메뉴 건너뛰기




Volumn , Issue JUNE, 2011, Pages

Molecular mechanisms underlying cell death in spinal networks in relation to locomotor activity after acute injury in vitro

Author keywords

Apoptosis; Fictive locomotion; Isolated spinal cord; Motoneuron; Organotypic cultures; Parthanatos; Spinal cord injury; Synaptic transmission

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1;

EID: 83055163963     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2011.00009     Document Type: Review
Times cited : (51)

References (135)
  • 1
    • 0035289536 scopus 로고    scopus 로고
    • Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke
    • Abdelkarim, G. E., Gertz, K., Harms, C., Katchanov, J., Dirnagl, U., Szabo, C., and Endres, M. (2001). Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int. J. Mol. Med. 7, 255-260.
    • (2001) Int. J. Mol. Med , vol.7 , pp. 255-260
    • Abdelkarim, G.E.1    Gertz, K.2    Harms, C.3    Katchanov, J.4    Dirnagl, U.5    Szabo, C.6    Endres, M.7
  • 3
    • 34548241254 scopus 로고    scopus 로고
    • Lapbelt injuries and the seatbeltsyndromeinpediatricspinal cord injury
    • Achildi, O., Betz, R. R., and Grewal, H. (2007). Lapbelt injuries and the seatbeltsyndromeinpediatricspinal cord injury. J. Spinal Cord Med. 30(Suppl. 1), S21-S24.
    • (2007) J. Spinal Cord Med , vol.30 , Issue.SUPPL. 1
    • Achildi, O.1    Betz, R.R.2    Grewal, H.3
  • 4
    • 84862611562 scopus 로고    scopus 로고
    • Pathogenesis of acute spinal cord injury and theoretical bases of neurological recovery
    • ed, (Oxford) Blackwell Publishing, Ltd
    • Amar, A. P. (ed.) (2007). Pathogenesis of acute spinal cord injury and theoretical bases of neurological recovery, in Surgical management of spinal cord injury: controversies and consensus (Oxford: Blackwell Publishing, Ltd), 1-17.
    • (2007) Surgical Management of Spinal Cord Injury: Controversies and Consensus , pp. 1-17
    • Amar, A.P.1
  • 5
    • 57649233085 scopus 로고    scopus 로고
    • Mitochondrial and nuclear cross talk in cell death: Parthanatos
    • Andrabi, S. A., Dawson, T. M., and Dawson, V. L. (2008). Mitochondrial and nuclear cross talk in cell death: parthanatos. Ann. N. Y. Acad. Sci. 1147, 233-241.
    • (2008) Ann. N. Y. Acad. Sci , vol.1147 , pp. 233-241
    • Andrabi, S.A.1    Dawson, T.M.2    Dawson, V.L.3
  • 8
    • 67650945243 scopus 로고    scopus 로고
    • Autophagymediated stress response in motor neuron after transient ischemia in rabbits
    • Baba, H., Sakurai, M., Abe, K., and Tominaga, R. (2009). Autophagymediated stress response in motor neuron after transient ischemia in rabbits. J. Vasc. Surg. 50, 381-387.
    • (2009) J. Vasc. Surg , vol.50 , pp. 381-387
    • Baba, H.1    Sakurai, M.2    Abe, K.3    Tominaga, R.4
  • 9
    • 33646571167 scopus 로고    scopus 로고
    • Pharmacological approaches to repair the injured spinal cord
    • Baptiste, D. C., and Fehlings, M. G. (2006). Pharmacological approaches to repair the injured spinal cord. J. Neurotrauma 23, 318-334.
    • (2006) J. Neurotrauma , vol.23 , pp. 318-334
    • Baptiste, D.C.1    Fehlings, M.G.2
  • 11
    • 0033793564 scopus 로고    scopus 로고
    • Review of current evidence for apoptosis after spinal cord injury
    • Beattie, M. S., Farooqui, A. A., and Bresnahan, J. C. (2000). Review of current evidence for apoptosis after spinal cord injury. J. Neurotrauma 17, 915-925.
    • (2000) J. Neurotrauma , vol.17 , pp. 915-925
    • Beattie, M.S.1    Farooqui, A.A.2    Bresnahan, J.C.3
  • 12
    • 0035821647 scopus 로고    scopus 로고
    • Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms
    • Belmokhtar, C. A., Hillion, J., and Ségal-Bendirdjian, E. (2001). Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms. Oncogene 20, 3354-3362.
    • (2001) Oncogene , vol.20 , pp. 3354-3362
    • Belmokhtar, C.A.1    Hillion, J.2    Ségal-Bendirdjian, E.3
  • 13
    • 0034333266 scopus 로고    scopus 로고
    • Kainate, a double agent that generates seizures: Two decades of progress
    • Ben-Ari, Y., and Cossart, R. (2000). Kainate, a double agent that generates seizures: two decades of progress. Trends Neurosci. 23, 580-587.
    • (2000) Trends Neurosci , vol.23 , pp. 580-587
    • Ben-Ari, Y.1    Cossart, R.2
  • 14
    • 0021997074 scopus 로고
    • Poly(ADP-ribose) in the cellular response to DNA damage
    • Berger, N. A. (1985). Poly(ADP-ribose) in the cellular response to DNA damage. Radiat. Res. 101, 4-15.
    • (1985) Radiat. Res , vol.101 , pp. 4-15
    • Berger, N.A.1
  • 16
    • 72549109502 scopus 로고    scopus 로고
    • Strategies to restore motor functions after spinal cord injury
    • Boulenguez, P., and Vinay, L. (2009). Strategies to restore motor functions after spinal cord injury. Curr. Opin. Neurobiol. 19, 587-600.
    • (2009) Curr. Opin. Neurobiol , vol.19 , pp. 587-600
    • Boulenguez, P.1    Vinay, L.2
  • 17
    • 0029911123 scopus 로고    scopus 로고
    • Localization of rhythmogenic networks responsible for spontaneous bursts induced by strychnine and bicuculline in the rat isolated spinal cord
    • Bracci, E., Ballerini, L., and Nistri, A. (1996). Localization of rhythmogenic networks responsible for spontaneous bursts induced by strychnine and bicuculline in the rat isolated spinal cord. J. Neurosci. 16, 7063-7076.
