-
1
-
-
0025943384
-
LyF-1, a transcriptional regulator that interactswith a novel class of promoters for lymphocyte-specific genes
-
Lo K, Landau NR, Smale ST. LyF-1, a transcriptional regulator that interactswith a novel class of promoters for lymphocyte-specific genes. Mol Cell Biol. 1991;11:5229-43.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 5229-5243
-
-
Lo, K.1
Landau, N.R.2
Smale, S.T.3
-
2
-
-
0026451087
-
Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
-
Georgopoulos K, Moore DD, Derfler B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 1992;258(5083):808-12.
-
(1992)
Science
, vol.258
, Issue.5083
, pp. 808-812
-
-
Georgopoulos, K.1
Moore, D.D.2
Derfler, B.3
-
3
-
-
0028152483
-
The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene
-
Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol Cell Biol. 1994;14(11):7111-23.
-
(1994)
Mol Cell Biol
, vol.14
, Issue.11
, pp. 7111-7123
-
-
Hahm, K.1
Ernst, P.2
Lo, K.3
Kim, G.S.4
Turck, C.5
Smale, S.T.6
-
4
-
-
84856909174
-
Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene
-
doi: 10.1002/pbc.23160, Epub ahead of print
-
Goldman FD, Gurel Z, Al-Zubeidi D, Fried AJ, Icardi M, Song C, Dovat S. Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene. Pediatr Blood Cancer. 2011. doi: 10.1002/pbc.23160. [Epub ahead of print]
-
(2011)
Pediatr Blood Cancer
-
-
Goldman, F.D.1
Gurel, Z.2
Al-Zubeidi, D.3
Fried, A.J.4
Icardi, M.5
Song, C.6
Dovat, S.7
-
5
-
-
0029831978
-
Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
-
Sun L, Liu A, Georgopoulos K. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. Embo J. 1996;15(19):5358-69.
-
(1996)
Embo J
, vol.15
, Issue.19
, pp. 5358-5369
-
-
Sun, L.1
Liu, A.2
Georgopoulos, K.3
-
6
-
-
0030933151
-
The role of the Ikaros gene in lymphocyte development and homeostasis
-
Georgopoulos K, Winandy S, Avitahl N. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu Rev Immunol. 1997;15:155-76.
-
(1997)
Annu Rev Immunol
, vol.15
, pp. 155-176
-
-
Georgopoulos, K.1
Winandy, S.2
Avitahl, N.3
-
7
-
-
34047251670
-
Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms
-
Ronni T, Payne KJ, Ho S, Bradley MN, Dorsam G, Dovat S. Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms. J Biol Chem. 2007;282(4):2538-47.
-
(2007)
J Biol Chem
, vol.282
, Issue.4
, pp. 2538-2547
-
-
Ronni, T.1
Payne, K.J.2
Ho, S.3
Bradley, M.N.4
Dorsam, G.5
Dovat, S.6
-
8
-
-
63849152625
-
Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing
-
Kim JH, Ebersole T, Kouprina N, Noskov VN, Ohzeki J, Masumoto H, Mravinac B, Sullivan BA, Pavlicek A, Dovat S, Pack SD, Kwon YW, Flanagan PT, Loukinov D, Lobanenkov V, Larionov V. Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. Genome Res. 2009;19(4):533-44.
-
(2009)
Genome Res
, vol.19
, Issue.4
, pp. 533-544
-
-
Kim, J.H.1
Ebersole, T.2
Kouprina, N.3
Noskov, V.N.4
Ohzeki, J.5
Masumoto, H.6
Mravinac, B.7
Sullivan, B.A.8
Pavlicek, A.9
Dovat, S.10
Pack, S.D.11
Kwon, Y.W.12
Flanagan, P.T.13
Loukinov, D.14
Lobanenkov, V.15
Larionov, V.16
-
9
-
-
0027230072
-
Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene
-
Ernst P, Hahm K, Smale ST. Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Mol Cell Biol. 1993;13(5):2982-92.
-
(1993)
Mol Cell Biol
, vol.13
, Issue.5
, pp. 2982-2992
-
-
Ernst, P.1
Hahm, K.2
Smale, S.T.3
-
10
-
-
0028019274
-
The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins
-
Molnár A, Georgopoulos K. The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol Cell Biol. 1994;14(12):8292-303.
-
(1994)
Mol Cell Biol
, vol.14
, Issue.12
, pp. 8292-8303
-
-
Molnár, A.1
Georgopoulos, K.2
-
11
-
-
0031437119
-
Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
-
Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell. 1997;91(6): 845-854.
-
(1997)
Cell
, vol.91
, Issue.6
, pp. 845-854
-
-
Brown, K.E.1
Guest, S.S.2
Smale, S.T.3
Hahm, K.4
Merkenschlager, M.5
Fisher, A.G.6
-
12
-
-
0037066767
-
Unconventional potentiation of gene expression by ikaros
-
Koipally J, Heller EJ, Seavitt JR, Georgopoulos K. Unconventional potentiation of gene expression by ikaros. J Biol Chem. 2002;277(15):13007-15.
