-
1
-
-
33645296826
-
ClC chloride channels viewed through a transporter lens
-
Miller C. ClC chloride channels viewed through a transporter lens. Nature 2006; 440:484-489. This is a superb and elegant review of newly recognized transporter behaviors of ClC proteins with emphasis on structural determinants of permeation.
-
(2006)
Nature
, vol.440
, pp. 484-489
-
-
Miller, C.1
-
3
-
-
22944479662
-
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins
-
- channels. This observation raises questions about the proposed mechanism for role of ClC-5 in providing a shunt conductance in endosomes.
-
(2005)
Nature
, vol.436
, pp. 424-427
-
-
Scheel, O.1
Zdebik, A.A.2
Lourdel, S.3
-
4
-
-
22944475536
-
Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5
-
+ exchangers, and further examined proton transport in other ClC proteins.
-
(2005)
Nature
, vol.436
, pp. 420-423
-
-
Picollo, A.1
Pusch, M.2
-
5
-
-
0033534733
-
Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents
-
Friedrich T, Breiderhoff T, Jentsch TJ. Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents. J Biol Chem 1999; 274:896-902.
-
(1999)
J Biol Chem
, vol.274
, pp. 896-902
-
-
Friedrich, T.1
Breiderhoff, T.2
Jentsch, T.J.3
-
6
-
-
0036521873
-
Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells
-
London
-
Vanoye CG, George AL Jr. Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells. J Physiol (London) 2002; 539:373-383.
-
(2002)
J Physiol
, vol.539
, pp. 373-383
-
-
Vanoye, C.G.1
George Jr., A.L.2
-
7
-
-
30444442312
-
Ion-binding properties of the ClC chloride selectivity filter
-
Lobet S, Dutzler R. Ion-binding properties of the ClC chloride selectivity filter. EMBO J 2006; 25:24-33. This is an x-ray crystallographic study delineating chloride ion binding sites within the bacterial ClCec-1 protein.
-
(2006)
EMBO J
, vol.25
, pp. 24-33
-
-
Lobet, S.1
Dutzler, R.2
-
8
-
-
0034637572
-
Functional and structural analysis of ClC-K chloride channels involved in renal disease
-
Waldegger S, Jentsch TJ. Functional and structural analysis of ClC-K chloride channels involved in renal disease. J Biol Chem 2000; 275:24527-24533.
-
(2000)
J Biol Chem
, vol.275
, pp. 24527-24533
-
-
Waldegger, S.1
Jentsch, T.J.2
-
9
-
-
22244489419
-
Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule
-
Engh AM, Maduke M. Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule. J Gen Physiol 2005; 125:601-617.
-
(2005)
J Gen Physiol
, vol.125
, pp. 601-617
-
-
Engh, A.M.1
Maduke, M.2
-
10
-
-
28244457359
-
+ exchanger
-
+ transport in bacterial ClCec-1. These observations provide valuable insight into the structural/ functional differences between ClC channels and transporters.
-
(2005)
J Gen Physiol
, vol.126
, pp. 563-570
-
-
Accardi, A.1
Walden, M.2
Nguitragool, W.3
-
11
-
-
33646174153
-
Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte
-
Denton J, Nehrke K, Yin X, et al. Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte. Am J Physiol Cell Physiol 2006; 290:C1109-C1118.
-
(2006)
Am J Physiol Cell Physiol
, vol.290
-
-
Denton, J.1
Nehrke, K.2
Yin, X.3
-
12
-
-
33646190688
-
Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity
-
He L, Denton J, Nehrke K. Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity. Biophys J 2006; 90:3570-3581.
-
(2006)
Biophys J
, vol.90
, pp. 3570-3581
-
-
He, L.1
Denton, J.2
Nehrke, K.3
-
13
-
-
24144461620
-
Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels
-
Hebeisen S, Fahlke C. Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels. Biophys J 2005; 3:1710-1720.
-
(2005)
Biophys J
, vol.3
, pp. 1710-1720
-
-
Hebeisen, S.1
Fahlke, C.2
-
14
-
-
0030838729
-
Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1
-
Schmidt-Rose T, Jentsch TJ. Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1. J Biol Chem 1997; 272:20515-20521.