    • (1996) J. Neurosci , vol.16 , pp. 7063-7076
    • Bracci, E.1    Ballerini, L.2    Nistri, A.3
  • 18
    • 36749084556 scopus 로고    scopus 로고
    • Strategies for delineating spinal locomotor rhythm generating networks and the possible role of Hb9 interneurones in rhythmogenesis
    • Brownstone, R. M., and Wilson, J. M. (2008). Strategies for delineating spinal locomotor rhythm generating networks and the possible role of Hb9 interneurones in rhythmogenesis. Brain Res. Rev. 57, 64-76.
    • (2008) Brain Res. Rev , vol.57 , pp. 64-76
    • Brownstone, R.M.1    Wilson, J.M.2
  • 19
    • 0033541403 scopus 로고    scopus 로고
    • The mechanisms of pyknosis: Hypercondensation and death
    • Burgoyne, L. A. (1999). The mechanisms of pyknosis: hypercondensation and death. Exp. Cell Res. 248, 214-222.
    • (1999) Exp. Cell Res , vol.248 , pp. 214-222
    • Burgoyne, L.A.1
  • 20
    • 0029077682 scopus 로고
    • Localization and organization of the central pattern generator for hindlimb locomotion in newborn rat
    • Cazalets, J. R., Borde, M., and Clarac, F. (1995). Localization and organization of the central pattern generator for hindlimb locomotion in newborn rat. J. Neurosci. 15(7 Pt 1), 4943-4951.
    • (1995) J. Neurosci , vol.15 , Issue.7 PART 1 , pp. 4943-4951
    • Cazalets, J.R.1    Borde, M.2    Clarac, F.3
  • 21
    • 0026737329 scopus 로고
    • Activation of the central pattern generators for locomotion by serotonin and exci- tatory amino acids in neonatal rat
    • Cazalets, J. R., Sqalli-Houssaini, Y., and Clarac, F. (1992). Activation of the central pattern generators for locomotion by serotonin and exci- tatory amino acids in neonatal rat. J. Physiol. 455, 187-204.
    • (1992) J. Physiol , vol.455 , pp. 187-204
    • Cazalets, J.R.1    Sqalli-Houssaini, Y.2    Clarac, F.3
  • 22
    • 46649100324 scopus 로고    scopus 로고
    • Caspase-independent programmed cell death following ischemic stroke
    • Cho, B. B., and Toledo-Pereyra, L. H. (2008). Caspase-independent programmed cell death following ischemic stroke. J. Invest. Surg. 21, 141-147.
    • (2008) J. Invest. Surg , vol.21 , pp. 141-147
    • Cho, B.B.1    Toledo-Pereyra, L.H.2
  • 24
    • 0031017588 scopus 로고    scopus 로고
    • Regional distribution of the locomotor pattern-generating network in the neonatal rat spinal cord
    • Cowley, K. C., and Schmidt, B. J. (1997). Regional distribution of the locomotor pattern-generating network in the neonatal rat spinal cord. J. Neurophysiol. 77, 247-259.
    • (1997) J. Neurophysiol , vol.77 , pp. 247-259
    • Cowley, K.C.1    Schmidt, B.J.2
  • 25
    • 0023077675 scopus 로고
    • Kainic acid: Insights into excitatory mechanisms causing selective neuronal degeneration
    • Coyle, J. T. (1987). Kainic acid: insights into excitatory mechanisms causing selective neuronal degeneration. Ciba Found. Symp.126, 186-203.
    • (1987) Ciba Found. Symp , vol.126 , pp. 186-203
    • Coyle, J.T.1
  • 28
    • 0347418174 scopus 로고    scopus 로고
    • Over expression of parvalbumin in transgenic mice rescues motoneurons frominjury-inducedcelldeath
    • Dekkers, J., Bayley, P., Dick, J. R., Schwaller, B., Berchtold, M. W., and Greensmith, L. (2004). Over- expression of parvalbumin in transgenic mice rescues motoneurons frominjury-inducedcelldeath. Neuroscience 123, 459-466.
    • (2004) Neuroscience , vol.123 , pp. 459-466
    • Dekkers, J.1    Bayley, P.2    Dick, J.R.3    Schwaller, B.4    Berchtold, M.W.5    Greensmith, L.6
  • 29
    • 0030962160 scopus 로고    scopus 로고
    • Locomotion in patients with spinal cord injuries
    • Dietz, V., Wirz, M., and Jensen, L. (1997). Locomotion in patients with spinal cord injuries. Phys. Ther. 77, 508-516.
    • (1997) Phys. Ther , vol.77 , pp. 508-516
    • Dietz, V.1    Wirz, M.2    Jensen, L.3
  • 31
    • 0030769922 scopus 로고    scopus 로고
    • Functional skills after the rehabilitation of spinal cord injury patients; observation period of 3 years
    • Dzidic, I., and Moslavac, S. (1997). Functional skills after the rehabilitation of spinal cord injury patients; observation period of 3 years. Spinal Cord 35, 620-623.
    • (1997) Spinal Cord , vol.35 , pp. 620-623
    • Dzidic, I.1    Moslavac, S.2
  • 32
    • 77956177653 scopus 로고    scopus 로고
    • Persistent inward currents in spinal motoneurons: Important for normal function but potentially harmful after spinal cord injury and in amyotrophic lateral sclerosis
    • ElBasiouny, S. M., Schuster, J. E., and Heckman, C. J. (2010). Persistent inward currents in spinal motoneurons: important for normal function but potentially harmful after spinal cord injury and in amyotrophic lateral sclerosis. Clin. Neurophysiol. 121, 1669-1679.
    • (2010) Clin. Neurophysiol , vol.121 , pp. 1669-1679
    • Elbasiouny, S.M.1    Schuster, J.E.2    Heckman, C.J.3
  • 35
    • 0030832874 scopus 로고    scopus 로고
    • Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase
    • Endres, M., Wang, Z. Q., Namura, S., Waeber, C., and Moskowitz, M. A. (1997). Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J. Cereb. Blood Flow Metab. 17, 1143-1151.
    • (1997) J. Cereb. Blood Flow Metab , vol.17 , pp. 1143-1151
    • Endres, M.1    Wang, Z.Q.2    Namura, S.3    Waeber, C.4    Moskowitz, M.A.5
  • 36
    • 0035893504 scopus 로고    scopus 로고
    • The role and timing of decompression in acute spinal cord injury: What do we know? What should we do?
