Zinc, metallothioneins and immunosenescence: Effect of zinc supply as nutrigenomic approach

Biogerontology

Volumn 12, Issue 5, 2011, Pages 455-465

  Mocchegiani, Eugenio ^a   Costarelli, Laura ^a   Giacconi, Robertina ^a   Piacenza, Francesco ^a   Basso, Andrea ^a   Malavolta, Marco ^a  

^a INRCA   (Italy)

Author keywords

Ageing; IL 6; Inflammatory immune response; Longevity; Metallothioneins; Nutrigenomic approach; Zinc supplementation

Indexed keywords

ALPHA INTERFERON; ENDOTOXIN; INTERLEUKIN 6; METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; METALLOTHIONEIN III; THIOL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; ZINC;

ADAPTIVE IMMUNITY; AGING; ALLELE; CONFERENCE PAPER; CYTOKINE PRODUCTION; CYTOTOXICITY; DIETARY INTAKE; GENE EXPRESSION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; ION TRANSPORT; LYMPHOCYTE; NATURAL KILLER CELL; NONHUMAN; NUTRIGENOMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SECOND MESSENGER; SENESCENCE; SIGNAL TRANSDUCTION; STRESS; ZINC DEFICIENCY;

AGED; AGING; ANIMALS; DIETARY SUPPLEMENTS; HUMANS; METALLOTHIONEIN; MICE; NUTRIGENOMICS; ZINC;

EID: 83255192157     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-011-9337-4     Document Type: Conference Paper

References (84)

