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Volumn 69, Issue 3, 2010, Pages 290-299

Zinc, metallothioneins and immunosenescence

Author keywords

Ageing; Immune response; Inflammation; Longevity; Metallothioneins; Zinc signalling; Zinc supplementation; Zinc transporters

Indexed keywords

ALPHA INTERFERON; FLUORESCENT DYE; GLYCOPROTEIN GP 130; INTERLEUKIN 1; INTERLEUKIN 6; ISOPROTEIN; MESSENGER RNA; METALLOTHIONEIN; METALLOTHIONEIN I; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; STEM CELL FACTOR; TETANUS TOXOID; THYMULIN; TRACE ELEMENT; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; ZINC; ZINC TRANSPORTER;

EID: 77957348605     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665110001862     Document Type: Conference Paper
Times cited : (28)

References (70)
  • 1
    • 0033792903 scopus 로고    scopus 로고
    • Metabolic age modelling: The lesson from centenarians
    • Paolisso G, Barbieri M, Bonafè M et al. (2000) Metabolic age modelling: the lesson from centenarians. Eur J Clin Invest 10, 888-894.
    • (2000) Eur. J. Clin. Invest. , vol.10 , pp. 888-894
    • Paolisso, G.1    Barbieri, M.2    Bonafè, M.3
  • 2
    • 33845212090 scopus 로고    scopus 로고
    • Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage
    • Ames BN (2006) Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc Natl Acad Sci USA 103, 17589-17594.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17589-17594
    • Ames, B.N.1
  • 3
    • 0033796739 scopus 로고    scopus 로고
    • Consumption of energy-dense, nutrient-poor foods by adult Americans: Nutritional and health implications. The third national health and nutrition examination survey, 1988-1994
    • Kant AK (2000) Consumption of energy-dense, nutrient-poor foods by adult Americans: nutritional and health implications. The Third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 72, 929-936.
    • (2000) Am J. Clin. Nutr. , vol.72 , pp. 929-936
    • Kant, A.K.1
  • 4
    • 0034848652 scopus 로고    scopus 로고
    • Nutrition and aging in developing countries
    • Tucker KL & Buranapin S (2001) Nutrition and aging in developing countries. J Nutr 9, 2417S-2423S.
    • (2001) J. Nutr. , vol.9
    • Tucker, K.L.1    Buranapin, S.2
  • 5
    • 0037656519 scopus 로고    scopus 로고
    • Trace elements and host defense: Recent advances and continuing challenges
    • Failla ML (2003) Trace elements and host defense: recent advances and continuing challenges. J Nutr 133, Suppl. 1, 1443S-1447S.
    • (2003) J. Nutr. , vol.133 , Issue.1 SUPPL.
    • Failla, M.L.1
  • 6
    • 0035179427 scopus 로고    scopus 로고
    • Nutrition and health promotion in older adults
    • Chernoff R (2001) Nutrition and health promotion in older adults. J Gerontol A Biol Sci Med Sci 56, 47-53.
    • (2001) J. Gerontol a Biol. Sci. Med. Sci. , vol.56 , pp. 47-53
    • Chernoff, R.1
  • 7
    • 70350126591 scopus 로고    scopus 로고
    • Zinc: Role in immunity, oxidative stress and chronic inflammation
    • Prasad AS (2009) Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care 12, 646-652.
    • (2009) Curr. Opin. Clin. Nutr Metab. Care , vol.12 , pp. 646-652
    • Prasad, A.S.1
  • 8
    • 1042288472 scopus 로고    scopus 로고
    • The many roles of apoptosis in immunity as modified by aging and nutritional status
    • Fraker PJ & Lill-Elghanian DA (2004) The many roles of apoptosis in immunity as modified by aging and nutritional status. J Nutr Health Aging 8, 56-63.
    • (2004) J. Nutr Health Aging , vol.8 , pp. 56-63
    • Fraker, P.J.1    Lill-Elghanian, D.A.2
  • 9
    • 33646128026 scopus 로고    scopus 로고
    • Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response
    • Mocchegiani E, Costarelli L, Giacconi R et al. (2006) Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response. Mech Ageing Dev 127, 517-525.
