메뉴 건너뛰기




Volumn 10, Issue 1, 2011, Pages 132-145

Metallothionein and the biology of aging

Author keywords

Caloric restriction; Diet; GH; IGF 1; Longevity; MTF 1

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOKINE; FREE RADICAL; INSULIN; METALLOTHIONEIN;

EID: 78650229303     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2010.09.007     Document Type: Review
Times cited : (73)

References (156)
  • 1
    • 77955348524 scopus 로고    scopus 로고
    • Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury
    • Agarwal R., Goel S.K., Behari J.R. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. J. Appl. Toxicol. 2010, 30:457-468.
    • (2010) J. Appl. Toxicol. , vol.30 , pp. 457-468
    • Agarwal, R.1    Goel, S.K.2    Behari, J.R.3
  • 2
    • 0035696187 scopus 로고    scopus 로고
    • Cellular zinc sensors: MTF-1 regulation of gene expression
    • Andrews G.K. Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals 2001, 14:223-237.
    • (2001) Biometals , vol.14 , pp. 223-237
    • Andrews, G.K.1
  • 4
    • 77952875418 scopus 로고    scopus 로고
    • Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity
    • Bahadorani S., Mukai S., Egli D., Hilliker A.J. Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity. Neurobiol. Aging 2010, 31:1215-1226.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1215-1226
    • Bahadorani, S.1    Mukai, S.2    Egli, D.3    Hilliker, A.J.4
  • 5
    • 0019952692 scopus 로고
    • Radioresistance in cells with high content of metallothionein
    • Bakka A., Johnsen A.S., Endresen L., Rugstad H.E. Radioresistance in cells with high content of metallothionein. Experientia 1982, 38:381-383.
    • (1982) Experientia , vol.38 , pp. 381-383
    • Bakka, A.1    Johnsen, A.S.2    Endresen, L.3    Rugstad, H.E.4
  • 6
    • 0035082093 scopus 로고    scopus 로고
    • Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
    • Barsyte D., Lovejoy D.A., Lithgow G.J. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J. 2001, 15:627-634.
    • (2001) FASEB J. , vol.15 , pp. 627-634
    • Barsyte, D.1    Lovejoy, D.A.2    Lithgow, G.J.3
  • 7
    • 33747880238 scopus 로고    scopus 로고
    • Endocrine signaling in Caenorhabditis elegans controls stress response and longevity
    • Baumeister R., Schaffitzel E., Hertweck M. Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. J. Endocrinol. 2006, 190:191-202.
    • (2006) J. Endocrinol. , vol.190 , pp. 191-202
    • Baumeister, R.1    Schaffitzel, E.2    Hertweck, M.3
  • 12
    • 33646731782 scopus 로고    scopus 로고
    • Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
    • Bonkowski M.S., Rocha J.S., Masternak M.M., Al Regaiey K.A., Bartke A. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:7901-7905.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 7901-7905
    • Bonkowski, M.S.1    Rocha, J.S.2    Masternak, M.M.3    Al Regaiey, K.A.4    Bartke, A.5
  • 13
    • 33746896909 scopus 로고    scopus 로고
    • Longevity in mice: is stress resistance a common factor?
    • Brown-Borg H.M. Longevity in mice: is stress resistance a common factor?. Age (Dordr) 2006, 28:145-162.
    • (2006) Age (Dordr) , vol.28 , pp. 145-162
    • Brown-Borg, H.M.1
  • 15
    • 32244433433 scopus 로고    scopus 로고
    • Metallothionein and liver cell regeneration
    • Cherian M.G., Kang Y.J. Metallothionein and liver cell regeneration. Exp. Biol. Med. (Maywood) 2006, 231:138-144.
    • (2006) Exp. Biol. Med. (Maywood) , vol.231 , pp. 138-144
    • Cherian, M.G.1    Kang, Y.J.2
  • 16
    • 34249804498 scopus 로고    scopus 로고
    • Using FlyAtlas to identify better Drosophila melanogaster models of human disease
    • Chintapalli V.R., Wang J., Dow J.A. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat. Genet. 2007, 39:715-720.
    • (2007) Nat. Genet. , vol.39 , pp. 715-720
    • Chintapalli, V.R.1    Wang, J.2    Dow, J.A.3
  • 17
    • 34547836490 scopus 로고    scopus 로고
    • Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population
    • Cipriano C., Malavolta M., Costarelli L., Giacconi R., Muti E., et al. Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population. Biogerontology 2006, 7:357-365.
    • (2006) Biogerontology , vol.7 , pp. 357-365
    • Cipriano, C.1    Malavolta, M.2    Costarelli, L.3    Giacconi, R.4    Muti, E.5
  • 18
    • 50649116605 scopus 로고    scopus 로고
    • Positive reasons for publishing negative findings
    • Connor J.T. Positive reasons for publishing negative findings. Am. J. Gastroenterol. 2008, 103:2181-2183.
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 2181-2183
    • Connor, J.T.1
  • 20
    • 1642298968 scopus 로고    scopus 로고
    • Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria
    • Costello L.C., Guan Z., Franklin R.B., Feng P. Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria. J. Inorg. Biochem. 2004, 98:664-666.
    • (2004) J. Inorg. Biochem. , vol.98 , pp. 664-666
    • Costello, L.C.1    Guan, Z.2    Franklin, R.B.3    Feng, P.4
  • 21
    • 34548658230 scopus 로고    scopus 로고
    • Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
    • Dai C., Whitesell L., Rogers A.B., Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007, 130:1005-1018.
    • (2007) Cell , vol.130 , pp. 1005-1018
    • Dai, C.1    Whitesell, L.2    Rogers, A.B.3    Lindquist, S.4
  • 23
    • 0029814835 scopus 로고    scopus 로고
    • Transgenic mice overexpressing metallothionein are not resistant to adriamycin cardiotoxicity
    • DiSilvestro R.A., Liu J., Klaassen C.D. Transgenic mice overexpressing metallothionein are not resistant to adriamycin cardiotoxicity. Res. Commun. Mol. Pathol. Pharmacol. 1996, 93:163-170.
    • (1996) Res. Commun. Mol. Pathol. Pharmacol. , vol.93 , pp. 163-170
    • DiSilvestro, R.A.1    Liu, J.2    Klaassen, C.D.3
  • 24
    • 34548434021 scopus 로고    scopus 로고
    • Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis
    • Dong F., Li Q., Sreejayan N., Nunn J.M., Ren J. Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis. Diabetes 2007, 56:2201-2212.
    • (2007) Diabetes , vol.56 , pp. 2201-2212
    • Dong, F.1    Li, Q.2    Sreejayan, N.3    Nunn, J.M.4    Ren, J.5
  • 25
    • 0030727705 scopus 로고    scopus 로고
    • Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
    • Dunn S.E., Kari F.W., French J., Leininger J.R., Travlos G., et al. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res. 1997, 57:4667-4672.