-
(2002)
J Biol Chem
, vol.277
, Issue.15
, pp. 13007-13015
-
-
Koipally, J.1
Heller, E.J.2
Seavitt, J.R.3
Georgopoulos, K.4
-
13
-
-
0033152491
-
Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
-
Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Embo J. 1999;18(11):3090-3100.
-
(1999)
Embo J
, vol.18
, Issue.11
, pp. 3090-3100
-
-
Koipally, J.1
Renold, A.2
Kim, J.3
Georgopoulos, K.4
-
14
-
-
0033103374
-
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
-
Kim J, Sif S, Jones B, Jackson A, Koipally J, Heller E, Winandy S, Viel A, Sawyer A, Ikeda T, Kingston R, Georgopoulos K. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 1999;10(3):345-355.
-
(1999)
Immunity
, vol.10
, Issue.3
, pp. 345-355
-
-
Kim, J.1
Sif, S.2
Jones, B.3
Jackson, A.4
Koipally, J.5
Heller, E.6
Winandy, S.7
Viel, A.8
Sawyer, A.9
Ikeda, T.10
Kingston, R.11
Georgopoulos, K.12
-
16
-
-
0034733563
-
Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
-
Koipally J, Georgopoulos K. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J Biol Chem. 2000;275(26):19594-602.
-
(2000)
J Biol Chem
, vol.275
, Issue.26
, pp. 19594-19602
-
-
Koipally, J.1
Georgopoulos, K.2
-
17
-
-
0033805828
-
An ikaros-containing chromatinremodeling complex in adult-type erythroid cells
-
O'Neill DW, Schoetz SS, Lopez RA, Castle M, Rabinowitz L, Shor E, Krawchuk D, Goll MG, Renz M, Seelig HP, Han S, Seong RH, Park SD, Agalioti T, Munshi N, Thanos D, Erdjument-Bromage H, Tempst P, Bank A. An ikaros-containing chromatinremodeling complex in adult-type erythroid cells. Mol Cell Biol. 2000;20(20):7572-82.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.20
, pp. 7572-7582
-
-
O'Neill, D.W.1
Schoetz, S.S.2
Lopez, R.A.3
Castle, M.4
Rabinowitz, L.5
Shor, E.6
Krawchuk, D.7
Goll, M.G.8
Renz, M.9
Seelig, H.P.10
Han, S.11
Seong, R.H.12
Park, S.D.13
Agalioti, T.14
Munshi, N.15
Thanos, D.16
Erdjument-Bromage, H.17
Tempst, P.18
Bank, A.19
-
18
-
-
0033870658
-
Dominant negative isoform of the Ikaros gene in patients with adult B- cell acute lymphoblastic leukemia
-
Nakase K, Ishimaru F, Avitahl N, Dansako H, Matsuo K, Fujii K, Sezaki N, Nakayama H, Yano T, Fukuda S, Imajoh K, Takeuchi M, Miyata A, Hara M, Yasukawa M, Takahashi I, Taguchi H, Matsue K, Nakao S, Niho Y, Takenaka K, Shinagawa K, Ikeda K, Niiya K, Harada M. Dominant negative isoform of the Ikaros gene in patients with adult B- cell acute lymphoblastic leukemia. Cancer Res. 2000;60(15):4062-5.
-
(2000)
Cancer Res
, vol.60
, Issue.15
, pp. 4062-4065
-
-
Nakase, K.1
Ishimaru, F.2
Avitahl, N.3
Dansako, H.4
Matsuo, K.5
Fujii, K.6
Sezaki, N.7
Nakayama, H.8
Yano, T.9
Fukuda, S.10
Imajoh, K.11
Takeuchi, M.12
Miyata, A.13
Hara, M.14
Yasukawa, M.15
Takahashi, I.16
Taguchi, H.17
Matsue, K.18
Nakao, S.19
Niho, Y.20
Takenaka, K.21
Shinagawa, K.22
Ikeda, K.23
Niiya, K.24
Harada, M.25
more..
-
19
-
-
2942720402
-
Submicroscopic deletions in 5q- associated malignancies
-
Crescenzi B, La Starza R, Romoli S, Beacci D, Matteucci C, Barba G, Aventin A, Marynen P, Ciolli S, Nozzoli C, Martelli MF, Mecucci C. Submicroscopic deletions in 5q- associated malignancies. Haematologica. 2004;89(3):281-5.
-
(2004)
Haematologica
, vol.89
, Issue.3
, pp. 281-285
-
-
Crescenzi, B.1
la Starza, R.2
Romoli, S.3
Beacci, D.4
Matteucci, C.5
Barba, G.6
Aventin, A.7
Marynen, P.8
Ciolli, S.9
Nozzoli, C.10
Martelli, M.F.11
Mecucci, C.12
-
20
-
-
0037082455
-
High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: Implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis
-
Yagi T, Hibi S, Takanashi M, Kano G, Tabata Y, Imamura T, Inaba T, Morimoto A, Todo S, Imashuku S. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood. 2002;99(4):1350-5.