    • (2006) Mech Ageing Dev. , vol.127 , pp. 517-525
    • Mocchegiani, E.1    Costarelli, L.2    Giacconi, R.3
  • 10
    • 18744376312 scopus 로고    scopus 로고
    • Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
    • Liuzzi JP & Lichten LA, Rivera S et al. (2005) Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci USA 102, 6843-6848.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 6843-6848
    • Liuzzi, J.P.1    Lichten, L.A.2    Rivera, S.3
  • 11
    • 0034213058 scopus 로고    scopus 로고
    • Zinc and immunoresistance to infection in aging: New biological tools
    • Mocchegiani E, Muzzioli M & Giacconi R (2000) Zinc and immunoresistance to infection in aging: new biological tools. Trends Pharmacol Sci 21, 205-208.
    • (2000) Trends Pharmacol. Sci. , vol.21 , pp. 205-208
    • Mocchegiani, E.1    Muzzioli, M.2    Giacconi, R.3
  • 12
    • 33747723380 scopus 로고    scopus 로고
    • Mammalian zinc transport, trafficking, and signals
    • Cousins RJ, Liuzzi JP & Lichten LA (2006) Mammalian zinc transport, trafficking, and signals. J Biol Chem 281, 24085-24089.
    • (2006) J. Biol. Chem. , vol.281 , pp. 24085-24089
    • Cousins, R.J.1    Liuzzi, J.P.2    Lichten, L.A.3
  • 13
    • 34447106867 scopus 로고    scopus 로고
    • The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling
    • Krezel A, Hao Q & Maret W (2007) The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling. Arch Biochem Biophys 463, 188-200.
    • (2007) Arch. Biochem. Biophys. , vol.463 , pp. 188-200
    • Krezel, A.1    Hao, Q.2    Maret, W.3
  • 14
    • 0036239958 scopus 로고    scopus 로고
    • Recent studies on metallothionein: Protection against toxicity of heavy metals and oxygen free radicals
    • Sato M & Kondoh M (2002) Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med 196, 9-22.
    • (2002) Tohoku J. Exp. Med. , vol.196 , pp. 9-22
    • Sato, M.1    Kondoh, M.2
  • 15
    • 0029987684 scopus 로고    scopus 로고
    • Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice
    • Kelly EJ, Quaife CJ, Froelick GJ et al. (1996) Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr 126, 1782-1790.
    • (1996) J. Nutr. , vol.126 , pp. 1782-1790
    • Kelly, E.J.1    Quaife, C.J.2    Froelick, G.J.3
  • 16
    • 18244378255 scopus 로고    scopus 로고
    • MTmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: Lessons from very old mice and humans
    • Mocchegiani E, Giacconi R, Cipriano C et al. (2002) MTmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans. Exp Gerontol 37, 349-357.
    • (2002) Exp. Gerontol , vol.37 , pp. 349-357
    • Mocchegiani, E.1    Giacconi, R.2    Cipriano, C.3
  • 17
    • 0042697664 scopus 로고    scopus 로고
    • Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence
    • Williams PD & Day T (2003) Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence. Evolution Int J Org Evolution 57, 1478-1488.
    • (2003) Evolution Int. J. Org Evolution , vol.57 , pp. 1478-1488
    • Williams, P.D.1    Day, T.2
  • 18
    • 31044444489 scopus 로고    scopus 로고
    • Interrelationship among neutrophil efficiency, inflammation, antioxidant activity and zinc pool in very old age
    • Moroni F, Di Paolo ML, Rigo A et al. (2005) Interrelationship among neutrophil efficiency, inflammation, antioxidant activity and zinc pool in very old age. Biogerontology 6, 271-281.
    • (2005) Biogerontology , vol.6 , pp. 271-281
    • Moroni, F.1    Di Paolo, M.L.2    Rigo, A.3
  • 19
    • 33744456501 scopus 로고    scopus 로고
    • Metallothionein prolongs survival and antagonizes senescence associated cardiomyocyte diastolic dysfunction: Role of oxidative stress
    • Yang X, Doser TA, Fang CX et al. (2006) Metallothionein prolongs survival and antagonizes senescence associated cardiomyocyte diastolic dysfunction: role of oxidative stress. FASEB J 20, 1024-1026.
    • (2006) FASEB J. , vol.20 , pp. 1024-1026
    • Yang, X.1    Doser, T.A.2    Fang, C.X.3
  • 20
    • 0035082093 scopus 로고    scopus 로고
    • Longevity and heavy metal resistance in daf-2 and age-1 long lived mutants of Caenorhabditis elegans
    • Barsyte D, Lovejoy DA & Lithgow GJ (2001) Longevity and heavy metal resistance in daf-2 and age-1 long lived mutants of Caenorhabditis elegans. FASEB J 15, 627-634.