    • (1997) Cancer Res. , vol.57 , pp. 4667-4672
    • Dunn, S.E.1    Kari, F.W.2    French, J.3    Leininger, J.R.4    Travlos, G.5
  • 26
    • 42649106170 scopus 로고    scopus 로고
    • The possible biological role of metallothionein in apoptosis
    • Dutsch-Wicherek M., Sikora J., Tomaszewska R. The possible biological role of metallothionein in apoptosis. Front. Biosci. 2008, 13:4029-4038.
    • (2008) Front. Biosci. , vol.13 , pp. 4029-4038
    • Dutsch-Wicherek, M.1    Sikora, J.2    Tomaszewska, R.3
  • 27
    • 52649129348 scopus 로고    scopus 로고
    • Systematic review of the empirical evidence of study publication bias and outcome reporting bias
    • Dwan K., Altman D.G., Arnaiz J.A., Bloom J., Chan A.W., et al. Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS One 2008, 3:e3081.
    • (2008) PLoS One , vol.3
    • Dwan, K.1    Altman, D.G.2    Arnaiz, J.A.3    Bloom, J.4    Chan, A.W.5
  • 28
    • 15744373545 scopus 로고    scopus 로고
    • Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease
    • Ebadi M., Brown-Borg H., El Refaey H., Singh B.B., Garrett S., et al. Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease. Brain Res. Mol. Brain Res. 2005, 134:67-75.
    • (2005) Brain Res. Mol. Brain Res. , vol.134 , pp. 67-75
    • Ebadi, M.1    Brown-Borg, H.2    El Refaey, H.3    Singh, B.B.4    Garrett, S.5
  • 30
    • 0030598648 scopus 로고    scopus 로고
    • Insulin/IGF-1 modulation of the expression of two estrogen-induced genes in MCF-7 cells
    • el-Tanani M.K., Green C.D. Insulin/IGF-1 modulation of the expression of two estrogen-induced genes in MCF-7 cells. Mol. Cell Endocrinol. 1996, 121:29-35.
    • (1996) Mol. Cell Endocrinol. , vol.121 , pp. 29-35
    • el-Tanani, M.K.1    Green, C.D.2
  • 31
    • 0035811073 scopus 로고    scopus 로고
    • Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    • Flurkey K., Papaconstantinou J., Miller R.A., Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:6736-6741.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 6736-6741
    • Flurkey, K.1    Papaconstantinou, J.2    Miller, R.A.3    Harrison, D.E.4
  • 32
    • 64549083295 scopus 로고    scopus 로고
    • The scientific basis of caloric restriction leading to longer life
    • Fontana L. The scientific basis of caloric restriction leading to longer life. Curr. Opin. Gastroenterol. 2009, 25:144-150.
    • (2009) Curr. Opin. Gastroenterol. , vol.25 , pp. 144-150
    • Fontana, L.1
  • 33
    • 0037387682 scopus 로고    scopus 로고
    • Genotype and age influence the effect of caloric intake on mortality in mice
    • Forster M.J., Morris P., Sohal R.S. Genotype and age influence the effect of caloric intake on mortality in mice. FASEB J. 2003, 17:690-692.
    • (2003) FASEB J. , vol.17 , pp. 690-692
    • Forster, M.J.1    Morris, P.2    Sohal, R.S.3
  • 34
    • 77954960062 scopus 로고    scopus 로고
    • Phenotypic robustness conferred by apparently redundant transcriptional enhancers
    • Frankel N., Davis G.K., Vargas D., Wang S., Payre F., et al. Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature 2010, 466:490-493.
    • (2010) Nature , vol.466 , pp. 490-493
    • Frankel, N.1    Davis, G.K.2    Vargas, D.3    Wang, S.4    Payre, F.5
  • 35
    • 0023831256 scopus 로고
    • A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
    • Friedman D.B., Johnson T.E. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 1988, 118:75-86.
    • (1988) Genetics , vol.118 , pp. 75-86
    • Friedman, D.B.1    Johnson, T.E.2
  • 36
    • 33749427563 scopus 로고    scopus 로고
    • Involvement of oxidative stress in the synthesis of metallothionein induced by mitochondrial inhibitors
    • Futakawa N., Kondoh M., Ueda S., Higashimoto M., Takiguchi M., et al. Involvement of oxidative stress in the synthesis of metallothionein induced by mitochondrial inhibitors. Biol. Pharm. Bull. 2006, 29:2016-2020.
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 2016-2020
    • Futakawa, N.1    Kondoh, M.2    Ueda, S.3    Higashimoto, M.4    Takiguchi, M.5
  • 37
    • 39649110574 scopus 로고    scopus 로고
    • Stress-response hormesis and aging: "that which does not kill us makes us stronger"
    • Gems D., Partridge L. Stress-response hormesis and aging: "that which does not kill us makes us stronger" Cell Metab. 2008, 7:200-203.
    • (2008) Cell Metab. , vol.7 , pp. 200-203
    • Gems, D.1    Partridge, L.2
  • 38
    • 0032561191 scopus 로고    scopus 로고
    • Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid
    • Ghoshal K., Wang Y., Sheridan J.F., Jacob S.T. Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid. J. Biol. Chem. 1998, 273:27904-27910.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27904-27910
    • Ghoshal, K.1    Wang, Y.2    Sheridan, J.F.3    Jacob, S.T.4
  • 39
    • 0345280793 scopus 로고    scopus 로고
    • Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes
    • Haïdara K., Moffatt P., Denizeau F. Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes. Toxicol. Sci. 1999, 49:297-305.
    • (1999) Toxicol. Sci. , vol.49 , pp. 297-305
    • Haïdara, K.1    Moffatt, P.2    Denizeau, F.3
  • 40
    • 77953283266 scopus 로고    scopus 로고
    • Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease
    • Hands S.L., Mason R., Sajjad M.U., Giorgini F., Wyttenbach A. Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease. Biochem. Soc. Trans. 2010, 38:552-558.
    • (2010) Biochem. Soc. Trans. , vol.38 , pp. 552-558
    • Hands, S.L.1    Mason, R.2    Sajjad, M.U.3    Giorgini, F.4    Wyttenbach, A.5
  • 41
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 42
  • 43
    • 33751246228 scopus 로고    scopus 로고
    • Does caloric restriction extend life in wild mice?
    • Harper J.M., Leathers C.W., Austad S.N. Does caloric restriction extend life in wild mice?. Aging Cell 2006, 5:441-449.
    • (2006) Aging Cell , vol.5 , pp. 441-449
    • Harper, J.M.1    Leathers, C.W.2    Austad, S.N.3
  • 44
    • 0028358324 scopus 로고
    • The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression
    • Heuchel R., Radtke F., Georgiev O., Stark G., Aguet M., et al. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 1994, 13:2870-2875.