-
(2002)
Blood
, vol.99
, Issue.4
, pp. 1350-1355
-
-
Yagi, T.1
Hibi, S.2
Takanashi, M.3
Kano, G.4
Tabata, Y.5
Imamura, T.6
Inaba, T.7
Morimoto, A.8
Todo, S.9
Imashuku, S.10
-
21
-
-
0033566987
-
Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia
-
Nakayama H, Ishimaru F, Avitahl N, Sezaki N, Fujii N, Nakase K, Ninomiya Y, Harashima A, Minowada J, Tsuchiyama J, Imajoh K, Tsubota T, Fukuda S, Sezaki T, Kojima K, Hara M, Takimoto H, Yorimitsu S, Takahashi I, Miyata A, Taniguchi S, Tokunaga Y, Gondo H, Niho Y, Nakao S, Kyo T, Dohy H, Kamada N, Harada M. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia. Cancer Res. 1999;59(16):3931-4.
-
(1999)
Cancer Res
, vol.59
, Issue.16
, pp. 3931-3934
-
-
Nakayama, H.1
Ishimaru, F.2
Avitahl, N.3
Sezaki, N.4
Fujii, N.5
Nakase, K.6
Ninomiya, Y.7
Harashima, A.8
Minowada, J.9
Tsuchiyama, J.10
Imajoh, K.11
Tsubota, T.12
Fukuda, S.13
Sezaki, T.14
Kojima, K.15
Hara, M.16
Takimoto, H.17
Yorimitsu, S.18
Takahashi, I.19
Miyata, A.20
Taniguchi, S.21
Tokunaga, Y.22
Gondo, H.23
Niho, Y.24
Nakao, S.25
Kyo, T.26
Dohy, H.27
Kamada, N.28
Harada, M.29
more..
-
22
-
-
34147224008
-
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
-
Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, Downing JR. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007;446(7137):758-764.
-
(2007)
Nature
, vol.446
, Issue.7137
, pp. 758-764
-
-
Mullighan, C.G.1
Goorha, S.2
Radtke, I.3
Miller, C.B.4
Coustan-Smith, E.5
Dalton, J.D.6
Girtman, K.7
Mathew, S.8
Ma, J.9
Pounds, S.B.10
Su, X.11
Pui, C.H.12
Relling, M.V.13
Evans, W.E.14
Shurtleff, S.A.15
Downing, J.R.16
-
23
-
-
43049139905
-
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
-
Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH, Relling MV, Shurtleff SA, Downing JR. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature. 2008;453(7191):110-4.
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 110-114
-
-
Mullighan, C.G.1
Miller, C.B.2
Radtke, I.3
Phillips, L.A.4
Dalton, J.5
Ma, J.6
White, D.7
Hughes, T.P.8
le Beau, M.M.9
Pui, C.H.10
Relling, M.V.11
Shurtleff, S.A.12
Downing, J.R.13
-
24
-
-
70449719091
-
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report
-
Martinelli G, Iacobucci I, Storlazzi CT, Vignetti M, Paoloni F, Cilloni D, Soverini S, Vitale A, Chiaretti S, Cimino G, Papayannidis C, Paolini S, Elia L, Fazi P, Meloni G, Amadori S, Saglio G, Pane F, Baccarani M, Foa R. IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. J Clin Oncol. 2009;27(31):5202-7.
-
(2009)
J Clin Oncol
, vol.27
, Issue.31
, pp. 5202-5207
-
-
Martinelli, G.1
Iacobucci, I.2
Storlazzi, C.T.3
Vignetti, M.4
Paoloni, F.5
Cilloni, D.6
Soverini, S.7
Vitale, A.8
Chiaretti, S.9
Cimino, G.10
Papayannidis, C.11
Paolini, S.12
Elia, L.13
Fazi, P.14
Meloni, G.15
Amadori, S.16
Saglio, G.17
Pane, F.18
Baccarani, M.19
Foa, R.20
more..
-
25
-
-
70349242044
-
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: On behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)
-
Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, Soverini S, Astolfi A, Chiaretti S, Vitale A, Messa F, Impera L, Baldazzi C, D'Addabbo P, Papayannidis C, Lonoce A, Colarossi S, Vignetti M, Piccaluga PP, Paolini S, Russo D, Pane F, Saglio G, Baccarani M, Foa R, Martinelli G. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood. 2009;114(10):2159-67.