    • (2001) FASEB J. , vol.15 , pp. 627-634
    • Barsyte, D.1    Lovejoy, D.A.2    Lithgow, G.J.3
  • 21
    • 19744375548 scopus 로고    scopus 로고
    • Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts
    • Feng W, Cai J, Pierce WM et al. (2005) Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts. Biochem Biophys Res Commun 332, 853-858.
    • (2005) Biochem. Biophys. Res. Commun. , vol.332 , pp. 853-858
    • Feng, W.1    Cai, J.2    Pierce, W.M.3
  • 22
    • 34547836490 scopus 로고    scopus 로고
    • Polymorphisms in MT1a gene with longevity in Italian central female population
    • Cipriano C, Malavolta M, Costarelli L et al. (2006) Polymorphisms in MT1a gene with longevity in Italian central female population. Biogerontology 7, 357-365.
    • (2006) Biogerontology , vol.7 , pp. 357-365
    • Cipriano, C.1    Malavolta, M.2    Costarelli, L.3
  • 23
    • 26444577831 scopus 로고    scopus 로고
    • Metallothionein mediates leukocyte chemotaxis
    • Yin X, Knecht DA & Lynes MA (2005) Metallothionein mediates leukocyte chemotaxis. BMC Immunol 6, 21-31.
    • (2005) BMC Immunol. , vol.6 , pp. 21-31
    • Yin, X.1    Knecht, D.A.2    Lynes, M.A.3
  • 24
    • 0028789116 scopus 로고
    • Polymorphonuclear leukocyte chemotaxis induced by zinc, copper and nickel in vitro
    • Hujanen ES, Seppa ST & Virtanen K (1995) Polymorphonuclear leukocyte chemotaxis induced by zinc, copper and nickel in vitro. Biochim Biophys Acta 1245, 145-152.
    • (1995) Biochim Biophys. Acta , vol.1245 , pp. 145-152
    • Hujanen, E.S.1    Seppa, S.T.2    Virtanen, K.3
  • 25
    • 36348941803 scopus 로고    scopus 로고
    • Zinc-bound metallothioneins and immune plasticity: Lessons from very old mice and humans
    • Mocchegiani E, Giacconi R, Muti E et al. (2007) Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans. Immun Ageing 4, 7-12.
    • (2007) Immun Ageing , vol.4 , pp. 7-12
    • Mocchegiani, E.1    Giacconi, R.2    Muti, E.3
  • 26
    • 0037204527 scopus 로고    scopus 로고
    • Metallothioneins (I + II) and thyroid-thymus axis efficiency in old mice: Role of corticosterone and zinc supply
    • Mocchegiani E, Giacconi R, Cipriano C et al. (2002) Metallothioneins (I + II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply. Mech Ageing Dev 123, 675-694.
    • (2002) Mech Ageing Dev. , vol.123 , pp. 675-694
    • Mocchegiani, E.1    Giacconi, R.2    Cipriano, C.3
  • 27
    • 0033402179 scopus 로고    scopus 로고
    • Metallothionein-induced suppression of cytotoxic T lymphocyte function: An important immunoregulatory control
    • Youn J & Lynes MA (1999) Metallothionein-induced suppression of cytotoxic T lymphocyte function: an important immunoregulatory control. Toxicol Sci 52, 199-208.
    • (1999) Toxicol Sci. , vol.52 , pp. 199-208
    • Youn, J.1    Lynes, M.A.2
  • 28
    • 58149236973 scopus 로고    scopus 로고
    • Agedependent signature of metallothionein expression in primary CD4T cell responses is due to sustained zinc signaling
    • Lee WW, Cui D, Czesnikiewicz-Guzik M et al. (2008) Agedependent signature of metallothionein expression in primary CD4T cell responses is due to sustained zinc signaling. Rejuvenation Res 11, 1001-1011.
    • (2008) Rejuvenation Res. , vol.11 , pp. 1001-1011
    • Lee, W.W.1    Cui, D.2    Czesnikiewicz-Guzik, M.3
  • 29
    • 42649144123 scopus 로고    scopus 로고
    • Metallothionein downregulation in very old age: A phenomenon associated with cellular senescence?
