Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels

Leukemia and Lymphoma

Volumn 49, Issue 5, 2008, Pages 965-973

  Kano, Gen ^a   Morimoto, Akira ^a   Takanashi, Mami ^a   Hibi, Shigeyoshi ^a   Sugimoto, Tohru ^a   Inaba, Tohru ^a   Yagi, Tomohito ^a   Imashuku, Shinsaku ^b  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b Takasago seibu Hospital   (Japan)

Author keywords

Bcl xl; CD45R; Ikaros; JAK2 STAT5 pathway

Indexed keywords

BARRIER TO AUTOINTEGRATION FACTOR; BETA ACTIN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; IKAROS TRANSCRIPTION FACTOR; IKAROS TRANSCRIPTION FACTOR 6; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 3; INTERLEUKIN 7 RECEPTOR ALPHA; JANUS KINASE 2; JANUS KINASE INHIBITOR; L SELECTIN; LEUKOSIALIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BCL X 1; PROTEIN MCL 1; PROTEIN STAT 3; PROTEIN STAT 5; STAT PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; GENE FUNCTION; GENE OVEREXPRESSION; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRECURSOR B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; CELL LINE; CELL SURVIVAL; HUMANS; IKAROS TRANSCRIPTION FACTOR; INTERLEUKIN-3; JANUS KINASE 2; MICE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR CELLS, B-LYMPHOID; PROTEIN ISOFORMS; STAT5 TRANSCRIPTION FACTOR; TRANSFECTION; UP-REGULATION;

EID: 46749117575     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190801993462     Document Type: Article

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