Genetics of salt-sensitive hypertension

Current Hypertension Reports

Volumn 13, Issue 1, 2011, Pages 55-66

  Sanada, Hironobu ^b   Jones, John E ^a,c   Jose, Pedro A ^a,c  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b NATIONAL VETERINARY ASSAY LABORATORY   (Japan)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Blood pressure; Cardiovascular disease; Genes; Kidney disease; Low salt diet; Proteins; Renal sodium transport; Renin angiotensin system; Salt sensitivity; Sodium

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; ADDUCIN; ADRENERGIC RECEPTOR; ADRENOMEDULLIN; ALDOSTERONE SYNTHASE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSINOGEN; BRAIN NATRIURETIC PEPTIDE; CHLORIDE CHANNEL; CYTOCHROME P450 3A; DIPEPTIDYL CARBOXYPEPTIDASE; DOPAMINE; DOPAMINE RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN; EPITHELIAL SODIUM CHANNEL; G PROTEIN COUPLED RECEPTOR KINASE 4; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; ICOSANOID; KALLIKREIN; KININ; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM CHLORIDE;

ADRENERGIC SYSTEM; ARTICLE; CELL FUNCTION; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; HUMAN; HYPERTENSION; NONHUMAN; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SALT INTAKE; SODIUM TRANSPORT; TRANSGENIC MOUSE;

BLOOD PRESSURE; CARDIOVASCULAR DISEASES; GENE EXPRESSION; HUMANS; HYPERTENSION; KIDNEY DISEASES; NITRIC OXIDE SYNTHASE; RENIN-ANGIOTENSIN SYSTEM; RISK FACTORS; SODIUM, DIETARY; SYMPATHETIC NERVOUS SYSTEM; UNITED STATES;

EID: 79551556794     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-010-0167-6     Document Type: Article

References (142)

1. MH Weinberger NS Fineberg SE Fineberg, et al. 2001 Salt sensitivity, pulse pressure, and death in normal and hypertensive humans Hypertension 37 429 432 1:CAS:528:DC%2BD3MXhvVShu74%3D 11230313
2. P Strazzullo L D'Elia NB Kandala, et al. 2009 Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies BMJ 339 b4567 19934192 10.1136/bmj.b4567 This article reviews the health-related consequences of increased salt intake
3. FJ He GA MacGregor 2010 Reducing population salt intake worldwide: from evidence to implementation Prog Cardiovasc Dis 52 363 382 1:CAS:528: DC%2BC3cXltFGjsLk%3D 20226955 10.1016/j.pcad.2009.12.006 This article reviews the health-related consequences of increased salt intake
4. JM Sullivan 1991 Salt sensitivity. Definition, conception, methodology, and long-term issues Hypertension 17 1 suppl I61 I68 1:STN:280: DyaK3M%2FpvF2jtg%3D%3D 1987013
5. M Larrousse E Bragulat M Segarra, et al. 2006 Increased levels of atherosclerosis markers in salt-sensitive hypertension Am J Hypertens 19 87 93 1:CAS:528:DC%2BD28Xht1OrtL0%3D 16461197 10.1016/j.amjhyper.2005.06.019 (Pubitemid 43217040)
6. MS Yatabe J Yatabe M Yoneda, et al. 2010 Salt sensitivity is associated with insulin resistance, sympathetic overactivity, and decreased suppression of circulating renin activity in lean patients with essential hypertension Am J Clin Nutr 92 77 82 1:CAS:528:DC%2BC3cXotlags7Y%3D 20444953 10.3945/ajcn.2009. 29028
7. A de la Sierra V Giner E Bragulat, et al. 2002 Lack of correlation between two methods for the assessment of salt sensitivity in essential hypertension J Hum Hypertens 16 255 260 11967719 10.1038/sj.jhh.1001375
8. T Kawasaki CS Delea FC Bartter, et al. 1978 The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension Am J Med 64 193 198 1:CAS:528: DyaE1cXhsFSisrg%3D 629267 10.1016/0002-9343(78)90045-1
9. N Kato T Kanda M Sagara, et al. 2002 Proposition of a feasible protocol to evaluate salt sensitivity in a population-based setting Hypertens Res 25 801 809 12484501 10.1291/hypres.25.801
10. AC Shore ND Markandu GA MacGregor 1988 A randomized crossover study to compare the blood pressure response to sodium loading with and without chloride in patients with essential hypertension J Hypertens 6 613 617 1:STN:280:DyaL1M%2FjsFCisQ%3D%3D 3183367 10.1097/00004872-198808000-00003
11. O Schmidlin A Forman A Sebastian, et al. 2007 Sodium-selective salt sensitivity: its occurrence in blacks Hypertension 50 1085 1092 1:CAS:528:DC%2BD2sXht1yku7jJ 17938378 10.1161/HYPERTENSIONAHA.107.091694 (Pubitemid 350172930)
12. C Kitiyakara T Chabrashvili Y Chen, et al. 2003 Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase J Am Soc Nephrol 14 2775 2782 1:CAS:528:DC%2BD3sXotFWntr8%3D 14569087 10.1097/01.ASN.0000092145.90389.65 (Pubitemid 37305640)
13. H Oberleithner C Riethmüller H Schillers, et al. 2007 Plasma sodium stiffens vascular endothelium and reduces nitric oxide release Proc Natl Acad Sci U S A 104 16281 16286 1:CAS:528:DC%2BD2sXhtF2gsr%2FI 17911245 10.1073/pnas.0707791104 (Pubitemid 350099397)
14. BS Huang MS Amin FH Leenen 2006 The central role of the brain in salt-sensitive hypertension Curr Opin Cardiol 21 295 304 16755197 10.1097/01.hco.0000231398.64362.94 (Pubitemid 44315061)
15. E Pimenta KK Gaddam S Oparil, et al. 2009 Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension: results from a randomized trial al. Hypertension 54 475 481 1:CAS:528: DC%2BD1MXpsleksbY%3D 10.1161/HYPERTENSIONAHA.109.131235 This study shows the importance of dietary sodium in resistant hypertension
16. •• Egan BM, Zhao Y, Axon RN: US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 2010, 303:2043-2050. This is a very important update on essential hypertension in the United States.
