Tumor necrosis factor α induces expression of genes for matrix degradation in human chondrocyte-like HCS-2/8 cells through activation of NF-κB: Abrogation of the tumor necrosis factor α effect by proteasome inhibitors

Journal of Bone and Mineral Research

Volumn 16, Issue 7, 2001, Pages 1272-1280

  Sakai, T ^a   Kambe, F ^a   Mitsuyama, H ^a   Ishiguro, N ^a   Kurokouchi, K ^a   Takigawa, M ^a   Iwata, H ^a   Seo, H ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Chondrocytes; I B; Nuclear factor B; Proteasome inhibitors; Tumor necrosis factor

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PROTEASOME INHIBITOR; PROTEIN P50; STROMELYSIN; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BONE ATROPHY; CARTILAGE CELL; CARTILAGE MATRIX; CHONDROLYSIS; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CHONDROCYTES; CYCLOOXYGENASE 2; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INDUCTION; EPIDERMAL GROWTH FACTOR; HUMANS; I-KAPPA B PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; ISOENZYMES; LEUPEPTINS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MEMBRANE PROTEINS; MULTIENZYME COMPLEXES; NF-KAPPA B; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, MESSENGER; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034972517     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.7.1272     Document Type: Article

References (46)

1. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes
2. Factors involved in the regulation of proteoglycan metabolism in articular cartilage
3. Production of cytokines by chondrocytes and its role in proteoglycan degradation
4. Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
5. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis
6. Cytokines in osteoarthritis: Mediators or markers of joint destruction?
7. Tumor necrosis factor-alpha receptor expression on chondrocytes isolated from human articular cartilage
8. Preferential expression of tumor necrosis factor receptor 55 (TNF-R55) on human articular chondrocytes: Selective transcriptional upregulation of TNF-R75 by proinflammatory cytokines interleukin 1beta, tumor necrosis factor-alpha, and basis fibroblast growth factor
9. Tumor necrosis factor alpha and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes
10. Protein kinase regulation of tumor necrosis factor alpha stimulated collagenase and stromelysin message levels in chondrocytes
11. The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells
12. Intercellular adhesion molecule-1 (ICAM-1) and MHC class II on chondrocytes in arthritic joints from pigs experimentally infected with Erysipelothrix rhusiopathiae
13. Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin 1alpha, tumor necrosis factor-alpha, glucocorticoids, and 17beta-estradiol
14. Function and activation of NF-kappa B in the immune system
15. Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity
16. I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B
17. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
18. Inhibition of NF-kappa B activation in vitro and in vivo: Role of 26S proteasome
19. Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes
20. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
21. Intracellular signaling in rat cultured vascular smooth muscle cells: Roles of nuclear factor-kappaB and p38 mitogen-activated protein kinase on tumor necrosis factor-alpha production
22. Osmotic response element is required for the induction of aldose reductase by tumor necrosis factor-alpha
23. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
24. Activation of transcriptionally active nuclear factor-kappaB by tumor necrosis factor-alpha and its inhibition by antioxidants in rat thyroid FRTL-5 cells
25. Cloning of a complementary deoxyribonucleic acid coding for human thyroxine-binding globulin (TBG): Existence of two TBG messenger ribonucleic acid species possessing different 3′-untranslated regions
26. Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein
27. Human skin fibroblast stromelysin: Structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells
28. Factor(s) present in sera from patients on long-term hemodialysis increase(s) mRNAs for collagenase and stromelysin in synovial cells
29. Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroid FRTL-5 cells
30. Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B
31. Increase in Ref-1 mRNA and protein by thyrotropin in rat thyroid FRTL-5 cells
32. Culture in vector-averaged gravity under clinostat rotation results in apoptosis of osteoblastic ROS 17/2.8 cells
33. Induction of collagenase secretion in human fibroblast cultures by growth promoting factors
34. Requirement for los gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters
35. A sustained reduction in IkappaB-beta may contribute to persistent NF-kappaB activation in human endothelial cells
36. Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
37. Proteasome inhibitors: Valuable new tools for cell biologists
38. Cytokine regulation of metalloproteinase gene expression
39. Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis
40. Highly increased levels of active stromelysin in rheumatoid synovial fluid determined by a selective fluorogenic assay
41. Markers of cartilage and synovial metabolism in joint fluid and serum of patients with chondromalacia of the patella
42. Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage
43. Expression of matrix metalloproteinase 7 (matrilysin) in human osteoarthritic cartilage
44. Expression of ICAM-1 on intact cartilage and isolated chondrocytes
45. A phase I/II open label study of the safety and efficacy of an anti-ICAM-1 (intercellular adhesion molecule-1; CD54) monoclonal antibody in early rheumatoid arthritis
46. Superinduction of cyclooxygenase-2 activity in human osteoarthritis- affected cartilage. Influence of nitric oxide