    • Fehlings, M. G., Sekhon, L. H., and Tator, C. (2001). The role and timing of decompression in acute spinal cord injury: what do we know? What should we do? Spine 26(24 Suppl), S101-110.
    • (2001) Spine , vol.26 , Issue.24 SUPPL
    • Fehlings, M.G.1    Sekhon, L.H.2    Tator, C.3
  • 37
    • 0019725433 scopus 로고
    • Organotypic monolayer cultures of nervous tissue
    • Gahwiler, B. H. (1981). Organotypic monolayer cultures of nervous tissue. J. Neurosci. Methods 4, 329-342.
    • (1981) J. Neurosci. Methods , vol.4 , pp. 329-342
    • Gahwiler, B.H.1
  • 39
    • 41549111029 scopus 로고    scopus 로고
    • Role of free radicals and poly(ADP- ribose)polymerase-1 in the devel- opment of spinal cord injury: New potential therapeutic targets
    • Genovese, T., and Cuzzocrea, S. (2008). Role of free radicals and poly(ADP- ribose)polymerase-1 in the devel- opment of spinal cord injury: new potential therapeutic targets. Curr. Med. Chem. 15, 477-487.
    • (2008) Curr. Med. Chem , vol.15 , pp. 477-487
    • Genovese, T.1    Cuzzocrea, S.2
  • 41
    • 33846018602 scopus 로고    scopus 로고
    • Cell death by necrosis: Towards a molecular definition
    • Golstein, P., and Kroemer, G. (2007). Cell death by necrosis: towards a molecular definition. Trends Biochem. Sci. 32, 37-43.
    • (2007) Trends Biochem. Sci , vol.32 , pp. 37-43
    • Golstein, P.1    Kroemer, G.2
  • 43
    • 72549088712 scopus 로고    scopus 로고
    • Measured motion: Searching for simplicity in spinal locomotor net- works
    • Grillner, S., and Jessell, T. M. (2009). Measured motion: searching for simplicity in spinal locomotor net- works. Curr. Opin. Neurobiol. 19, 572-586.
    • (2009) Curr. Opin. Neurobiol , vol.19 , pp. 572-586
    • Grillner, S.1    Jessell, T.M.2
  • 45
    • 70349134293 scopus 로고    scopus 로고
    • Drug screening of neuroprotective agents on an organotypic-based model of spinal cord excitotoxic damage
    • Guzman-Lenis, M. S., Navarro, X., and Casas, C. (2009). Drug screening of neuroprotective agents on an organotypic-based model of spinal cord excitotoxic damage. Restor. Neurol. Neurosci. 27, 335-349.
    • (2009) Restor. Neurol. Neurosci , vol.27 , pp. 335-349
    • Guzman-Lenis, M.S.1    Navarro, X.2    Casas, C.3
  • 47
    • 0031970954 scopus 로고    scopus 로고
    • Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia
    • Hayashi, T., Sakurai, M., Abe, K., Sadahiro, M., Tabayashi, K., and Itoyama, Y. (1998). Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia. Stroke 29, 1007-1012.
    • (1998) Stroke , vol.29 , pp. 1007-1012
    • Hayashi, T.1    Sakurai, M.2    Abe, K.3    Sadahiro, M.4    Tabayashi, K.5    Itoyama, Y.6
  • 48
    • 13244298118 scopus 로고    scopus 로고
    • Persis- tent inward currents in moto neuron dendrites: Implications for motor output
    • Heckmann, C. J., Gorassini, M. A., and Bennett, D. J. (2005). Persis- tent inward currents in moto neuron dendrites: implications for motor output. Muscle Nerve 31, 135-156.
    • (2005) Muscle Nerve , vol.31 , pp. 135-156
    • Heckmann, C.J.1    Gorassini, M.A.2    Bennett, D.J.3
  • 49
    • 0032564133 scopus 로고    scopus 로고
    • Stroke treatment: Time is brain
    • Hill, M. D., and Hachinski, V. (1998). Stroke treatment: time is brain. Lancet 352, SIII10-SIII14.
    • (1998) Lancet , vol.352
    • Hill, M.D.1    Hachinski, V.2
  • 50
    • 79955835945 scopus 로고    scopus 로고
    • Neuronal dysfunction in chronic spinal cord injury
    • Hubli, M., Bolliger, M., and Dietz, V. (2010). Neuronal dysfunction in chronic spinal cord injury. Spinal Cord 49, 582-587.
    • (2010) Spinal Cord , vol.49 , pp. 582-587
    • Hubli, M.1    Bolliger, M.2    Dietz, V.3
  • 51
    • 0034520112 scopus 로고    scopus 로고
    • The enigma of cell death in neurodegenerative disorders
    • Jellinger, K. A., and Stadelmann, C. H. (2000). The enigma of cell death in neurodegenerative disorders. J. Neural Transm. Suppl. 60, 21-36.
    • (2000) J. Neural Transm. Suppl , vol.60 , pp. 21-36
    • Jellinger, K.A.1    Stadelmann, C.H.2
  • 53
    • 0023772934 scopus 로고
    • Aninvestigationof possible transynaptic neuronal degeneration in human spinal cord injury
    • Kaelan, C., Jacobsen, P. F., and Kakulas, B.A.(1988).Aninvestigationof possible transynaptic neuronal degeneration in human spinal cord injury. J. Neurol. Sci. 86, 231-237.
    • (1988) J. Neurol. Sci , vol.86 , pp. 231-237
    • Kaelan, C.1    Jacobsen, P.F.2    Kakulas, B.A.3
  • 54
    • 65249104617 scopus 로고    scopus 로고
    • Theroleof autophagy in spinal cord injury
    • Kanno, H., Ozawa, H., Sekiguchi, A., and Itoi, E. (2009).Theroleof autophagy in spinal cord injury. Autophagy 5, 390-392.
    • (2009) Autophagy , vol.5 , pp. 390-392
    • Kanno, H.1    Ozawa, H.2    Sekiguchi, A.3    Itoi, E.4
  • 55
    • 39849083520 scopus 로고    scopus 로고
    • Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra
    • Kaushal, V., and Schlichter, L. C. (2008). Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J. Neurosci. 28, 2221-2230.