    • (1994) EMBO J. , vol.13 , pp. 2870-2875
    • Heuchel, R.1    Radtke, F.2    Georgiev, O.3    Stark, G.4    Aguet, M.5
  • 45
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Honda Y., Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 1999, 13:1385-1393.
    • (1999) FASEB J. , vol.13 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 47
    • 0029617981 scopus 로고
    • Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats
    • Iszard M.B., Liu J., Klaassen C.D. Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats. Toxicology 1995, 104:25-33.
    • (1995) Toxicology , vol.104 , pp. 25-33
    • Iszard, M.B.1    Liu, J.2    Klaassen, C.D.3
  • 48
    • 0032804191 scopus 로고    scopus 로고
    • Induction of metallothionein by stress and its molecular mechanisms
    • Jacob S.T., Ghoshal K., Sheridan J.F. Induction of metallothionein by stress and its molecular mechanisms. Gene Expr. 1999, 7:301-310.
    • (1999) Gene Expr. , vol.7 , pp. 301-310
    • Jacob, S.T.1    Ghoshal, K.2    Sheridan, J.F.3
  • 49
    • 34247857349 scopus 로고    scopus 로고
    • Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter
    • Jahng J.W., Kim J.G., Kim H.J., Kim B.T., Kang D.W., et al. Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter. Brain Res. 2007, 1150:100-107.
    • (2007) Brain Res. , vol.1150 , pp. 100-107
    • Jahng, J.W.1    Kim, J.G.2    Kim, H.J.3    Kim, B.T.4    Kang, D.W.5
  • 52
    • 70649090177 scopus 로고    scopus 로고
    • Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells
    • Kadota Y., Suzuki S., Ideta S., Fukinbara Y., Kawakami T., et al. Enhanced metallothionein gene expression induced by mitochondrial oxidative stress is reduced in phospholipid hydroperoxide glutathione peroxidase-overexpressed cells. Eur. J. Pharmacol. 2010, 626:166-170.
    • (2010) Eur. J. Pharmacol. , vol.626 , pp. 166-170
    • Kadota, Y.1    Suzuki, S.2    Ideta, S.3    Fukinbara, Y.4    Kawakami, T.5
  • 53
    • 0025304294 scopus 로고
    • Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents
    • Kaina B., Lohrer H., Karin M., Herrlich P. Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:2710-2714.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 2710-2714
    • Kaina, B.1    Lohrer, H.2    Karin, M.3    Herrlich, P.4
  • 55
    • 0030803635 scopus 로고    scopus 로고
    • Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity
    • Kang Y.J., Chen Y., Yu A., Voss-McCowan M., Epstein P.N. Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J. Clin. Invest. 1997, 100:1501-1506.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1501-1506
    • Kang, Y.J.1    Chen, Y.2    Yu, A.3    Voss-McCowan, M.4    Epstein, P.N.5
  • 56
    • 0027771804 scopus 로고
    • C. elegans mutant that lives twice as long as wild type
    • Kenyon C., Chang J., Gensch E., Rudner A., Tabtiang R.A. C. elegans mutant that lives twice as long as wild type. Nature 1993, 366:461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.A.5
  • 57
    • 76749138903 scopus 로고    scopus 로고
    • Effects of exogenous metallothionein against thallium-induced oxidative stress in rat liver
    • Kiliç G.A., Kutlu M. Effects of exogenous metallothionein against thallium-induced oxidative stress in rat liver. Food Chem. Toxicol. 2010, 48:980-987.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 980-987
    • Kiliç, G.A.1    Kutlu, M.2
  • 60
    • 0023903491 scopus 로고
    • A potential role for prolactin in zinc homeostasis
    • Koppelman M.C. A potential role for prolactin in zinc homeostasis. Med. Hypotheses 1988, 65-68.
    • (1988) Med. Hypotheses , pp. 65-68
    • Koppelman, M.C.1
  • 62
    • 44249093277 scopus 로고    scopus 로고
    • Expression analysis of G Protein-Coupled Receptors in mouse macrophages
    • Lattin J.E., Schroder K., Su A.I., Walker J.R., Zhang J., et al. Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Res. 2008, 4:5.
    • (2008) Immunome Res. , vol.4 , pp. 5
    • Lattin, J.E.1    Schroder, K.2    Su, A.I.3    Walker, J.R.4    Zhang, J.5
  • 63
    • 0028944114 scopus 로고
    • Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes
    • Lazo J.S., Kondo Y., Dellapiazza D., Michalska A.E., Choo K.H., et al. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 1995, 270:5506-5510.
    • (1995) J. Biol. Chem. , vol.270 , pp. 5506-5510
    • Lazo, J.S.1    Kondo, Y.2    Dellapiazza, D.3    Michalska, A.E.4    Choo, K.H.5
  • 64
    • 0032952723 scopus 로고    scopus 로고
    • Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression
    • Lee D.K., Carrasco J., Hidalgo J., Andrews G.K. Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression. Biochem. J. 1999, 337:59-65.
    • (1999) Biochem. J. , vol.337 , pp. 59-65
    • Lee, D.K.1    Carrasco, J.2    Hidalgo, J.3    Andrews, G.K.4
  • 65
    • 78650036223 scopus 로고    scopus 로고
    • Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Res. doi:10.1089/rej.2010.1031
    • Lee, K.S., Lee, B.S., Semnani, S., Avanesian, A., Um, C.Y., et al., 2010. Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Res., doi:10.1089/rej.2010.1031.
    • (2010)
    • Lee, K.S.1    Lee, B.S.2    Semnani, S.3    Avanesian, A.4    Um, C.Y.5
  • 66
    • 75149117017 scopus 로고    scopus 로고
    • Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice
    • Leiser S.F., Miller R.A. Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. Mol. Cell. Biol. 2010, 30:871-884.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 871-884
    • Leiser, S.F.1    Miller, R.A.2
  • 67
    • 72749118269 scopus 로고    scopus 로고
    • Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways
    • Leung Y.K., Pankhurst M., Dunlop S.A., Ray S., Dittmann J., et al. Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways. Exp. Neurol. 2010, 221:98-106.
    • (2010) Exp. Neurol. , vol.221 , pp. 98-106
    • Leung, Y.K.1    Pankhurst, M.2    Dunlop, S.A.3    Ray, S.4    Dittmann, J.5
  • 68
    • 76249097841 scopus 로고    scopus 로고
    • Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
    • Liao C.Y., Rikke B.A., Johnson T.E., Diaz V., Nelson J.F. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell 2010, 9:92-95.