    • Malavolta M, Cipriano C, Costarelli L et al. (2008) Metallothionein downregulation in very old age: a phenomenon associated with cellular senescence? Rejuvenation Res 11, 455-459.
    • (2008) Rejuvenation Res. , vol.11 , pp. 455-459
    • Malavolta, M.1    Cipriano, C.2    Costarelli, L.3
  • 30
    • 33644866812 scopus 로고    scopus 로고
    • Metallothionein disulfides are present in metallothionein-overexpressing transgenic mouse heart and increase under conditions of oxidative stress
    • Feng W, Benz FW, Cai J et al. (2006) Metallothionein disulfides are present in metallothionein-overexpressing transgenic mouse heart and increase under conditions of oxidative stress. J Biol Chem 281, 681-687.
    • (2006) J. Biol. Chem. , vol.281 , pp. 681-687
    • Feng, W.1    Benz, F.W.2    Cai, J.3
  • 31
    • 0035344459 scopus 로고    scopus 로고
    • Nitric oxide selectively releases metals from the amino-terminal domain of metallothioneins: Potential role at inflammatory sites
    • Zangger K, Oz G, Haslinger E et al. (2001) Nitric oxide selectively releases metals from the amino-terminal domain of metallothioneins: potential role at inflammatory sites. FASEB J 15, 1303-1305.
    • (2001) FASEB J. , vol.15 , pp. 1303-1305
    • Zangger, K.1    Oz, G.2    Haslinger, E.3
  • 33
    • 33750006606 scopus 로고    scopus 로고
    • Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: Relationship with metallothioneins
    • Malavolta M, Costarelli L, Giacconi R et al. (2006) Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: relationship with metallothioneins. Cytometry A 69, 1043-1053.
    • (2006) Cytometry A , vol.69 , pp. 1043-1053
    • Malavolta, M.1    Costarelli, L.2    Giacconi, R.3
  • 34
    • 33646126495 scopus 로고    scopus 로고
    • Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells
    • Haase H, Hebel S, Engelhardt G et al. (2006) Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells. Anal Biochem 352, 222-230.
    • (2006) Anal. Biochem. , vol.352 , pp. 222-230
    • Haase, H.1    Hebel, S.2    Engelhardt, G.3
  • 35
    • 33745837058 scopus 로고    scopus 로고
    • Novel - 209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: Relationship with inflammation (IL-6) and zinc
    • Giacconi R, Cipriano C, Muti E et al. (2005) Novel - 209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc. Biogerontology 6, 407-413.
    • (2005) Biogerontology , vol.6 , pp. 407-413
    • Giacconi, R.1    Cipriano, C.2    Muti, E.3
  • 36
    • 52949135993 scopus 로고    scopus 로고
    • ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in antihormone-resistant breast cancer cells
    • Taylor KM, Vichova P, Jordan N et al. (2008) ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in antihormone-resistant breast cancer cells. Endocrinology 149, 4912-4920.
    • (2008) Endocrinology , vol.149 , pp. 4912-4920
    • Taylor, K.M.1    Vichova, P.2    Jordan, N.3
  • 37
    • 67650050212 scopus 로고    scopus 로고
    • Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-{gamma} expression in activated human T cells
    • Aydemir TB, Liuzzi JP, McClellan S et al. (2009) Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-{gamma} expression in activated human T cells. J Leukoc Biol 86, 337-348.
    • (2009) J. Leukoc Biol. , vol.86 , pp. 337-348
    • Aydemir, T.B.1    Liuzzi, J.P.2    McClellan, S.3
  • 38
    • 58749098604 scopus 로고    scopus 로고
    • Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes
    • Haase H, Ober-Blobaum JL, Engelhardt G et al. (2008) Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes. J Immunol 181, 6491-6502.
    • (2008) J. Immunol. , vol.181 , pp. 6491-6502
    • Haase, H.1    Ober-Blobaum, J.L.2    Engelhardt, G.3
  • 39
    • 3142536766 scopus 로고    scopus 로고
    • Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans
    • Andree KB, Kim J, Kirschke CP et al. (2004) Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. J Nutr 134, 1716-1723.
    • (2004) J. Nutr. , vol.134 , pp. 1716-1723
    • Andree, K.B.1    Kim, J.2    Kirschke, C.P.3
  • 40
    • 0034578489 scopus 로고    scopus 로고
    • Zinc, metallothioneins, immune responses, survival and ageing
    • Mocchegiani E, Muzzioli M & Giacconi R (2000). Zinc, metallothioneins, immune responses, survival and ageing. Biogerontology 1, 133-143.