    • (2008) J. Neurosci , vol.28 , pp. 2221-2230
    • Kaushal, V.1    Schlichter, L.C.2
  • 56
    • 0015383455 scopus 로고
    • Apoptosis:A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F., Wyllie, A. H., and Currie, A. R. (1972). Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 57
    • 33744901157 scopus 로고    scopus 로고
    • Locomotor circuits in the mammalian spinal cord
    • Kiehn, O. (2006). Locomotor circuits in the mammalian spinal cord. Annu. Rev. Neurosci. 29, 279-306.
    • (2006) Annu. Rev. Neurosci , vol.29 , pp. 279-306
    • Kiehn, O.1
  • 59
    • 0029810066 scopus 로고    scopus 로고
    • Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: A lesion study
    • Kjaerulff, O., and Kiehn, O. (1996). Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. J. Neurosci. 16, 5777-5794.
    • (1996) J. Neurosci , vol.16 , pp. 5777-5794
    • Kjaerulff, O.1    Kiehn, O.2
  • 62
    • 77953807546 scopus 로고    scopus 로고
    • Extensive occurrence of glial apoptosis develops early after hypoxic- dysmetabolic insult to the neonatal rat spinal cord in vitro
    • Kuzhandaivel, A., Margaryan, G., Nistri, A., and Mladinic, M. (2010a). Extensive occurrence of glial apoptosis develops early after hypoxic- dysmetabolic insult to the neonatal rat spinal cord in vitro. Neuroscience 169, 325-338.
    • (2010) Neuroscience , vol.169 , pp. 325-338
    • Kuzhandaivel, A.1    Margaryan, G.2    Nistri, A.3    Mladinic, M.4
  • 63
    • 77957709715 scopus 로고    scopus 로고
    • Kainate- mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (parthanatos)
    • Kuzhandaivel, A., Nistri, A., and Mladinic, M. (2010b). Kainate- mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (parthanatos). Cell. Mol. Neurobiol. 30, 1001-1012.
    • (2010) Cell. Mol. Neurobiol , vol.30 , pp. 1001-1012
    • Kuzhandaivel, A.1    Nistri, A.2    Mladinic, M.3
  • 64
    • 0032828302 scopus 로고    scopus 로고
    • Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord
    • Li, G. L., Farooque, M., Holtz, A., and Olsson, Y. (1999). Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord. Acta Neuropathol. 98, 473-480.
    • (1999) Acta Neuropathol , vol.98 , pp. 473-480
    • Li, G.L.1    Farooque, M.2    Holtz, A.3    Olsson, Y.4
  • 65
    • 0041816000 scopus 로고    scopus 로고
    • Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats
    • Li, Y., and Bennett, D. J. (2003). Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats. J. Neurophysiol. 90, 857-869.
    • (2003) J. Neurophysiol , vol.90 , pp. 857-869
    • Li, Y.1    Bennett, D.J.2
  • 67
    • 33646373730 scopus 로고    scopus 로고
    • Organotypic culture, a powerful model for studying rat and mouse fetal testis development
    • Livera, G., Delbes, G., Pairault, C., Rouiller-Fabre, V., and Habert, R. (2006). Organotypic culture, a powerful model for studying rat and mouse fetal testis development. Cell Tissue Res. 324, 507-521.
    • (2006) Cell Tissue Res , vol.324 , pp. 507-521
    • Livera, G.1    Delbes, G.2    Pairault, C.3    Rouiller-Fabre, V.4    Habert, R.5
  • 68
    • 0031610371 scopus 로고    scopus 로고
    • Measurement of cell death
    • Loo, D. T., and Rillema, J. R. (1998). Measurement of cell death. Methods Cell Biol. 57, 251-264.
    • (1998) Methods Cell Biol , vol.57 , pp. 251-264
    • Loo, D.T.1    Rillema, J.R.2
  • 69
    • 67650492537 scopus 로고    scopus 로고
    • Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS
    • Lossi, L., Alasia, S., Salio, C., and Merighi, A. (2009). Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS. Prog. Neurobiol. 88, 221-245.
    • (2009) Prog. Neurobiol , vol.88 , pp. 221-245
    • Lossi, L.1    Alasia, S.2    Salio, C.3    Merighi, A.4
  • 71
    • 72749123228 scopus 로고    scopus 로고
    • Neuro protection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro
    • Margaryan, G., Mattioli, C., Mladinic, M., and Nistri, A. (2010). Neuro protection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro. Neuroscience 165, 996-1010.
    • (2010) Neuroscience , vol.165 , pp. 996-1010
    • Margaryan, G.1    Mattioli, C.2    Mladinic, M.3    Nistri, A.4
  • 72
    • 69249205462 scopus 로고    scopus 로고
    • Extracellular Mg2+ enhances the damage to locomotor networks produced by metabolic perturbation mimicking spinal injury in the neonatal rat spinal cord in vitro
    • Margaryan, G., Mladinic, M., Mattioli, C., and Nistri, A. (2009). Extra- cellular Mg2+ enhances the damage to locomotor networks produced by metabolic perturbation mimic- king spinal injury in the neonatal rat spinal cord in vitro. Neuroscience 163, 669-682.
    • (2009) Neuroscience , vol.163 , pp. 669-682
    • Margaryan, G.1    Mladinic, M.2    Mattioli, C.3    Nistri, A.4
  • 73
    • 77952875450 scopus 로고    scopus 로고
    • Kainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord
    • Mazzone, G. L., Margaryan, G., Kuzhandaivel, A., Nasrabady, S. E., Mladinic, M., and Nistri, A. (2010). Kainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord. Neuroscience 168, 451-462.
    • (2010) Neuroscience , vol.168 , pp. 451-462
    • Mazzone, G.L.1    Margaryan, G.2    Kuzhandaivel, A.3    Nasrabady, S.E.4    Mladinic, M.5    Nistri, A.6
  • 74
    • 79953043583 scopus 로고    scopus 로고
    • Electrochemical detection of endogenous glutamate release from rat spinal cord organotypic slices as a real-time method to monitor excitotoxicity
    • Mazzone, G. L., and Nistri, A. (2011a). Electrochemical detection of endogenous glutamate release from rat spinal cord organotypic slices as a real-time method to monitor excitotoxicity. J. Neurosci. Methods 197, 128-132.
    • (2011) J. Neurosci. Methods , vol.197 , pp. 128-132
    • Mazzone, G.L.1    Nistri, A.2
  • 75
    • 79955554974 scopus 로고    scopus 로고
    • Effect of the PARP-1 inhibitor PJ 34 on excitotoxic damage evoked by kainate on rat spinal cord organ- otypicslices
    • Mazzone, G. L., and Nistri, A. (2011b). Effect of the PARP-1 inhibitor PJ 34 on excitotoxic damage evoked by kainate on rat spinal cord organ- otypicslices.Cell.Mol.Neurobiol.31, 469-478.