    • (2010) Aging Cell , vol.9 , pp. 92-95
    • Liao, C.Y.1    Rikke, B.A.2    Johnson, T.E.3    Diaz, V.4    Nelson, J.F.5
  • 69
    • 0031906024 scopus 로고    scopus 로고
    • Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity
    • Liu J., Liu Y., Habeebu S.S., Klaassen C.D. Metallothionein (MT)-null mice are sensitive to cisplatin-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 1998, 149:24-31.
    • (1998) Toxicol. Appl. Pharmacol. , vol.149 , pp. 24-31
    • Liu, J.1    Liu, Y.2    Habeebu, S.S.3    Klaassen, C.D.4
  • 70
    • 70350041696 scopus 로고    scopus 로고
    • Changes in hepatic gene expression in response to hepatoprotective levels of zinc
    • Liu J., Zhou Z.X., Zhang W., Bell M.W., Waalkes M.P. Changes in hepatic gene expression in response to hepatoprotective levels of zinc. Liver Int. 2009, 29:1222-1229.
    • (2009) Liver Int. , vol.29 , pp. 1222-1229
    • Liu, J.1    Zhou, Z.X.2    Zhang, W.3    Bell, M.W.4    Waalkes, M.P.5
  • 71
    • 0024358109 scopus 로고
    • Overexpression of metallothionein in CHO cells and its effect on cell killing by ionizing radiation and alkylating agents
    • Lohrer H., Robson T. Overexpression of metallothionein in CHO cells and its effect on cell killing by ionizing radiation and alkylating agents. Carcinogenesis 1989, 10:2279-2284.
    • (1989) Carcinogenesis , vol.10 , pp. 2279-2284
    • Lohrer, H.1    Robson, T.2
  • 72
    • 0032873790 scopus 로고    scopus 로고
    • Effect of acute and chronic oral zinc administration in hyperprolactinemic patients
    • Madureira G., Bloise W., Mendonca B.B., Brandão-Neto J. Effect of acute and chronic oral zinc administration in hyperprolactinemic patients. Met. Based Drugs 1999, 6:159-162.
    • (1999) Met. Based Drugs , vol.6 , pp. 159-162
    • Madureira, G.1    Bloise, W.2    Mendonca, B.B.3    Brandão-Neto, J.4
  • 74
    • 33947463103 scopus 로고
    • A cadmium protein from equine kidney cortex
    • Margoshes M., Vallee B.L. A cadmium protein from equine kidney cortex. J. Am. Chem. Soc. 1957, 79:4813.
    • (1957) J. Am. Chem. Soc. , vol.79 , pp. 4813
    • Margoshes, M.1    Vallee, B.L.2
  • 75
    • 22744445281 scopus 로고    scopus 로고
    • Overview of caloric restriction and ageing
    • Masoro E.J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 2005, 126:913-922.
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 913-922
    • Masoro, E.J.1
  • 76
    • 0029848121 scopus 로고    scopus 로고
    • The evolution of the antiaging action of dietary restriction: a hypothesis
    • Masoro E.J., Austad S.N. The evolution of the antiaging action of dietary restriction: a hypothesis. J. Gerontol. A Biol. Sci. Med. Sci. 1996, 51:B387-B391.
    • (1996) J. Gerontol. A Biol. Sci. Med. Sci. , vol.51
    • Masoro, E.J.1    Austad, S.N.2
  • 77
    • 0027204069 scopus 로고
    • Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse
    • Michalska A.E., Choo K.H. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:8088-8092.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 8088-8092
    • Michalska, A.E.1    Choo, K.H.2
  • 80
    • 20444403004 scopus 로고    scopus 로고
    • Gene expression profiles in the liver and kidney of metallothionein-null mice
    • Miura N., Koizumi S. Gene expression profiles in the liver and kidney of metallothionein-null mice. Biochem. Biophys. Res. Commun. 2005, 332:949-955.
    • (2005) Biochem. Biophys. Res. Commun. , vol.332 , pp. 949-955
    • Miura, N.1    Koizumi, S.2
  • 81
    • 36348941803 scopus 로고    scopus 로고
    • Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans
    • Mocchegiani E., Giacconi R., Muti E., Cipriano C., Costarelli L., et al. Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans. Immun. Ageing 2007, 4:7.
    • (2007) Immun. Ageing , vol.4 , pp. 7
    • Mocchegiani, E.1    Giacconi, R.2    Muti, E.3    Cipriano, C.4    Costarelli, L.5
  • 82
    • 3242724034 scopus 로고    scopus 로고
    • Zinc, immune plasticity, aging, and successful aging: role of metallothionein
    • Mocchegiani E., Giacconi R., Muti E., Rogo C., Bracci M., et al. Zinc, immune plasticity, aging, and successful aging: role of metallothionein. Ann. N Y Acad. Sci. 2004, 1019:127-134.
    • (2004) Ann. N Y Acad. Sci. , vol.1019 , pp. 127-134
    • Mocchegiani, E.1    Giacconi, R.2    Muti, E.3    Rogo, C.4    Bracci, M.5
  • 83
    • 0028856195 scopus 로고
    • Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice
    • Mocchegiani E., Santarelli L., Muzzioli M., Fabris N. Reversibility of the thymic involution and of age-related peripheral immune dysfunctions by zinc supplementation in old mice. Int. J. Immunopharmacol. 1995, 17:703-718.
    • (1995) Int. J. Immunopharmacol. , vol.17 , pp. 703-718
    • Mocchegiani, E.1    Santarelli, L.2    Muzzioli, M.3    Fabris, N.4
  • 84
    • 0032525839 scopus 로고    scopus 로고
    • Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival
    • Mocchegiani E., Santarelli L., Tibaldi A., Muzzioli M., Bulian D., et al. Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival. J. Neuroimmunol. 1998, 86:111-122.
    • (1998) J. Neuroimmunol. , vol.86 , pp. 111-122
    • Mocchegiani, E.1    Santarelli, L.2    Tibaldi, A.3    Muzzioli, M.4    Bulian, D.5
  • 85
    • 0033569919 scopus 로고    scopus 로고
    • Regulation of metallothionein gene transcription. Identification of upstream regulatory elements and transcription factors responsible for cell-specific expression of the metallothionein genes from Caenorhabditis elegans
    • Moilanen L.H., Fukushige T., Freedman J.H. Regulation of metallothionein gene transcription. Identification of upstream regulatory elements and transcription factors responsible for cell-specific expression of the metallothionein genes from Caenorhabditis elegans. J. Biol. Chem. 1999, 274:29655-29665.
    • (1999) J. Biol. Chem. , vol.274 , pp. 29655-29665
    • Moilanen, L.H.1    Fukushige, T.2    Freedman, J.H.3
  • 86
    • 51349162170 scopus 로고    scopus 로고
    • Exogenous metallothionein-IIA promotes accelerated healing after a burn wound
    • Morellini N.M., Giles N.L., Rea S., Adcroft K.F., Falder S., et al. Exogenous metallothionein-IIA promotes accelerated healing after a burn wound. Wound Repair Regen. 2008, 16:682-690.
