Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis

BioMetals

Volumn 24, Issue 5, 2011, Pages 875-890

  Lamore, Sarah D ^a   Wondrak, Georg T ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Heat shock response; HSPA1A; ICP MS; Keratinocyte; Reconstructed epidermis; Zinc pyrithione

Indexed keywords

HEAT SHOCK PROTEIN 70; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; PYRITHIONE ZINC; ZINC ION;

ARTICLE; BIOACCUMULATION; CELL DEATH; CELLULAR STRESS RESPONSE; CHELATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYCLIN DEPENDENT KINASE INHIBITOR 1A GENE; DNAJ HOMOLOG SUBFAMILY A MEMBER 1 GENE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; GENE; GENE EXPRESSION REGULATION; GLUTATHIONE S TRANSFERASE MU 3 GENE; HEAT SHOCK PROTEIN A1A GENE; HEAT SHOCK PROTEIN A1L GENE; HEAT SHOCK PROTEIN A6 GENE; HEAT SHOCK PROTEIN B5 GENE; HEAT SHOCK PROTEIN D1 GENE; HEAT SHOCK PROTEIN E1 GENE; HEAT SHOCK PROTEIN H1 GENE; HEAT SHOCK RESPONSE; HEME OXYGENASE 1 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MASS SPECTROMETRY; METALLOTHIONEIN 2A GENE; NICK END LABELING; NUCLEOTIDE SEQUENCE; SENSITIVITY ANALYSIS; SUPEROXIDE DISMUTASE 2 GENE; UNINDEXED SEQUENCE; UPREGULATION; ZINC METABOLISM;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMIS; HOMEOSTASIS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KERATINOCYTES; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION; ZINC;

EID: 80052415904     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-011-9441-6     Document Type: Article

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