Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography

Journal of Chromatography A

Volumn 1104, Issue 1-2, 2006, Pages 1-10

  Li, Zhong ^a   Jacobus, Laura K ^a   Wuelfing, W Peter ^a   Golden, Mary ^a   Martin, Gregory P ^a   Reed, Robert A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aldehydes; Excipients; GC MS; Headspace; Negative chemical ionization; Pentafluorobenzylhydroxylamine hydrochloride

Indexed keywords

CHEMICAL ANALYSIS; CHEMICAL RESISTANCE; DRUG PRODUCTS; GAS CHROMATOGRAPHY; IONIZATION; MASS SPECTROMETRY; MOLECULAR WEIGHT; ORGANIC SOLVENTS;

EXCIPIENTS; GC-MS; HEADSPACE; NEGATIVE CHEMICAL IONIZATION; PENTAFLUOROBENZYLHYDROXYLAMINE HYDROCHLORIDE;

ALDEHYDES;

ACETALDEHYDE; ALDEHYDE; BENZALDEHYDE; BUTYRALDEHYDE; CHLORINE DERIVATIVE; CITRIC ACID TRIETHYL ESTER; CROSCARMELLOSE SODIUM; CROSPOVIDONE; ETHYL CELLULOSE; EXCIPIENT; FORMALDEHYDE; HEXANAL; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; MACROGOL 400; MACROGOL 4000; MICROCRYSTALLINE CELLULOSE; PENTAFLUOROBENZYLHYDROXYLAMINE HYDROCHLORIDE; POLOXAMER; POVIDONE; PROPIONALDEHYDE; STARCH; STARCH GLYCOLATE SODIUM; UNCLASSIFIED DRUG;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; DERIVATIZATION; DRUG DETERMINATION; DRUG QUALITY; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; PRIORITY JOURNAL;

ALDEHYDES; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXCIPIENTS; MOLECULAR WEIGHT; SENSITIVITY AND SPECIFICITY;

EID: 30744436305     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2005.10.084     Document Type: Article

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