-
(2009)
Blood
, vol.114
, Issue.10
, pp. 2159-2167
-
-
Iacobucci, I.1
Storlazzi, C.T.2
Cilloni, D.3
Lonetti, A.4
Ottaviani, E.5
Soverini, S.6
Astolfi, A.7
Chiaretti, S.8
Vitale, A.9
Messa, F.10
Impera, L.11
Baldazzi, C.12
D'Addabbo, P.13
Papayannidis, C.14
Lonoce, A.15
Colarossi, S.16
Vignetti, M.17
Piccaluga, P.P.18
Paolini, S.19
Russo, D.20
Pane, F.21
Saglio, G.22
Baccarani, M.23
Foa, R.24
Martinelli, G.25
more..
-
26
-
-
58749109707
-
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
-
Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB, Ma J, Liu W, Cheng C, Schulman BA, Harvey RC, Chen IM, Clifford RJ, Carroll WL, Reaman G, Bowman WP, Devidas M, Gerhard DS, Yang W, Relling MV, Shurtleff SA, Campana D, Borowitz MJ, Pui CH, Smith M, Hunger SP, Willman CL, Downing JR. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med. 2009;360(5):470-80.
-
(2009)
N Engl J Med
, vol.360
, Issue.5
, pp. 470-480
-
-
Mullighan, C.G.1
Su, X.2
Zhang, J.3
Radtke, I.4
Phillips, L.A.5
Miller, C.B.6
Ma, J.7
Liu, W.8
Cheng, C.9
Schulman, B.A.10
Harvey, R.C.11
Chen, I.M.12
Clifford, R.J.13
Carroll, W.L.14
Reaman, G.15
Bowman, W.P.16
Devidas, M.17
Gerhard, D.S.18
Yang, W.19
Relling, M.V.20
Shurtleff, S.A.21
Campana, D.22
Borowitz, M.J.23
Pui, C.H.24
Smith, M.25
Hunger, S.P.26
Willman, C.L.27
Downing, J.R.28
more..
-
27
-
-
77954659221
-
IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL
-
Kuiper RP, Waanders E, van der Velden VH, van Reijmersdal SV, Venkatachalam R, Scheijen B, Sonneveld E, van Dongen JJ, Veerman AJ, van Leeuwen FN, van Kessel AG, Hoogerbrugge PM. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia. 2010;24(7):1258-64.
-
(2010)
Leukemia
, vol.24
, Issue.7
, pp. 1258-1264
-
-
Kuiper, R.P.1
Waanders, E.2
van der Velden, V.H.3
van Reijmersdal, S.V.4
Venkatachalam, R.5
Scheijen, B.6
Sonneveld, E.7
van Dongen, J.J.8
Veerman, A.J.9
van Leeuwen, F.N.10
van Kessel, A.G.11
Hoogerbrugge, P.M.12
-
28
-
-
58749097408
-
A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: A genome-wide classification study
-
Den Boer ML, van Slegtenhorst M, De Menezes RX, Cheok MH, Buijs-Gladdines JG, Peters ST, Van Zutven LJ, Beverloo HB, Van der Spek PJ, Escherich G, Horstmann MA, Janka-Schaub GE, Kamps WA, Evans WE, Pieters R. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol. 2009;10(2):125-34.
-
(2009)
Lancet Oncol
, vol.10
, Issue.2
, pp. 125-134
-
-
Boer, M.L.D.1
van Slegtenhorst, M.2
de Menezes, R.X.3
Cheok, M.H.4
Buijs-Gladdines, J.G.5
Peters, S.T.6
van Zutven, L.J.7
Beverloo, H.B.8
van der Spek, P.J.9
Escherich, G.10
Horstmann, M.A.11
Janka-Schaub, G.E.12
Kamps, W.A.13
Evans, W.E.14
Pieters, R.15
-
29
-
-
69349091330
-
Germline genomic variants associated with childhood acute lymphoblastic leukemia
-
Trevino LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, Willman C, Neale G, Downing J, Raimondi SC, Pui CH, Evans WE, Relling MV. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet. 2009;41(9):1001-5.
-
(2009)
Nat Genet
, vol.41
, Issue.9
, pp. 1001-1005
-
-
Trevino, L.R.1
Yang, W.2
French, D.3
Hunger, S.P.4
Carroll, W.L.5
Devidas, M.6
Willman, C.7
Neale, G.8
Downing, J.9
Raimondi, S.C.10
Pui, C.H.11
Evans, W.E.12
Relling, M.V.13
-
30
-
-
69349101565
-
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
-
Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet. 2009;41(9):1006-10.
-
(2009)
Nat Genet
, vol.41
, Issue.9
, pp. 1006-1010
-
-
Papaemmanuil, E.1
Hosking, F.J.2
Vijayakrishnan, J.3
Price, A.4
Olver, B.5
Sheridan, E.6
Kinsey, S.E.7
Lightfoot, T.8
Roman, E.9
Irving, J.A.10
Allan, J.M.11
Tomlinson, I.P.12
Taylor, M.13
Greaves, M.14
Houlston, R.S.15
-
31
-
-
77954516863
-
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
-
Harvey RC, Mullighan CG, Chen IM, Wharton W, Mikhail FM, Carroll AJ, Kang H, Liu W, Dobbin KK, Smith MA, Carroll WL, Devidas M, Bowman WP, Camitta BM, Reaman GH, Hunger SP, Downing JR, Willman CL. Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood. 2010;115(26):5312-21.
-
(2010)
Blood
, vol.115
, Issue.26
, pp. 5312-5321
-
-
Harvey, R.C.1
Mullighan, C.G.2
Chen, I.M.3
Wharton, W.4
Mikhail, F.M.5
Carroll, A.J.6
Kang, H.7
Liu, W.8
Dobbin, K.K.9
Smith, M.A.10
Carroll, W.L.11
Devidas, M.12
Bowman, W.P.13
Camitta, B.M.14
Reaman, G.H.15
Hunger, S.P.16
Downing, J.R.17
Willman, C.L.18
-
32
-
-
77954500629
-
Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol
-
Cario G, Zimmermann M, Romey R, Gesk S, Vater I, Harbott J, Schrauder A, Moericke A, Izraeli S, Akasaka T, Dyer MJ, Siebert R, Schrappe M, Stanulla M. Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. Blood. 2010;115(26):5393-97.
-
(2010)
Blood
, vol.115
, Issue.26
, pp. 5393-5397
-
-
Cario, G.1
Zimmermann, M.2
Romey, R.3
Gesk, S.4
Vater, I.5
Harbott, J.6
Schrauder, A.7
Moericke, A.8
Izraeli, S.9
Akasaka, T.10
Dyer, M.J.11
Siebert, R.12
Schrappe, M.13
Stanulla, M.14
-
33
-
-
0035525762
-
Forced expression of the Ikaros 6 isoform in human placental blood CD34(+) cells impairs their ability to differentiate toward the B- lymphoid lineage
-
Tonnelle C, Bardin F, Maroc C, Imbert AM, Campa F, Dalloul A, Schmitt C, Chabannon C. Forced expression of the Ikaros 6 isoform in human placental blood CD34(+) cells impairs their ability to differentiate toward the B- lymphoid lineage. Blood. 2001;98(9):2673-80.
-
(2001)
Blood
, vol.98
, Issue.9
, pp. 2673-2680
-
-
Tonnelle, C.1
Bardin, F.2
Maroc, C.3
Imbert, A.M.4
Campa, F.5
Dalloul, A.6
Schmitt, C.7
Chabannon, C.8
-
34
-
-
77957995706
-
Ikzf1 Haploinsufficiency Contributes to the Pathogenesis of BCR-ABL1 Positive Acute Lymphoblastic Leukemia
-
abstract 678
-
Collins-Underwood JR, Miller CB, Downing JR, Mullighan CG. Ikzf1 Haploinsufficiency Contributes to the Pathogenesis of BCR-ABL1 Positive Acute Lymphoblastic Leukemia. Blood. 2009;114:(abstract 678).
-
(2009)
Blood
, vol.114
-
-
Collins-Underwood, J.R.1
Miller, C.B.2
Downing, J.R.3
Mullighan, C.G.4
-
35
-
-
77954609243
-
Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia
-
Virely C, Moulin S, Cobaleda C, Lasgi C, Alberdi A, Soulier J, Sigaux F, Chan S, Kastner P, Ghysdael J. Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia. Leukemia. 2010;24(6):1200-4.
-
(2010)
Leukemia
, vol.24
, Issue.6
, pp. 1200-1204
-
-
Virely, C.1
Moulin, S.2
Cobaleda, C.3
Lasgi, C.4
Alberdi, A.5
Soulier, J.6
Sigaux, F.7
Chan, S.8
Kastner, P.9
Ghysdael, J.10
-
36
-
-
6544243426
-
Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia
-
Sun L, Crotty ML, Sensel M, Sather H, Navara C, Nachman J, Steinherz PG, Gaynon PS, Seibel N, Mao C, Vassilev A, Reaman GH, Uckun FM. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia. Clin Cancer Res. 1999;5(8):2112-20.
-
(1999)
Clin Cancer Res
, vol.5
, Issue.8
, pp. 2112-2120
-
-
Sun, L.1
Crotty, M.L.2
Sensel, M.3
Sather, H.4
Navara, C.5
Nachman, J.6
Steinherz, P.G.7
Gaynon, P.S.8
Seibel, N.9
Mao, C.10
Vassilev, A.11
Reaman, G.H.12
Uckun, F.M.13
-
37
-
-
1842506138
-
Overexpression of the Ikaros 6 isoform is restricted to t(4;11) acute lymphoblastic leukaemia in children and infants and has a role in B-cell survival
-
Ruiz A, Jiang J, Kempski H, Brady HJ. Overexpression of the Ikaros 6 isoform is restricted to t(4;11) acute lymphoblastic leukaemia in children and infants and has a role in B-cell survival. Br J Haematol. 2004;125(1):317.
