메뉴 건너뛰기




Volumn 15, Issue 5, 2006, Pages 511-516

Molecular physiology of renal ClC chloride channels/transporters

Author keywords

Bartter syndrome; Chloride channel; Hypertension; Ion transporter; Polymorphism

Indexed keywords

FUROSEMIDE; PROTEIN NKCC1; PROTEIN NKCC2; PROTEIN OSR1; PROTEIN SERINE THREONINE KINASE; PROTEIN SPAK; PROTEIN WNK; RENIN; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG;

EID: 33747361255     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mnh.0000242177.36953.be     Document Type: Review
Times cited : (14)

References (54)
  • 1
    • 33645296826 scopus 로고    scopus 로고
    • ClC chloride channels viewed through a transporter lens
    • Miller C. ClC chloride channels viewed through a transporter lens. Nature 2006; 440:484-489. This is a superb and elegant review of newly recognized transporter behaviors of ClC proteins with emphasis on structural determinants of permeation.
    • (2006) Nature , vol.440 , pp. 484-489
    • Miller, C.1
  • 3
    • 22944479662 scopus 로고    scopus 로고
    • Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins
    • - channels. This observation raises questions about the proposed mechanism for role of ClC-5 in providing a shunt conductance in endosomes.
    • (2005) Nature , vol.436 , pp. 424-427
    • Scheel, O.1    Zdebik, A.A.2    Lourdel, S.3
  • 4
    • 22944475536 scopus 로고    scopus 로고
    • Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5
    • + exchangers, and further examined proton transport in other ClC proteins.
    • (2005) Nature , vol.436 , pp. 420-423
    • Picollo, A.1    Pusch, M.2
  • 5
    • 0033534733 scopus 로고    scopus 로고
    • Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents
    • Friedrich T, Breiderhoff T, Jentsch TJ. Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents. J Biol Chem 1999; 274:896-902.
    • (1999) J Biol Chem , vol.274 , pp. 896-902
    • Friedrich, T.1    Breiderhoff, T.2    Jentsch, T.J.3
  • 6
    • 0036521873 scopus 로고    scopus 로고
    • Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells
    • London
    • Vanoye CG, George AL Jr. Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells. J Physiol (London) 2002; 539:373-383.
    • (2002) J Physiol , vol.539 , pp. 373-383
    • Vanoye, C.G.1    George Jr., A.L.2
  • 7
    • 30444442312 scopus 로고    scopus 로고
    • Ion-binding properties of the ClC chloride selectivity filter
    • Lobet S, Dutzler R. Ion-binding properties of the ClC chloride selectivity filter. EMBO J 2006; 25:24-33. This is an x-ray crystallographic study delineating chloride ion binding sites within the bacterial ClCec-1 protein.
    • (2006) EMBO J , vol.25 , pp. 24-33
    • Lobet, S.1    Dutzler, R.2
  • 8
    • 0034637572 scopus 로고    scopus 로고
    • Functional and structural analysis of ClC-K chloride channels involved in renal disease
    • Waldegger S, Jentsch TJ. Functional and structural analysis of ClC-K chloride channels involved in renal disease. J Biol Chem 2000; 275:24527-24533.
    • (2000) J Biol Chem , vol.275 , pp. 24527-24533
    • Waldegger, S.1    Jentsch, T.J.2
  • 9
    • 22244489419 scopus 로고    scopus 로고
    • Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule
    • Engh AM, Maduke M. Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule. J Gen Physiol 2005; 125:601-617.
    • (2005) J Gen Physiol , vol.125 , pp. 601-617
    • Engh, A.M.1    Maduke, M.2
  • 10
    • 28244457359 scopus 로고    scopus 로고
    • + exchanger
    • + transport in bacterial ClCec-1. These observations provide valuable insight into the structural/ functional differences between ClC channels and transporters.
    • (2005) J Gen Physiol , vol.126 , pp. 563-570
    • Accardi, A.1    Walden, M.2    Nguitragool, W.3
  • 11
    • 33646174153 scopus 로고    scopus 로고
    • Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte
    • Denton J, Nehrke K, Yin X, et al. Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte. Am J Physiol Cell Physiol 2006; 290:C1109-C1118.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Denton, J.1    Nehrke, K.2    Yin, X.3
  • 12
    • 33646190688 scopus 로고    scopus 로고
    • Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity
    • He L, Denton J, Nehrke K. Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity. Biophys J 2006; 90:3570-3581.
    • (2006) Biophys J , vol.90 , pp. 3570-3581
    • He, L.1    Denton, J.2    Nehrke, K.3
  • 13
    • 24144461620 scopus 로고    scopus 로고
    • Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels
    • Hebeisen S, Fahlke C. Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels. Biophys J 2005; 3:1710-1720.
    • (2005) Biophys J , vol.3 , pp. 1710-1720
    • Hebeisen, S.1    Fahlke, C.2
  • 14
    • 0030838729 scopus 로고    scopus 로고
    • Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1
    • Schmidt-Rose T, Jentsch TJ. Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1. J Biol Chem 1997; 272:20515-20521.
    • (1997) J Biol Chem , vol.272 , pp. 20515-20521
    • Schmidt-Rose, T.1    Jentsch, T.J.2
  • 15
    • 0032477820 scopus 로고    scopus 로고
    • Formation of CLC-0 chloride channels from separated transmembrane and cytoplasmic domains
    • Maduke M, Williams C, Miller C. Formation of CLC-0 chloride channels from separated transmembrane and cytoplasmic domains. Biochemistry 1998; 37:1315-1321.
    • (1998) Biochemistry , vol.37 , pp. 1315-1321
    • Maduke, M.1    Williams, C.2    Miller, C.3
  • 16
    • 0032510969 scopus 로고    scopus 로고
    • 2 and COOH terminus of the yeast CLC putative chloride channel Gef1p
    • 2 and COOH terminus of the yeast CLC putative chloride channel Gef1p. J Biol Chem 1998; 273:15110-15118.
    • (1998) J Biol Chem , vol.273 , pp. 15110-15118
    • Schwappach, B.1    Stobrawa, S.2    Hechenberger, M.3
  • 17
    • 0141793708 scopus 로고    scopus 로고
    • A role for CBS domain 2 in trafficking of chloride channel CLC-5
    • Carr G, Simmons N, Sayer J. A role for CBS domain 2 in trafficking of chloride channel CLC-5. Biochem Biophys Res Commun 2003; 310:600-605.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 600-605
    • Carr, G.1    Simmons, N.2    Sayer, J.3
  • 18
    • 1842424664 scopus 로고    scopus 로고
    • The role of the carboxy-terminus in ClC chloride channel function
    • Hebeisen S, Biela A, Giese B, et al. The role of the carboxy-terminus in ClC chloride channel function. J Biol Chem 2004; 279:13140-13147.
    • (2004) J Biol Chem , vol.279 , pp. 13140-13147
    • Hebeisen, S.1    Biela, A.2    Giese, B.3
  • 19
    • 3042648417 scopus 로고    scopus 로고
    • Functional and structural conservation of CBS domains from CLC chloride channels
    • London
    • Estevez R, Pusch M, Ferrer-Costa C, et al. Functional and structural conservation of CBS domains from CLC chloride channels. J Physiol (London) 2004; 557:363-378.
    • (2004) J Physiol , vol.557 , pp. 363-378
    • Estevez, R.1    Pusch, M.2    Ferrer-Costa, C.3
  • 20
    • 85047691317 scopus 로고    scopus 로고
    • CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
    • Scott JW, Hawley SA, Green KA, et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J Clin Invest 2004; 113:274-284.
    • (2004) J Clin Invest , vol.113 , pp. 274-284
    • Scott, J.W.1    Hawley, S.A.2    Green, K.A.3
  • 21
    • 25444467180 scopus 로고    scopus 로고
    • Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels
    • Bennetts B, Rychkov GY, Ng HL, et al. Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. J Biol Chem 2005; 280:32452-32458.
    • (2005) J Biol Chem , vol.280 , pp. 32452-32458
    • Bennetts, B.1    Rychkov, G.Y.2    Ng, H.L.3
  • 22
    • 7944234789 scopus 로고    scopus 로고
    • Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies
    • Niemeyer MI, Yusef YR, Cornejo I, et al. Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies. Physiol Genomics 2004; 19:74-83.
    • (2004) Physiol Genomics , vol.19 , pp. 74-83
    • Niemeyer, M.I.1    Yusef, Y.R.2    Cornejo, I.3
  • 23
    • 32044449196 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the chloride channel ClC-0
    • Meyer S, Dutzler R. Crystal structure of the cytoplasmic domain of the chloride channel ClC-0. Structure 2006; 14:299-307. This is an x-ray crystallographic study defining a high resolution structure for the carboxyl-terminus of the eukaryotic ClC-0 purified from T. marmorata with emphasis on the CBS subdomains.
    • (2006) Structure , vol.14 , pp. 299-307
    • Meyer, S.1    Dutzler, R.2
  • 24
    • 33645287670 scopus 로고    scopus 로고
    • Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain
    • Yusef YR, Zuniga L, Catalan M, et al. Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain. J Physiol 2006; 572:173-181.
    • (2006) J Physiol , vol.572 , pp. 173-181
    • Yusef, Y.R.1    Zuniga, L.2    Catalan, M.3
  • 25
    • 14844293074 scopus 로고    scopus 로고
    • Impaired acidification in early endosomes of CIC-5 deficient proximal tubule
