Upstream of Ikaros

Trends in Immunology

Volumn 24, Issue 11, 2003, Pages 567-570

  Liberg, David ^a   Smale, Stephen T ^b   Merkenschlager, Matthias ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN;

BONE MARROW CELL; BRAIN CELL; CELL TYPE; HEMATOPOIETIC STEM CELL; LYMPHOID CELL; MUSCLE CELL; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW; ZINC FINGER MOTIF;

EID: 0242302586     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2003.09.008     Document Type: Short Survey

References (27)

1. Lo K., et al. LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol. Cell. Biol. 11:1991;5229-5243.
2. Hahm K., et al. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol. Cell. Biol. 14:1994;7111-7123.
3. Georgopoulos K., et al. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 258:1992;808-812.
4. Hahm K., et al. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 12:1998;782-796.
5. Georgopoulos K., et al. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu. Rev. Immunol. 15:1997;155-176.
6. Honma Y., et al. Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. FEBS Lett. 447:1999;76-80.
7. Perdomo J., et al. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. J. Biol. Chem. 275:2000;38347-38354.
8. Georgopoulos K., et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 79:1994;143-156.
9. Wang J.H., et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity. 5:1996;537-549.
10. Winandy S., et al. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell. 83:1995;289-299.
11. Clevers H.C., Grosschedl R. Transcriptional control of lymphoid development: lessons from gene targeting. Immunol. Today. 17:1996;336-343.
12. Papathanasiou P., et al. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity. 19:2003;131-144.
13. Fisher A.G., Merkenschlager M. Gene silencing, cell fate and nuclear organisation. Curr. Opin. Genet. Dev. 12:2002;193-197.
14. Jenuwein T., Allis C.D. Translating the histone code. Science. 293:2001;1074-1080.
15. Brown K.E., et al. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell. 91:1997;845-854.
16. Brown K.E., et al. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Mol. Cell. 3:1999;207-217.
17. Grogan J.L., et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 14:2001;205-215.
18. Trinh L.A., et al. Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes Dev. 15:2001;1817-1832.
19. Sabbattini P., et al. Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation. Embo J. 20:2001;2812-2822.
20. Kim J., et al. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity. 10:1999;345-355.
21. Koipally J., et al. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. Embo J. 18:1999;3090-3100.
22. Koipally J., Georgopoulos K. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. J. Biol. Chem. 275:2000;19594-19602.
23. Harker N., et al. The CD8α gene locus is regulated by the Ikaros family of proteins. Mol. Cell. 10:2002;1403-1415.
24. Kaufmann C., et al. A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis. Embo J. 22:2003;2211-2223.
25. Souabni A., et al. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 17:2002;781-793.
26. Levine M., Tjian R. Transcription regulation and animal diversity. Nature. 424:2003;147-151.
27. Schebesta M., et al. Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene. Immunity. 17:2002;473-485.