-
(1997)
J Biol Chem
, vol.272
, pp. 20515-20521
-
-
Schmidt-Rose, T.1
Jentsch, T.J.2
-
15
-
-
0032477820
-
Formation of CLC-0 chloride channels from separated transmembrane and cytoplasmic domains
-
Maduke M, Williams C, Miller C. Formation of CLC-0 chloride channels from separated transmembrane and cytoplasmic domains. Biochemistry 1998; 37:1315-1321.
-
(1998)
Biochemistry
, vol.37
, pp. 1315-1321
-
-
Maduke, M.1
Williams, C.2
Miller, C.3
-
17
-
-
0141793708
-
A role for CBS domain 2 in trafficking of chloride channel CLC-5
-
Carr G, Simmons N, Sayer J. A role for CBS domain 2 in trafficking of chloride channel CLC-5. Biochem Biophys Res Commun 2003; 310:600-605.
-
(2003)
Biochem Biophys Res Commun
, vol.310
, pp. 600-605
-
-
Carr, G.1
Simmons, N.2
Sayer, J.3
-
18
-
-
1842424664
-
The role of the carboxy-terminus in ClC chloride channel function
-
Hebeisen S, Biela A, Giese B, et al. The role of the carboxy-terminus in ClC chloride channel function. J Biol Chem 2004; 279:13140-13147.
-
(2004)
J Biol Chem
, vol.279
, pp. 13140-13147
-
-
Hebeisen, S.1
Biela, A.2
Giese, B.3
-
19
-
-
3042648417
-
Functional and structural conservation of CBS domains from CLC chloride channels
-
London
-
Estevez R, Pusch M, Ferrer-Costa C, et al. Functional and structural conservation of CBS domains from CLC chloride channels. J Physiol (London) 2004; 557:363-378.
-
(2004)
J Physiol
, vol.557
, pp. 363-378
-
-
Estevez, R.1
Pusch, M.2
Ferrer-Costa, C.3
-
20
-
-
85047691317
-
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
-
Scott JW, Hawley SA, Green KA, et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J Clin Invest 2004; 113:274-284.
-
(2004)
J Clin Invest
, vol.113
, pp. 274-284
-
-
Scott, J.W.1
Hawley, S.A.2
Green, K.A.3
-
21
-
-
25444467180
-
Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels
-
Bennetts B, Rychkov GY, Ng HL, et al. Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. J Biol Chem 2005; 280:32452-32458.
-
(2005)
J Biol Chem
, vol.280
, pp. 32452-32458
-
-
Bennetts, B.1
Rychkov, G.Y.2
Ng, H.L.3
-
22
-
-
7944234789
-
Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies
-
Niemeyer MI, Yusef YR, Cornejo I, et al. Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies. Physiol Genomics 2004; 19:74-83.
-
(2004)
Physiol Genomics
, vol.19
, pp. 74-83
-
-
Niemeyer, M.I.1
Yusef, Y.R.2
Cornejo, I.3
-
23
-
-
32044449196
-
Crystal structure of the cytoplasmic domain of the chloride channel ClC-0
-
Meyer S, Dutzler R. Crystal structure of the cytoplasmic domain of the chloride channel ClC-0. Structure 2006; 14:299-307. This is an x-ray crystallographic study defining a high resolution structure for the carboxyl-terminus of the eukaryotic ClC-0 purified from T. marmorata with emphasis on the CBS subdomains.
-
(2006)
Structure
, vol.14
, pp. 299-307
-
-
Meyer, S.1
Dutzler, R.2
-
24
-
-
33645287670
-
Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain
-
Yusef YR, Zuniga L, Catalan M, et al. Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain. J Physiol 2006; 572:173-181.
-
(2006)
J Physiol
, vol.572
, pp. 173-181
-
-
Yusef, Y.R.1
Zuniga, L.2
Catalan, M.3
-
25
-
-
14844293074
-
Impaired acidification in early endosomes of CIC-5 deficient proximal tubule
-
Hara-Chikuma M, Wang YH, Guggino SE, et al. Impaired acidification in early endosomes of CIC-5 deficient proximal tubule. Biochem Biophys Res Commun 2005; 329:941-946.