17. JA Cutler EJ Roccella 2006 Salt reduction for preventing hypertension and cardiovascular disease: a population approach should include children Hypertension 48 818 819 1:CAS:528:DC%2BD28Xht1SjtLnP 17015775 10.1161/01.HYP.0000245673.93844.6d (Pubitemid 44610986)
18. FJ He GA MacGregor 2006 Importance of salt in determining blood pressure in children: meta-analysis of controlled trials Hypertension 48 861 869 1:CAS:528:DC%2BD28XhtVKjtLrK 17000923 10.1161/01.HYP.0000245672.27270.4a (Pubitemid 44610998)
19. HW Cohen MH Alderman 2007 Sodium, blood pressure, and cardiovascular disease Curr Opin Cardiol 22 306 310 17556882 10.1097/HCO.0b013e3281527901 (Pubitemid 46897281)
20. DW Harsha FM Sacks E Obarzanek, et al. 2004 Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trial Hypertension 43 393 398 1:CAS:528:DC%2BD2cXitVajsbk%3D 14707154 10.1161/01.HYP.0000113046.83819.a2 (Pubitemid 38174145)
21. MH Alderman 2004 Dietary sodium and cardiovascular health in hypertensive patients: the case against universal sodium restriction J Am Soc Nephrol 15 Suppl 1 S47 S50 1:CAS:528:DC%2BD3sXps1Siur4%3D 14684672 10.1097/01.ASN. 0000093236.74397.F3
22. N Ruiz-Opazo LV Lopez J Tonkiss 2004 Modulation of learning and memory in Dahl rats by dietary salt restriction Hypertension 43 797 802 1:CAS:528:DC%2BD2cXit12mtrc%3D 14967836 10.1161/01.HYP.0000120153.04064.8d (Pubitemid 38405590)
23. P Meneton X Jeunemaitre HE de Wardener, et al. 2005 Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases Physiol Rev 85 679 715 1:CAS:528:DC%2BD2MXjt12lsLo%3D 15788708 10.1152/physrev.00056.2003 (Pubitemid 40404639)
24. P Strazzullo F Galletti 2007 Genetics of salt-sensitive hypertension Curr Hypertens Rep 9 25 32 1:CAS:528:DC%2BD2sXhtVenur3N 17362668 10.1007/s11906-007-0006-6 (Pubitemid 46546695)
25. AG Logan O Friedman 2009 Can nocturnal hypertension predict cardiovascular risk? Integrated Blood Pressure Control 2 25 37 This article reviews the role of abnormal salt handling in the pathogenesis of nocturnal hypertension
26. E O'Brien 2009 Dipping comes of age. The importance of nocturnal blood pressure Hypertension 53 446 447 19171787 10.1161/HYPERTENSIONAHA.108.127571 1:CAS:528:DC%2BD1MXit1yitLo%3D
27. SD Crowley SB Gurley MJ Herrera, et al. 2006 Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney Proc Natl Acad Sci U S A 103 17985 17990 1:CAS:528:DC%2BD28Xht1Kmsr%2FP 17090678 10.1073/pnas.0605545103 (Pubitemid 44852272)
28. 5 R knockout mice.