    • (2011) Cell. Mol. Neurobiol , vol.31 , pp. 469-478
    • Mazzone, G.L.1    Nistri, A.2
  • 76
    • 36749003752 scopus 로고    scopus 로고
    • Organization of mammalian loco motor rhythm and pattern generation
    • McCrea, D. A., and Rybak, I. A. (2008). Organization of mammalian loco motor rhythm and pattern generation. Brain Res. Rev. 57, 134-146.
    • (2008) Brain Res. Rev , vol.57 , pp. 134-146
    • McCrea, D.A.1    Rybak, I.A.2
  • 77
    • 0033067847 scopus 로고    scopus 로고
    • Nontraumatic spinal cord injury: Incidence, epidemiology, and functional outcome
    • McKinley, W. O., Seel, R. T., and Hardman, J. T. (1999). Nontraumatic spinal cord injury: incidence, epidemiology, and functional outcome. Arch. Phys. Med. Rehabil. 80, 619-623.
    • (1999) Arch. Phys. Med. Rehabil , vol.80 , pp. 619-623
    • McKinley, W.O.1    Seel, R.T.2    Hardman, J.T.3
  • 79
    • 38649092421 scopus 로고    scopus 로고
    • Poly(ADP- ribose)polymerase 1 (PARP-1) and postischemic brain damage
    • Moroni, F. (2008). Poly(ADP- ribose)polymerase 1 (PARP-1) and postischemic brain damage. Curr. Opin. Pharmacol. 8, 96-103.
    • (2008) Curr. Opin. Pharmacol , vol.8 , pp. 96-103
    • Moroni, F.1
  • 80
    • 70349772693 scopus 로고    scopus 로고
    • Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of postischaemic brain damage
    • Moroni, F., Formentini, L., Gerace, E., Camaioni, E., Pellegrini-Giampietro, D. E., Chiarugi, A., and Pellicciari, R. (2009). Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of postischaemic brain damage. Br. J. Pharmacol. 157, 854-862.
    • (2009) Br. J. Pharmacol , vol.157 , pp. 854-862
    • Moroni, F.1    Formentini, L.2    Gerace, E.3    Camaioni, E.4    Pellegrini-Giampietro, D.E.5    Chiarugi, A.6    Pellicciari, R.7
  • 81
    • 24944496987 scopus 로고    scopus 로고
    • Nontraumatic spinal cord lesions: A prospective study of medical complications during in- patient rehabilitation
    • Nair, K. P., Taly, A. B., Maheshwarappa, B. M., Kumar, J., Murali, T., and Rao, S. (2005). Nontraumatic spinal cord lesions: a prospective study of medical complications during in- patient rehabilitation. Spinal Cord 43, 558-564.
    • (2005) Spinal Cord , vol.43 , pp. 558-564
    • Nair, K.P.1    Taly, A.B.2    Maheshwarappa, B.M.3    Kumar, J.4    Murali, T.5    Rao, S.6
  • 82
  • 83
    • 79955560138 scopus 로고    scopus 로고
    • A. Effects of 6(5H)- phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord
    • Nasrabady, S. E., Kuzhandaivel, A., Mladinic, M., and Nistri, A. (2011a). A. Effects of 6(5H)- phenanthridinone, an inhibitor of poly(ADP-ribose)polymerase-1 activity (PARP-1), on locomotor networks of the rat isolated spinal cord. Cell. Mol. Neurobiol. 31, 503-508.
    • (2011) Cell. Mol. Neurobiol , vol.31 , pp. 503-508
    • Nasrabady, S.E.1    Kuzhandaivel, A.2    Mladinic, M.3    Nistri, A.4
  • 84
    • 79959336484 scopus 로고    scopus 로고
    • Studies of locomotornetworkneuroprotection by the selective PARP-1 inhibitor PJ-34 against excitotoxic injury to the rat spinal cord in vitro
    • doi: 10.1111/j.1460- 9568.2011.07714.x., [Epub ahead of print]
    • Nasrabady, S. E., Kuzhandaivel, A., and Nistri, A. (2011b). Studies of locomotornetworkneuroprotection by the selective PARP-1 inhibitor PJ-34 against excitotoxic injury to the rat spinal cord in vitro. Eur. J. Neurosci. doi: 10.1111/j.1460- 9568.2011.07714.x. [Epub ahead of print].
    • (2011) Eur. J. Neurosci
    • Nasrabady, S.E.1    Kuzhandaivel, A.2    Nistri, A.3
  • 85
    • 33645510222 scopus 로고    scopus 로고
    • Tuning and playing a motor rhythm: How metabotropic glutamate receptors orchestrate generation of motor patterns in the mammalian central nervous system
    • Nistri, A., Ostroumov, K., Sharifullina, E., and Taccola, G. (2006). Tuning and playing a motor rhythm: how metabotropic glutamate receptors orchestrate generation of motor patterns in the mammalian central nervous system. J. Physiol. 572(Pt 2), 323-334.
    • (2006) J. Physiol , vol.572 , Issue.PART 2 , pp. 323-334
    • Nistri, A.1    Ostroumov, K.2    Sharifullina, E.3    Taccola, G.4
  • 86
  • 87
    • 12344276497 scopus 로고    scopus 로고
    • Organotypic brain slice cultures: An efficient and reliable method for neuro toxicological screening and mechanistic studies
    • Noraberg, J. (2004). Organotypic brain slice cultures: an efficient and reliable method for neuro toxicological screening and mechanistic studies. Altern. Lab. Anim. 32, 329-337.
    • (2004) Altern. Lab. Anim , vol.32 , pp. 329-337
    • Noraberg, J.1
  • 88
    • 1942425481 scopus 로고    scopus 로고
    • The pathology of human spinal cord injury: Defining the problems
    • Norenberg, M. D., Smith, J., and Marcillo, A. (2004). The pathology of human spinal cord injury: defining the problems. J. Neurotrauma 21, 429-440.