1. Abo T, Kawamura T, Watanabe H (2000) Physiological responses of extrathymic T cells in the liver. Immunol Rev 174:135-149 (Pubitemid 30201385)
2. Ames BN (2006) Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci USA 103:17589-17594 (Pubitemid 44852204)
3. Anantharaju A, Feller A, Chedid A (2002) Aging liver. Gerontology 48:343-353
4. Bahadorani S, Mukai S, Egli D, Hilliker AJ (2010) Overexpression of metalresponsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity. Neurobiol Aging 31:1215-1226
5. Barsyte D, Lovejoy DA, Lithgow GJ (2001) Longevity and heavy metal resistance in daf-2 and age-1 long lived mutants of Caenorhabditis elegans. FASEB J 15:627-634 (Pubitemid 32245981)
6. Bauer JH, Helfand SL (2006) New tricks of an old molecule: lifespan regulation by p53. Aging Cell 5:437-440 (Pubitemid 44322539)
7. Bauer J, Ganter U, Abel J, Strauss S, Jonas U, Weiss R, Gebicke- Haerter P, Volk B, Berger M (1993) Effects of interleukin-1 and interleukin-6 on metallothionein and amyloid precursor protein expression in human neuroblastoma cells. Evidence that interleukin-6 possibly acts via a receptor different from the 80-kDa interleukin-6 receptor. J Neuroimmunol 45:163-173
8. Bui LM, Dressendorfer RH, Keen CL, Summary JJ, Dubick MA (1994) Zinc status and interleukin-1 beta-induced alterations in mineral metabolism in rats. Proc Soc Exp Biol Med 206:438-444
9. Cai L, Satoh M, Tohyama C, Cherian MG (1999) Metallothionein in radiation exposure: its induction and protective role. Toxicology 132:85-98 (Pubitemid 29121947)
10. Chimienti F, Seve M, Richard S, Mathieu J, Favier A (2001) Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors. Biochem Pharmacol 62:51-62 (Pubitemid 32488977)
11. Cipriano C, Malavolta M, Costarelli L, Giacconi R, Muti E, Gasparini N, Cardelli M, Monti D, Mariani E, Mocchegiani E (2006) Polymorphisms in MT1a gene with longevity in Italian Central female population. Biogerontology 7: 357-365
12. Cousins RJ, Liuzzi JP, Lichten LA (2006) Mammalian zinc transport, trafficking, and signals. J Biol Chem 281: 24085-24089 (Pubitemid 44274182)
13. Dardenne M, Boukaiba N, Gagnerault MC, Homo-Delarche F, Chappuis P, Lemonnier D, Savino W (1993) Restoration of the thymus in aging mice by in vivo zinc supplementation. Clin Immunol Immunopathol 66:127-135 (Pubitemid 23111962)
14. Driessen C, Hirv K, Rink L, Kirchner H (1994) Induction of cytokines by zinc ions in human peripheral blood mononuclear cells and separated monocytes. Lymphokine Cytokine Res 13:15-20 (Pubitemid 24080650)
15. Ebadi M, Swanson S (1988) The status of zinc, copper, and metallothionein in cancer patients. Prog Clin Biol Res 259: 161-175
16. Failla ML (2003) Trace elements and host defence: recent advances and continuing challenges. J Nutr 133(Suppl. 1): 1443S-1447S (Pubitemid 36548722)
17. Feng W, Cai J, Pierce WM, Franklin RB, Maret W, Benz FW, Kang YJ (2005) Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts. Biochem Biophys Res Commun 332:853-858 (Pubitemid 40745191)
18. Feng W, Benz FW, Cai J, Pierce WM, Kang YJ (2006) Metallothionein disulfides are present in metallothioneinoverexpressing transgenic mouse heart and increase under conditions of oxidative stress. J Biol Chem 281:681-687
19. Fraker PJ (2005) Roles for cell death in zinc deficiency. J Nutr 135:359-362 (Pubitemid 40365188)
20. Goode HF, Kelleher J, Walker BE (1989) Zinc concentrations in pure populations of peripheral blood neutrophils, lymphocytes and monocytes. Ann Clin Biochem 26:85-95
21. Haase H, Rink L (2009) The immune system and the impact of zinc during aging. Immun Ageing 6:9-17
22. Habeebu SS, Liu J, Liu Y, Klaassen CD (2000) Metallothionein- null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. Toxicol Sci 56:211-219 (Pubitemid 30441481)
23. Hernández J, Molinero A, Campbell IL, Hidalgo J (1997) Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice. Brain Res Mol Brain Res 48:125-131 (Pubitemid 27298136)
24. Hujanen ES, Seppa ST, Virtanen K (1995) Polymorphonuclear leukocyte chemotaxis induced by zinc, copper and nickel in vitro. Biochim Biophys Acta 1245:145-152
25. Ibs KH, Rink L (2003) Zinc-altered immune function. J Nutr 133(Suppl 1):1452S-1456S (Pubitemid 36548724)
26. Iwata T, Incefy GS, Tanaka T, Fernandes G, Menendez-Botet CJ, Pih K, Good RA (1979) Circulating thymic hormone levels in zinc deficiency. Cell Immunol 47:100-105 (Pubitemid 10223037)
27. Kagi JH, Schaffer A (1998) Biochemistry of metallothionein. Biochemistry 127:8509-8515
28. Kant AK (2000) Consumption of energy-dense, nutrient-poor foods by adult Americans: nutritional, health implications. The third National Health, Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 72:929-936
29. Kelly EJ, Quaife CJ, Froelick GJ, Palmiter RD (1996) Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr 126:1782-1790 (Pubitemid 26231444)