29. T Uzu G Kimura 1999 Diuretics shift circadian rhythm of blood pressure from nondipper to dipper in essential hypertension Circulation 100 1635 1638 1:STN:280:DyaK1MvkvVWlsg%3D%3D 10517735
30. RP Lifton AG Gharavi DS Geller 2001 Molecular mechanisms of human hypertension Cell 104 545 556 1:CAS:528:DC%2BD3MXis1Kks7w%3D 11239411 10.1016/S0092-8674(01)00241-0 (Pubitemid 32201949)
31. PA Jose GM Eisner RA Felder 1998 The renal dopamine receptors in health and hypertension Pharmacol Ther 80 149 182 1:CAS:528:DyaK1cXmslyrsrk%3D 9839770 10.1016/S0163-7258(98)00027-8 (Pubitemid 28498226)
32. JP Granger BT Alexander M Llinas 2002 Mechanisms of pressure natriuresis Curr Hypertens Rep 4 152 159 11884271 10.1007/s11906-002-0040-3
33. AW Cowley Jr 2008 Renal medullary oxidative stress, pressure-natriuresis, and hypertension Hypertension 52 777 786 1:CAS:528:DC%2BD1cXht1GgtbvN 18852392 10.1161/HYPERTENSIONAHA.107.092858
34. SN Orlov AA Mongin 2007 Salt-sensing mechanisms in blood pressure regulation and hypertension Am J Physiol Heart Circ Physiol 293 H2039 H2053 1:CAS:528:DC%2BD2sXht1WlurvN 17693546 10.1152/ajpheart.00325.2007 (Pubitemid 47605848)
35. P Bie 2009 Blood volume, blood pressure and total body sodium: internal signalling and output control Acta Physiol (Oxf) 195 187 196 1:CAS:528:DC%2BD1MXns1Srtw%3D%3D 10.1111/j.1748-1716.2008.01932.x
36. 2+ exchanger and TRPC proteins. Biochim Biophys Acta 2010 Mar 6 (Epub ahead of print). This is a review on the role of endogenous ouabain in salt retention and hypertension.
37. RJ Johnson B Rodriguez-Iturbe D Kang, et al. 2005 A unifying pathway for essential hypertension Am J Hypertens 18 431 440 15797666 10.1016/j.amjhyper. 2004.08.035 (Pubitemid 40409928)
38. E Beeks AG Kessels AA Kroon, et al. 2004 Genetic predisposition to salt-sensitivity: a systematic review J Hypertens 22 1243 1249 1:CAS:528:DC%2BD2cXkvVGjurg%3D 15201536 10.1097/01.hjh.0000125443.28861.0d (Pubitemid 38888066)
39. H Kobori M Nangaku LG Navar A Nishiyama 2007 The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease Physiol Rev 59 251 287 1:CAS:528:DC%2BD2sXht1ahsr3E
40. J Varagic AJ Trask JA Jessup, et al. 2008 New angiotensins J Mol Med 86 663 671 1:CAS:528:DC%2BD1cXls1Klt7w%3D 18437333 10.1007/s00109-008-0340-4
41. SH Padia BA Kemp NL Howell, et al. 2008 Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats Hypertension 51 460 465 1:CAS:528:DC%2BD1cXot1KrsQ%3D%3D 18158338 10.1161/HYPERTENSIONAHA.107.103242 (Pubitemid 351156433)
42. LJ Salomone NL Howell HE McGrath, et al. 2007 Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism Hypertension 49 155 161 1:CAS:528:DC%2BD28XhtlSrs7nM 17116755 10.1161/01.HYP.0000251881.89610.ee (Pubitemid 46360355)
43. J Caprioli C Mele C Mossali, et al. 2008 Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension Can J Physiol Pharmacol 86 505 510 1:CAS:528:DC%2BD1cXhtVGnurnE 18758497 10.1139/Y08-045
44. L Zhang K Miyaki J Araki, et al. 2006 Interaction of angiotensin I-converting enzyme insertion-deletion polymorphism and daily salt intake influences hypertension in Japanese men Hypertens Res 29 751 758 1:CAS:528:DC%2BD2sXnt1ektQ%3D%3D 17283861 10.1291/hypres.29.751 (Pubitemid 44842809)
45. E Poch D Gonzalez V Giner, et al. 2001 Molecular basis of salt sensitivity in human hypertension Evaluation of renin-angiotensin-aldosterone system gene polymorphisms. Hypertension 38 1204 1209 1:CAS:528: DC%2BD3MXovVOrt7s%3D
46. T Katsuya K Ishikawa K Sugimoto, et al. 2003 Salt sensitivity of Japanese from the viewpoint of gene polymorphism Hypertens Res 26 521 525 12924618 10.1291/hypres.26.521 (Pubitemid 36974993)
47. AJ Mangrum RA Gomez VF Norwood 2002 Effects of AT1A receptor deletion on blood pressure and sodium excretion during altered dietary salt intake Am J Physiol Renal Physiol 283 F447 F453 1:CAS:528:DC%2BD38XntFOntr0%3D 12167595
48. D Gu TN Kelly JE Hixson, et al. 2010 Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure J Hypertens 28 1210 1220 1:CAS:528:DC%2BC3cXmtVSmsL8%3D 20486282
49. V Pinto MJ Pinho U Hopfer, et al. 2008 Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells Mol Cell Biochem 310 191 201 1:CAS:528:DC%2BD1cXitlWnsrc%3D 18095144 10.1007/s11010-007-9680-6
50. N Trochen S Ganapathipillai P Ferrari, et al. 2004 Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients Nephrol Dial Transplant 19 2499 2504 1:CAS:528:DC%2BD2cXnvVOlurY%3D 15304560 10.1093/ndt/gfh417 (Pubitemid 39360095)
51. Rao AD, Sun B, Hopkins P, et al.: Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 genes are associated with blood pressure and renin response to dietary salt intake in humans [abstract]. Presented at the High Blood Pressure Council Research 2010 Scientific Sessions. Washington, DC; October 13-16, 2010.