-
(2005)
Biochem Biophys Res Commun
, vol.329
, pp. 941-946
-
-
Hara-Chikuma, M.1
Wang, Y.H.2
Guggino, S.E.3
-
26
-
-
33644861728
-
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function
-
Lange PF, Wartosch L, Jentsch TJ, et al. ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. Nature 2006; 440:220-223.
-
(2006)
Nature
, vol.440
, pp. 220-223
-
-
Lange, P.F.1
Wartosch, L.2
Jentsch, T.J.3
-
27
-
-
0038722029
-
Proteolysis, the ubiquitin-proteasome system, and renal diseases
-
Debigare R, Price SR. Proteolysis, the ubiquitin-proteasome system, and renal diseases. Am J Physiol Renal Physiol 2003; 285:F1-F8.
-
(2003)
Am J Physiol Renal Physiol
, vol.285
-
-
Debigare, R.1
Price, S.R.2
-
30
-
-
11244331526
-
Nedd4-2 functionally interacts with ClC-5 - Involvement in constitutive albumin endocytosis in proximal tubule cells
-
Hryciw DH, Ekberg J, Lee A, et al. Nedd4-2 functionally interacts with ClC-5 - Involvement in constitutive albumin endocytosis in proximal tubule cells. J Biol Chem 2004; 279:54996-55007.
-
(2004)
J Biol Chem
, vol.279
, pp. 54996-55007
-
-
Hryciw, D.H.1
Ekberg, J.2
Lee, A.3
-
31
-
-
20044382873
-
Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases
-
Embark HM, Bohmer C, Palmada M, et al. Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. Kidney Int 2004; 66:1918-1925.
-
(2004)
Kidney Int
, vol.66
, pp. 1918-1925
-
-
Embark, H.M.1
Bohmer, C.2
Palmada, M.3
-
34
-
-
0035936780
-
Molecular mechanisms of human hypertension
-
Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104:545-556.
-
(2001)
Cell
, vol.104
, pp. 545-556
-
-
Lifton, R.P.1
Gharavi, A.G.2
Geller, D.S.3
-
36
-
-
16944366243
-
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III
-
Simon DB, Bindra RS, Mansfield TA, et al. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nature Genet 1997; 17:171-178.
-
(1997)
Nature Genet
, vol.17
, pp. 171-178
-
-
Simon, D.B.1
Bindra, R.S.2
Mansfield, T.A.3
-
37
-
-
0035189356
-
Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure
-
Birkenhager R, Otto E, Schurmann MJ, et al. Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Nature Genet 2001; 29:310-314.
-
(2001)
Nature Genet
, vol.29
, pp. 310-314
-
-
Birkenhager, R.1
Otto, E.2
Schurmann, M.J.3
-
38
-
-
1642366722
-
Salt wasting and deafness resulting from mutations in two chloride channels
-
Schlingmann KP, Konrad M, Jeck N, et al. Salt wasting and deafness resulting from mutations in two chloride channels. N Engl J Med 2004; 350:1314-1319.
-
(2004)
N Engl J Med
, vol.350
, pp. 1314-1319
-
-
Schlingmann, K.P.1
Konrad, M.2
Jeck, N.3
-
39
-
-
0347362500
-
A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity
-
Jeck N, Waldegger P, Doroszewicz J, et al. A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity. Kidney Int 2004; 65:190-197.
-
(2004)
Kidney Int
, vol.65
, pp. 190-197
-
-
Jeck, N.1
Waldegger, P.2
Doroszewicz, J.3
-
40
-
-
2542446285
-
Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension
-
Jeck N, Waldegger S, Lampert A, et al. Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Hypertension 2004; 43:1175-1181.
-
(2004)
Hypertension
, vol.43
, pp. 1175-1181
-
-
Jeck, N.1
Waldegger, S.2
Lampert, A.3
-
41
-
-
14644432480
-
Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population - The Suita Study
-
Kokubo Y, Iwai N, Tago N, et al. Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population-the Suita Study. Circ J 2005; 69:138-142.
-
(2005)
Circ J
, vol.69
, pp. 138-142
-
-
Kokubo, Y.1
Iwai, N.2
Tago, N.3
-
42
-
-
33646051988
-
Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds
-
Frey A, Lampert A, Waldegger S, et al. Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds. Hear Res 2006; 214:68-75.
