Oral tolerance induction by partially hydrolyzed whey protein in mice is associated with enhanced numbers of Foxp3 + regulatory T-cells in the mesenteric lymph nodes

Pediatric Allergy and Immunology

Volumn 22, Issue 8, 2011, Pages 820-826

  van Esch, Betty C A M ^a,b   Schouten, Bastiaan ^a   de Kivit, Sander ^a   Hofman, Gerard A ^a   Knippels, Léon M J ^a,b   Willemsen, Linette E M ^a   Garssen, Johan ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b DANONE RESEARCH   (Netherlands)

Author keywords

Avoidance, prevention; Cow's milk allergy; Extensive whey hydrolyzates; Food allergy; Foxp3 + regulatory T cells; Hypoallergenic formulas; Oral tolerance; Partial whey hydrolyzates; Transfer

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; MAST CELL DEGRANULATING PEPTIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MESENTERY LYMPH NODE; MILK ALLERGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; REGULATORY T LYMPHOCYTE; SENSITIZATION; SKIN ALLERGY; TH1 CELL; TH2 CELL; WHEY;

ADMINISTRATION, ORAL; ALLERGENS; ANIMALS; CELLS, CULTURED; CHYMASES; DESENSITIZATION, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; HYDROLYSIS; IMMUNE TOLERANCE; IMMUNOGLOBULIN E; LYMPH NODES; MESENTERY; MICE; MICE, INBRED C3H; MILK HYPERSENSITIVITY; MILK PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH1-TH2 BALANCE;

EID: 82455212055     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2011.01205.x     Document Type: Article

References (26)

1. Ozdemir C, Akdis M, Akdis CA. T regulatory cells and their counterparts: masters of immune regulation. Clin Exp Allergy 2009: 39: 626-39.
2. Dubois B, Goubier A, Joubert G, Kaiserlian D. Oral tolerance and regulation of mucosal immunity. Cell Mol Life Sci 2005: 62: 1322-32.
3. Chehade M, Mayer L. Oral tolerance and its relation to food hypersensitivities. J Allergy Clin Immunol 2005: 115: 3-12. quiz 3.
4. Fukaya T, Takagi H, Sato Y, et al. Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance. Blood 2010: 116: 2266-76.
5. Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004: 199: 1679-88.
6. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 2009: 123: 43-52 e7.
7. Von Berg A, Koletzko S, Grubl A, et al. The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol 2003: 111: 533-40.
8. Halken S, Hansen KS, Jacobsen HP, et al. Comparison of a partially hydrolyzed infant formula with two extensively hydrolyzed formulas for allergy prevention: a prospective, randomized study. Pediatr Allergy Immunol 2000: 11: 149-61.
9. Chan YH, Shek LP, Aw M, Quak SH, Lee BW. Use of hypoallergenic formula in the prevention of atopic disease among Asian children. J Paediatr Child Health 2002: 38: 84-8.
10. Host A, Halken S, Muraro A, et al. Dietary prevention of allergic diseases in infants and small children. Pediatr Allergy Immunol 2008: 19: 1-4.
11. Hays T, Wood RA. A systematic review of the role of hydrolyzed infant formulas in allergy prevention. Arch Pediatr Adolesc Med 2005: 159: 810-6.
12. Von Der Weid T, Bulliard C, Fritsche R. Suppression of specific and bystander IgE responses in a mouse model of oral sensitization to beta-lactoglobulin. Int Arch Allergy Immunol 2001: 125: 307-15.
13. Christensen HR, Kjaer TM, Frokiaer H. Low-dose oral tolerance due to antigen in the diet suppresses differentially the cholera toxin-adjuvantized IgE, IgA and IgG response. Int Arch Allergy Immunol 2003: 132: 248-57.
14. Kato H, Fujihashi K, Kato R, Yuki Y, Mcghee JR. Oral tolerance revisited: prior oral tolerization abrogates cholera toxin-induced mucosal IgA responses. J Immunol 2001: 166: 3114-21.
15. Frossard CP, Tropia L, Hauser C, Eigenmann PA. Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy. J Allergy Clin Immunol 2004: 113: 958-64.
16. Van Esch BC, Schouten B, Hofman GA, et al. Acute allergic skin response as a new tool to evaluate the allergenicity of whey hydrolysates in a mouse model of orally induced cow's milk allergy. Pediatr Allergy Immunol 2010: 21(4Pt2): e780-6. Epub accepted 2009
17. Schouten B, Van Esch BC, Hofman GA, et al. Cow milk allergy symptoms are reduced in mice fed dietary synbiotics during oral sensitization with whey. J Nutr 2009: 139: 1398-403.
18. Kashyap M, Thornton AM, Norton SK, et al. Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol 2008: 180: 2039-43.
19. Gri G, Piconese S, Frossi B, et al. CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity 2008: 29: 771-81.
20. Peng HJ, Su SN, Tsai JJ, et al. Effect of ingestion of cow's milk hydrolysed formulas on whey protein-specific Th2 immune responses in naive and sensitized mice. Clin Exp Allergy 2004: 34: 663-70.
21. Fritsche R, Pahud JJ, Pecquet S, Pfeifer A. Induction of systemic immunologic tolerance to beta-lactoglobulin by oral administration of a whey protein hydrolysate. J Allergy Clin Immunol 1997: 100: 266-73.
22. Pecquet S, Bovetto L, Maynard F, Fritsche R. Peptides obtained by tryptic hydrolysis of bovine beta-lactoglobulin induce specific oral tolerance in mice. J Allergy Clin Immunol 2000: 105: 514-21.
23. Thorstenson KM, Khoruts A. Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J Immunol 2001: 167: 188-95.
24. Zhang X, Izikson L, Liu L, Weiner HL. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol 2001: 167: 4245-53.
25. Hauet-Broere F, Unger WW, Garssen J, et al. Functional CD25- and CD25+ mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48h after oral antigen application. Eur J Immunol 2003: 33: 2801-10.
26. Tsuji NM, Kosaka A. Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells. Trends Immunol 2008: 29: 532-40.