    • (2008) Wound Repair Regen. , vol.16 , pp. 682-690
    • Morellini, N.M.1    Giles, N.L.2    Rea, S.3    Adcroft, K.F.4    Falder, S.5
  • 88
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 2003, 424:277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5
  • 89
    • 56749182467 scopus 로고    scopus 로고
    • Design of aging intervention studies: the NIA interventions testing program
    • Nadon N.L., Strong R., Miller R.A., Nelson J., Javors M., et al. Design of aging intervention studies: the NIA interventions testing program. Age (Dordr) 2008, 30:187-199.
    • (2008) Age (Dordr) , vol.30 , pp. 187-199
    • Nadon, N.L.1    Strong, R.2    Miller, R.A.3    Nelson, J.4    Javors, M.5
  • 90
    • 0031864785 scopus 로고    scopus 로고
    • Involvement of oxidative stress in paraquat-induced metallothionein synthesis under glutathione depletion
    • Nakagawa I., Suzuki M., Imura N., Naganuma A. Involvement of oxidative stress in paraquat-induced metallothionein synthesis under glutathione depletion. Free Radic. Biol. Med. 1998, 24:1390-1395.
    • (1998) Free Radic. Biol. Med. , vol.24 , pp. 1390-1395
    • Nakagawa, I.1    Suzuki, M.2    Imura, N.3    Naganuma, A.4
  • 91
    • 0029552163 scopus 로고
    • Effect of glutathione depletion on metallothionein synthesis induced by paraquat in mice
    • Nakagawa I., Suzuki M., Yanagiya T., Imura N., Naganuma A. Effect of glutathione depletion on metallothionein synthesis induced by paraquat in mice. Tohoku J. Exp. Med. 1995, 177:249-262.
    • (1995) Tohoku J. Exp. Med. , vol.177 , pp. 249-262
    • Nakagawa, I.1    Suzuki, M.2    Yanagiya, T.3    Imura, N.4    Naganuma, A.5
  • 92
    • 85128738703 scopus 로고    scopus 로고
    • The balance between life and death of cells: roles of metallothioneins
    • Nielsen A.E., Bohr A., Penkowa M. The balance between life and death of cells: roles of metallothioneins. Biomark. Insights 2007, 1:99-111.
    • (2007) Biomark. Insights , vol.1 , pp. 99-111
    • Nielsen, A.E.1    Bohr, A.2    Penkowa, M.3
  • 93
  • 94
    • 58349097705 scopus 로고    scopus 로고
    • Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination
    • Papaconstantinou J. Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Mol. Cell. Endocrinol. 2009, 299:89-100.
    • (2009) Mol. Cell. Endocrinol. , vol.299 , pp. 89-100
    • Papaconstantinou, J.1
  • 95
    • 33750600258 scopus 로고    scopus 로고
    • Novel roles for metallothionein-I+II (MT-I+II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: insights from global gene expression profiling in wild-type and MT-I+II knockout mice
    • Penkowa M., Cáceres M., Borup R., Nielsen F.C., Poulsen C.B., et al. Novel roles for metallothionein-I+II (MT-I+II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: insights from global gene expression profiling in wild-type and MT-I+II knockout mice. J. Neurosci. Res. 2006, 84:1452-1474.
    • (2006) J. Neurosci. Res. , vol.84 , pp. 1452-1474
    • Penkowa, M.1    Cáceres, M.2    Borup, R.3    Nielsen, F.C.4    Poulsen, C.B.5
  • 97
    • 59049086591 scopus 로고    scopus 로고
    • The overexpression of major antioxidant enzymes does not extend the lifespan of mice
    • Pérez V.I., Van Remmen H., Bokov A., Epstein C.J., Vijg J., et al. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 2009, 8:73-75.
    • (2009) Aging Cell , vol.8 , pp. 73-75
    • Pérez, V.I.1    Van Remmen, H.2    Bokov, A.3    Epstein, C.J.4    Vijg, J.5
  • 98
    • 34948853679 scopus 로고    scopus 로고
    • Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis
    • Ran Q., Liang H., Ikeno Y., Qi W., Prolla T.A., et al. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J. Gerontol. A Biol. Sci. Med. Sci. 2007, 62:932-942.
    • (2007) J. Gerontol. A Biol. Sci. Med. Sci. , vol.62 , pp. 932-942
    • Ran, Q.1    Liang, H.2    Ikeno, Y.3    Qi, W.4    Prolla, T.A.5
  • 99
    • 34247103512 scopus 로고    scopus 로고
    • Hormetic modulation of aging and longevity by mild heat stress
    • Rattan S.I. Hormetic modulation of aging and longevity by mild heat stress. Dose Response 2006, 3:533-546.
    • (2006) Dose Response , vol.3 , pp. 533-546
    • Rattan, S.I.1
  • 100
    • 33645767663 scopus 로고    scopus 로고
    • Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells
    • Reinecke F., Levanets O., Olivier Y., Louw R., Semete B., et al. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochem. J. 2006, 395:405-415.
    • (2006) Biochem. J. , vol.395 , pp. 405-415
    • Reinecke, F.1    Levanets, O.2    Olivier, Y.3    Louw, R.4    Semete, B.5
  • 101
    • 33744799727 scopus 로고    scopus 로고
    • Publishing negative results: the problem of publication bias
    • Rockwell S., Kimler B.F., Moulder J.E. Publishing negative results: the problem of publication bias. Radiat. Res. 2006, 165:623-625.
    • (2006) Radiat. Res. , vol.165 , pp. 623-625
    • Rockwell, S.1    Kimler, B.F.2    Moulder, J.E.3
  • 102
    • 77952861579 scopus 로고    scopus 로고
    • Zinc supplement greatly improves the condition of parkin mutant Drosophila
    • Saini N., Schaffner W. Zinc supplement greatly improves the condition of parkin mutant Drosophila. Biol. Chem. 2010, 391:513-518.
    • (2010) Biol. Chem. , vol.391 , pp. 513-518
    • Saini, N.1    Schaffner, W.2
  • 103
    • 21044450084 scopus 로고    scopus 로고
    • Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress
    • Salmon A.B., Murakami S., Bartke A., Kopchick J., Yasumura K., et al. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am. J. Physiol. Endocrinol. Metab. 2005, 289:E23-E29.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Salmon, A.B.1    Murakami, S.2    Bartke, A.3    Kopchick, J.4    Yasumura, K.5
  • 104
    • 75149165994 scopus 로고    scopus 로고
    • Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?
    • Salmon A.B., Richardson A., Pérez V.I. Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?. Free Radic. Biol. Med. 2010, 48:642-655.