    • (2000) Biogerontology , vol.1 , pp. 133-143
    • Mocchegiani, E.1    Muzzioli, M.2    Giacconi, R.3
  • 41
    • 34248646765 scopus 로고    scopus 로고
    • Signal transduction in monocytes: The role of zinc ions
    • Haase H & Rink L (2007) Signal transduction in monocytes: the role of zinc ions. Biometals 20, 579-85.
    • (2007) Biometals , vol.20 , pp. 579-85
    • Haase, H.1    Rink, L.2
  • 42
    • 33749460409 scopus 로고    scopus 로고
    • Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects
    • Ostan R, Alberti S, Bucci L et al. (2006) Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects. Biogerontology 7, 437-447.
    • (2006) Biogerontology , vol.7 , pp. 437-447
    • Ostan, R.1    Alberti, S.2    Bucci, L.3
  • 43
    • 0031947772 scopus 로고    scopus 로고
    • Flow cytometric analysis of CD3/TCR complex, zinc, and glucocorticoid-mediated regulation of apoptosis and cell cycle distribution in thymocytes from old mice
    • Provinciali M, Di Stefano G & Stronati S (1998). Flow cytometric analysis of CD3/TCR complex, zinc, and glucocorticoid-mediated regulation of apoptosis and cell cycle distribution in thymocytes from old mice. Cytometry 32, 1-8.
    • (1998) Cytometry , vol.32 , pp. 1-8
    • Provinciali, M.1    Di Stefano, G.2    Stronati, S.3
  • 44
    • 18044397492 scopus 로고    scopus 로고
    • Zinc pyrithione induces apoptosis and increases expression of Bim
    • Mann JJ & Fraker PJ (2005) Zinc pyrithione induces apoptosis and increases expression of Bim. Apoptosis 10, 369-379.
    • (2005) Apoptosis , vol.10 , pp. 369-379
    • Mann, J.J.1    Fraker, P.J.2
  • 45
    • 0018718372 scopus 로고
    • Circulating thymic hormone levels in zinc deficiency
    • Iwata T, Incefy GS, Tanaka T et al. (1979) Circulating thymic hormone levels in zinc deficiency. Cell Immunol 47, 100-105.
    • (1979) Cell. Immunol. , vol.47 , pp. 100-105
    • Iwata, T.1    Incefy, G.S.2    Tanaka, T.3
  • 46
    • 0027533814 scopus 로고
    • Restoration of the thymus in aging mice by in vivo zinc supplementation
    • Dardenne M, Boukaiba N, Gagnerault MC et al. (1993) Restoration of the thymus in aging mice by in vivo zinc supplementation. Clin Immunol Immunopathol 66, 127-135.
    • (1993) Clin. Immunol. Immunopathol , vol.66 , pp. 127-135
    • Dardenne, M.1    Boukaiba, N.2    Gagnerault, M.C.3
  • 47
    • 67649946274 scopus 로고    scopus 로고
    • Zinc supplementation increases zinc status and thymopoiesis in aged mice
    • Wong CP, Song Y, Elias VD et al. (2009) Zinc supplementation increases zinc status and thymopoiesis in aged mice. J Nutr 139, 1393-1397.
    • (2009) J. Nutr. , vol.139 , pp. 1393-1397
    • Wong, C.P.1    Song, Y.2    Elias, V.D.3
  • 48
    • 36549005537 scopus 로고    scopus 로고
    • Zinc, metallothioneins, and longevity effect of zinc supplementation: Zincage study
    • Mocchegiani E, Giacconi R, Cipriano C et al. (2007) Zinc, metallothioneins, and longevity effect of zinc supplementation: zincage study. Ann NY Acad Sci 1119, 129-46.
    • (2007) Ann. NY Acad. Sci. , vol.1119 , pp. 129-46
    • Mocchegiani, E.1    Giacconi, R.2    Cipriano, C.3
  • 50
    • 0027515928 scopus 로고
    • A physiological amount of zinc supplementation: Effects on nutritional, lipid, and thymic status in an elderly population
    • Boukaiba N, Flament C, Acher S et al. (1993) A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population. Am J Clin Nutr 57, 566-572.