-
(2004)
Br J Haematol
, vol.125
, Issue.1
, pp. 317
-
-
Ruiz, A.1
Jiang, J.2
Kempski, H.3
Brady, H.J.4
-
38
-
-
0036212926
-
Overexpression of novel short isoforms of Helios in a patient with T- cell acute lymphoblastic leukemia
-
Nakase K, Ishimaru F, Fujii K, Tabayashi T, Kozuka T, Sezaki N, Matsuo Y, Harada M. Overexpression of novel short isoforms of Helios in a patient with T- cell acute lymphoblastic leukemia. Exp Hematol. 2002;30(4):313-7.
-
(2002)
Exp Hematol
, vol.30
, Issue.4
, pp. 313-317
-
-
Nakase, K.1
Ishimaru, F.2
Fujii, K.3
Tabayashi, T.4
Kozuka, T.5
Sezaki, N.6
Matsuo, Y.7
Harada, M.8
-
39
-
-
34250863886
-
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
-
Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007;447(7147):966-71.
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 966-971
-
-
Maser, R.S.1
Choudhury, B.2
Campbell, P.J.3
Feng, B.4
Wong, K.K.5
Protopopov, A.6
O'Neil, J.7
Gutierrez, A.8
Ivanova, E.9
Perna, I.10
Lin, E.11
Mani, V.12
Jiang, S.13
McNamara, K.14
Zaghlul, S.15
Edkins, S.16
Stevens, C.17
Brennan, C.18
Martin, E.S.19
Wiedemeyer, R.20
Kabbarah, O.21
Nogueira, C.22
Histen, G.23
Aster, J.24
Mansour, M.25
Duke, V.26
Foroni, L.27
Fielding, A.K.28
Goldstone, A.H.29
Rowe, J.M.30
Wang, Y.A.31
Look, A.T.32
Stratton, M.R.33
Chin, L.34
Futreal, P.A.35
Depinho, R.A.36
more..
-
40
-
-
34249733805
-
High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression
-
Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, van Kessel AG, van Leeuwen FN, Hoogerbrugge PM. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia. 2007;21(6):1258-66.
-
(2007)
Leukemia
, vol.21
, Issue.6
, pp. 1258-1266
-
-
Kuiper, R.P.1
Schoenmakers, E.F.2
van Reijmersdal, S.V.3
Hehir-Kwa, J.Y.4
van Kessel, A.G.5
van Leeuwen, F.N.6
Hoogerbrugge, P.M.7
-
41
-
-
77049110561
-
Genetic inactivation of Ikaros is a rare event in human T-ALL
-
Marcais A, Jeannet R, Hernandez L, Soulier J, Sigaux F, Chan S, Kastner P. Genetic inactivation of Ikaros is a rare event in human T-ALL. Leuk Res. 2010;34(4):426-9.
-
(2010)
Leuk Res
, vol.34
, Issue.4
, pp. 426-429
-
-
Marcais, A.1
Jeannet, R.2
Hernandez, L.3
Soulier, J.4
Sigaux, F.5
Chan, S.6
Kastner, P.7
-
42
-
-
76749127429
-
Tumor suppression in T cell leukemia-the role of Ikaros
-
Dovat S, Payne KJ. Tumor suppression in T cell leukemia-the role of Ikaros. Leuk Res. 2010;34(4):416-17.
-
(2010)
Leuk Res
, vol.34
, Issue.4
, pp. 416-417
-
-
Dovat, S.1
Payne, K.J.2
-
43
-
-
33947153094
-
Ikaros DNA-binding proteins as integral components of B cell developmental-stagespecific regulatory circuits
-
Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, Merkenschlager M. Ikaros DNA-binding proteins as integral components of B cell developmental-stagespecific regulatory circuits. Immunity. 2007;26(3): 335-44.
-
(2007)
Immunity
, vol.26
, Issue.3
, pp. 335-344
-
-
Thompson, E.C.1
Cobb, B.S.2
Sabbattini, P.3
Meixlsperger, S.4
Parelho, V.5
Liberg, D.6
Taylor, B.7
Dillon, N.8
Georgopoulos, K.9
Jumaa, H.10
Smale, S.T.11
Fisher, A.G.12
Merkenschlager, M.13
-
44
-
-
0035355509
-
Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation
-
Sabbattini P, Lundgren M, Georgiou A, Chow C, Warnes G, Dillon N. Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation. Embo J. 2001;20(11):2812-22.
-
(2001)
Embo J
, vol.20
, Issue.11
, pp. 2812-2822
-
-
Sabbattini, P.1
Lundgren, M.2
Georgiou, A.3
Chow, C.4
Warnes, G.5
Dillon, N.6
-
45
-
-
47849118209
-
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros
-
Reynaud D, I AD, K LR, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008; 9(8):927-936.