52. R Alikhani-Koupaei F Fouladkou P Fustier, et al. 2007 Identification of polymorphisms in the human 11beta-hydroxysteroid dehydrogenase type 2 gene promoter: functional characterization and relevance for salt sensitivity FASEB J 21 3618 3622 1:CAS:528:DC%2BD2sXht12jsbnL 17551100 10.1096/fj.07-8140com (Pubitemid 350075151)
53. EE Thompson H Kuttab-Boulos D Witonsky, et al. 2004 CYP3A variation and the evolution of salt-sensitivity variants Am J Hum Genet 75 1059 1069 1:CAS:528:DC%2BD2cXhtVegsrnF 15492926 10.1086/426406 (Pubitemid 39534403)
54. CB Eap M Bochud RC Elston, et al. 2007 CYP3A5 and ABCB1 genes influence blood pressure and response to treatment, and their effect is modified by salt Hypertension 49 1007 1014 1:CAS:528:DC%2BD2sXktFagsb4%3D 17372036 10.1161/HYPERTENSIONAHA.106.084236 (Pubitemid 351664314)
55. L Zhang K Miyaki W Wang, et al. 2010 CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men J Hum Hypertens 24 345 350 1:CAS:528:DC%2BC3cXkvVGjtrc%3D 19812606 10.1038/jhh.2009.74
56. JW Osborn GD Fink AF Sved, et al. 2007 Circulating angiotensin II and dietary salt: converging signals for neurogenic hypertension Curr Hypertens Rep 9 228 235 1:CAS:528:DC%2BD2sXhtVenur%2FE 17519130 10.1007/s11906-007-0041-3 (Pubitemid 46900043)
57. CS Weber JF Thayer M Rudat, et al. 2008 Salt-sensitive men show reduced heart rate variability, lower norepinephrine and enhanced cortisol during mental stress J Hum Hypertens 22 423 431 1:CAS:528:DC%2BD1cXlvFSjsr8%3D 18337758 10.1038/jhh.2008.11 (Pubitemid 351712389)
58. Rao F, Zhang K, Zhang L, et al.: Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension. Cell Mol Neurobiol 2010 Jun 23 (Epub ahead of print).
59. L Pojoga NS Kolatkar JS Williams, et al. 2006 β-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension Hypertension 48 892 900 1:CAS:528:DC%2BD28XhtVKjtLrP 17015767 10.1161/01.HYP.0000244688. 45472.95 (Pubitemid 44611002)
60. D Gu S Su D Ge, et al. 2006 Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese Hypertension 47 1147 1154 1:CAS:528:DC%2BD28XksVOmurs%3D 16636198 10.1161/01.HYP.0000219041. 66702.45 (Pubitemid 44289172)
61. C Bengra TE Mifflin Y Khripin, et al. 2002 Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers Clin Chem 48 2131 2140 1:CAS:528: DC%2BD38Xptlamsr0%3D 12446468
62. F Sayk D Heutling C Dodt, et al. 2010 Sympathetic function in human carriers of melanocortin-4 receptor gene mutations J Clin Endocrinol Metab 95 1998 2002 1:CAS:528:DC%2BC3cXltFSntr8%3D 20147580 10.1210/jc.2009-2297
63. JR Greenfield JW Miller JM Keogh, et al. 2009 Modulation of blood pressure by central melanocortinergic pathways N Engl J Med 360 44 52 1:CAS:528:DC%2BD1MXhvFOrug%3D%3D 19092146 10.1056/NEJMoa0803085
64. LS Tallam DE Stec MA Willis, et al. 2005 Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia Hypertension 46 326 332 1:CAS:528:DC%2BD2MXmtlSisrY%3D 16027245 10.1161/01.HYP.0000175474.99326.bf (Pubitemid 41099165)
65. J Dahlberg 2007 Nilsson LO, von Wowern F, Melander O: Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP PLoS One 2 5 e432 17487281 10.1371/journal.pone.0000432 1:CAS:528:DC%2BD2sXmvFykt7s%3D
66. P Manunta G Lavery C Lanzani, et al. 2008 Physiological interaction between α-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation Hypertension 52 366 372 1:CAS:528:DC%2BD1cXosFyqu7k%3D 18591455 10.1161/HYPERTENSIONAHA.108.113977
67. I Rubera J Loffing LG Palmer, et al. 2003 Collecting duct-specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance J Clin Invest 112 554 565 1:CAS:528:DC%2BD3sXms1Wnur8%3D 12925696
68. FZ Marques AE Campain YH Yang, et al. 2010 Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension Hypertension 56 319 324 1:CAS:528:DC%2BC3cXovVyqt7s%3D 20585107 10.1161/HYPERTENSIONAHA.110.155366
69. PG Bagos AL Elefsinioti GK Nikolopoulos, et al. 2007 The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14, 094 cases and 17, 760 controls J Hypertens 25 487 500 1:CAS:528: DC%2BD2sXhtlGqur0%3D 17278960 10.1097/HJH.0b013e328011db24 (Pubitemid 46213782)
70. DN Martín EP Andreu 2005 Ramírez Lorca R, et al.: G-protein beta-3 subunit gene C825T polymorphism: influence on plasma sodium and potassium concentrations in essential hypertensive patients Life Sci 77 2879 2886 16002097 10.1016/j.lfs.2005.02.030 1:CAS:528:DC%2BD2MXhtVGrt7%2FM (Pubitemid 41390952)
71. Turner ST, Schwartz GL, Chapman AB, et al.: C825T polymorphism of the G protein beta(3)-subunit and antihypertensive response to a thiazide diuretic. Hypertension 2001, 37(2 Part 2):739-743.