    • (1993) Am. J. Clin. Nutr. , vol.57 , pp. 566-572
    • Boukaiba, N.1    Flament, C.2    Acher, S.3
  • 51
    • 0025552871 scopus 로고
    • Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly
    • Bogden JD, Oleske JM, Lavenhar MA et al. (1990) Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. J Am Coll Nutr 9, 214-25.
    • (1990) J. Am. Coll. Nutr. , vol.9 , pp. 214-25
    • Bogden, J.D.1    Oleske, J.M.2    Lavenhar, M.A.3
  • 52
    • 0030845070 scopus 로고    scopus 로고
    • Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons
    • Cakman I, Kirchner H & Rink L (1997) Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons. J Interferon Cytokine Res 17, 469-472.
    • (1997) J. Interferon. Cytokine Res. , vol.17 , pp. 469-472
    • Cakman, I.1    Kirchner, H.2    Rink, L.3
  • 53
    • 0031974582 scopus 로고    scopus 로고
    • The effect of zinc and vitamin A supplementation on immune response in an older population
    • Fortes C, Forastiere F, Agabiti N et al. (1998) The effect of zinc and vitamin A supplementation on immune response in an older population. J Am Geriatr Soc 46, 19-26.
    • (1998) J. Am. Geriatr Soc. , vol.46 , pp. 19-26
    • Fortes, C.1    Forastiere, F.2    Agabiti, N.3
  • 54
    • 34548120712 scopus 로고    scopus 로고
    • Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH Study
    • Hodkinson CF, Kelly M, Alexander HD et al. (2007) Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: the ZENITH Study. J Gerontol A Biol Sci Med Sci 62, 598-608.
    • (2007) J. Gerontol a Biol. Sci. Med. Sci. , vol.62 , pp. 598-608
    • Hodkinson, C.F.1    Kelly, M.2    Alexander, H.D.3
  • 55
    • 39449124109 scopus 로고    scopus 로고
    • Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions
    • Kahmann L, Uciechowski P, Warmuth S et al. (2008) Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. Rejuvenation Res 11, 227-237.
    • (2008) Rejuvenation Res. , vol.11 , pp. 227-237
    • Kahmann, L.1    Uciechowski, P.2    Warmuth, S.3
  • 56
    • 0019458347 scopus 로고
    • Beneficial effects of oral zinc supplementation on the immune response of old people
    • Duchateau J, Delepesse G, Vrijens R et al. (1981) Beneficial effects of oral zinc supplementation on the immune response of old people. Am J Med 70, 1001-1004.
    • (1981) Am. J. Med. , vol.70 , pp. 1001-1004
    • Duchateau, J.1    Delepesse, G.2    Vrijens, R.3
  • 57
    • 0020422303 scopus 로고
    • Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing
    • Sandstead HH, Henriksen LK, Greger JL et al. (1982) Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing. Am J Clin Nutr 36, 1046-1059.
    • (1982) Am. J. Clin. Nutr. , vol.36 , pp. 1046-1059
    • Sandstead, H.H.1    Henriksen, L.K.2    Greger, J.L.3
  • 58
    • 0024369980 scopus 로고
    • T-lymphocyte dysfunction in the elderly associated with zinc deficiency and subnormal nucleoside phosphorylase activity: Effect of zinc supplementation
    • Cossack ZT (1989) T-lymphocyte dysfunction in the elderly associated with zinc deficiency and subnormal nucleoside phosphorylase activity: effect of zinc supplementation. Eur J Cancer Clin Oncol 25, 973-976.
    • (1989) Eur. J. Cancer Clin. Oncol. , vol.25 , pp. 973-976
    • Cossack, Z.T.1
  • 60
    • 33847788242 scopus 로고    scopus 로고
    • Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress
    • Prasad AS, Beck FW, Bao B et al. (2007) Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 85, 837-844.
    • (2007) Am. J. Clin. Nutr. , vol.85 , pp. 837-844
    • Prasad, A.S.1    Beck, F.W.2    Bao, B.3
  • 61
    • 0023740787 scopus 로고
    • Zinc and immunocompetence in elderly people: Effects of zinc supplementation for 3 months
    • Bogden JD, Oleske JM, Lavenhar MA et al. (1988) Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. Am J Clin Nutr 48, 655-663.
