Epidemiology, demographics, and pathophysiology of acute spinal cord injury

Spine

Volumn 26, Issue 24 SUPPL., 2001, Pages

  Sekhon, Lali H S ^a   Fehlings, Michael G ^b,c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b TORONTO WESTERN HOSPITAL   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Epidemiology; Methylprednisolone; Pathophysiology; Spinal cord injury; Surgery

Indexed keywords

AMINO ACID; CALCIUM; FREE RADICAL; METHYLPREDNISOLONE; SODIUM;

ADOLESCENT; ADULT; AGED; APOPTOSIS; CHILD; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; HUMAN; INCIDENCE; INFANT; MAJOR CLINICAL STUDY; MEDIATOR RELEASE; NEUROLOGIC DISEASE; NEWBORN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECREATION; REVIEW; SPINAL CORD INJURY; SURVIVAL; TRAFFIC ACCIDENT; TREATMENT PLANNING; VIOLENCE;

EID: 0035893632     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200112151-00002     Document Type: Review

References (150)

1. 2+ exchanger
2. The role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
3. Epidemiology, physiopathology, and experimental therapeutics of acute spinal cord injury
4. Surgery for experimental lesions of spinal cord equivalent to crush injury of fracture dislocation of spinal column: A preliminary report
5. Remarks on the histopathological changes in spinal cord due to impact: An experimental study
6. Pathophysiology of spinal cord trauma
7. Microvascular perfusion and metabolism in injured spinal cord after methylprednisolone treatment
8. Spinal cord energy metabolism following compression trauma to the feline spinal cord
9. Lipid hydrolysis and peroxidation in injured spinal cord: Partial protection with methylprednisolone or vitamin E and selenium
10. The National Head and Spinal Cord Injury Survey: Assessment of some uncertainties affecting the findings
11. Apoptosis: Mechanisms and role in pathology
12. Experimental traumatic paraplegia: The vascular and pathological changes seen in reversible and irreversible spinalcord lesions
13. Spinal shock
14. Pathology of experimental spinal cord trauma: II. Ultrastructure of axons and myelin
15. Death from natural and unnatural causes: Elegant studies of the nematode are providing answers to the question of how programmed cell death and neurodegeneration are regulated
16. Does oligodendrocyte survival depend on axons?
17. Apoptosis in brain-specific autoimmune disease
18. Blood flow in normal and injured monkey spinal cord
19. A model for the future care of acute spinal cord injuries
20. Treatment of acute spinal cord injury with methylprednisolone: Results of a multicenter, randomized clinical trial
21. Efficacy of methylprednisolone in acute spinal cord injury
22. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2
23. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury: Results of the Second National Acute Spinal Cord Injury Study
24. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-Year follow-up data. Results of the Second National Acute Spinal Cord Injury Study
25. Methylprednisolone and neurological function 1 year after spinal cord injury: Results of the National Acute Spinal Cord Injury Study
26. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury: Results of the third national acute spinal cord injury randomized controlled trial. National acute spinal cord injury study
27. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-Year follow up. Results of the third national acute spinal cord injury randomized controlled trial
28. Spinal cord injury: A ten-year report
29. Incidence, characteristics, and outcome of spinal cord injury at trauma centers in North America
30. Etiology of traumatic spinal cord injury: Statistics of more than 1,100 cases
31. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and P75 expression following spinal cord injury
32. Factors predictive of hospital mortality and mechanical ventilation in patients with cervical spinal cord injury
33. Apoptosis
34. A review and update of experimental and clinical studies of spinal cord injury
35. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
36. Rehospitalization after initial rehabilitation for acute spinal cord injury: Incidence and risk factors
37. Spinal cord injury: Review of basic and applied research
38. The free radical pathology and the microcirculation in the major central nervous system disorders
39. Membrane perturbations in central nervous system injury: Theoretical basis for free radical damage and a review of the experimental data