    • Hara-Chikuma M, Wang YH, Guggino SE, et al. Impaired acidification in early endosomes of CIC-5 deficient proximal tubule. Biochem Biophys Res Commun 2005; 329:941-946.
    • (2005) Biochem Biophys Res Commun , vol.329 , pp. 941-946
    • Hara-Chikuma, M.1    Wang, Y.H.2    Guggino, S.E.3
  • 26
    • 33644861728 scopus 로고    scopus 로고
    • ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function
    • Lange PF, Wartosch L, Jentsch TJ, et al. ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. Nature 2006; 440:220-223.
    • (2006) Nature , vol.440 , pp. 220-223
    • Lange, P.F.1    Wartosch, L.2    Jentsch, T.J.3
  • 27
    • 0038722029 scopus 로고    scopus 로고
    • Proteolysis, the ubiquitin-proteasome system, and renal diseases
    • Debigare R, Price SR. Proteolysis, the ubiquitin-proteasome system, and renal diseases. Am J Physiol Renal Physiol 2003; 285:F1-F8.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • Debigare, R.1    Price, S.R.2
  • 30
    • 11244331526 scopus 로고    scopus 로고
    • Nedd4-2 functionally interacts with ClC-5 - Involvement in constitutive albumin endocytosis in proximal tubule cells
    • Hryciw DH, Ekberg J, Lee A, et al. Nedd4-2 functionally interacts with ClC-5 - Involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem 2004; 279:54996-55007.
    • (2004) J Biol Chem , vol.279 , pp. 54996-55007
    • Hryciw, D.H.1    Ekberg, J.2    Lee, A.3
  • 31
    • 20044382873 scopus 로고    scopus 로고
    • Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases
    • Embark HM, Bohmer C, Palmada M, et al. Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. Kidney Int 2004; 66:1918-1925.
    • (2004) Kidney Int , vol.66 , pp. 1918-1925
    • Embark, H.M.1    Bohmer, C.2    Palmada, M.3
  • 34
    • 0035936780 scopus 로고    scopus 로고
    • Molecular mechanisms of human hypertension
    • Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104:545-556.
    • (2001) Cell , vol.104 , pp. 545-556
    • Lifton, R.P.1    Gharavi, A.G.2    Geller, D.S.3
  • 36
    • 16944366243 scopus 로고    scopus 로고
    • Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III
    • Simon DB, Bindra RS, Mansfield TA, et al. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nature Genet 1997; 17:171-178.
    • (1997) Nature Genet , vol.17 , pp. 171-178
    • Simon, D.B.1    Bindra, R.S.2    Mansfield, T.A.3
  • 37
    • 0035189356 scopus 로고    scopus 로고
    • Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure
    • Birkenhager R, Otto E, Schurmann MJ, et al. Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Nature Genet 2001; 29:310-314.
    • (2001) Nature Genet , vol.29 , pp. 310-314
    • Birkenhager, R.1    Otto, E.2    Schurmann, M.J.3
  • 38
    • 1642366722 scopus 로고    scopus 로고
    • Salt wasting and deafness resulting from mutations in two chloride channels
    • Schlingmann KP, Konrad M, Jeck N, et al. Salt wasting and deafness resulting from mutations in two chloride channels. N Engl J Med 2004; 350:1314-1319.
    • (2004) N Engl J Med , vol.350 , pp. 1314-1319
    • Schlingmann, K.P.1    Konrad, M.2    Jeck, N.3
  • 39
    • 0347362500 scopus 로고    scopus 로고
    • A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity
    • Jeck N, Waldegger P, Doroszewicz J, et al. A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity. Kidney Int 2004; 65:190-197.
    • (2004) Kidney Int , vol.65 , pp. 190-197
    • Jeck, N.1    Waldegger, P.2    Doroszewicz, J.3
  • 40
    • 2542446285 scopus 로고    scopus 로고
    • Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension
    • Jeck N, Waldegger S, Lampert A, et al. Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Hypertension 2004; 43:1175-1181.
    • (2004) Hypertension , vol.43 , pp. 1175-1181
    • Jeck, N.1    Waldegger, S.2    Lampert, A.3
  • 41
    • 14644432480 scopus 로고    scopus 로고
    • Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population - The Suita Study
    • Kokubo Y, Iwai N, Tago N, et al. Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population-the Suita Study. Circ J 2005; 69:138-142.
    • (2005) Circ J , vol.69 , pp. 138-142
    • Kokubo, Y.1    Iwai, N.2    Tago, N.3
  • 42
    • 33646051988 scopus 로고    scopus 로고
    • Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds
    • Frey A, Lampert A, Waldegger S, et al. Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds. Hear Res 2006; 214:68-75.
    • (2006) Hear Res , vol.214 , pp. 68-75
    • Frey, A.1    Lampert, A.2    Waldegger, S.3
  • 43
    • 33747342855 scopus 로고    scopus 로고
    • Functional characterization of BSND variants
    • Sile S, Vanoye CG, Byre LM, et al. Functional characterization of BSND variants. J Am Soc Nephrol 2005; 16:367A.
    • (2005) J Am Soc Nephrol , vol.16
    • Sile, S.1    Vanoye, C.G.2    Byre, L.M.3
  • 44
    • 0032947011 scopus 로고    scopus 로고
    • Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel
    • Matsumura Y, Uchida S, Kondo Y, et al. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Nature Genet 1999; 21:95-98.
    • (1999) Nature Genet , vol.21 , pp. 95-98
    • Matsumura, Y.1    Uchida, S.2    Kondo, Y.3
  • 45
    • 4344666270 scopus 로고    scopus 로고
    • Molecular determinants of differential pore blocking of kidney CLC-K chloride channels
    • Picollo A, Liantonio A, Didonna MP, et al. Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep 2004; 5:584-589.
    • (2004) EMBO Rep , vol.5 , pp. 584-589
    • Picollo, A.1    Liantonio, A.2    Didonna, M.P.3
  • 46
    • 9144241252 scopus 로고    scopus 로고
    • Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers
    • Liantonio A, Pusch M, Picollo A, et al. Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers. J Am Soc Nephrol 2004; 15:13-20.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 13-20
    • Liantonio, A.1    Pusch, M.2    Picollo, A.3
  • 47
    • 30044450910 scopus 로고    scopus 로고
    • Activation and inhibition of kidney CLC-K chloride channels by fenamates
    • Liantonio A, Picollo A, Babini E, et al. Activation and inhibition of kidney CLC-K chloride channels by fenamates. Mol Pharmacol 2006; 69:165-173.
    • (2006) Mol Pharmacol , vol.69 , pp. 165-173
    • Liantonio, A.1    Picollo, A.2    Babini, E.3
  • 48
    • 2642687664 scopus 로고    scopus 로고
    • The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells
    • Obermuller N, Gretz N, Kriz W, et al. The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells. J Clin Invest 1998; 101:635-642.
    • (1998) J Clin Invest , vol.101 , pp. 635-642
    • Obermuller, N.1    Gretz, N.2    Kriz, W.3
  • 49
    • 0028832124 scopus 로고
    • Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1
    • Uchida S, Sasaki S, Nitta K, et al. Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1. J Clin Invest 1995; 95:104-113.
    • (1995) J Clin Invest , vol.95 , pp. 104-113
    • Uchida, S.1    Sasaki, S.2    Nitta, K.3
  • 50
    • 0032949770 scopus 로고    scopus 로고
    • Localization of rat CLC-K2 chloride channel mRNA in the kidney
    • Yoshikawa M, Uchida S, Yamauchi A, et al. Localization of rat CLC-K2 chloride channel mRNA in the kidney. Am J Physiol 1999; 276:F552-F558.
    • (1999) Am J Physiol , vol.276
    • Yoshikawa, M.1    Uchida, S.2    Yamauchi, A.3
  • 51
    • 0034920817 scopus 로고    scopus 로고
    • Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney
    • Kobayashi K, Uchida S, Mizutani S, et al. Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. J Am Soc Nephrol 2001; 12:1327-1334.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1327-1334
    • Kobayashi, K.1    Uchida, S.2    Mizutani, S.3
  • 52
    • 0041706014 scopus 로고    scopus 로고
    • The chloride channel ClC-4 contributes to endosomal acidification and trafficking
    • Mohammad-Panah R, Harrison R, Dhani S, et al. The chloride channel ClC-4 contributes to endosomal acidification and trafficking. J Biol Chem 2003; 278:29267-29277.
    • (2003) J Biol Chem , vol.278 , pp. 29267-29277
    • Mohammad-Panah, R.1    Harrison, R.2    Dhani, S.3
  • 53
    • 0032953770 scopus 로고    scopus 로고
    • Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease
    • Devuyst O, Christie PT, Courtoy PJ, et al. Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease. Hum Mol Genet 1999; 8:247-257.
    • (1999) Hum Mol Genet , vol.8 , pp. 247-257
    • Devuyst, O.1    Christie, P.T.2    Courtoy, P.J.3
  • 54
    • 0035080771 scopus 로고    scopus 로고
    • Localization of mouse CLC-6 and CLC-7 mRNA and their functional complementation of yeast CLC gene mutant
    • Kida Y, Uchida S, Miyazaki H, et al. Localization of mouse CLC-6 and CLC-7 mRNA and their functional complementation of yeast CLC gene mutant. Histochem Cell Biol 2001; 115:189-194.
    • (2001) Histochem Cell Biol , vol.115 , pp. 189-194
    • Kida, Y.1    Uchida, S.2    Miyazaki, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.