72. TN Kelly TK Rice D Gu, et al. 2009 Novel genetic variants in the α-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure Am J Hypertens 22 985 992 1:CAS:528:DC%2BD1MXhtVGrsbrK 19574959 10.1038/ajh.2009.118
73. C Barlassina C Dal Fiume C Lanzani, et al. 2007 Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension Hum Mol Genet 16 1630 1638 1:CAS:528:DC%2BD2sXosFektLo%3D 17510212 10.1093/hmg/ddm112 (Pubitemid 47050676)
74. +-ATPase activity is lacking in Dahl salt-sensitive rats Hypertension 21 767 771 1:CAS:528:DyaK3sXlslymtbo%3D 8099063 (Pubitemid 23171638)
75. R Efendiev RT Krmar G Ogimoto, et al. 2004 Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+, K∈+∈-ATPase trafficking in response to GPCR signals and intracellular sodium Circ Res 95 1100 1108 1:CAS:528:DC%2BD2cXpvVGmur4%3D 15528469 10.1161/01.RES.0000149570.20845.89 (Pubitemid 39557897)
76. L Torielli S Tivodar RC Montella, et al. 2008 α-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption Am J Physiol Renal Physiol 295 F478 F487 1:CAS:528:DC%2BD1cXhtVaktL%2FL 18524856 10.1152/ajprenal.90226. 2008
77. R Wang B Zhong Y Liu C Wang 2010 Association between α-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis J Appl Genet 51 87 94 1:STN:280:DC%2BC3c3otFKksA%3D%3D 20145305 10.1007/BF03195715
78. P Manunta M Maillard C Tantardini, et al. 2008 Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension J Hypertens 26 914 920 1:CAS:528:DC%2BD1cXktl2rtLg%3D 18398333 10.1097/HJH.0b013e3282f5315f (Pubitemid 351520978)
79. C Fava M Montagnana P Almgren, et al. 2007 Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender Am J Hypertens 20 981 989 1:CAS:528:DC%2BD2sXpvF2qtL4%3D 17765140 10.1016/j.amjhyper.2007.04.007 (Pubitemid 47313624)
80. JG Wang L Liu L Zagato, et al. 2004 Blood pressure in relation to three candidate genes in a Chinese population J Hypertens 22 937 944 1:CAS:528:DC%2BD2cXltFCmur0%3D 15097233 10.1097/00004872-200405000-00015 (Pubitemid 38680468)
81. K Stenström H Takemori G Bianchi, et al. 2009 Blocking the salt-inducible kinase 1 network prevents the increases in cell sodium transport caused by a hypertension-linked mutation in human α-adducin J Hypertens 27 2452 2457 19657284 10.1097/HJH.0b013e328330cf15 1:CAS:528:DC%2BD1MXhsVanu7jE
82. V Tikhonoff T Kuznetsova K Stolarz, et al. 2003 β-Adducin polymorphisms, blood pressure, and sodium excretion in three European populations Am J Hypertens 16 840 846 1:CAS:528:DC%2BD3sXnvFWis7c%3D 14553963 10.1016/S0895-7061(03)00975-0 (Pubitemid 37204681)
83. F Yoshihara S Suga N Yasui, et al. 2005 Chronic administration of adrenomedullin attenuates the hypertension and increases renal nitric oxide synthase in Dahl salt-sensitive rats Regul Pept 128 7 13 1:CAS:528: DC%2BD2MXhsVOgur8%3D 15721482 10.1016/j.regpep.2004.12.028 (Pubitemid 40255529)
84. Y Fujisawa Y Nagai A Miyatake, et al. 2004 Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats Eur J Pharmacol 497 75 80 1:CAS:528:DC%2BD2cXmsVGgu7g%3D 15321737 10.1016/j.ejphar.2004.06.039 (Pubitemid 39099215)
85. Y Li JA Staessen LH Li, et al. 2006 Blood pressure and urinary sodium excretion in relation to the A-1984 G adrenomedullin polymorphism in a Chinese population Kidney Int 69 1153 1158 1:CAS:528:DC%2BD28XivFOmtr4%3D 16609682 10.1038/sj.ki.5000213 (Pubitemid 43212238)
86. AA Banday MF Lokhandwala 2008 Dopamine receptors and hypertension Curr Hypertens Rep 10 268 275 1:CAS:528:DC%2BD1cXpvVWisrk%3D 18625155 10.1007/s11906-008-0051-9
87. C Zeng I Armando Y Luo, et al. 2008 Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice Am J Physiol Heart Circ Physiol 294 H551 H569 1:CAS:528: DC%2BD1cXit1ymu7g%3D 18083900 10.1152/ajpheart.01036.2007 (Pubitemid 351253262)
88. MR Citarella MR Choi MM Gironacci, et al. 2009 Urodilatin and dopamine: a new interaction in the kidney Regul Pept 153 19 24 1:CAS:528: DC%2BD1MXitVGjsr4%3D 19101594 10.1016/j.regpep.2008.11.009
