Interactions between drug substances and excipients. 1. Fluorescence and HPLC studies of triazolophthalazine derivatives from hydralazin hydrochloride and starch

Journal of Pharmaceutical Sciences

Volumn 85, Issue 3, 1996, Pages 326-329

  Lessen, Tania ^a   Zhao, Da Chuan ^a  

^a Novopharm Ltd   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HYDRALAZINE; STARCH; TRIAZOLO[3,4 A]PHTHALAZINE DERIVATIVE;

ARTICLE; CATALYSIS; DIAGNOSTIC ACCURACY; DOSE RESPONSE; DRUG DEGRADATION; DRUG EFFECT; DRUG STORAGE; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; HYPERTENSION;

EID: 0029881476     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950218x     Document Type: Article

References (14)

1. AMA Drug Evaluations, 4th Ed.: American Medical Association: Chicago, IL, 1980; especially p 557.
2. A liquid composite method was used to avoid possible loss of hydralazine hydrochloride during the grinding of the tablets using an electric mill This type of problem, due to grinding has been reported by Doucette,Y. in: Variability of assay results for hydralazine hydrochloride tablets due to the use of electric mill comminution during sample preparation. Drug Dev. Ind. Pharm. 1987, 13, 289-302
3. Shaban, M. A. E.; Ali, R. S.; El-Badry, S. M. Carbohydr. Res. 1981, 95, 51-60.
4. Noda, H; Minemoto, M.; Noda, A.; Ushio, T. Chem. Pharm. Bull. 1986, 34, 3499-3501.
5. Druey, J.; Ringier, B. H. Helv. Chim. Acta. 1951, 34, 195-210.
6. Young, A. H. In Starch, Chemistry and Technology, 2nd ed.: Whistler, R L., Bemiller, J. N., Paschall, E. F., Eds.; Academic Press: Orlando, 1984; especially p 257.
7. Naik, D. V.; Davis, B. R.; Minnet, K. M.; Schulman, S. G. J. Pharm. Sci. 1976, 65, 274-276 .
8. m respectively. Starch has been shown to be susceptible to oxidative modification in both neutral and alkaline aqueous solutions at elevated temperature (Baum, H; Gilbert, G. A.; Scott, N. D. Nature, 1956, 177, 889). Degradation of starch into smaller chains during its isolation and fractionation can hardly be avoided (Greenwood, C. T.; Roberson, J. S. M. J. Chem. Soc. 1954, 3769). Such smaller chains, if present, also react with hydralazine hydrochloride. Stricktly speaking, the starch residue R in eq 1 should not be deemed to be a pure starch chain with a definite and unambiguous chemical structure, but rather a symbol for a mixture of multisaccharides and modified ones with various molecular weights.
9. m respectively. Starch has been shown to be susceptible to oxidative modification in both neutral and alkaline aqueous solutions at elevated temperature (Baum, H; Gilbert, G. A.; Scott, N. D. Nature, 1956, 177, 889). Degradation of starch into smaller chains during its isolation and fractionation can hardly be avoided (Greenwood, C. T.; Roberson, J. S. M. J. Chem. Soc. 1954, 3769). Such smaller chains, if present, also react with hydralazine hydrochloride. Stricktly speaking, the starch residue R in eq 1 should not be deemed to be a pure starch chain with a definite and unambiguous chemical structure, but rather a symbol for a mixture of multisaccharides and modified ones with various molecular weights.
10. Amer, A.; Zimmer, H. J. Heterocycl. Chem. 1983, 20, 1231-1238.
11. Gilchrist, T. L. Heterocyclic Chemistry; Pitman Publishing Ltd.: London, 1985; p 194, and references cited therein.
12. Nolan, N. L.; Faubion, J. M.; Hoseney, R. C. Cereal Chem. 1986, 63, 287-291.
13. French, A. D.; Murphy, V. G. Cereal Food World 1977, 22, 61-63, 66-70.
14. Yamashita, Y.; Monobe, K. J. Polym. Sci. A-2 1971, 9, 1471-1481.