    • (1988) Am. J. Clin. Nutr. , vol.48 , pp. 655-663
    • Bogden, J.D.1    Oleske, J.M.2    Lavenhar, M.A.3
  • 62
    • 0031791782 scopus 로고    scopus 로고
    • Effect of zinc or zinc plus arginine supplementation on antibody titre and lymphocyte subsets after influenza vaccination in elderly subjects: A randomized controlled trial
    • Provinciali M, Montenovo A, Di Stefano G et al. (1998) Effect of zinc or zinc plus arginine supplementation on antibody titre and lymphocyte subsets after influenza vaccination in elderly subjects: a randomized controlled trial. Age Ageing 27, 715-722.
    • (1998) Age Ageing , vol.27 , pp. 715-722
    • Provinciali, M.1    Montenovo, A.2    Di Stefano, G.3
  • 63
    • 37349111072 scopus 로고    scopus 로고
    • Taste acuity in response to zinc supplementation in older Europeans
    • Stewart-Knox BJ, Simpson EE, Parr H et al. (2008) Taste acuity in response to zinc supplementation in older Europeans. Br J Nutr 99, 129-136.
    • (2008) Br. J. Nutr. , vol.99 , pp. 129-136
    • Stewart-Knox, B.J.1    Simpson, E.E.2    Parr, H.3
  • 64
    • 0037398726 scopus 로고    scopus 로고
    • Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: Parallelism with nonagenarians and old infected humans. Effect of zinc supply
    • Mocchegiani E, Muzzioli M, Giacconi R et al. (2003) Metallothioneins/ PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply. Mech Ageing Dev 124, 459-468.
    • (2003) Mech Ageing Dev. , vol.124 , pp. 459-468
    • Mocchegiani, E.1    Muzzioli, M.2    Giacconi, R.3
  • 65
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 66
    • 2342504611 scopus 로고    scopus 로고
    • The variation during the circadian cycle of liver CD1dunrestricted NK1.1 + TCRγδ + cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice
    • Mocchegiani E, Giacconi R, Cipriano C et al. (2004) The variation during the circadian cycle of liver CD1dunrestricted NK1.1 + TCRγδ + cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice. Exp Gerontol 39, 775-788.
    • (2004) Exp. Gerontol , vol.39 , pp. 775-788
    • Mocchegiani, E.1    Giacconi, R.2    Cipriano, C.3
  • 67
    • 0033788507 scopus 로고    scopus 로고
    • Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians
    • Miyaji C, Watanabe H, Toma H et al. (2000) Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians. Hum Immunol 61, 908-916.
    • (2000) Hum Immunol. , vol.61 , pp. 908-916
    • Miyaji, C.1    Watanabe, H.2    Toma, H.3
  • 68
    • 42149116835 scopus 로고    scopus 로고
    • Zinc deficiency and IL-6-174G/C polymorphism in old people from different European countries: Effect of zinc supplementation. ZINCAGE study
    • Mocchegiani E, Giacconi R, Costarelli L et al. (2008) Zinc deficiency and IL-6-174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study. Exp Gerontol 43, 433-444.
    • (2008) Exp. Gerontol , vol.43 , pp. 433-444
    • Mocchegiani, E.1    Giacconi, R.2    Costarelli, L.3
  • 69
    • 42149193103 scopus 로고    scopus 로고
    • Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: Interactive influence of + 647 MT1a and - 174 IL-6 polymorphic alleles
    • Mariani E, Neri S, Cattini L et al. (2008) Effect of zinc supplementation on plasma IL-6 and MCP-1 production and NK cell function in healthy elderly: Interactive influence of + 647 MT1a and - 174 IL-6 polymorphic alleles. Exp Gerontol 43, 462-471.
    • (2008) Exp. Gerontol , vol.43 , pp. 462-471
    • Mariani, E.1    Neri, S.2    Cattini, L.3
  • 70
    • 42049097467 scopus 로고    scopus 로고
    • Effects of interleukin-6-174C/G and metallothionein 1A +647A/C single-nucleotide polymorphisms on zinc-regulated gene expression in ageing
    • Mazzatti DJ, Malavolta M, White AJ et al. (2008) Effects of interleukin-6-174C/G and metallothionein 1A +647A/C single-nucleotide polymorphisms on zinc-regulated gene expression in ageing. Exp Gerontol 43, 423-432.
    • (2008) Exp. Gerontol , vol.43 , pp. 423-432
    • Mazzatti, D.J.1    Malavolta, M.2    White, A.J.3


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