89. B Yao RC Harris MZ Zhang 2009 Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway Hypertension 54 1077 1083 1:CAS:528:DC%2BD1MXht1ymsr3F 19770404 10.1161/HYPERTENSIONAHA.109.137174
90. +-ATPase activity in the proximal tubule Am J Physiol Renal Physiol 292 F1435 F1442 1:CAS:528:DC%2BD2sXlslShurs%3D 17264308 10.1152/ajprenal.00176. 2006 (Pubitemid 46701871)
91. C Yu Z Yang H Ren, et al. 2009 D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs Am J Hypertens 22 877 883 1:CAS:528:DC%2BD1MXptlGru70%3D 19390510 10.1038/ajh.2009.80
92. C Zeng Y Han H Huang, et al. 2009 D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression J Hypertens 27 1033 1041 1:CAS:528: DC%2BD1MXltVahu7c%3D 19293728 10.1097/HJH.0b013e3283293c7b
93. U Venkatakrishnan C Chen MF Lokhandwala 2000 The role of intrarenal nitric oxide in the natriuretic response to dopamine-receptor activation Clin Exp Hypertens 22 309 324 1:CAS:528:DC%2BD3cXjsFSitbw%3D 10803736 10.1081/CEH-100100080 (Pubitemid 30305954)
94. S Crambert A Sjöberg AC Eklöf, et al. 2010 Prolactin and dopamine 1-like receptor interaction in renal proximal tubular cells Am J Physiol Renal Physiol 299 F49 F54 1:CAS:528:DC%2BC3cXpsVOrtbc%3D 20462969 10.1152/ajprenal.00582.2009
95. F Khan Z Spicarová S Zelenin, et al. 2008 Negative reciprocity between angiotensin II type 1 and dopamine D1 receptors in rat renal proximal tubule cells Am J Physiol Renal Physiol 295 F1110 F1116 1:CAS:528: DC%2BD1cXht1ymu77K 18701624 10.1152/ajprenal.90336.2008
96. H Li I Armando P Yu, et al. 2008 Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells J Clin Invest 118 2180 2189 1:CAS:528:DC%2BD1cXpsVOku74%3D 18464932 10.1172/JCI33637C1
97. • Jose PA, Soares-da-Silva P, Eisner GM, Felder RA: Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation. Biochim Biophys Acta 2010 Feb 12 (Epub ahead of print). This article reviews the role of GRK4 gene variants in regulating blood pressure.
98. NV Olsen 1998 Effects of dopamine on renal haemodynamics tubular function and sodium excretion in normal humans Dan Med Bull 45 282 297 1:CAS:528:DyaK1cXlsVOnt78%3D 9675540
99. DP O'Connell NV Ragsdale DG Boyd, et al. 1997 Differential human renal tubular responses to dopamine type 1 receptor stimulation are determined by blood pressure status Hypertension 29 1 Pt 1 115 122 9039090
100. T Hussain R Abdul-Wahab DK Kotak, et al. 1998 Bromocriptine regulates angiotensin II response on sodium pump in proximal tubules Hypertension 32 1054 1059 1:CAS:528:DyaK1MXitVWitw%3D%3D 9856973
101. A Ueda R Ozono T Oshima, et al. 2003 Disruption of the type 2 dopamine receptor gene causes a sodium-dependent increase in blood pressure in mice Am J Hypertens 16 853 858 1:CAS:528:DC%2BD3sXnvFWisL8%3D 14553965 10.1016/S0895-7061(03)01013-6 (Pubitemid 37204683)
102. Z Yang LD Asico P Yu, et al. 2006 D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure Am J Physiol Regul Integr Comp Physiol 290 R96 R104 1:CAS:528:DC%2BD28XhsVKisbw%3D 16352863
103. T Staudacher B Pech M Tappe, et al. 2007 Arterial blood pressure and renal sodium excretion in dopamine D3 receptor knockout mice Hypertens Res 30 93 101 1:CAS:528:DC%2BD2sXjvFWltbk%3D 17460376 10.1291/hypres.30.93
104. S Rudberg C Lemne B Persson, et al. 1997 The dopaminuric response to high salt diet in insulin-dependent diabetes mellitus and in family history of hypertension Pediatr Nephrol 11 169 173 1:STN:280:DyaK2s3ks1Sntw%3D%3D 9090656 10.1007/s004670050251 (Pubitemid 27122685)
105. JR Sowers MB Zemel P Zemel, et al. 1988 Salt sensitivity in blacks. Salt intake and natriuretic substances Hypertension 12 485 490 1:STN:280: DyaL1M%2FltlCltA%3D%3D 2973438
106. A Damasceno A Santos P Serrão, et al. 1999 Deficiency of renal dopaminergic-dependent natriuretic response to acute sodium load in black salt-sensitive subjects in contrast to salt-resistant subjects J Hypertens 17 1995 2001 1:CAS:528:DC%2BD3cXhtV2ktbc%3D 10703901 10.1097/00004872-199917121- 00033
