메뉴 건너뛰기




Volumn 33, Issue 2, 2012, Pages 277-285

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin

Author keywords

secretase; Aph 1; Mutagenesis; Nct; PS; Transmembrane domain

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; NICASTRIN; PRESENILIN;

EID: 82755191634     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2009.12.028     Document Type: Article
Times cited : (7)

References (32)
  • 1
    • 0033497867 scopus 로고    scopus 로고
    • Schematic representation of residue-based protein context-dependent data: an application to transmembrane proteins
    • Campagne F., Weinstein H. Schematic representation of residue-based protein context-dependent data: an application to transmembrane proteins. J. Mol. Graph. Modell 1999, 17:207-213.
    • (1999) J. Mol. Graph. Modell , vol.17 , pp. 207-213
    • Campagne, F.1    Weinstein, H.2
  • 2
    • 50649119079 scopus 로고    scopus 로고
    • Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
    • Chavez-Gutierrez L., Tolia A., Maes E., Li T., Wong P.C., de Strooper B. Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. J. Biol. Chem 2008, 283:20096-20105.
    • (2008) J. Biol. Chem , vol.283 , pp. 20096-20105
    • Chavez-Gutierrez, L.1    Tolia, A.2    Maes, E.3    Li, T.4    Wong, P.C.5    de Strooper, B.6
  • 3
    • 70350353076 scopus 로고    scopus 로고
    • GLU333 of nicastrin directly participates in gamma-secretase activity
    • Dries D.R., Shah S., Han Y.H., Yu C., Yu S., Shearman M.S., Yu G. GLU333 of nicastrin directly participates in gamma-secretase activity. J. Biol. Chem 2009, 284(43):29714-29724.
    • (2009) J. Biol. Chem , vol.284 , Issue.43 , pp. 29714-29724
    • Dries, D.R.1    Shah, S.2    Han, Y.H.3    Yu, C.4    Yu, S.5    Shearman, M.S.6    Yu, G.7
  • 5
    • 0942298101 scopus 로고    scopus 로고
    • Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex
    • Fortna R.R., Crystal A.S., Morais V.A., Pijak D.S., Lee V.M., Doms R.W. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex. J. Biol. Chem 2004, 279:3685-3693.
    • (2004) J. Biol. Chem , vol.279 , pp. 3685-3693
    • Fortna, R.R.1    Crystal, A.S.2    Morais, V.A.3    Pijak, D.S.4    Lee, V.M.5    Doms, R.W.6
  • 6
    • 0347093518 scopus 로고    scopus 로고
    • Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex
    • Fraering P.C., LaVoie M.J., Ye W., Ostaszewski B.L., Kimberly W.T., Selkoe D.J., Wolfe M.S. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry 2004, 43:323-333.
    • (2004) Biochemistry , vol.43 , pp. 323-333
    • Fraering, P.C.1    LaVoie, M.J.2    Ye, W.3    Ostaszewski, B.L.4    Kimberly, W.T.5    Selkoe, D.J.6    Wolfe, M.S.7
  • 8
    • 0036898485 scopus 로고    scopus 로고
    • Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases
    • Haass C., Steiner H. Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends Cell Biol 2002, 12:556-562.
    • (2002) Trends Cell Biol , vol.12 , pp. 556-562
    • Haass, C.1    Steiner, H.2
  • 9
    • 0038360879 scopus 로고    scopus 로고
    • Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
    • Hu Y., Fortini M.E. Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J. Cell Biol 2003, 161:685-690.
    • (2003) J. Cell Biol , vol.161 , pp. 685-690
    • Hu, Y.1    Fortini, M.E.2
  • 10
    • 0036007117 scopus 로고    scopus 로고
    • Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor
    • Hu Y., Ye Y., Fortini M.E. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2002, 2:69-78.
    • (2002) Dev. Cell , vol.2 , pp. 69-78
    • Hu, Y.1    Ye, Y.2    Fortini, M.E.3
  • 11
    • 0037076540 scopus 로고    scopus 로고
    • GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles
    • Kleiger G., Grothe R., Mallick P., Eisenberg D. GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles. Biochemistry 2002, 41:5990-5997.
    • (2002) Biochemistry , vol.41 , pp. 5990-5997
    • Kleiger, G.1    Grothe, R.2    Mallick, P.3    Eisenberg, D.4
  • 12
    • 0033947073 scopus 로고    scopus 로고
    • Interactive construction of residue-based diagrams of proteins: the RbDe web service
    • Konvicka K., Campagne F., Weinstein H. Interactive construction of residue-based diagrams of proteins: the RbDe web service. Protein Eng 2000, 13:395-396.
    • (2000) Protein Eng , vol.13 , pp. 395-396