40. Further studies on free-radical pathology in the major central nervous system disorders: Effect of very high doses of methylprednisolone on the functional outcome, mor phology, and chemistry of experimental spinal cord impact injury
41. The fine structure of endothelial surfaces in the microcirculation of experimentally injured feline spinal cords
42. Prevalence of spinal cord injury: A reestimation employing life table techniques
43. Cause of death for patients with spinal cord injuries
44. Trends in spinal cord injury demographics and treatment outcomes between 1973 and 1986
45. Prognostic factors for 12-year survival after spinal cord injury
46. Microcirculation of traumatized spinal cord: A correlation of microangiography and blood flow patterns in transitory and permanent paraplegia
47. Intramedullary blood flow patterns in transitory traumatic paraplegia
48. Effects of deep barbiturate coma on acute spinal cord injury in the cat
49. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
50. Cervical sagittal spinal canal size in spine injury
51. Apoptosis after traumatic human spinal cord injury
52. Spinal cord injury in the United States: A statistical update
53. Trends in the treatment of patients with spinal cord lesions seen within a period of 20 years in German centers
54. Thyrotropin-releasing hormone improves neurologic recovery after spinal trauma in cars
55. Comparison of early and late naloxone treatment in experimental spinal injury
56. Evaluation of calcium channel antagonist nimodipine in experimental spinal cord ischemia
57. A potential role for excitotoxins in the pathophysiology of spinal cord injury
58. Microangiographic study of experimental spinal injuries in dogs and rabbits
59. Posterior plates in the management of cervical instability: Long term results in 44 patients
60. Initial stabilization and medical management of acute spinal cord injury
61. The optimal radiological method to assess spinal canal compromise and cord compression in patients with cervical spinal cord injury: II. Results of a multicenter study
62. Cellular, ionic and biomolecular mechanisms of the injury process
63. The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury
64. Microangiographic observations of the experimentally traumatized spinal cord
65. Incidence of traumatic paraplegia and tetraplegia in Norway: A statistical survey of the years 1974 and 1975
66. Mortality, survival and prevalence: Traumatic spinal cord injury in Olmsted County, Minnesota, 1935-1981
67. Traumatic spinal cord injury in Olmsted County, Minnesota, 1935-1981
68. Spinal cord blood flow after acute experimental cord injury in dogs
69. Vascular permeability to protein and vasogenic edema in experimental concussive injuries to the canine spinal cord
70. Acute cardiovascular effects of experimental spinal cord injury
71. Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats
72. Idealized care of the acutely injured spinal cord in Switzerland
73. Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and Na+ +(K+)-ATPase activity. Dose-response analysis during 1st hour after contusion injury in the cat
74. Glucocorticoid mechanisms in acute spinal cord injury: A review and therapeutic rationale
75. Free radicals in CNS injury
76. Post-traumatic spinal cord ischemia: Relationship to injury severity and physiological parameters
77. Effects of a single large dose of methyl-prednisolone sodium succinate on experimental posttraumatic spinal cord ischemia: Dose-response and time-action analysis
78. Correlation between attenuation of posttraumatic spinal cord ischemia and preservation of tissue vitamin E by the 21-aminosteroid U74006F: Evidence for an in vivo antioxidant mechanism
79. Acute spinal cord injury patients: Who cares?
80. The prognosis of patients sustaining severe cervical spine injury (C2-C7 inclusive)
81. New estimates of traumatic SCI prevalence: A survey-based approach
82. New estimates of the direct costs of traumatic spinal cord injuries: Results of a nationwide survey
83. Local blood flow, oxygen tension, and oxygen consumption in the rat spinal cord
84. Functional outcome following spinal cord injury: A comparison of specialized spinal cord injury center vs general hospital short-term care
85. Programmed cell death in the developing nervous system
86. Defining apoptosis
87. Vascular permeability in experimental spinal cord injury
88. Biomechanical responses to open experimental spinal cord injury
89. Nonhemorrhagic venous infarction of the spinal cord
90. Local spinal cord blood flow in experimental traumatic myelopathy
