Neuronal dysfunction in chronic spinal cord injury

Spinal Cord

Volumn 49, Issue 5, 2011, Pages 582-587

  Hubli, M ^a   Bolliger, M ^a   Dietz, V ^a  

^a BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

chronic spinal cord injury; locomotor activity; neuronal dysfunction; spinal reflex

Indexed keywords

BRAIN FUNCTION; ELECTROMYOGRAPHY; HUMAN; LOCOMOTION; MESENCEPHALON; NERVE CELL; NERVE DEGENERATION; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY;

CHRONIC DISEASE; HUMANS; NEURONS; PARALYSIS; SPINAL CORD; SPINAL CORD INJURIES;

EID: 79955835945     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2010.147     Document Type: Review

References (51)

1. Raineteau O, Schwab ME. Plasticity of motor systems after incomplete spinal cord injury. NatRev Neurosci 2001; 2: 263-273. (Pubitemid 33673067)
2. Buchli AD, Rouiller E, Mueller R, Dietz V, Schwab ME. Repair of the injured spinal cord. A joint approach of basic and clinical research. Neuro-Degenerative Diseases 2007; 4: 51-56. (Pubitemid 46586560)
3. Zeman RJ, Feng Y, Peng H, Visintainer PF, Moorthy CR, Couldwell WT et al. X-irradiation of the contusion site improves locomotor and histological outcomes in spinal cord-injured rats. Exp neurol 2001; 172: 228-234. (Pubitemid 33141168)
4. Raisman G. A promising therapeutic approach to spinal cord repair. J R So Med 2003; 96: 259-261. (Pubitemid 36714050)
5. Dietz V, Curt A. Neurological aspects of spinal-cord repair: promises and challenges. Lancet neurol 2006; 5: 688-694. (Pubitemid 44062418)
6. Deumens R, Koopmans GC, Joosten EA. Regeneration of descending axon tracts after spinal cord injury. Prog Neurobiol 2005; 77: 57-89. (Pubitemid 41654773)
7. Richter MW, Roskams AJ. Olfactory ensheathing cell transplanta-tion following spinal cord injury: hype or hope? Exp neurol 2008; 209: 353-367. (Pubitemid 351174130)
8. Ramon-Cueto A, Cordero MI, Santos-Benito FF, Avila J. Func-tional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 2000; 25: 425-435.
9. Li Y, Field PM, Raisman G. Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science (New York, N.Y) 1997; 277: 2000-2002. (Pubitemid 27449143)
10. Barnett SC, Chang L. Olfactory ensheathing cells and CNS repair: going solo or in need of a friend? Trends Neurosci 2004; 27: 54-60. (Pubitemid 38040070)
11. Chhabra HS, Lima C, Sachdeva S, Mittal A, Nigam V, Chaturvedi D et al. Autologous olfactory mucosal transplant in chronic spinal cord injury: an Indian Pilot Study Spinal Cord 2009; 47: 887-895.
12. Curt A, Dietz V. Controversial treatments for spinal-cord injuries. Lancet 2005; 365: 841.
13. Dobkin BH, Curt A, Guest J. Cellular transplants in China: observational study from the largest human experiment in chronic spinal cord injury Neurorehabil Neural Repair 2006; 20: 5-13. (Pubitemid 43214453)
14. Mackay-Sim A, Feron F, Cochrane J, Bassingthwaighte L, Bayliss C, Davies W et al. Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. Brain 2008; 131(Part 9): 2376-2386.
15. Lima C, Escada P, Pratas-Vital J, Branco C, Arcangeli CA, Lazzeri G et al. Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury Neurorehabil Neural Repair 2010; 24: 10-22.
16. Klapka N, Hermanns S, Straten G, Masanneck C, Duis S, Hamers FP et al. Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur J Neurosci 2005; 22: 3047-3058. (Pubitemid 43001988)
17. Houle JD, Tessler A. Repair of chronic spinal cord injury Exp Neurol 2003; 182: 247-260.
18. Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Morshead CM, Fehlings MG. Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci 2006; 26: 3377-3389.
19. Nomura H, Baladie B, Katayama Y, Morshead CM, Shoichet MS, Tator CH. Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury. Neurosurgery 2008; 63: 127-141;discussion 141-3.
20. Ye JH, Houle JD. Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Exp Neurol 1997; 143: 70-81. (Pubitemid 27049133)
21. Dietz V, Grillner S, Trepp A, Hubli M, Bolliger M. Changes in spinal reflex and locomotor activity after a complete spinal cord injury: a common mechanism? Brain 2009; 132(Part 8): 2196-2205.
22. Dietz V, Muller R. Degradation of neuronal function following a spinal cord injury: mechanisms and countermeasures. Brain 2004; 127(Part 10): 2221-2231. (Pubitemid 39382231)
23. Lavrov I, Gerasimenko YP, Ichiyama RM, Courtine G, Zhong H, Roy RR et al. Plasticity of spinal cord reflexes after a complete transection in adult rats: relationship to stepping ability. J Neurophysiol 2006; 96: 1699-1710. (Pubitemid 44527427)
24. Dietz V, Colombo G, Jensen L. Locomotor activity in spinal man. Lancet 1994; 344: 1260-1263. (Pubitemid 24334682)