-
(2008)
Nat Immunol
, vol.9
, Issue.8
, pp. 927-936
-
-
Reynaud, D.1
Ad, I.2
Lr, K.3
Schjerven, H.4
Bertolino, E.5
Chen, Z.6
Smale, S.T.7
Winandy, S.8
Singh, H.9
-
46
-
-
0035878121
-
Down-regulation of TdT transcription in CD4+CD8+ thymocytes by Ikaros proteins in direct competition with an Ets activator
-
Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST. Down-regulation of TdT transcription in CD4+CD8+ thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes and Development. 2001;15:1817-32.
-
(2001)
Genes and Development
, vol.15
, pp. 1817-1832
-
-
Trinh, L.A.1
Ferrini, R.2
Cobb, B.S.3
Weinmann, A.S.4
Hahm, K.5
Ernst, P.6
Garraway, I.P.7
Merkenschlager, M.8
Smale, S.T.9
-
47
-
-
0029824044
-
A potential role for Elf-1 in terminal transferase gene regulation
-
Ernst P, Hahm K, Trinh L, Davis JN, Roussel MF, Turck CW, Smale ST. A potential role for Elf-1 in terminal transferase gene regulation. Mol Cell Biol. 1996;16(11):6121-31.
-
(1996)
Mol Cell Biol
, vol.16
, Issue.11
, pp. 6121-6131
-
-
Ernst, P.1
Hahm, K.2
Trinh, L.3
Davis, J.N.4
Roussel, M.F.5
Turck, C.W.6
Smale, S.T.7
-
48
-
-
14244261752
-
Assembly of silent chromatin during thymocyte development
-
Su RC, Sridharan R, Smale ST. Assembly of silent chromatin during thymocyte development. Semin Immunol. 2005;17(2):129-40.
-
(2005)
Semin Immunol
, vol.17
, Issue.2
, pp. 129-140
-
-
Su, R.C.1
Sridharan, R.2
Smale, S.T.3
-
49
-
-
43749107094
-
Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation
-
Gurel Z, Ronni T, Ho S, Kuchar J, Payne KJ, Turk CW, Dovat S. Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation. J Biol Chem. 2008;283(13): 8291-300.
-
(2008)
J Biol Chem
, vol.283
, Issue.13
, pp. 8291-8300
-
-
Gurel, Z.1
Ronni, T.2
Ho, S.3
Kuchar, J.4
Payne, K.J.5
Turk, C.W.6
Dovat, S.7
-
50
-
-
0036886895
-
The CD8alpha gene locus is regulated by the Ikaros family of proteins
-
Harker N, Naito T, Cortes M, Hostert A, Hirschberg S, Tolaini M, Roderick K, Georgopoulos K, Kioussis D. The CD8alpha gene locus is regulated by the Ikaros family of proteins. Mol Cell. 2002;10(6):1403-15.
-
(2002)
Mol Cell
, vol.10
, Issue.6
, pp. 1403-1415
-
-
Harker, N.1
Naito, T.2
Cortes, M.3
Hostert, A.4
Hirschberg, S.5
Tolaini, M.6
Roderick, K.7
Georgopoulos, K.8
Kioussis, D.9
-
51
-
-
36049032122
-
Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression
-
Naito T, Gomez-Del Arco P, Williams CJ, Georgopoulos K. Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. Immunity. 2007;27(5):723-34.
-
(2007)
Immunity
, vol.27
, Issue.5
, pp. 723-734
-
-
Naito, T.1
Gomez-Del Arco, P.2
Williams, C.J.3
Georgopoulos, K.4
-
52
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JPT, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306(5694):269-71.
-
(2004)
Science
, vol.306
, Issue.5694
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.P.T.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
53
-
-
13444266145
-
A wide role for NOTCH1 signaling in acute leukemia
-
Chiaramonte R, Basile A, Tassi E, Calzavara E, Cecchinato V, Rossi V, Biondi A, Comi P. A wide role for NOTCH1 signaling in acute leukemia. Cancer Lett. 2005;219(1):113-20.
-
(2005)
Cancer Lett
, vol.219
, Issue.1
, pp. 113-120
-
-
Chiaramonte, R.1
Basile, A.2
Tassi, E.3
Calzavara, E.4
Cecchinato, V.5
Rossi, V.6
Biondi, A.7
Comi, P.8
-
54
-
-
33645227683
-
Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice
-
Dumortier A, Jeannet R, Kirstetter P, Kleinmann E, Sellars M, dos Santos NR, Thibault C, Barths J, Ghysdael J, Punt JA, Kastner P, Chan S. Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol. 2006;26(1):209-20.
-
(2006)
Mol Cell Biol
, vol.26
, Issue.1
, pp. 209-220
-
-
Dumortier, A.1
Jeannet, R.2
Kirstetter, P.3
Kleinmann, E.4
Sellars, M.5
dos Santos, N.R.6
Thibault, C.7
Barths, J.8
Ghysdael, J.9
Punt, J.A.10
Kastner, P.11
Chan, S.12
-
55
-
-
0037710256
-
Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis
-
Beverly LJ, Capobianco AJ. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell. 2003;3(6):551-64.
