Purification of pharmaceutical excipients with supercritical fluid extraction

Pharmaceutical Development and Technology

Volumn 10, Issue 4, 2005, Pages 507-516

  Ashraf Khorassani, Mehdi ^a   Taylor, Larry T ^a   Waterman, Kenneth C ^b,c   Narayan, Padma ^b   Brannegan, Daniel R ^b   Reid, George L ^b  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c PFIZER INC   (United States)

Author keywords

Drug stability; Excipient purification; Supercritical fluid extraction

Indexed keywords

CARBON DIOXIDE; EXCIPIENT; FORMALDEHYDE; FORMIC ACID; HYDROGEN PEROXIDE; HYDROXYPROPYLCELLULOSE; MACROGOL; MICROCRYSTALLINE CELLULOSE; POLYOX; POVIDONE; PURITY 21; SOLVENT; STARCH; STARCH 1500; WSR 205; WSR N60K;

ARTICLE; DIFFUSION; DRUG FORMULATION; DRUG STABILITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PURIFICATION; SOLUBILITY; STATISTICAL SIGNIFICANCE; SUPERCRITICAL FLUID EXTRACTION;

CARBON DIOXIDE; CHROMATOGRAPHY, SUPERCRITICAL FLUID; DRUG CONTAMINATION; EXCIPIENTS; FORMALDEHYDE; FORMIC ACIDS; HYDROGEN PEROXIDE; PHARMACEUTICAL PREPARATIONS; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 28844433264     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450500299958     Document Type: Article

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