    • (2004) J. Neurotrauma , vol.21 , pp. 429-440
    • Norenberg, M.D.1    Smith, J.2    Marcillo, A.3
  • 89
    • 36049040405 scopus 로고    scopus 로고
    • Rat models of traumatic spinal cord injury to assess motor recovery
    • Onifer, S. M., Rabchevsky, A. G., and Scheff, S. W. (2007). Rat models of traumatic spinal cord injury to assess motor recovery. ILAR J. 48, 385-395.
    • (2007) ILAR J , vol.48 , pp. 385-395
    • Onifer, S.M.1    Rabchevsky, A.G.2    Scheff, S.W.3
  • 90
    • 0022633995 scopus 로고
    • The absence of significant postnatal motoneuron death in the brachial and lum- bar spinal cord of the rat
    • Oppenheim, R. W. (1986). The absence of significant postnatal motoneuron death in the brachial and lum- bar spinal cord of the rat. J. Comp. Neurol. 246, 281-286.
    • (1986) J. Comp. Neurol , vol.246 , pp. 281-286
    • Oppenheim, R.W.1
  • 91
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: A review with an emphasis on the implications for white matter degeneration
    • Park, E., Velumian, A. A., and Fehlings, M. G. (2004). The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J. Neurotrauma 21, 754-774.
    • (2004) J. Neurotrauma , vol.21 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 92
    • 0037989744 scopus 로고    scopus 로고
    • Calpain in the patho physiology of spinal cord injury: Neuro protection with cal pain inhibitors
    • Ray, S. K., Hogan, E. L., and Banik, N. L. (2003). Calpain in the patho physiology of spinal cord injury: Neuro protection with cal pain inhibitors. Brain Res. Brain Res. Rev. 42, 169-185.
    • (2003) Brain Res. Brain Res. Rev , vol.42 , pp. 169-185
    • Ray, S.K.1    Hogan, E.L.2    Banik, N.L.3
  • 95
    • 63849340879 scopus 로고    scopus 로고
    • Current status of acute spinal cord injury pathophysiology and emerging therapies: Promise on the horizon
    • Rowland, J. W., Hawryluk, G. W., Kwon, B., and Fehlings, M. G. (2008). Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg. Focus 25, E2.
    • (2008) Neurosurg. Focus , vol.25
    • Rowland, J.W.1    Hawryluk, G.W.2    Kwon, B.3    Fehlings, M.G.4
  • 96
    • 0037326363 scopus 로고    scopus 로고
    • Survival and death-promoting events after transient spinal cord ischemia in rabbits: Induction of Akt and caspase3 in motor neurons
    • Sakurai, M., Nagata, T., Abe, K., Horinouchi, T., Itoyama, Y., and Tabayashi, K. (2003). Survival and death-promoting events after transient spinal cord ischemia in rabbits: induction of Akt and caspase3 in motor neurons. J. Thorac. Cardiovasc. Surg. 125, 370-377.
    • (2003) J. Thorac. Cardiovasc. Surg , vol.125 , pp. 370-377
    • Sakurai, M.1    Nagata, T.2    Abe, K.3    Horinouchi, T.4    Itoyama, Y.5    Tabayashi, K.6
  • 97
    • 4644312193 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro
    • Scott, G. S., Szabó, C., and Hooper, D. C. (2004). Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro. J. Neu- rotrauma 21, 1255-1263.
    • (2004) J. Neu- Rotrauma , vol.21 , pp. 1255-1263
    • Scott, G.S.1    Szabó, C.2    Hooper, D.C.3
  • 98
    • 0035893632 scopus 로고    scopus 로고
    • Epidemiology, demo- graphics, and pathophysiology of acute spinal cord injury
    • Sekhon, L. H., and Fehlings, M. G. (2001). Epidemiology, demo- graphics, and pathophysiology of acute spinal cord injury. Spine 26, S2-S12.
    • (2001) Spine , vol.26
    • Sekhon, L.H.1    Fehlings, M.G.2
  • 99
    • 2942746304 scopus 로고    scopus 로고
    • Primary cultures of neonatal rat spinal cord
    • Seybold, V. S., and Abrahams, L. G. (2004). Primary cultures of neonatal rat spinal cord. Methods Mol. Med. 99, 203-213.
    • (2004) Methods Mol. Med , vol.99 , pp. 203-213
    • Seybold, V.S.1    Abrahams, L.G.2
  • 101
    • 0030695396 scopus 로고    scopus 로고
    • Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats
    • Shuman, S. L., Bresnahan, J. C., and Beattie, M. S. (1997). Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. J. Neurosci. Res. 50, 798-808.
    • (1997) J. Neurosci. Res , vol.50 , pp. 798-808
    • Shuman, S.L.1    Bresnahan, J.C.2    Beattie, M.S.3
  • 102
    • 68749117418 scopus 로고    scopus 로고
    • GABAergic and glycinergic interneuron expression during spinal cord development: Dynamic interplay between inhibition and excitation in the control of ventral network outputs
    • Sibilla, S., and Ballerini, L. (2009). GABAergic and glycinergic interneuron expression during spinal cord development: dynamic interplay between inhibition and excitation in the control of ventral network outputs. Prog. Neurobiol. 89, 46-60.
    • (2009) Prog. Neurobiol , vol.89 , pp. 46-60
    • Sibilla, S.1    Ballerini, L.2
  • 103
    • 0034076161 scopus 로고    scopus 로고
    • Motor neurones in culture as a model to study ALS
    • Silani, V., Braga, M., Ciammola, A., Cardin, V., and Scarlato, G. (2000). Motor neurones in culture as a model to study ALS. J. Neurol. 247(Suppl. 1), I28-I36.
    • (2000) J. Neurol , vol.247 , Issue.SUPPL. 1
    • Silani, V.1    Braga, M.2    Ciammola, A.3    Cardin, V.4    Scarlato, G.5
  • 104
    • 0025935416 scopus 로고
    • A norganotypic spinal cord - dorsal root gan- glion - skeletal muscle coculture of embryonic rat. I. The morphological correlates of the spinal reflex arc
    • Spenger, C., Braschler, U. F., Streit, J., andLuscher, H.R.(1991). A norganotypic spinal cord - dorsal root gan- glion - skeletal muscle coculture of embryonic rat. I. The morphological correlates of the spinal reflex arc. Eur. J. Neurosci. 3, 1037-1053.