30. Kindermann B, Döring F, Fuchs D, Pfaffl MW, Daniel H (2005) Effects of increased cellular zinc levels on gene and protein expression in HT-29 cells. Biometals 18:243-253 (Pubitemid 40685247)
31. Kondo Y, Rusnak JM, Hoyt DG, Settineri CE, Pitt BR, Lazo JS (1997) Enhanced apoptosis in metallothionein null cells. Mol Pharmacol 52:195-201 (Pubitemid 27349610)
32. Kroncke KD, Klotz LO, Suschek CV, Sies H (2002) Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO. J Biol Chem 277:13294-13301 (Pubitemid 34952701)
33. Kuppusamy UR, Dharmani M, Kanthimathi MS, Indran M (2005) Antioxidant enzyme activities of human peripheral blood mononuclear cells exposed to trace elements. Biol Trace Elem Res 106:29-40
34. Lamore SD, Wondrak GT (2011) Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis. Biometals. doi: 10.1007/s10534-011-9441-6
35. Lee WW, Cui D, Czesnikiewicz-Guzik M, Vencio RZ, Shmulevich I, Aderem A, Weyand CM, Goronzy JJ (2008) Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Rejuvenation Res 11:1001-1011
36. Lesourd B (2006) Nutritional factors and immunological ageing. Proc Nutr Soc 65:319-325 (Pubitemid 46323845)
37. Liu J, Atamna H, Kuratsune H, Ames BN (2002) Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann NY Acad Sci 959:133-166 (Pubitemid 34457559)
38. Liuzzi JP, Cousins RJ (2004) Mammalian zinc transporters. Annu Rev Nutr 24:151-172 (Pubitemid 38949814)
39. Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ (2005) Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci USA 102:6843-6848 (Pubitemid 40675404)
40. Magda D, Lecane P, Wang Z, Hu W, Thiemann P, Ma X, Dranchak PK, Wang X, Lynch V, Wei W, Csokai V, Hacia JG, Sessler JL (2008) Synthesis and anticancer properties of water-soluble zinc ionophores. Cancer Res 68:5318-5325
41. Malavolta M, Costarelli L, Giacconi R, Muti E, Bernardini G, Tesei S, Cipriano C, Mocchegiani E (2006) Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: relationship with metallothioneins. Cytometry A 69:1043-1053 (Pubitemid 44570199)
42. Malavolta M, Cipriano C, Costarelli L, Giacconi R, Tesei S, Muti E, Piacenza F, Pierpaoli S, Larbi A, Pawelec G, Dedoussis G, Herbein G, Monti D, Jajte J, Rink L, Mocchegiani E (2008) Metallothionein downregulation in very old age: a phenomenon associated with cellular senescence? Rejuvenation Res 11:455-459 (Pubitemid 351601185)
43. Mann JJ, Fraker PJ (2005) Zinc pyrithione induces apoptosis and increases expression of Bim. Apoptosis 10:369-379 (Pubitemid 40603490)
44. Maret W (2003) Cellular zinc and redox states converge in the metallothionein/thionein pair. J Nutr 133:S1460-S1462
45. Maret W, Vallee BL (1998) Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc Natl Acad Sci USA 95:3478-3482 (Pubitemid 28173153)
46. Mariani E, Neri S, Cattini L, Mocchegiani E, Malavolta M, Dedoussis GV, Kanoni S, Rink L, Jajte J, Facchini A (2008) Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: Interactive influence of +647 MT1a and -174 IL-6 polymorphic alleles. Exp Gerontol 43:462-471
47. Mattson MP (2008) Hormesis and disease resistance: activation of cellular stress response pathways. Hum Exp Toxicol 27:155-162
48. Meydani M (2001) Nutrition interventions in aging and ageassociated disease. Ann NY Acad Sci 928:226-235 (Pubitemid 32386084)
49. Mocchegiani E, Malavolta M (2008) Zinc-gene interaction related to inflammatory/immune response in ageing. Genes Nutr 3:61-75
50. Mocchegiani E, Santarelli L, Muzzioli M, Muzzioli M, Fabris N (1995) Reversibility of the thymic involution and of agerelated peripheral immune dysfunctions by zinc supplementation in old mice. Int J Immunopharmacol 17:703-718
51. Mocchegiani E, Muzzioli M, Cipriano C, Giacconi R (1998) Zinc, T-cell pathways, aging: role of metallothioneins. Mech Ageing Dev 106:183-204 (Pubitemid 28559284)
52. Mocchegiani E, Muzzioli M, Giacconi R (2000a) Zinc and immunoresistance to infection in aging: new biological tools. Trends Pharmacol Sci 21:205-208 (Pubitemid 30331087)
53. Mocchegiani E, Muzzioli M, Giacconi R (2000b) Zinc, metallothioneins, immune responses, survival and ageing. Biogerontology 1:133-143
54. Mocchegiani E, Giacconi R, Cipriano C, Gasparini N, Orlando F, Stecconi R, Muzzioli M, Isani G, Carpenè E (2002a) Metallothioneins (I+II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply. Mech Ageing Dev 123:675-694 (Pubitemid 34159232)
55. Mocchegiani E, Giacconi R, Cipriano C, Muzzioli M, Gasparini N, Moresi R, Stecconi R, Suzuki H, Cavalieri E, Mariani E (2002b) MTmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans. Exp Gerontol 37:349-357 (Pubitemid 34073553)
56. Mocchegiani E, Giacconi R, Cipriano C, Gasparini N, Bernardini G, Malavolta M, Menegazzi M, Cavalieri E, Muzzioli M, Ciampa AR, Suzuki H (2004) The variation during the circadian cycle of liver CD1d-unrestricted NK1.1+TCRγδ+ cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice. Exp Gerontol 39:775-788 (Pubitemid 38586818)
