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Volumn 92, Issue 1, 2011, Pages 45-53

Impact of the penicillium chrysogenum genome on industrial production of metabolites

Author keywords

Antibiotics; Genomics; Industrial production; Metabolites; Penicillium chrysogenum

Indexed keywords

CURRENT PRODUCTION; GENOME SEQUENCES; GENOMICS; INDUSTRIAL PRODUCTION; INTRACELLULAR METABOLISM; PENICILLIUM CHRYSOGENUM; REBALANCING; STRAIN IMPROVEMENT;

EID: 82455164305     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3476-z     Document Type: Review
Times cited : (34)

References (93)
  • 1
    • 0036321084 scopus 로고    scopus 로고
    • Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum
    • DOI 10.1007/s00438-002-0697-y
    • Abe Y, Suzuki T, Ono C, Iwamoto K, Hosobuchi M, Yoshikawa H (2002) Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. Mol Genet Genomics 267:636-646 (Pubitemid 34824193)
    • (2002) Molecular Genetics and Genomics , vol.267 , Issue.5 , pp. 636-646
    • Abe, Y.1    Suzuki, T.2    Ono, C.3    Iwamoto, K.4    Hosobuchi, M.5    Yoshikawa, H.6
  • 2
    • 0033799520 scopus 로고    scopus 로고
    • The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production
    • Andrade AC, Van Nistelrooy JG, Peery RB, Skatrud PL, De Waard MA (2000) The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production. Mol Gen Genet 263:966-977
    • (2000) Mol Gen Genet , vol.263 , pp. 966-977
    • Andrade, A.C.1    Van Nistelrooy, J.G.2    Peery, R.B.3    Skatrud, P.L.4    De Waard, M.A.5
  • 3
    • 4143090400 scopus 로고    scopus 로고
    • LaeA, a regulator of secondary metabolism in Aspergillus spp
    • DOI 10.1128/EC.3.2.527-535.2004
    • Bok JW, Keller NP (2004) LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell 3:527-535 (Pubitemid 38497990)
    • (2004) Eukaryotic Cell , vol.3 , Issue.2 , pp. 527-535
    • Bok, J.W.1    Keller, N.P.2
  • 5
    • 78650198931 scopus 로고    scopus 로고
    • Fungal secondary metabolites-strategies to activate silent gene clusters
    • Brakhage AA, Schroeckh V (2011) Fungal secondary metabolites-strategies to activate silent gene clusters. Fungal Genet Biol 48:15-22
    • (2011) Fungal Genet Biol , vol.48 , pp. 15-22
    • Brakhage, A.A.1    Schroeckh, V.2
  • 6
    • 20444417098 scopus 로고    scopus 로고
    • Evolution of β-lactam biosynthesis genes and recruitment of trans-acting factors
    • DOI 10.1016/j.phytochem.2005.02.030, PII S0031942205001822
    • Brakhage AA, Al-Abdallah Q, Tüncher A, Spröte P (2005) Evolution of beta-lactam biosynthesis genes and recruitment of trans-Acting factors. Phytochemistry 66:1200-1210 (Pubitemid 40793874)
    • (2005) Phytochemistry , vol.66 , Issue.11 SPEC. ISS. , pp. 1200-1210
    • Brakhage, A.A.1    Al-Abdallah, Q.2    Tuncher, A.3    Sprote, P.4
  • 8
    • 35848941193 scopus 로고    scopus 로고
    • Transposons in biotechnologically relevant strains of Aspergillus niger and Penicillium chrysogenum
    • DOI 10.1016/j.fgb.2007.07.010, PII S1087184507001338
    • Braumann I, van den Berg MA, Kempken F (2007) Transposons in biotechnologically relevant strains of Aspergillus niger and Penicillium chrysogenum. Fungal Genet Biol 44:1399-1414 (Pubitemid 350054918)
    • (2007) Fungal Genetics and Biology , vol.44 , Issue.12 , pp. 1399-1414
    • Braumann, I.1    Van Den Berg, M.2    Kempken, F.3
  • 9
    • 42249109368 scopus 로고    scopus 로고
    • Repeat induced point mutation in two asexual fungi, Aspergillus niger and Penicillium chrysogenum
    • Braumann I, van den Berg MA, Kempken F (2008) Repeat induced point mutation in two asexual fungi, Aspergillus niger and Penicillium chrysogenum. Curr Genet 53:287-297
    • (2008) Curr Genet , vol.53 , pp. 287-297
    • Braumann, I.1    Van Den Berg, M.A.2    Kempken, F.3
  • 11
    • 79952535527 scopus 로고    scopus 로고
    • Comparison of the secondary metabolites in Penicillium chrysogenum between pilot and industrial penicillin G fermentations
    • Cao YX, Qiao B, Lu H, Chen Y, Yuan YJ (2011) Comparison of the secondary metabolites in Penicillium chrysogenum between pilot and industrial penicillin G fermentations. Appl Microbiol Biotechnol 89:1193-1202