    • Konvicka, K.1    Campagne, F.2    Weinstein, H.3
  • 13
    • 0141733241 scopus 로고    scopus 로고
    • Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin
    • LaVoie M.J., Fraering P.C., Ostaszewski B.L., Ye W., Kimberly W.T., Wolfe M.S., Selkoe D.J. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J. Biol. Chem 2003, 278:37213-37222.
    • (2003) J. Biol. Chem , vol.278 , pp. 37213-37222
    • LaVoie, M.J.1    Fraering, P.C.2    Ostaszewski, B.L.3    Ye, W.4    Kimberly, W.T.5    Wolfe, M.S.6    Selkoe, D.J.7
  • 16
    • 0037659067 scopus 로고    scopus 로고
    • Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals
    • Li T., Ma G., Cai H., Price D.L., Wong P.C. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. J. Neurosci 2003, 23:3272-3277.
    • (2003) J. Neurosci , vol.23 , pp. 3272-3277
    • Li, T.1    Ma, G.2    Cai, H.3    Price, D.L.4    Wong, P.C.5
  • 18
    • 12144250683 scopus 로고    scopus 로고
    • APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
    • Ma G., Li T., Price D.L., Wong P.C. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci 2005, 25:192-198.
    • (2005) J. Neurosci , vol.25 , pp. 192-198
    • Ma, G.1    Li, T.2    Price, D.L.3    Wong, P.C.4
  • 19
    • 70349093083 scopus 로고    scopus 로고
    • Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators
    • Panza F., Solfrizzi V., Frisardi V., Capurso C., D'Introno A., Colacicco A.M., Vendemiale G., Capurso A., Imbimbo B.P. Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators. Drugs Aging 2009, 26:537-555.
    • (2009) Drugs Aging , vol.26 , pp. 537-555
    • Panza, F.1    Solfrizzi, V.2    Frisardi, V.3    Capurso, C.4    D'Introno, A.5    Colacicco, A.M.6    Vendemiale, G.7    Capurso, A.8    Imbimbo, B.P.9
  • 21
    • 2542454942 scopus 로고    scopus 로고
    • Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex
    • Prokop S., Shirotani K., Edbauer D., Haass C., Steiner H. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. J. Biol. Chem 2004, 279:23255-23261.
    • (2004) J. Biol. Chem , vol.279 , pp. 23255-23261
    • Prokop, S.1    Shirotani, K.2    Edbauer, D.3    Haass, C.4    Steiner, H.5
  • 23
    • 0034711958 scopus 로고    scopus 로고
    • Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions
    • Senes A., Gerstein M., Engelman D.M. Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. J. Mol. Biol 2000, 296:921-936.
    • (2000) J. Mol. Biol , vol.296 , pp. 921-936
    • Senes, A.1    Gerstein, M.2    Engelman, D.M.3
  • 26
    • 3042520872 scopus 로고    scopus 로고
    • Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1
    • Shirotani K., Edbauer D., Kostka M., Steiner H., Haass C. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. J. Neurochem 2004, 89:1520-1527.
    • (2004) J. Neurochem , vol.89 , pp. 1520-1527
    • Shirotani, K.1    Edbauer, D.2    Kostka, M.3    Steiner, H.4    Haass, C.5
  • 27
    • 4744375540 scopus 로고    scopus 로고
    • Identification of distinct gamma-secretase complexes with different APH-1 variants
    • Shirotani K., Edbauer D., Prokop S., Haass C., Steiner H. Identification of distinct gamma-secretase complexes with different APH-1 variants. J. Biol. Chem 2004, 279:41340-41345.
    • (2004) J. Biol. Chem , vol.279 , pp. 41340-41345
    • Shirotani, K.1    Edbauer, D.2    Prokop, S.3    Haass, C.4    Steiner, H.5
  • 28
    • 0042591493 scopus 로고    scopus 로고
    • Building protein diagrams on the web with the residue-based diagram editor RbDe
    • Skrabanek L., Campagne F., Weinstein H. Building protein diagrams on the web with the residue-based diagram editor RbDe. Nucleic Acids Res 2003, 31:3856-3858.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3856-3858
    • Skrabanek, L.1    Campagne, F.2    Weinstein, H.3
  • 29
    • 58049193592 scopus 로고    scopus 로고
    • Chemical crosslinking provides a model of the gamma -secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1
    • Steiner H., Winkler E., Haass C. Chemical crosslinking provides a model of the gamma -secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. J. Biol. Chem 2008, 283:34677-34686.
    • (2008) J. Biol. Chem , vol.283 , pp. 34677-34686
    • Steiner, H.1    Winkler, E.2    Haass, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.