57. Mocchegiani E, Giacconi R, Cipriano C, Costarelli L, Muti E, Tesei S, Giuli C, Papa R, Marcellini F, Mariani E, Rink L, Herbein G, Varin A, Fulop T, Monti D, Jajte J, Dedoussis G, Gonos ES, Trougakos IP, Malavolta M (2007a) Zinc, metallothioneins, and longevity effect of zinc supplementation: zincage study. Ann NY Acad Sci 1119: 129-146 (Pubitemid 350191246)
58. Mocchegiani E, Giacconi R, Muti E, Cipriano C, Costarelli L, Tesei S, Gasparini N, Malavolta M (2007b) Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans. Immun Ageing 4:7-12
59. Mocchegiani E, Giacconi R, Costarelli L, Muti E, Cipriano C, Tesei S, Pierpaoli S, Giuli C, Papa R, Marcellini F, Gasparini N, Pierandrei R, Piacenza F, Mariani E, Monti D, Dedoussis G, Kanoni S, Herbein G, Fulop T, Rink L, Jajte J, Malavolta M (2008) Zinc deficiency and IL-6 - 174G/C polymorphism in old people from different European countries: Effect of zinc supplementation. ZINCAGE study. Exp Gerontol 43:433-444
60. Mocchegiani E, Malavolta M, Costarelli L, Giacconi R, Cipriano C, Piacenza F, Tesei S, Basso A, Pierpaoli S, Lattanzio F (2010) Zinc, metallothioneins and immunosenescence. Proc Nutr Soc 69:290-299
61. Moroni F, Di Paolo ML, Rigo A, Cipriano C, Giacconi R, Recchioni R, Marcheselli F, Malavolta M, Mocchegiani E (2005) Interrelationship among neutrophil efficiency, inflammation, antioxidant activity and zinc pool in very old age. Biogerontology 6:271-281 (Pubitemid 43118466)
62. Ostan R, Alberti S, Bucci L, Salvioli S, Pasi S, Cevenini E, Capri M, Di Iorio A, Ginaldi L, De Martinis M, Franceschi C, Monti D (2006) Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects. Biogerontology 7: 437-447 (Pubitemid 44515718)
63. Paolisso G, Barbieri M, Bonafè M, Franceschi C (2000) Metabolic age modelling: the lesson from centenarians. Eur J Clin Invest 10:888-894
64. Provinciali M, Di Stefano G, Stronati S (1998) Flow cytometric analysis of CD3/TCR complex, zinc, and glucocorticoidmediated regulation of apoptosis and cell cycle distribution in thymocytes from old mice. Cytometry 32:1-8 (Pubitemid 28222102)
65. Putics A, Vödrös D, Malavolta M, Mocchegiani E, Csermely P, Soti C (2008) Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes. Exp Gerontol 43: 452-461
66. Rattan SI, Demirovic D (2009) Hormesis can and does work in humans. Dose Response 8:58-63
67. Rink L, Haase H (2007) Zinc homeostasis and immunity. Trends Immunol 28:1-4 (Pubitemid 44960160)
68. Sato M, Kondoh M (2002) Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med 196:9-22 (Pubitemid 34464405)
69. Satoh M, Nishimura N, Kanayama Y, Naganuma A, Suzuki T, Tohyama C (1997) Enhanced renal toxicity by inorganic mercury in metallothionein-null mice. J Pharmacol Exp Ther 283:1529-1533 (Pubitemid 28016530)
70. Schroeder JJ, Cousins RJ (1990) Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc Natl Acad Sci USA 87:3137-3141
71. Shenkin A (2006) Micronutrients in health and disease. Postgrad Med J 82:559-567 (Pubitemid 44476210)
72. 2+ release. Proc Natl Acad Sci USA 100:13952-13957 (Pubitemid 37499172)
73. Swindell WR (2010) Metallothionein and the biology of aging. Ageing Res Rev 10:132-145
74. Truong-Tran AQ, Carter J, Ruffin RE, Zalewski PD (2001) The role of zinc in caspase activation and apoptotic cell death. Biometals 14:315-330 (Pubitemid 34066635)
75. Tucker KL, Buranapin S (2001) Nutrition and aging in developing countries. J Nutr 9:2417S-2423S (Pubitemid 32851887)
76. Turnlund JR, Durkin N, Costa F, Margen S (1986) Stable isotope studies of zinc absorption and retention in young and elderly men. J Nutr 116:1239-1247 (Pubitemid 16053862)
77. Vallee BL, Falchuk KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73:79-118 (Pubitemid 23065434)
78. West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (1990) Human metallothionein genes: structure of the functional locus at 16q13. Genomics 8:513-518
79. Williams PD, Day T (2003) Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence. Evol Int J Org Evol 57:1478-1488 (Pubitemid 36953637)
80. Wong CP, Song Y, Elias VD, Magnusson KR, Ho E (2009) Zinc supplementation increases zinc status and thymopoiesis in aged mice. J Nutr 139:1393-1397
81. Yang X, Doser TA, Fang CX, Nunn JM, Janardhanan R, Zhu M, Sreejayan N, Quinn MT, Ren J (2006) Metallothionein prolongs survival and antagonizes senescence associated cardiomyocyte diastolic dysfunction: role of oxidative stress. FASEB J 20:1024-1026
82. Youn J, Lynes MA (1999) Metallothionein-induced suppression of cytotoxic T lymphocyte function: an important immunoregulatory control. Toxicol Sci 52:199-208 (Pubitemid 30017595)
83. Yu CW, Chen JH, Lin LY (1997) Metal-induced metallothionein gene expression can be inactivated by protein kinase C inhibitor. FEBS Lett 420:69-73
84. Zangger K, Oz G, Haslinger E, Kunert O, Armitage IM (2001) Nitric oxide selectively releases metals from the aminoterminal domain of metallothioneins: potential role at inflammatory sites. FASEB J 15:1303-1305