68, 213-234.
14. Prescott, J.K.; Garcia, T.P. A solid dosage and blend content uniformity troubleshooting diagram. Pharm. Technol. 2001, 25, 68-88.
15. Prescott, J.K.; Carson, J.W. Analyzing and overcoming industrial blending and segregation problems. Solid Mech. Appl. 2000, 81, 89-101.