Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension

American Journal of Physiology - Renal Physiology

Volumn 295, Issue 2, 2008, Pages

  Capasso, Giovambattista ^a   Rizzo, Maria ^a   Garavaglia, Maria Lisa ^g   Trepiccione, Francesco ^a   Zacchia, Miriam ^a   Mugione, Alessandra ^a   Ferrari, Patrizia ^b   Paulmichl, Markus ^f   Lang, Florian ^c   Loffing, Johannes ^d   Carrel, Monique ^d   Damiano, Sara ^a   Wagner, Carsten A ^d   Bianchi, Giuseppe ^e   Meyer, Giuliano ^g  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Prassis Sigma Tau Research Institute   (Italy)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f PARACELSUS MEDICAL UNIVERSITY   (Austria)

^g UNIVERSITY OF MILAN   (Italy)

Author keywords

Aldosterone; Epithelial sodium channel; Kidney specific chloride channel; Pendrin; Sodium chloride cotransporter; Sodium potassium 2 chloride cotransporter; Type 3 sodium hydrogen exchanger

Indexed keywords

BENDROFLUMETHIAZIDE; CHLORIDE CHANNEL; MESSENGER RNA; PENDRIN; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; SODIUM PROTON EXCHANGE PROTEIN 3; ALDOSTERONE; BICARBONATE CHLORIDE ANTIPORTER; CLCNK1 PROTEIN, RAT; EPITHELIAL SODIUM CHANNEL; PENDRIN PROTEIN, RAT; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3; SODIUM-POTASSIUM CHLORIDE COTRANSPORTER 2 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; HYPERTENSION; IMMUNOCYTOCHEMISTRY; KIDNEY CORTEX; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; GENETICS; KIDNEY MEDULLA; METABOLISM; PATHOPHYSIOLOGY; RAT STRAIN; SALT INTAKE;

ALDOSTERONE; ANIMALS; CHLORIDE CHANNELS; CHLORIDE-BICARBONATE ANTIPORTERS; DISEASE MODELS, ANIMAL; EPITHELIAL SODIUM CHANNEL; HYPERTENSION; KIDNEY CORTEX; KIDNEY MEDULLA; PATCH-CLAMP TECHNIQUES; RATS; RATS, INBRED STRAINS; RNA, MESSENGER; SODIUM CHLORIDE SYMPORTERS; SODIUM CHLORIDE, DIETARY; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; UP-REGULATION;

EID: 52449095393     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00340.2007     Document Type: Article

References (46)

