IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: Involvement of Src/PI-3k/AKT pathway

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Montaseri, Azadeh ^a   Busch, Franziska ^b   Mobasheri, Ali ^c   Buhrmann, Constanze ^b   Aldinger, Constance ^b   Rad, Jafar Soleimani ^a   Shakibaei, Mehdi ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CASPASE 3; COLLAGEN TYPE 2; CYCLOOXYGENASE 2; GENE PRODUCT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN SHC; PROTEOGLYCAN; SOMATOMEDIN C; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR SOX9; WORTMANNIN; 4(2' AMINOETHYL)AMINO 1,8 DIMETHYLIMIDAZO(1,2 A)QUINOXALINE; 4(2'-AMINOETHYL)AMINO-1,8-DIMETHYLIMIDAZO(1,2-A)QUINOXALINE; I KAPPA B; IMIDAZOLE DERIVATIVE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PLATELET DERIVED GROWTH FACTOR B; PLATELET-DERIVED GROWTH FACTOR BB; PROTEIN TYROSINE KINASE; QUINOXALINE DERIVATIVE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL DEDIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG POTENTIATION; ELECTRON MICROSCOPY; IMMUNOBLOTTING; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CARTILAGE; CELL CULTURE; CELL DIFFERENTIATION; DOG; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; EXTRACELLULAR MATRIX; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; ULTRASTRUCTURE;

ANIMALS; ANTIGENS, CD29; APOPTOSIS; CARTILAGE; CELL DIFFERENTIATION; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; DOGS; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; I-KAPPA B PROTEINS; IMIDAZOLES; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-1BETA; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-SIS; QUINOXALINES; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; SOX9 TRANSCRIPTION FACTOR; SRC-FAMILY KINASES;

EID: 83355173227     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028663     Document Type: Article

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