    • (2010) Free Radic. Biol. Med. , vol.48 , pp. 642-655
    • Salmon, A.B.1    Richardson, A.2    Pérez, V.I.3
  • 105
    • 77953163811 scopus 로고    scopus 로고
    • Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila
    • Sanz A., Fernández-Ayala D.J., Stefanatos R.K., Jacobs H.T. Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY) 2010, 2:220-223.
    • (2010) Aging (Albany NY) , vol.2 , pp. 220-223
    • Sanz, A.1    Fernández-Ayala, D.J.2    Stefanatos, R.K.3    Jacobs, H.T.4
  • 106
    • 0027533507 scopus 로고
    • Oxygen free radicals and metallothionein
    • Sato M., Bremner I. Oxygen free radicals and metallothionein. Free Radic. Biol. Med. 1993, 14:325-337.
    • (1993) Free Radic. Biol. Med. , vol.14 , pp. 325-337
    • Sato, M.1    Bremner, I.2
  • 107
    • 77954451875 scopus 로고    scopus 로고
    • Development of high-fat-diet-induced obesity in female metallothionein-null mice
    • Sato M., Kawakami T., Kondoh M., Takiguchi M., Kadota Y., et al. Development of high-fat-diet-induced obesity in female metallothionein-null mice. FASEB J. 2010, 24:2375-2384.
    • (2010) FASEB J. , vol.24 , pp. 2375-2384
    • Sato, M.1    Kawakami, T.2    Kondoh, M.3    Takiguchi, M.4    Kadota, Y.5
  • 108
    • 0028844377 scopus 로고
    • Induction of metallothionein synthesis by glutathione depletion after trans- and cis-stilbene oxide administration in rats
    • Sato M., Sasaki M., Oguro T., Kuroiwa Y., Yoshida T. Induction of metallothionein synthesis by glutathione depletion after trans- and cis-stilbene oxide administration in rats. Chem. Biol. Interact. 1995, 98:15-25.
    • (1995) Chem. Biol. Interact. , vol.98 , pp. 15-25
    • Sato, M.1    Sasaki, M.2    Oguro, T.3    Kuroiwa, Y.4    Yoshida, T.5
  • 109
    • 0030945681 scopus 로고    scopus 로고
    • Protective role of metallothionein in renal toxicity of cisplatinum
    • Satoh M., Aoki Y., Tohyama C. Protective role of metallothionein in renal toxicity of cisplatinum. Cancer Chemother. Pharmacol. 1997, 40:358-362.
    • (1997) Cancer Chemother. Pharmacol. , vol.40 , pp. 358-362
    • Satoh, M.1    Aoki, Y.2    Tohyama, C.3
  • 110
    • 0026565899 scopus 로고
    • Effect of preinduction of metallothionein on paraquat toxicity in mice
    • Satoh M., Naganuma A., Imura N. Effect of preinduction of metallothionein on paraquat toxicity in mice. Arch. Toxicol. 1992, 66:145-148.
    • (1992) Arch. Toxicol. , vol.66 , pp. 145-148
    • Satoh, M.1    Naganuma, A.2    Imura, N.3
  • 111
    • 0034578520 scopus 로고    scopus 로고
    • Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice
    • Satoh M., Shimada A., Zhang B., Tohyama C. Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice. Biochem. Pharmacol. 2000, 60:1729-1734.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1729-1734
    • Satoh, M.1    Shimada, A.2    Zhang, B.3    Tohyama, C.4
  • 113
    • 21144434217 scopus 로고    scopus 로고
    • Extension of murine life span by overexpression of catalase targeted to mitochondria
    • Schriner S.E., Linford N.J., Martin G.M., Treuting P., Ogburn C.E., et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005, 308:1909-1911.
    • (2005) Science , vol.308 , pp. 1909-1911
    • Schriner, S.E.1    Linford, N.J.2    Martin, G.M.3    Treuting, P.4    Ogburn, C.E.5
  • 114
    • 0028340352 scopus 로고
    • Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity
    • Schwarz M.A., Lazo J.S., Yalowich J.C., Reynolds I., Kagan V.E., et al. Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity. J. Biol. Chem. 1994, 269:15238-15243.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15238-15243
    • Schwarz, M.A.1    Lazo, J.S.2    Yalowich, J.C.3    Reynolds, I.4    Kagan, V.E.5
  • 115
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    • Selman C., Tullet J.M., Wieser D., Irvine E., Lingard S.J., et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009, 326:140-144.
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1    Tullet, J.M.2    Wieser, D.3    Irvine, E.4    Lingard, S.J.5
  • 117
    • 0030762518 scopus 로고    scopus 로고
    • Calcium, magnesium, and zinc status in experimental hyperthyroidism
    • Simsek G., Andican G., Unal E., Hatemi H., Yigit G., et al. Calcium, magnesium, and zinc status in experimental hyperthyroidism. Biol. Trace Elem. Res. 1997, 57:131-137.
    • (1997) Biol. Trace Elem. Res. , vol.57 , pp. 131-137
    • Simsek, G.1    Andican, G.2    Unal, E.3    Hatemi, H.4    Yigit, G.5
  • 118
    • 0344496708 scopus 로고    scopus 로고
    • The changes of hepatic metallothionein synthesis and the hepatic damage induced by starvation in mice
    • Sogawa N., Sogawa C.A., Fukuoka H., Mukubo Y., Yoneyama T., et al. The changes of hepatic metallothionein synthesis and the hepatic damage induced by starvation in mice. Methods Find. Exp. Clin. Pharmacol. 2003, 25:601-606.
    • (2003) Methods Find. Exp. Clin. Pharmacol. , vol.25 , pp. 601-606
    • Sogawa, N.1    Sogawa, C.A.2    Fukuoka, H.3    Mukubo, Y.4    Yoneyama, T.5
  • 119
    • 31344439942 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice
    • Sohal R.S., Kamzalov S., Sumien N., Ferguson M., Rebrin I., et al. Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice. Free Radic. Biol. Med. 2006, 40:480-487.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 480-487
    • Sohal, R.S.1    Kamzalov, S.2    Sumien, N.3    Ferguson, M.4    Rebrin, I.5
  • 120
    • 77952907560 scopus 로고    scopus 로고
    • Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells
    • Sreenivasulu K., Raghu P., Nair K.M. Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells. J. Food Sci. 2010, 75:H123-H128.
    • (2010) J. Food Sci. , vol.75
    • Sreenivasulu, K.1    Raghu, P.2    Nair, K.M.3
  • 121
    • 33846260825 scopus 로고    scopus 로고
    • Metallothioneins I and II: neuroprotective significance during CNS pathology
    • Stankovic R.K., Chung R.S., Penkowa M. Metallothioneins I and II: neuroprotective significance during CNS pathology. Int. J. Biochem. Cell Biol. 2007, 39:484-489.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 484-489
    • Stankovic, R.K.1    Chung, R.S.2    Penkowa, M.3
  • 122
    • 0036735062 scopus 로고    scopus 로고
    • Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity
    • Sun X., Kang Y.J. Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity. Exp. Biol. Med. (Maywood) 2002, 227:652-657.