91. Altered spinal cord blood flow as affected by changes in systemic arterial blood pressure
92. Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts: 1. Normal spinal cord
93. Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts: 2. Acute spinal cord injury
94. Silicone rubber microangiography of acute spinal cord injury in the rat
95. Epidemiologic features of head and spinal cord injury
96. Injury to the head and spinal cord: The epidemiological relevance of the medical literature published from 1960 to 1978
97. Incidence of traumatic spinal cord lesions
98. Epidemiology of spinal cord injury
99. Role of monoamines in experimental spinal cord injury in rats: Relationship between Na+-K+-ATPase and lipid peroxidation
100. Epidemiology of spinal cord injury
101. Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord
102. Neuronal and glial apoptosis after traumatic spinal cord injury
103. Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury
104. In vivo Bcl-2 oncogene neuronal expression in the rat spinal cord
105. Apoptosis, oncosis, and necrosis: An overview of cell death
106. Effect of multiple trauma on mortality and neurological recovery after spinal cord or cauda equina injury
107. Pelvis and limb injuries in patients with recent spinal cord injuries
108. Injuries to the spine
109. Paramagnetic species and radical products in cat spinal cord
110. Epidemiology of spinal cord injury in the Rhone-Alpes Region, France, 1970-75
111. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia
112. Morphological evidence of microcirculatory disturbances in experimental spinal cord trauma
113. Correlation between histopathologic features and magnetic resonance images of spinal cord lesions
114. Altered norepinephrine metabolism, following experimental spinal cord injury: 2. Protection against traumatic spinal cord hemorrhagic necrosis by norepinephrine synthesis blockade with alpha methyl tyrosine
115. Apoptosis in the nervous system in experimental allergic encephalomyelitis
116. Loss of ascorbic acid from injured feline spinal cord
117. Acute myelo secondary to spinal venous thrombosis
118. Evidence of apoptotic ofapoptotic cell death after experimental traumatic brain injury in the rat
119. Regional spinal cord blood flow in rats after severe cord trauma
120. The biomechanics of spinal injuries
121. Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates
122. Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue
123. Altered blood flow and secondary injury in experimental spinal cord trauma
124. Loss of autoregulation and posttraumatic ischemia following experimental spinal cord trauma
125. Microangiographic study of spinal cord injury and myelopathy
126. Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats
127. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
128. Vascular permeability changes in the contused feline spinal cord
129. The epidemiology and economics of spinal cord injury
130. The cost of economic consequences of traumatic spinal cord injury
131. The prevention of violent spinal cord injuries
132. Superoxide radicals play important roles in the pathogenesis of spinal cord injury
133. Spine-spinal cord relationships in spinal cordtrauma
134. Review of experimental spinal cord injury with emphasis on the local and systemic circulatory effects
135. Update on the pathophysiology and pathology of acute spinal cord injury
136. Epidemiology and general characteristics of the spinal cordinjured patient
137. Changes in epidemiology of acute spinal cord injury from 1947 to 1981
138. Complications and costs of management of acute spinal cord injury
139. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
140. Vascular mechanisms in the pathophysiology of human spinal cord injury
141. Effect of trauma dose on spinal cord edema
142. Relationship between posttraumatic ischemia and hemorrhage in the injured rat spinal cord as shown by colloidal carbon angiography
143. Local hypothermia in experimental spinal cord trauma
144. The disturbance of circulation in traumatic paraplegia in acute and late stages: A pathological study
145. Spinal cord injury: Associated general trauma and medical complications
146. Effect of sympathectomy on spinal blood flow autoregulation and posttraumatic ischemia
147. The role of the sympathetic nervous system in pressor responses induced by spinal injury
148. Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury
149. Potassium and calcium changes in injured spinal cords