107. M Haney AS Ward RW Foltin, et al. 2001 Effects of ecopipam, a selective dopamine D1 antagonist, on smoked cocaine self-administration by humans Psychopharmacology (Berl) 155 330 337 1:CAS:528:DC%2BD3MXkvFShurw%3D 10.1007/s002130100725 (Pubitemid 32523103)
108. AA Banday YS Lau MF Lokhandwala 2008 Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley rats Hypertension 51 367 375 1:CAS:528:DC%2BD1cXmt1Ojuw%3D%3D 18158345 10.1161/HYPERTENSIONAHA.107.102111 (Pubitemid 351159952)
109. JA Staessen T Kuznetsova H Zhang, et al. 2008 Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4 Hypertension 51 1643 1650 1:CAS:528:DC%2BD1cXlvFait7g%3D 18413491 10.1161/HYPERTENSIONAHA.107.109611
110. RA Felder H Sanada J Xu, et al. 2002 G protein-coupled receptor kinase 4 gene variants in human essential hypertension Proc Natl Acad Sci U S A 99 3872 3877 1:CAS:528:DC%2BD38Xis1Kltb4%3D 11904438 10.1073/pnas.062694599 (Pubitemid 34252198)
111. S Sen R Nesse L Sheng, et al. 2005 Association between a dopamine-4 receptor polymorphism and blood pressure Am J Hypertens 18 1206 1210 1:CAS:528:DC%2BD2MXhtVegurbK 16182111 10.1016/j.amjhyper.2005.04.010 (Pubitemid 41337974)
112. JJ Gildea I Shah R Weiss, et al. 2010 HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling Hypertension 56 505 511 1:CAS:528:DC%2BC3cXhtVCntrnN 20660820 10.1161/HYPERTENSIONAHA.110.152256
113. SM Williams MD Ritchie JA Phillips 3rd, et al. 2004 Multilocus analysis of hypertension: a hierarchical approach Hum Hered 57 28 38 15133310 10.1159/000077387 (Pubitemid 38608307)
114. H Sanada J Yatabe S Midorikawa, et al. 2006 Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension Clin Chem 52 352 360 1:CAS:528:DC%2BD28Xit1Shtrc%3D 16439609 10.1373/clinchem.2005.059139
115. HJ Speirs K Katyk NN Kumar, et al. 2004 Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension J Hypertens 22 931 936 1:CAS:528:DC%2BD2cXltFCmurw%3D 15097232 10.1097/00004872-200405000-00014 (Pubitemid 38680467)
116. H Zhu Y Lu X Wang, et al. 2006 The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents Pediatr Res 60 440 442 1:CAS:528:DC%2BD28XpvVOhs70%3D 16940246 10.1203/01.pdr.0000238250.64591.44 (Pubitemid 44427597)
117. C Zeng VA Villar GM Eisner, et al. 2008 G protein-coupled receptor kinase 4: role in blood pressure regulation Hypertension 51 1449 1455 1:CAS:528:DC%2BD1cXlvFaitr0%3D 18347232 10.1161/HYPERTENSIONAHA.107.096487
118. BK Rana PA Insel SH Payne, et al. 2007 Population-based sample reveals gene-gender interactions in blood pressure in white Americans Hypertension 49 96 106 1:CAS:528:DC%2BD28XhtlSrs7nO 17159089 10.1161/01.HYP.0000252029.35106.67 (Pubitemid 46360347)
119. KE Lohmueller LJ Wong MM Mauney, et al. 2006 Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure Ann Hum Genet 70 27 41 1:CAS:528:DC%2BD28XitVGlu7k%3D 16441255 10.1111/j.1529-8817.2005.00197.x (Pubitemid 43355559)
120. CJ Wang JB Zhao JL Xu, et al. 2009 Meta-analysis on the association of G894T polymorphism in endothelial nitric oxide synthase gene and essential hypertension in Chinese population Zhonghua Liu Xing Bing Xue Za Zhi 30 845 849 20193212
121. KT Moe ST Lim P Wong, et al. 2006 Association analysis of endothelial nitric oxide synthase gene polymorphism with primary hypertension in a Singapore population J Hum Hypertens 20 956 963 1:CAS:528:DC%2BD28Xht1akurnM 17024134 10.1038/sj.jhh.1002096 (Pubitemid 44782829)
122. TV Pereira M Rudnicki BM Cheung, et al. 2007 Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias J Hypertens 25 1763 1774 1:CAS:528:DC%2BD2sXpslalsbg%3D 17762636 10.1097/HJH.0b013e3281de740d (Pubitemid 47356613)
123. K Miyaki S Tohyama M Murata, et al. 2005 Salt intake affects the relation between hypertension and the T-786 C polymorphism in the endothelial nitric oxide synthase gene Am J Hypertens 18 1556 1562 1:CAS:528:DC%2BD2MXhtlCrs7jN 16364825 10.1016/j.amjhyper.2005.06.012 (Pubitemid 41814676)