-
(2003)
Cancer Cell
, vol.3
, Issue.6
, pp. 551-564
-
-
Beverly, L.J.1
Capobianco, A.J.2
-
56
-
-
57349122315
-
Ikaros represses the transcriptional response to Notch signaling in T-cell development
-
Kleinmann E, Geimer Le Lay AS, Sellars M, Kastner P, Chan S. Ikaros represses the transcriptional response to Notch signaling in T-cell development. Mol Cell Biol. 2008;28(24):7465-75.
-
(2008)
Mol Cell Biol
, vol.28
, Issue.24
, pp. 7465-7475
-
-
Kleinmann, E.1
le Lay, A.S.G.2
Sellars, M.3
Kastner, P.4
Chan, S.5
-
57
-
-
44849135932
-
Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: Implications for CD4 regulation
-
Kathrein KL, Chari S, Winandy S. Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation. J Biol Chem. 2008;283(16):10476-84.
-
(2008)
J Biol Chem
, vol.283
, Issue.16
, pp. 10476-10484
-
-
Kathrein, K.L.1
Chari, S.2
Winandy, S.3
-
58
-
-
77956630164
-
Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression
-
Ma S, Pathak S, Mandal M, Trinh L, Clark MR, Lu R. Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression. Mol Cell Biol;30(17):4149-58.
-
Mol Cell Biol
, vol.30
, Issue.17
, pp. 4149-4158
-
-
Ma, S.1
Pathak, S.2
Mandal, M.3
Trinh, L.4
Clark, M.R.5
Lu, R.6
-
59
-
-
12144291320
-
Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition
-
Gomez-del Arco P, Maki K, Georgopoulos K. Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition. Mol Cell Biol. 2004;24(7):2797-807.
-
(2004)
Mol Cell Biol
, vol.24
, Issue.7
, pp. 2797-2807
-
-
Gomez-Del Arco, P.1
Maki, K.2
Georgopoulos, K.3
-
60
-
-
33751520959
-
Tumorderived Ikaros 6 acetylates the Bcl-XL promoter to up-regulate a survival signal in pituitary cells
-
Ezzat S, Zhu X, Loeper S, Fischer S, Asa SL. Tumorderived Ikaros 6 acetylates the Bcl-XL promoter to up-regulate a survival signal in pituitary cells. Mol Endocrinol. 2006;20(11):2976-86.
-
(2006)
Mol Endocrinol
, vol.20
, Issue.11
, pp. 2976-2986
-
-
Ezzat, S.1
Zhu, X.2
Loeper, S.3
Fischer, S.4
Asa, S.L.5
-
61
-
-
46749117575
-
Ikaros dominant negative isoform (Ik6) induces IL-3- independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels
-
Kano G, Morimoto A, Takanashi M, Hibi S, Sugimoto T, Inaba T, Yagi T, Imashuku S. Ikaros dominant negative isoform (Ik6) induces IL-3- independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels. Leuk Lymphoma. 2008;49(5):965-73.
-
(2008)
Leuk Lymphoma
, vol.49
, Issue.5
, pp. 965-973
-
-
Kano, G.1
Morimoto, A.2
Takanashi, M.3
Hibi, S.4
Sugimoto, T.5
Inaba, T.6
Yagi, T.7
Imashuku, S.8
-
63
-
-
0036897132
-
A common mechanism for mitotic inactivation of C2H2 zinc finger DNAbinding domains
-
Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST. A common mechanism for mitotic inactivation of C2H2 zinc finger DNAbinding domains. Genes Dev. 2002;16(23): 2985-90.
-
(2002)
Genes Dev
, vol.16
, Issue.23
, pp. 2985-2990
-
-
Dovat, S.1
Ronni, T.2
Russell, D.3
Ferrini, R.4
Cobb, B.S.5
Smale, S.T.6
-
64
-
-
67649405070
-
Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1
-
Popescu M, Gurel Z, Ronni T, Song C, Hung KY, Payne KJ, Dovat S. Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem. 2009;284(20): 13869-80.
-
(2009)
J Biol Chem
, vol.284
, Issue.20
, pp. 13869-13880
-
-
Popescu, M.1
Gurel, Z.2
Ronni, T.3
Song, C.4
Hung, K.Y.5
Payne, K.J.6
Dovat, S.7
-
65
-
-
83255162376
-
Ikaros isoforms: The saga continues
-
Li Z, Perez-Casellas LA, Savic A, Song C, Dovat S. Ikaros isoforms: The saga continues. World J Biol Chem. 2011;2(6):140-5.
-
(2011)
World J Biol Chem
, vol.2
, Issue.6
, pp. 140-145
-
-
Li, Z.1
Perez-Casellas, L.A.2
Savic, A.3
Song, C.4
Dovat, S.5
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