25. Dietz V, Muller R, Colombo G. Locomotor activity in spinal man: significance of afferent input from joint and load receptors. Brain 2002; 125(Part 12): 2626-2634. (Pubitemid 35423512)
26. Halder P, Curt A, Brem S, Lang-Dullenkopf A, Bucher K, Kollias S et al. Preserved aspects of cortical foot control in paraplegia. NeuroImage 2006; 31: 692-698. (Pubitemid 43776677)
27. Dietz V, Harkema SJ. Locomotor activity in spinal cord-injured persons. J Appl Physiol 2004; 96: 1954-1960. (Pubitemid 38580025)
28. Hiersemenzel LP, Curt A, Dietz V. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury Neurology 2000; 54: 1574-1582. (Pubitemid 30226799)
29. Jones CA, Yang JF. Reflex behavior during walking in incomplete spinal-cord-injured subjects. Exp Neurol 1994; 128: 239-248. (Pubitemid 24376953)
30. Dietz V, Colombo G, Jensen L, Baumgartner L. Locomotor capacity of spinal cord in paraplegic patients. Ann Neurol 1995; 37: 574-582.
31. Dietz V, Quintern J, Berger W. Electrophysiological studies of gait in spasticity and rigidity Evidence that altered mechanical properties of muscle contribute to hypertonia. Brain 1981; 104: 431-449. (Pubitemid 12202190)
32. O'Dwyer NJ, Ada L, Neilson PD. Spasticity and muscle contrac-ture following stroke. Brain 1996; 119(Part 5): 1737-1749. (Pubitemid 26375740)
33. Ibrahim IK, Berger W, Trippel M, Dietz V. Stretch-induced electromyographic activity and torque in spastic elbow muscles. Differential modulation of reflex activity in passive and active motor tasks. Brain 1993; 116(Part 4): 971-989. (Pubitemid 23242818)
34. Lieber RL, Friden J. Spasticity causes a fundamental rearrange-ment of muscle-joint interaction. Muscle Nerve 2002; 25: 265-270. (Pubitemid 34117075)
35. Dietz V, Sinkjaer T. Spastic movement disorder: impaired reflex function and altered muscle mechanics. Lancet Neurol 2007; 6: 725-733. (Pubitemid 47058387)
36. Dietz V. Behavior of spinal neurons deprived of supraspinal input. Nat Rev Neurol 2010; 6: 167-174.
37. Muller R, Dietz V. Neuronal function in chronic spinal cord injury: divergence between locomotor and flexion-and H-reflex activity Clin Neurophysiol 2006; 117: 1499-1507. (Pubitemid 43947703)
38. Burns AS, Lemay MA, Tessler A. Abnormal spontaneous poten-tials in distal muscles in animal models of spinal cord injury. Muscle Nerve 2005; 31: 46-51. (Pubitemid 40053926)
39. Ginsberg SD, Martin LJ. Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons. J Neurotrauma 2002; 19: 99-109. (Pubitemid 34117099)
40. Wu YP, Ling EA. Transsynaptic changes of neurons and associated microglial reaction in the spinal cord of rats following middle cerebral artery occlusion. Neurosci Lett 1998; 256: 41-44.
41. Aisen ML, Brown W, Rubin M. Electrophysiologic changes in lumbar spinal cord after cervical cord injury Neurology 1992; 42 (3 Part 1): 623-626.
42. Chang CW. Evident transsynaptic degeneration of motor neurons after spinal cord injury: a study of neuromuscular jitter by axonal microstimulation. Am J Phy Med Rehabil/Association of Academic Physiatrists 1998; 77: 118-121.
43. Lin CS, Macefield VG, Elam M, Wallin BG, Engel S, Kiernan MC. Axonal changes in spinal cord injured patients distal to the site of injury Brain 2007; 130(Part 4): 985-994. (Pubitemid 47355583)
44. Nyboer VJ, Johnson HE. Electromyographic findings in lower extremities of patients with traumatic quadriplegia. Arch Phys MedRehabil 1971; 52: 256-259.
45. Grillner S, Deliagina T, Ekeberg O, el Manira A, Hill RH, Lansner A et al. Neural networks that co-ordinate locomotion and body orientation in lamprey. Trends Neurosci 1995; 18: 270-279.
46. Ichiyama RM, BromanJ, Edgerton VR, Havton LA. Ultrastructural synaptic features differ between alpha-and gamma-motoneurons innervating the tibialis anterior muscle in the rat. J Comp Neurol 2006; 499: 306-315. (Pubitemid 44454068)
47. Tillakaratne NJ, de Leon RD, Hoang TX, Roy RR, Edgerton VR, Tobin AJ. Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord. J Neurosci 2002; 22: 3130-3143. (Pubitemid 35379202)
48. de Leon RD, Tamaki H, Hodgson JA, Roy RR, Edgerton VR. Hindlimb locomotor and postural training modulates glycinergic inhibition in the spinal cord of the adult spinal cat J Neurophysiol 1999; 82: 359-369. (Pubitemid 29330090)
49. Maier IC, Ichiyama RM, Courtine G, Schnell L, Lavrov I, Edgerton VR et al. Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury. Brain 2009; 132(Part 6): 1426-1440.
50. Garcia-Alias G, Barkhuysen S, Buckle M, Fawcett JW. Chondroi-tinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nat Neurosci 2009; 12: 1145-1151.
51. Wirz M, Zemon DH, Rupp R, Scheel A, Colombo G, Dietz V et al. Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial. Arch Phys Med Rehabil 2005; 86: 672-680. (Pubitemid 40487831)