CLC-K channels: If the drug fits, use it

EMBO Reports

Volumn 5, Issue 6, 2004, Pages 565-566

  Fong, Peying ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Binding sites; Chloride channel; Drugs

Indexed keywords

2 (4 CHLOROPHENOXY) 3 PHENYLPROPIONIC ACID; 2 (4 CHLOROPHENOXY)PROPIONIC ACID; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BARTTER SYNDROME; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SENSITIVITY; DRUG TARGETING; DRUG URINE LEVEL; GENE MUTATION; HUMAN; HYPERTENSION; NEPHROGENIC DIABETES INSIPIDUS; NONHUMAN; PRIORITY JOURNAL; THOMSEN DISEASE;

2-METHYL-4-CHLOROPHENOXYACETIC ACID; ANIMALS; ANION TRANSPORT PROTEINS; CHLORIDE CHANNELS; HUMANS; MEMBRANE PROTEINS;

EID: 4344677396     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400168     Document Type: Article

References (12)

1. Birkenhäger R et al (2001) Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure. Nat Med 29: 310-314
2. Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R (2002) X-ray structure of a CLC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity. Nature 415: 287-294
3. +secretion. Nature 414: 558-561
4. Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M (2003) Conservation of chloride channel structure revealed by an inhibitor binding site in CIC-1. Neuron 38: 47-59
5. Jentsch TJ, Stein V, Weinreich F, Zdebik AA (2002) Molecular structure and physiological function of chloride channels. Physiol Rev 82: 503-568
6. Kieferle S, Fong P, Bens M, Vandewalle A, Jentsch TJ (1994) Two highly homologous members of the CIC chloride channel family in both rat and human kidney. Proc Natl Acad Sci USA 91: 6943-6947
7. Kobayashi K, Uchida S, Mizutani S, Sasaki S, Marumo F (2001) Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney. J Am Soc Nephrol 12:1327-1334
8. Liantonio A et al (2002) Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid. Mol Pharmacol 62: 265-271
9. Liantonio A et al (2004) Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers. J Am Soc Nephrol 15: 13-20
10. Matsumura Y et al (1999) Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Nat Genet 21: 95-98
11. Picollo A, Liantonio A, Didonna MP, Elia L, Conte Camerino D, Pusch M (2004) Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep 5: 584-589
12. Simon D et al (1997) Mutations in the chloride channel gene CLCNKB, cause Bartter's syndrome type III. Nat Genet 17: 171-178