    • (2002) Exp. Biol. Med. (Maywood) , vol.227 , pp. 652-657
    • Sun, X.1    Kang, Y.J.2
  • 123
    • 76749117956 scopus 로고    scopus 로고
    • Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet
    • Sun X., Seeberger J., Alberico T., Wang C., Wheeler C.T., et al. Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. Exp. Gerontol. 2010, 45:243-251.
    • (2010) Exp. Gerontol. , vol.45 , pp. 243-251
    • Sun, X.1    Seeberger, J.2    Alberico, T.3    Wang, C.4    Wheeler, C.T.5
  • 124
    • 0034615909 scopus 로고    scopus 로고
    • Astrocyte cultures from transgenic mice to study the role of metallothionein in cytotoxicity of tert-butyl hydroperoxide
    • Suzuki Y., Apostolova M.D., Cherian M.G. Astrocyte cultures from transgenic mice to study the role of metallothionein in cytotoxicity of tert-butyl hydroperoxide. Toxicology 2000, 145:51-62.
    • (2000) Toxicology , vol.145 , pp. 51-62
    • Suzuki, Y.1    Apostolova, M.D.2    Cherian, M.G.3
  • 125
    • 0030687606 scopus 로고    scopus 로고
    • Copper-metallothionein in the kidney of macular mice: a model for Menkes disease
    • Suzuki-Kurasaki M., Okabe M., Kurasaki M. Copper-metallothionein in the kidney of macular mice: a model for Menkes disease. J. Histochem. Cytochem. 1997, 45:1493-1501.
    • (1997) J. Histochem. Cytochem. , vol.45 , pp. 1493-1501
    • Suzuki-Kurasaki, M.1    Okabe, M.2    Kurasaki, M.3
  • 126
    • 36448984298 scopus 로고    scopus 로고
    • Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
    • Swindell W.R. Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging. BMC Genomics 2007, 8:353.
    • (2007) BMC Genomics , vol.8 , pp. 353
    • Swindell, W.R.1
  • 127
    • 39149086075 scopus 로고    scopus 로고
    • Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
    • Swindell W.R. Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues. Mech. Ageing Dev. 2008, 129:138-153.
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 138-153
    • Swindell, W.R.1
  • 128
    • 54249140000 scopus 로고    scopus 로고
    • Genes regulated by caloric restriction have unique roles within transcriptional networks
    • Swindell W.R. Genes regulated by caloric restriction have unique roles within transcriptional networks. Mech. Ageing Dev. 2008, 129:580-592.
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 580-592
    • Swindell, W.R.1
  • 129
    • 59749084724 scopus 로고    scopus 로고
    • Accelerated failure time models provide a useful statistical framework for aging research
    • Swindell W.R. Accelerated failure time models provide a useful statistical framework for aging research. Exp. Gerontol. 2009, 44:190-200.
    • (2009) Exp. Gerontol. , vol.44 , pp. 190-200
    • Swindell, W.R.1
  • 130
    • 73149086166 scopus 로고    scopus 로고
    • Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
    • Swindell W.R. Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genomics 2009, 10:585.
    • (2009) BMC Genomics , vol.10 , pp. 585
    • Swindell, W.R.1
  • 131
    • 77953925098 scopus 로고    scopus 로고
    • Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations
    • Swindell W.R. Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations. Aging (Albany NY) 2009, 1:573-577.
    • (2009) Aging (Albany NY) , vol.1 , pp. 573-577
    • Swindell, W.R.1
  • 132
    • 77951033595 scopus 로고    scopus 로고
    • In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene
    • Swindell W.R., Masternak M.M., Bartke A. In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene. Exp. Gerontol. 2010, 45:366-374.
    • (2010) Exp. Gerontol. , vol.45 , pp. 366-374
    • Swindell, W.R.1    Masternak, M.M.2    Bartke, A.3
  • 134
    • 33751090136 scopus 로고    scopus 로고
    • Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction
    • Szewczyk N.J., Udranszky I.A., Kozak E., Sunga J., Kim S.K., et al. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. J. Exp. Biol. 2006, 209:4129-4139.
    • (2006) J. Exp. Biol. , vol.209 , pp. 4129-4139
    • Szewczyk, N.J.1    Udranszky, I.A.2    Kozak, E.3    Sunga, J.4    Kim, S.K.5
  • 135
    • 11144346135 scopus 로고    scopus 로고
    • Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size
    • Takahashi M., Kamei Y., Ezaki O. Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am. J. Physiol. Endocrinol. Metab. 2005, 288:E117-E124.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288
    • Takahashi, M.1    Kamei, Y.2    Ezaki, O.3
  • 136
    • 3543035274 scopus 로고    scopus 로고
    • Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity
    • Taylor D.M., Minotti S., Agar J.N., Durham H.D. Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity. Neurotoxicology 2004, 25:79-92.
    • (2004) Neurotoxicology , vol.25 , pp. 79-92
    • Taylor, D.M.1    Minotti, S.2    Agar, J.N.3    Durham, H.D.4
  • 137
    • 0021944046 scopus 로고
    • Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
    • Thornalley P.J., Vasák M. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim. Biophys. Acta 1985, 827:36-44.
    • (1985) Biochim. Biophys. Acta , vol.827 , pp. 36-44
    • Thornalley, P.J.1    Vasák, M.2
  • 138
    • 26444504945 scopus 로고    scopus 로고
    • Metallothionein mRNA expression and cadmium tolerance in metal-stressed and reference populations of the springtail Orchesella cincta
    • Timmermans M.J., Ellers J., Roelofs D., van Straalen N.M. Metallothionein mRNA expression and cadmium tolerance in metal-stressed and reference populations of the springtail Orchesella cincta. Ecotoxicology 2005, 14:727-739.
    • (2005) Ecotoxicology , vol.14 , pp. 727-739
    • Timmermans, M.J.1    Ellers, J.2    Roelofs, D.3    van Straalen, N.M.4
  • 139
    • 34247568861 scopus 로고    scopus 로고
    • Allelic diversity of metallothionein in Orchesella cincta (L.): traces of natural selection by environmental pollution
    • Timmermans M.J., Ellers J., Van Straalen N.M. Allelic diversity of metallothionein in Orchesella cincta (L.): traces of natural selection by environmental pollution. Heredity 2007, 98:311-319.