    • (1991) Eur. J. Neurosci , vol.3 , pp. 1037-1053
    • Spenger, C.1    Braschler, U.F.2    Streit, J.3    Andluscher, H.R.4
  • 105
    • 0032790541 scopus 로고    scopus 로고
    • Activationof the caspase-3 apoptotic cascade in trau- matic spinal cord injury
    • Springer, J. E., Azbill, R. D., and Knapp, P.E.(1999). Activationof the caspase-3 apoptotic cascade in trau- matic spinal cord injury. Nat. Med. 5, 943-946.
    • (1999) Nat. Med , vol.5 , pp. 943-946
    • Springer, J.E.1    Azbill, R.D.2    Knapp, P.E.3
  • 107
    • 0025805120 scopus 로고
    • A simple method for organ- otypic cultures of nervous tissue
    • Stoppini, L., Buchs, P. A., and Muller, D. (1991). A simple method for organ- otypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182.
    • (1991) J. Neurosci. Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 108
    • 0026038918 scopus 로고
    • Anorganotypicspinalcord- dorsal root ganglion - skeletal mus- cle coculture of embryonic rat. II. Functional evidence for the forma- tion of spinal reflex arcs in vitro
    • Streit, J., Spenger, C., and Luscher, H. R. (1991). Anorganotypicspinalcord- dorsal root ganglion - skeletal mus- cle coculture of embryonic rat. II. Functional evidence for the forma- tion of spinal reflex arcs in vitro. Eur. J. Neurosci. 3, 1054-1068.
    • (1991) Eur. J. Neurosci , vol.3 , pp. 1054-1068
    • Streit, J.1    Spenger, C.2    Luscher, H.R.3
  • 110
    • 49349106393 scopus 로고    scopus 로고
    • Kainate and metabolic perturbation mimicking spinal injury differentially contribute to early damage of locomotor networks in the in vitro neonatal rat spinal cord
    • Taccola, G., Margaryan, G., Mladinic, M., and Nistri, A. (2008). Kainate and metabolic perturbation mimicking spinal injury differentially contribute to early damage of locomotor networks in the in vitro neonatal rat spinal cord. Neuroscience 155, 538-555.
    • (2008) Neuroscience , vol.155 , pp. 538-555
    • Taccola, G.1    Margaryan, G.2    Mladinic, M.3    Nistri, A.4
  • 111
    • 72949094210 scopus 로고    scopus 로고
    • Dynamics of early locomotor network dysfunction following a focal lesion in an in vitro model of spinal injury
    • Taccola, G., Mladinic, M., and Nistri, A. (2010). Dynamics of early locomotor network dysfunction following a focal lesion in an in vitro model of spinal injury. Eur. J. Neurosci. 31, 60-78.
    • (2010) Eur. J. Neurosci , vol.31 , pp. 60-78
    • Taccola, G.1    Mladinic, M.2    Nistri, A.3
  • 112
    • 36649004500 scopus 로고    scopus 로고
    • Oscillatory circuits underlying locomotor networks in the rat spinal cord
    • Taccola, G., and Nistri, A. (2006). Oscillatory circuits underlying locomotor networks in the rat spinal cord. Crit. Rev. Neurobiol. 18, 25-36.
    • (2006) Crit. Rev. Neurobiol , vol.18 , pp. 25-36
    • Taccola, G.1    Nistri, A.2
  • 113
    • 0031813589 scopus 로고    scopus 로고
    • Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells
    • Tan, S., Wood, M., and Maher, P. (1998). Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J. Neurochem. 71, 95-105.
    • (1998) J. Neurochem , vol.71 , pp. 95-105
    • Tan, S.1    Wood, M.2    Maher, P.3
  • 114
    • 34250749204 scopus 로고    scopus 로고
    • In vitro methods to prepare astrocyte and motoneuron cultures for the investigation of potential in vivo interactions
    • Taylor, A. R., Robinson, M. B., and Milligan, C. E. (2007). In vitro methods to prepare astrocyte and motoneuron cultures for the investigation of potential in vivo interactions. Nat. Protoc. 2, 1499-1507.
    • (2007) Nat. Protoc , vol.2 , pp. 1499-1507
    • Taylor, A.R.1    Robinson, M.B.2    Milligan, C.E.3
  • 115
    • 34547817700 scopus 로고    scopus 로고
    • Contribution of persistent sodium current to locomotor pattern gener- ation in neonatal rats
    • Tazerart, S., Viemari, J. C., Darbon, P., Vinay, L., and Brocard, F. (2007). Contribution of persistent sodium current to locomotor pattern gener- ation in neonatal rats. J. Neurophysiol. 98, 613-628.
    • (2007) J. Neurophysiol , vol.98 , pp. 613-628
    • Tazerart, S.1    Viemari, J.C.2    Darbon, P.3    Vinay, L.4    Brocard, F.5
  • 116
    • 0027141312 scopus 로고
    • The differen- tial expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray
    • Tolle, T. R., Berthele, A., Zieglgänsberger, W., Seeburg, P. H., and Wisden, W. (1993). The differen- tial expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13, 5009-5028.
    • (1993) J. Neurosci , vol.13 , pp. 5009-5028
    • Tolle, T.R.1    Berthele, A.2    Zieglgänsberger, W.3    Seeburg, P.H.4    Wisden, W.5
  • 117
    • 0017698204 scopus 로고
    • The numbers of limb motor neu- rons in the human lumbosacral cord throughout life
    • Tomlinson, B. E., and Irving, D. (1977). The numbers of limb motor neu- rons in the human lumbosacral cord throughout life. J. Neurol. Sci. 34, 213-219.
    • (1977) J. Neurol. Sci , vol.34 , pp. 213-219
    • Tomlinson, B.E.1    Irving, D.2
  • 121
    • 0032487656 scopus 로고    scopus 로고
    • Glial cells potentiate kainate-induced neuronal death in a moto neuron enriched spinal coculture system
    • Vandenberghe, W., Van Den, B. L., and Robberecht, W. (1998). Glial cells potentiate kainate-induced neuronal death in a moto neuron enriched spinal coculture system. Brain Res. 807, 1-10.
    • (1998) Brain Res , vol.807 , pp. 1-10
    • Vandenberghe, W.1    van Den, B.L.2    Robberecht, W.3
  • 122
    • 0032193692 scopus 로고    scopus 로고
    • Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidantinduced cell death
    • Virag, L., Salzman, A. L., and Szabo, C. (1998). Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant- induced cell death. J. Immunol. 161, 3753-3759.
