High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: Implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis

Blood

Volumn 99, Issue 4, 2002, Pages 1350-1355

  Yagi, Tomohito ^a,b   Hibi, Shigeyoshi ^a,b   Takanashi, Mami ^a,b   Kano, Gen ^a,b   Tabata, Yasuhiro ^a,b   Imamura, Toshihiko ^a,b   Inaba, Tohru ^a,b   Morimoto, Akira ^a,b   Todo, Shinjiro ^a,b   Imashuku, Shinsaku ^a,b  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b Kyoto City Institute of Health and Environmental Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; GENE PRODUCT; IKAROS 1 ISOPROTEIN; IKAROS 2 ISOPROTEIN; IKAROS 4 ISOPROTEIN; IKAROS 6 ISOPROTEIN; IKAROS 8 ISOPROTEIN; INTERLEUKIN 3; ISOPROTEIN; PROTEIN BCL XL; TETRACYCLINE; UNCLASSIFIED DRUG;

ACUTE MYELOMONOCYTIC LEUKEMIA; ANIMAL CELL; ANTIGEN DETECTION; ARTICLE; BINDING SITE; CARCINOGENESIS; CELL FUNCTION; CELL GROWTH; CELL MATURATION; CELL STRAIN COS7; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSFECTION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MALE; MONOCYTIC LEUKEMIA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; RNA SPLICING; TRANSCRIPTION REGULATION;

EID: 0037082455     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V99.4.1350     Document Type: Article

References (25)

1. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment
2. The Ikaros gene is required for the development of all lymphoid lineages
3. The role of the Ikaros gene in lymphocyte development and homeostasis
4. Transcription factors required for lymphoid lineage commitment
5. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
6. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
7. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse
8. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
9. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
10. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia
11. Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia
12. Low frequency of expression of dominant-negative Ikaros isoforms in human leukemia and lymphoma cell lines
13. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia
14. Distinct signals control the hematopoiesis of lymphoid-related dendritic cells
15. Detection of clonotypic IGH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia
16. Ikaros isoform 6 expression in Ph-positive ALL
17. Monocytic differentiation of HL-60 promyelocytic leukemia cells correlates with the induction of Bcl-xL
18. Pre-T cell receptor (TCR) and TCR controlled checkpoints in T cell differentiation are set by Ikaros
19. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
20. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
21. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
22. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
23. Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization
24. Aiolos regulates B cell activation and maturation to effector state
25. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation