Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel

Nature Genetics

Volumn 21, Issue 1, 1999, Pages 95-98

  Matsumura, Yoshihiro ^a   Uchida, Shinichi ^a   Kondo, Yoshiaki ^a   Miyazaki, Hiroaki ^a   Ko, Shigeru B H ^a   Hayama, Atsushi ^a   Morimoto, Tetuji ^a   Liu, Wen ^a   Arisawa, Mikio ^a   Sasaki, Sei ^a   Marumo, Fumiaki ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL;

ANIMAL TISSUE; ARTICLE; CHLORIDE TRANSPORT; GENE TARGETING; HENLE LOOP; KIDNEY CONCENTRATING CAPACITY; MOUSE; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CHLORIDE CHANNELS; DIABETES INSIPIDUS, NEPHROGENIC; DISEASE MODELS, ANIMAL; FEMALE; LOOP OF HENLE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

ANIMALIA; TRIXIS;

EID: 0032947011     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/5036     Document Type: Article

References (14)

1. Uchida, S. et al. Molecular cloning of a chloride channel that is regulated by dehydration and predominantly expressed in kidney medulla. J. Biol. Chem. 268, 3821-3824 (1993).
2. Uchida, S. et al. Localization and functional characterization of rat kidney-specific chloride channel, CIC-K1. J. Clin. Invest. 95, 104-113 (1995).
3. Imai, M. & Kokko, J.P. Mechanism of sodium and chloride transport in the thin ascending limb of Henle. J. Clin. Invest. 58, 1054-1060 (1976).
4. Kokko, J.P. & Rector, F.C. Jr Countercurrent multiplication system without active transport in inner medulla. Kidney Int. 2, 214-223 (1972).
5. Imai. M., Taniguchi, J. & Tabei, K. Function of thin loop of Henle. Kidney Int. 31, 565-579 (1987).
6. Simon, D.B. et al. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nature Genet. 17, 171-178 (1997).
7. Kieferle, S., Fong, P., Bens, M., Vandewalle, A. & Jentsch, T.J. Two highly homologous members of the CIC chloride channel family in both rat and human kidney. Proc. Natl Acad. Sci. USA 91, 6943-6947 (1994).
8. Takeuchi, Y., Uchida, S., Marumo, F. & Sasaki, S. Cloning, tissue distribution, and intrarenal localization of CIC chloride channels in human kidney. Kidney Int. 48, 1497-1503 (1995).
9. Kondo, Y., Yoshitomi, K. & Imai, M. Effect of anion transport inhibitors and ion substitution on Cl transport in the thin ascending limb of Henle's loop. Am. J. Physiol. 253, F1206-F1215 (1987).
10. Kondo, Y., Yoshitomi, K. & Imai, M. Effect of pH on Cl transport in the thin limb ascending limb of Henle's loop. Am. J. Physiol. 253, F1216-F1222 (1987).
11. Yoshitomi, K., Kondo, Y. & Imai, M. Evidence for conductive Cl pathways across the cell membranes of the thin ascending limb of Henle's loop. J. Clin. Invest. 82, 866-871 (1988).
12. Lolait, S.J. et al. Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus. Nature 357, 335-339 (1992).
13. Rosenthal, W. et al. Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus. Nature 359, 233-235 (1992).
14. Deen, P.M.T. et al. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264, 92-95 (1994).