    • (1998) J. Immunol , vol.161 , pp. 3753-3759
    • Virag, L.1    Salzman, A.L.2    Szabo, C.3
  • 123
    • 33750431048 scopus 로고    scopus 로고
    • Epidemiology of pediatric spinal cord injury in the United States: Years 1997 and 2000
    • Vitale, M. G., Goss, J. M., Matsumoto, H., and Roye, D. P. Jr. (2006). Epidemiology of pediatric spinal cord injury in the United States: years 1997 and 2000. J. Pediatr. Orthop. 26, 745-749.
    • (2006) J. Pediatr. Orthop , vol.26 , pp. 745-749
    • Vitale, M.G.1    Goss, J.M.2    Matsumoto, H.3    Roye, D.P.4
  • 124
    • 79951848558 scopus 로고    scopus 로고
    • Stereological estimate of the total number of neurons in spinal segment D9 of the red-eared turtle
    • Walløe, S., Nissen, U. V., Berg, R. W., Hounsgaard, J., and Pakkenberg, B. (2011). Stereological estimate of the total number of neurons in spinal segment D9 of the red-eared turtle. J. Neurosci. 31, 2431-2435.
    • (2011) J. Neurosci , vol.31 , pp. 2431-2435
    • Walløe, S.1    Nissen, U.V.2    Berg, R.W.3    Hounsgaard, J.4    Pakkenberg, B.5
  • 125
    • 59149098552 scopus 로고    scopus 로고
    • Roles of the major apoptotic nuclease-DNA fragmentation factor-in biology and disease
    • Widlak, P., and Garrard, W. T. (2009). Roles of the major apoptotic nuclease-DNA fragmentation factor-in biology and disease. Cell. Mol. Life Sci. 66, 263-274.
    • (2009) Cell. Mol. Life Sci , vol.66 , pp. 263-274
    • Widlak, P.1    Garrard, W.T.2
  • 126
    • 34249802899 scopus 로고    scopus 로고
    • Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis-inducing factor- dependent and caspase-dependent signaling pathways to induce apoptosis after spinal cord injury
    • Wu, K. L., Hsu, C., and Chan, J. Y. (2007). Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis-inducing factor- dependent and caspase-dependent signaling pathways to induce apoptosis after spinal cord injury. J. Neurochem. 101, 1552-1566.
    • (2007) J. Neurochem , vol.101 , pp. 1552-1566
    • Wu, K.L.1    Hsu, C.2    Chan, J.Y.3
  • 127
    • 69249132073 scopus 로고    scopus 로고
    • Nitric oxide and super-oxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translo- cation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury
    • Wu, K. L., Hsu, C., and Chan, J. Y. (2009). Nitric oxide and super- oxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translo- cation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury. J. Neurotrauma 26, 965-977.
    • (2009) J. Neurotrauma , vol.26 , pp. 965-977
    • Wu, K.L.1    Hsu, C.2    Chan, J.Y.3
  • 129
    • 58149119499 scopus 로고    scopus 로고
    • Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury
    • Yu, W. R., Liu, T., Fehlings, T. K., and Fehlings, M. G. (2009). Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury. Eur. J. Neurosci. 29, 114-131.
    • (2009) Eur. J. Neurosci , vol.29 , pp. 114-131
    • Yu, W.R.1    Liu, T.2    Fehlings, T.K.3    Fehlings, M.G.4
  • 130
    • 0141884305 scopus 로고    scopus 로고
    • Diversity in the mechanisms of neuronal cell death
    • Yuan, J., Lipinski, M., and Degterev, A. (2003). Diversity in the mechanisms of neuronal cell death. Neuron 40, 401-413.
    • (2003) Neuron , vol.40 , pp. 401-413
    • Yuan, J.1    Lipinski, M.2    Degterev, A.3
  • 131
    • 0029100217 scopus 로고
    • Poly(ADP-ribose) synthetase activation: An early indicator of neurotoxic DNA damage
    • Zhang, J., Pieper, A., and Snyder, S. H. (1995). Poly(ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage. J. Neurochem. 65, 1411-1414.
    • (1995) J. Neurochem , vol.65 , pp. 1411-1414
    • Zhang, J.1    Pieper, A.2    Snyder, S.H.3
  • 132
    • 33747012605 scopus 로고    scopus 로고
    • Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens
    • doi: 10.1186/1471-2202-7-49
    • Zhang, Y., and Bhavnani, B. R. (2006). Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neurosci. 7, 49. doi: 10.1186/1471-2202-7-49
    • (2006) BMC Neurosci , vol.7 , pp. 49
    • Zhang, Y.1    Bhavnani, B.R.2
  • 133
    • 34247507769 scopus 로고    scopus 로고
    • Persistent sodium currents participate in fictive locomotion generation in neonatal mouse spinal cord
    • Zhong, G., Masino, M. A., and Harris-Warrick, R. M. (2007). Persistent sodium currents participate in fictive locomotion generation in neonatal mouse spinal cord. J. Neurosci. 27, 4507-4518.
    • (2007) J. Neurosci , vol.27 , pp. 4507-4518
    • Zhong, G.1    Masino, M.A.2    Harris-Warrick, R.M.3
  • 134
    • 77954582210 scopus 로고    scopus 로고
    • Synaptic integration of rhythmogenic neurons in the locomotor circuitry:The case of Hb9 interneurons
    • Ziskind-Conhaim, L., Mentis, G. Z., Wiesner, E.P., andTitus, D.J. (2010). Synaptic integration of rhythmogenic neurons in the locomotor circuitry:the case of Hb9 interneurons. Ann. N. Y. Acad. Sci. 1198, 72-84.
    • (2010) Ann. N. Y. Acad. Sci , vol.1198 , pp. 72-84
    • Ziskind-Conhaim, L.1    Mentis, G.Z.2    Wiesner, E.P.3    Andtitus, D.J.4
  • 135
    • 57349178427 scopus 로고    scopus 로고
    • Persistent sodium current contributes to induced voltage oscillations in locomotor-related Hb9 interneurons in the mouse spinal cord
    • Ziskind-Conhaim, L., Wu, L., and Wiesner, E. P. (2008). Persistent sodium current contributes to induced voltage oscillations in locomotor-related Hb9 interneurons in the mouse spinal cord. J. Neurophysiol. 100, 2254-2264.
    • (2008) J. Neurophysiol , vol.100 , pp. 2254-2264
    • Ziskind-Conhaim, L.1    Wu, L.2    Wiesner, E.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.