    • (2007) Heredity , vol.98 , pp. 311-319
    • Timmermans, M.J.1    Ellers, J.2    Van Straalen, N.M.3
  • 140
    • 2942520998 scopus 로고    scopus 로고
    • Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells
    • Van Erk M.J., Teuling E., Staal Y.C., Huybers S., Van Bladeren P.J., et al. Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells. J. Carcinog. 2004, 3:8.
    • (2004) J. Carcinog. , vol.3 , pp. 8
    • Van Erk, M.J.1    Teuling, E.2    Staal, Y.C.3    Huybers, S.4    Van Bladeren, P.J.5
  • 141
    • 12144288373 scopus 로고    scopus 로고
    • Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
    • Van Remmen H., Ikeno Y., Hamilton M., Pahlavani M., Wolf N., et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics 2003, 16:29-37.
    • (2003) Physiol. Genomics , vol.16 , pp. 29-37
    • Van Remmen, H.1    Ikeno, Y.2    Hamilton, M.3    Pahlavani, M.4    Wolf, N.5
  • 142
    • 58149235102 scopus 로고    scopus 로고
    • Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death
    • Vanhooren V., Liu X.E., Desmyter L., Fan Y.D., Vanwalleghem L., et al. Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death. Rejuvenation Res. 2008, 11:1013-1020.
    • (2008) Rejuvenation Res. , vol.11 , pp. 1013-1020
    • Vanhooren, V.1    Liu, X.E.2    Desmyter, L.3    Fan, Y.D.4    Vanwalleghem, L.5
  • 144
    • 0034657231 scopus 로고    scopus 로고
    • Identification and expression analysis of leptin-regulated immediate early response and late target genes
    • Waelput W., Verhee A., Broekaert D., Eyckerman S., Vandekerckhove J., et al. Identification and expression analysis of leptin-regulated immediate early response and late target genes. Biochem. J. 2000, 348:55-61.
    • (2000) Biochem. J. , vol.348 , pp. 55-61
    • Waelput, W.1    Verhee, A.2    Broekaert, D.3    Eyckerman, S.4    Vandekerckhove, J.5
  • 145
    • 33749256951 scopus 로고    scopus 로고
    • Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2
    • Wakida K., Morimoto N., Shimazawa M., Hozumi I., Nagase H., et al. Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2. Brain Res. 2006, 1116:187-193.
    • (2006) Brain Res. , vol.1116 , pp. 187-193
    • Wakida, K.1    Morimoto, N.2    Shimazawa, M.3    Hozumi, I.4    Nagase, H.5
  • 146
    • 0041507039 scopus 로고    scopus 로고
    • Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals
    • Walker G.A., Lithgow G.J. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell 2003, 2:131-139.
    • (2003) Aging Cell , vol.2 , pp. 131-139
    • Walker, G.A.1    Lithgow, G.J.2
  • 147
    • 3042738968 scopus 로고    scopus 로고
    • Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver
    • Wang Y., Wimmer U., Lichtlen P., Inderbitzin D., Stieger B., et al. Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver. FASEB J. 2004, 18:1071-1079.
    • (2004) FASEB J. , vol.18 , pp. 1071-1079
    • Wang, Y.1    Wimmer, U.2    Lichtlen, P.3    Inderbitzin, D.4    Stieger, B.5
  • 149
    • 33744456501 scopus 로고    scopus 로고
    • Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress
    • Yang X., Doser T.A., Fang C.X., Nunn J.M., Janardhanan R., et al. Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress. FASEB J. 2006, 20:1024-1026.
    • (2006) FASEB J. , vol.20 , pp. 1024-1026
    • Yang, X.1    Doser, T.A.2    Fang, C.X.3    Nunn, J.M.4    Janardhanan, R.5
  • 150
    • 58149520136 scopus 로고    scopus 로고
    • Basal expression of metallothionein suppresses butenolide-induced oxidative stress in liver homogenates in vitro
    • Yang H.Y., Wang Y.M., Peng S.Q. Basal expression of metallothionein suppresses butenolide-induced oxidative stress in liver homogenates in vitro. Toxicon. 2009, 53:246-253.
    • (2009) Toxicon. , vol.53 , pp. 246-253
    • Yang, H.Y.1    Wang, Y.M.2    Peng, S.Q.3
  • 151
    • 0035956862 scopus 로고    scopus 로고
    • Zinc metallothionein imported into liver mitochondria modulates respiration
    • Ye B., Maret W., Vallee B.L. Zinc metallothionein imported into liver mitochondria modulates respiration. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:2317-2322.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 2317-2322
    • Ye, B.1    Maret, W.2    Vallee, B.L.3
  • 152
    • 58149279285 scopus 로고    scopus 로고
    • Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia
    • Yousuf S., Atif F., Ahmad M., Hoda N., Ishrat T., et al. Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia. Brain Res. 2009, 1250:242-253.
    • (2009) Brain Res. , vol.1250 , pp. 242-253
    • Yousuf, S.1    Atif, F.2    Ahmad, M.3    Hoda, N.4    Ishrat, T.5
  • 153
    • 0040951508 scopus 로고    scopus 로고
    • Re-evaluation of the binding of ATP to metallothionein
    • Zangger K., Oz G., Armitage I.M. Re-evaluation of the binding of ATP to metallothionein. J. Biol. Chem. 2000, 275:7534-7538.
    • (2000) J. Biol. Chem. , vol.275 , pp. 7534-7538
    • Zangger, K.1    Oz, G.2    Armitage, I.M.3
  • 154
    • 75149126964 scopus 로고    scopus 로고
    • Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity
    • Zhang Y., Ikeno Y., Qi W., Chaudhuri A., Li Y., et al. Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:1212-1220.
    • (2009) J. Gerontol. A Biol. Sci. Med. Sci. , vol.64 , pp. 1212-1220
    • Zhang, Y.1    Ikeno, Y.2    Qi, W.3    Chaudhuri, A.4    Li, Y.5
  • 155
    • 1642410889 scopus 로고    scopus 로고
    • Study of trace elements in blood of thyroid disorder subjects before and after 131I therapy
    • Zhang F., Liu N., Wang X., Zhu L., Chai Z. Study of trace elements in blood of thyroid disorder subjects before and after 131I therapy. Biol. Trace Elem. Res. 2004, 97:125-134.
    • (2004) Biol. Trace Elem. Res. , vol.97 , pp. 125-134
    • Zhang, F.1    Liu, N.2    Wang, X.3    Zhu, L.4    Chai, Z.5
  • 156
    • 70349438679 scopus 로고    scopus 로고
    • 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
    • Zid B.M., Rogers A.N., Katewa S.D., Vargas M.A., Kolipinski M.C., et al. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 2009, 139:149-160.
    • (2009) Cell , vol.139 , pp. 149-160
    • Zid, B.M.1    Rogers, A.N.2    Katewa, S.D.3    Vargas, M.A.4    Kolipinski, M.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.