CLCNKB-T481S and essential hypertension in a Ghanaian population

Journal of Hypertension

Volumn 27, Issue 2, 2009, Pages 298-304

  Sile, Saba ^a,d   Velez, Digna R ^a,b   Gillani, Niloufar B ^a   Narsia, Tinatin ^a   Moore, Jason H ^c   George Jr , Alfred L ^a,b   Vanoye, Carlos G ^a   Williams, Scott M ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d Division of Genetic Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; CHLORIDE CHANNEL KB; DNA; UNCLASSIFIED DRUG; CLCNKB PROTEIN, HUMAN;

AFRICAN AMERICAN; ARTICLE; BARTTIN GENE; CLC KB GENE; CLCNKB T481S GENE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; ETHNIC DIFFERENCE; EUROPEAN AMERICAN; GENE; GENE EXPRESSION REGULATION; GENE SEGREGATION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; GHANA; HUMAN; HUMAN CELL; KIDNEY TUBULE ABSORPTION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PATCH CLAMP; POPULATION GENETIC STRUCTURE; PRIORITY JOURNAL; WILD TYPE; XENOPUS; ADULT; AMINO ACID SUBSTITUTION; CAUCASIAN; CELL LINE; ELECTROPHYSIOLOGY; FEMALE; GENETICS; HYPERTENSION; METABOLISM; MIDDLE AGED; NEGRO; STATISTICAL MODEL;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AMINO ACID SUBSTITUTION; CELL LINE; CHLORIDE CHANNELS; ELECTROPHYSIOLOGY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; GHANA; HUMANS; HYPERTENSION; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 63849297175     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e3283140c9e     Document Type: Article

References (18)

1. Longini IM Jr, Higgins MW, Hinton PC, Moll PP, Keller JB. Environmental and genetic sources of familial aggregation of blood pressure in Tecumseh, Michigan. Am J Epidemiol 1984; 120:131-144.
2. Biron P, Mongeau JG, Bertrand D. Familial aggregation of blood pressure in 558 adopted children. Can Med Assoc J 1976; 115: 773-774.
3. Guyton AC. Abnormal renal function and autoregulation in essential hypertension. Hypertension 1991; 18 (5 Suppl):III49-III53.
4. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104:545-556.
5. Jeck N, Waldegger P, Doroszewicz J, Seyberth H, Waldegger S. A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity. Kidney Int 2004; 65:190-197.
6. Jeck N, Waldegger S, Lampert A, Boehmer C, Waldegger P, Lang PA, et al. Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Hypertension 2004; 43:1175-1181.
7. Williams SM, Stocki S, Jiang L, Brew K, Gordon S, Vaughan DE, et al. A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Ethn Dis 2007; 17:492-497.
8. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391:85-100.
9. + secretion. Nature 2001; 414:558-561.
10. Waldegger S, Jeck N, Barth P, Peters M, Vitzthum H, Wolf K, et al. Barttin increases surface expression and changes current properties of ClC-K channels. Pflugers Arch 2002; 444:411-418.
11. Sile S, Gillani NB, Velez DR, Vanoye CG, Yu C, Byrne LM, et al. Functional BSND variants in essential hypertension. Am J Hypertens 2007; 20:1176- 1182.
12. Hahn LW, Ritchie MD, Moore JH. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 2003; 19:376-382.
13. Fava C, Montagnana M, Almgren P, Rosberg L, Guidi GC, Berglund G, Melander O. The functional variant of the CLC-Kb channel T481S is not associated with blood pressure or hypertension in Swedes. J Hypertens 2007; 25:111-116.
14. Kokubo Y, Iwai N, Tago N, Inamoto N, Okayama A, Yamawaki H, et al. Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population: the Suita Study. Circ J 2005; 69:138-142.
15. Wang XF, Lin RY, Wang SZ, Zhang LP, Qian J, Lu DR, et al. Association study of variants in two ion-channel genes (TSC and CLCNKB) and hypertension in two ethnic groups in Northwest China. Clin Chim Acta 2008; 388:95-98.
16. Kojima S, Murakami K, Kimura G, Sanai T, Yoshida K, Imanishi M, et al. A gender difference in the association between salt sensitivity and family history of hypertension. Am J Hypertens 1992; 5:1-7.
17. Barlassina C, Dal Fiume C, Lanzani C, Manunta P, Guffanti G, Ruello A, et al. Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension. Hum Mol Genet 2007; 16:1630-1638.
18. Speirs HJ, Wang WY, Benjafield AV, Morris BJ. No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus chromosome 1p36. J Hypertens 2005; 23:1491- 1496.