In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension?

Journal of Hypertension

Volumn 30, Issue 1, 2012, Pages 153-167

  Liantonio, Antonella ^a   Gramegna, Gianluca ^a   Camerino, Giulia M ^a   Dinardo, Maria M ^a   Scaramuzzi, Antonia ^a   Potenza, Maria A ^b   Montagnani, Monica ^b   Procino, Giuseppe ^c   Lasorsa, Domenica R ^c   Mastrofrancesco, Lisa ^c   Laghezza, Antonio ^d   Fracchiolla, Giuseppe ^d   Loiodice, Fulvio ^d   Perrone, Maria G ^d   Lopedota, Angela ^d   Conte, Salvatore ^a   Penza, Rosa ^a   Valenti, Giovanna ^c   Svelto, Maria ^c   Camerino, Diana Conte ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Faculty of Medicine   (Italy)

^c Department of General and Environmental Physiology ^*  (Italy)

^d Faculty of Pharmacy   (Italy)

Author keywords

AQP2; blood pressure; CLC K chloride channels; diuretic; electrolytes; hypertension; in vivo treatment; polymorphism

Indexed keywords

AQUAPORIN 2; BENZOFURAN DERIVATIVE; CHLORIDE CHANNEL BLOCKING AGENT; DIURETIC AGENT; FUROSEMIDE; MESSENGER RNA; MT 189; RT 93; UNCLASSIFIED DRUG; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD INNER EAR BARRIER; CONTROLLED STUDY; DIURESIS; DIURETIC ACTIVITY; DOSE RESPONSE; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG PENETRATION; ELECTROLYTE BALANCE; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY MEDULLA; MALE; NONHUMAN; PERMEABILITY BARRIER; POLYURIA; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; URINE OSMOLALITY; URINE VOLUME;

EID: 83555164699     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32834d9eb9     Document Type: Article

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