-
(2006)
Hear Res
, vol.214
, pp. 68-75
-
-
Frey, A.1
Lampert, A.2
Waldegger, S.3
-
44
-
-
0032947011
-
Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel
-
Matsumura Y, Uchida S, Kondo Y, et al. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Nature Genet 1999; 21:95-98.
-
(1999)
Nature Genet
, vol.21
, pp. 95-98
-
-
Matsumura, Y.1
Uchida, S.2
Kondo, Y.3
-
45
-
-
4344666270
-
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels
-
Picollo A, Liantonio A, Didonna MP, et al. Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep 2004; 5:584-589.
-
(2004)
EMBO Rep
, vol.5
, pp. 584-589
-
-
Picollo, A.1
Liantonio, A.2
Didonna, M.P.3
-
46
-
-
9144241252
-
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers
-
Liantonio A, Pusch M, Picollo A, et al. Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers. J Am Soc Nephrol 2004; 15:13-20.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 13-20
-
-
Liantonio, A.1
Pusch, M.2
Picollo, A.3
-
47
-
-
30044450910
-
Activation and inhibition of kidney CLC-K chloride channels by fenamates
-
Liantonio A, Picollo A, Babini E, et al. Activation and inhibition of kidney CLC-K chloride channels by fenamates. Mol Pharmacol 2006; 69:165-173.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 165-173
-
-
Liantonio, A.1
Picollo, A.2
Babini, E.3
-
48
-
-
2642687664
-
The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells
-
Obermuller N, Gretz N, Kriz W, et al. The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells. J Clin Invest 1998; 101:635-642.
-
(1998)
J Clin Invest
, vol.101
, pp. 635-642
-
-
Obermuller, N.1
Gretz, N.2
Kriz, W.3
-
49
-
-
0028832124
-
Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1
-
Uchida S, Sasaki S, Nitta K, et al. Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1. J Clin Invest 1995; 95:104-113.
-
(1995)
J Clin Invest
, vol.95
, pp. 104-113
-
-
Uchida, S.1
Sasaki, S.2
Nitta, K.3
-
50
-
-
0032949770
-
Localization of rat CLC-K2 chloride channel mRNA in the kidney
-
Yoshikawa M, Uchida S, Yamauchi A, et al. Localization of rat CLC-K2 chloride channel mRNA in the kidney. Am J Physiol 1999; 276:F552-F558.
-
(1999)
Am J Physiol
, vol.276
-
-
Yoshikawa, M.1
Uchida, S.2
Yamauchi, A.3
-
51
-
-
0034920817
-
Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney
-
Kobayashi K, Uchida S, Mizutani S, et al. Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. J Am Soc Nephrol 2001; 12:1327-1334.
-
(2001)
J Am Soc Nephrol
, vol.12
, pp. 1327-1334
-
-
Kobayashi, K.1
Uchida, S.2
Mizutani, S.3
-
52
-
-
0041706014
-
The chloride channel ClC-4 contributes to endosomal acidification and trafficking
-
Mohammad-Panah R, Harrison R, Dhani S, et al. The chloride channel ClC-4 contributes to endosomal acidification and trafficking. J Biol Chem 2003; 278:29267-29277.
-
(2003)
J Biol Chem
, vol.278
, pp. 29267-29277
-
-
Mohammad-Panah, R.1
Harrison, R.2
Dhani, S.3
-
53
-
-
0032953770
-
Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease
-
Devuyst O, Christie PT, Courtoy PJ, et al. Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease. Hum Mol Genet 1999; 8:247-257.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 247-257
-
-
Devuyst, O.1
Christie, P.T.2
Courtoy, P.J.3
-
54
-
-
0035080771
-
Localization of mouse CLC-6 and CLC-7 mRNA and their functional complementation of yeast CLC gene mutant
-
Kida Y, Uchida S, Miyazaki H, et al. Localization of mouse CLC-6 and CLC-7 mRNA and their functional complementation of yeast CLC gene mutant. Histochem Cell Biol 2001; 115:189-194.
-
(2001)
Histochem Cell Biol
, vol.115
, pp. 189-194
-
-
Kida, Y.1
Uchida, S.2
Miyazaki, H.3
|