124. DR Dengel MD Brown RE Ferrell, et al. 2007 A preliminary study on T-786 C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium Physiol Res 56 393 401 1:CAS:528:DC%2BD2sXhtFGgt7nM 16925467
125. A Machnik A Dahlmann C Kopp, et al. 2010 Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces
126. A Machnik W Neuhofer J Jantsch, et al. 2009 Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism Nat Med 15 545 552 1:CAS:528: DC%2BD1MXltlSrs74%3D 19412173 10.1038/nm.1960
127. RJ Roman 2002 P-450 metabolites of arachidonic acid in the control of cardiovascular function Physiol Rev 82 131 185 1:CAS:528:DC%2BD38XovFSisQ%3D%3D 11773611
128. CL Laffer M Laniado-Schwartzman MH Wang, et al. 2003 20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension Hypertension 41 703 708 1:CAS:528:DC%2BD3sXhsFWktbg%3D 12623983 10.1161/01.HYP.0000051888.91497.47 (Pubitemid 36314578)
129. JH Capdevila 2007 Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases Curr Opin Nephrol Hypertens 16 465 467 17693763 10.1097/MNH.0b013e32827ab48c (Pubitemid 47254698)
130. JM Williams A Sarkis KM Hoagland, et al. 2008 Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury Am J Physiol Renal Physiol 295 F1764 F1777 1:CAS:528:DC%2BD1cXhsFSnurzF 18842817 10.1152/ajprenal.90525.2008
131. G D'Angelo AS Loria DM Pollock, et al. 2010 Endothelin activation of reactive oxygen species mediates stress-induced pressor response in Dahl salt-sensitive prehypertensive rats Hypertension 56 282 289 20547970 10.1161/HYPERTENSIONAHA.110.152629 1:CAS:528:DC%2BC3cXovVyqt74%3D
132. CE Gariepy T Ohuchi SC Williams, et al. 2000 Salt-sensitive hypertension in endothelin-B receptor-deficient rats J Clin Invest 105 925 933 1:CAS:528:DC%2BD3cXit1ynsrc%3D 10749572 10.1172/JCI8609
133. BR may be protective
134. C Bellini C Ferri A Piccoli, et al. 1993 The influence of salt sensitivity on the blood pressure response to exogenous kallikrein in essential hypertensive patients Nephron 65 28 35 1:STN:280:DyaK2c%2FhvF2qsA%3D%3D 8413787 10.1159/000187436
135. JT Yan T Wang J Li, et al. 2008 Recombinant adeno-associated virus-mediated human kallikrein gene therapy prevents high-salt diet-induced hypertension without effect on basal blood pressure in rats Acta Pharmacol Sin 29 808 814 1:CAS:528:DC%2BD1cXovVSms78%3D 18565278 10.1111/j.1745-7254.2008. 00815.x
136. J Chao JJ Zhang KF Lin, et al. 1998 Human kallikrein gene delivery attenuates hypertension, cardiac hypertrophy, and renal injury in Dahl salt-sensitive rats Hum Gene Ther 9 21 31 1:CAS:528:DyaK1cXlsVyqsg%3D%3D 9458239 10.1089/hum.1998.9.1-21 (Pubitemid 28050907)
137. L Cervenka LM Harrison-Bernard S Dipp, et al. 1999 Early onset salt-sensitive hypertension in bradykinin B2 receptor null mice Hypertension 34 176 180 1:CAS:528:DyaK1MXlvFGmtLo%3D 10454437
138. C Newton-Cheh MG Larson RS Vasan, et al. 2009 Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure Nat Genet 41 348 353 1:CAS:528:DC%2BD1MXhvFKjsbs%3D 19219041 10.1038/ng.328
139. S Rubattu A Evangelista D Barbato, et al. 2007 Atrial natriuretic peptide (ANP) gene promoter variant and increased susceptibility to early development of hypertension in humans J Hum Hypertens 21 822 824 1:CAS:528: DC%2BD2sXhtVKhsrrI 17525707 10.1038/sj.jhh.1002228 (Pubitemid 47450010)
140. U Schorr J Beige J Ringel, et al. 1997 Hpa II polymorphism of the atrial natriuretic peptide gene and the blood pressure response to salt intake in normotensive men J Hypertens 15 715 718 1:CAS:528:DyaK2sXkslaktLw%3D 9222938 10.1097/00004872-199715070-00002 (Pubitemid 27249986)
141. AM Glazier JH Nadeau TJ Aitman 2002 Finding genes that underlie complex traits Science 298 2345 2349 1:CAS:528:DC%2BD38Xps1Sju7Y%3D 12493905 10.1126/science.1076641 (Pubitemid 36014199)
142. O Abiola JM Angel P Avner, et al. 2003 Complex Trait Consortium: The nature and identification of quantitative trait loci: a community's view Nat Rev Genet 4 911 916 14634638