Quantitative study of solid-state acid-base reactions between polymorphs of flufenamic acid and magnesium oxide using X-ray powder diffraction

Journal of Pharmaceutical and Biomedical Analysis

Volumn 51, Issue 4, 2010, Pages 866-874

  Chen, Xiaoming ^a   Stowell, Joseph G ^a   Morris, Kenneth R ^a   Byrn, Stephen R ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Acid base reaction; Flufenamic acid; Interactive mix; Polymorph; Solid state; X ray powder diffraction

Indexed keywords

ANTIINFLAMMATORY AGENT; FLUFENAMIC ACID; MAGNESIUM FLUFENAMATE; MAGNESIUM OXIDE; POLYACRYLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG MIXTURE; DRUG STORAGE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; SOLID STATE; X RAY POWDER DIFFRACTION;

ACRYLIC RESINS; ANTI-INFLAMMATORY AGENTS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG STABILITY; EXCIPIENTS; FLUFENAMIC ACID; HUMIDITY; HYDROGEN-ION CONCENTRATION; MAGNESIUM OXIDE; POWDER DIFFRACTION; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 72149109006     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.09.021     Document Type: Article

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