1. Amemiya M, Loffing J, Lotscher M, Kaissling B, Alpern RJ, Moe OW. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int 48: 1206-1215, 1995.
2. Barlassina C, Dal FC, Lanzani C, Manunta P, Guffanti G, Ruello A, Bianchi G, Del VL, Macciardi F, Cusi D. Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension. Hum Mol Genet 16: 1630-1638, 2007.
3. Bianchi G. Genetic variations of tubular sodium reabsorption leading to "primary" hypertension: from gene polymorphism to clinical symptoms. Am J Physiol Regul Integr Comp Physiol 289: R1536-R1549, 2005.
4. Bianchi G, Baer PG, Fox U, Duzzi L, Pagetti D, Giovannetti AM. Changes in renin, water balance, and sodium balance during development of high blood pressure in genetically hypertensive rats. Circ Res 36: 153-161, 1975.
5. Bianchi G, Fox U, Di Francesco GF, Giovanetti AM, Pagetti D. Blood pressure changes produced by kidney cross-transplantation between spontaneously hypertensive rats and normotensive rats. Clin Sci Mol Med 47: 435-448, 1974.
6. Bostanjoglo M, Reeves WB, Reilly RF, Velazquez H, Robertson N, Litwack G, Morsing P, Dorup J, Bachmann S, Ellison DH, Bostonjoglo M. 11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules. J Am Soc Nephrol 9: 1347-1358, 1998.
7. Burry RW. Specificity controls for immunocytochemical methods. J Histochem Cytochem 48: 163-166, 2000.
8. Calo L, Davis PA, Semplicini A. Control of vascular tone in the syndromes of Bartter and Gitelman. Crit Rev Clin Lab Sci 37: 503-522, 2000.
9. + transporters in the early phase of genetic hypertension. Am J Physiol Renal Physiol 288: F1173-F1182, 2005.
10. Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci USA 103: 17985-17990, 2006.
11. Duc C, Farman N, Canessa CM, Bonvalet JP, Rossier BC. Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry. J Cell Biol 127: 1907-1921, 1994.
12. Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG, Knepper MA. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 279: F46-F53, 2000.
13. +-ATPase trafficking in response to GPCR signals and intracellular sodium. Circ Res 95: 1100-1108, 2004.
14. Fanestil DD. Steroid regulation of thiazide-sensitive transport. Semin Nephrol 12: 18-23, 1992.
15. Greger R, Oberleithner H, Schlatter E, Cassola AC, Weidtke C. Chloride activity in cells of isolated perfused cortical thick ascending limbs of rabbit kidney. Pflügers Arch 399: 29-34, 1983.
16. Hager H, Kwon TH, Vinnikova AK, Masilamani S, Brooks HL, Frokiaer J, Knepper MA, Nielsen S. Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney. Am J Physiol Renal Physiol 280: F1093-F1106, 2001.
17. + transport across renal brush-border membrane vesicles from rats of the Milan hypertensive strain. Biochim Biophys Acta 819: 179-186, 1985.
18. Hierholzer K, Wiederholt M, Stolte H. The impairment of sodium resorption in the proximal and distal convolution of adrenalectomized rats. Pflügers Arch 291: 43-62, 1966.
19. Hughes CA, Bennett V. Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. J Biol Chem 270: 18990-18996, 1995.
20. Jeck N, Waldegger S, Lampert A, Boehmer C, Waldegger P, Lang PA, Wissinger B, Friedrich B, Risler T, Moehle R, Lang UE, Zill P, Bondy B, Schaeffeler E, sante-Poku S, Seyberth H, Schwab M, Lang F. Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension. Hypertension 43: 1175-1181, 2004.
21. Jentsch TJ. Chloride transport in the kidney: lessons from human disease and knockout mice. J Am Soc Nephrol 16: 1549-1561, 2005.
22. Kaplan MR, Plotkin MD, Lee WS, Xu ZC, Lytton J, Hebert SC. Apical localization of the Na-K-Cl cotransporter, rBSC1, on rat thick ascending limbs. Kidney Int 49: 40-47, 1996.
23. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
24. Kim GH, Masilamani S, Turner R, Mitchell C, Wade JB, Knepper MA. The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci USA 95: 14552-14557, 1998.
25. Loffing J, Kaissling B. Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. Am J Physiol Renal Physiol 284: F628-F643, 2003.
26. Loffing J, Vallon V, Loffing-Cueni D, Aregger F, Richter K, Pietri L, Bloch-Faure M, Hoenderop JG, Shull GE, Meneton P, Kaissling B. Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol 15: 2276-2288, 2004.
27. Mansfield TA, Simon DB, Farfel Z, Bia M, Tucci JR, Lebel M, Gutkin M, Vialettes B, Christofilis MA, Kauppinen-Makelin R, Mayan H, Risch N, Lifton RP. Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet 16: 202-205, 1997.
28. Mantero F, Nussdorfer GG, Robba C, Opocher G, Ferrari P, Bianchi G. Evidence for mineralcorticoid hyperactivity in the Milan hypertensive strain of rats. J Hypertens 1, Suppl 2: 150-153, 1983.
29. Masilamani S, Kim GH, Mitchell C, Wade JB, Knepper MA. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 104: R19-R23, 1999.
30. Melzi ML, Syren ML, Assael BM, Sereni F, Aperia A. Increased renal tubular Na-K-ATPase activity in Milan hypertensive rats in the prehypertensive period. Pediatr Nephrol 5: 700-703, 1991.
31. -. Biochem Biophys Res Commun 276: 312-320, 2000.
32. Nissant A, Lourdel S, Baillet S, Paulais M, Marvao P, Teulon J, Imbert-Teboul M. Heterogeneous distribution of chloride channels along the distal convoluted tubule probed by single-cell RT-PCR and patch clamp. Am J Physiol Renal Physiol 287: F1233-F1243, 2004.
33. - channels of the distal nephron. Am J Physiol Renal Physiol 291: F1157-F1168, 2006.
34. - exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Am J Physiol Renal Physiol 287: F1179-F1188, 2004.
35. Schafer JA, Watkins ML, Li L, Herter P, Haxelmans S, Schlatter E. A simplified method for isolation of large numbers of defined nephron segments. Am J Physiol Renal Physiol 273: F650-F657, 1997.
36. Scheinman SJ, Guay-Woodford LM, Thakker RV, Warnock DG. Genetic disorders of renal electrolyte transport. N Engl J Med 340: 1177-1187, 1999.
37. Sciarrone MT, Stella P, Barlassina C, Manunta P, Lanzani C, Bianchi G, Cusi D. ACE and alpha-adducin polymorphism as markers of individual response to diuretic therapy. Hypertension 41: 398-403, 2003.
38. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, Findling JW, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.
39. Simon DB, Bindra RS, Mansfield TA, Nelson-Williams C, Mendonca E, Stone R, Schurman S, Nayir A, Alpay H, Bakkaloglu A, Rodriguez-Soriano J, Morales JM, Sanjad SA, Taylor CM, Pilz D, Brem A, Trachtman H, Griswold W, Richard GA, John E, Lifton RP. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet 17: 171-178, 1997.
40. Stanton BA. Regulation by adrenal corticosteroids of sodium and potassium transport in loop of Henle and distal tubule of rat kidney. J Clin Invest 78: 1612-1620, 1986.
41. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, Menegon A, Ferrari P, Marchisio PC, Bianchi G. Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. J Clin Invest 97: 2815-2822, 1996.
42. Vandewalle A, Cluzeaud F, Bens M, Kieferle S, Steinmeyer K, Jentsch TJ. Localization and induction by dehydration of ClC-K chloride channels in the rat kidney. Am J Physiol Renal Physiol 272: F678-F688, 1997.
43. Velazquez H, Bartiss A, Bernstein P, Ellison DH. Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. Am J Physiol Renal Fluid Electrolyte Physiol 270: F211-F219, 1996.
44. Wagner CA. The emerging role of pendrin in renal chloride reabsorption. Am J Physiol Renal Physiol 292: F912-F913, 2007.
45. Waldegger S, Jeck N, Barth P, Peters M, Vitzthum H, Wolf K, Kurtz A, Konrad M, Seyberth HW. Barttin increases surface expression and changes current properties of ClC-K channels. Pflügers Arch 444: 411-418, 2002.
46. Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks HL, Nielsen S, Knepper MA. The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest 108: 215-222, 2001.