    • (2011) Appl Microbiol Biotechnol , vol.89 , pp. 1193-1202
    • Cao, Y.X.1    Qiao, B.2    Lu, H.3    Chen, Y.4    Yuan, Y.J.5
  • 12
    • 77954200418 scopus 로고    scopus 로고
    • Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum
    • Chooi YH, Cacho R, Tang Y (2010) Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol 17:483-494
    • (2010) Chem Biol , vol.17 , pp. 483-494
    • Chooi, Y.H.1    Cacho, R.2    Tang, Y.3
  • 14
    • 77956255989 scopus 로고    scopus 로고
    • Intracellular metabolite determination in the presence of extracellular abundance: Application to the penicillin biosynthesis pathway in Penicillium chrysogenum
    • Douma RD, de Jonge LP, Jonker CT, Seifar RM, Heijnen JJ, van Gulik WM (2010a) Intracellular metabolite determination in the presence of extracellular abundance: Application to the penicillin biosynthesis pathway in Penicillium chrysogenum. Biotechnol Bioeng 107:105-115
    • (2010) Biotechnol Bioeng , vol.107 , pp. 105-115
    • Douma, R.D.1    De Jonge, L.P.2    Jonker, C.T.3    Seifar, R.M.4    Heijnen, J.J.5    Van Gulik, W.M.6
  • 15
    • 77954306424 scopus 로고    scopus 로고
    • Dynamic gene expression regulation model for growth and penicillin production in Penicillium chrysogenum
    • Douma RD, Verheijen PJ, de Laat WT, Heijnen JJ, van Gulik WM (2010b) Dynamic gene expression regulation model for growth and penicillin production in Penicillium chrysogenum. Biotechnol Bioeng 106:608-618
    • (2010) Biotechnol Bioeng , vol.106 , pp. 608-618
    • Douma, R.D.1    Verheijen, P.J.2    De Laat, W.T.3    Heijnen, J.J.4    Van Gulik, W.M.5
  • 17
    • 34547438062 scopus 로고    scopus 로고
    • University of Wisconsin contributions to the early development of penicillin and cephalosporin antibiotics
    • Elander RP (2002) University of Wisconsin contributions to the early development of penicillin and cephalosporin antibiotics. SIM News 52:270-278
    • (2002) SIM News , vol.52 , pp. 270-278
    • Elander, R.P.1
  • 18
    • 13544276953 scopus 로고    scopus 로고
    • The ABC transporter gene in the sirodesmin biosynthetic gene cluster of Leptosphaeria maculans is not essential for sirodesmin production but facilitates self-protection
    • DOI 10.1016/j.fgb.2004.12.001
    • Gardiner DM, Jarvis RS, Howlett BJ (2005) The ABC transporter gene in the sirodesmin biosynthetic gene cluster of Leptosphaeria maculans is not essential for sirodesmin production but facilitates self-protection. Fungal Genet Biol 42:257-263 (Pubitemid 40222107)
    • (2005) Fungal Genetics and Biology , vol.42 , Issue.3 , pp. 257-263
    • Gardiner, D.M.1    Jarvis, R.S.2    Howlett, B.J.3
  • 20
    • 0028998750 scopus 로고
    • The penicillin biosynthetic gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences
    • Fierro F, Barredo JL, Diez B, Gutierrez S, Fernandez FJ, Martin JF (1995) The penicillin biosynthetic gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc Natl Acad Sci U S A 92:6200-6204
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 6200-6204
    • Fierro, F.1    Barredo, J.L.2    Diez, B.3    Gutierrez, S.4    Fernandez, F.J.5    Martin, J.F.6
  • 21
    • 0030070112 scopus 로고    scopus 로고
    • Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin gene cluster at a specific site within a conserved hexanucleotide sequence
    • DOI 10.1007/s002530050605
    • Fierro F, Montenegro E, Gutierrez S, Martin JF (1996) Mutants blocked in penicillin biosynthesis show a deletion of the entire penicillin biosynthetic gene cluster at a specific site within a conserved hexanucleotide sequence. Appl Microbiol Biotechnol 44:597-604 (Pubitemid 26051900)
    • (1996) Applied Microbiology and Biotechnology , vol.44 , Issue.5 , pp. 597-604
    • Fierro, F.1    Montenegro, E.2    Gutierrez, S.3    Martin, J.F.4
  • 22
    • 0000378637 scopus 로고
    • On the antibacterial action of cultures of Penicillium, with special reference to their use in the isolation of B. influenzae
    • Fleming A (1929) On the antibacterial action of cultures of Penicillium, with special reference to their use in the isolation of B. influenzae. Br J Exp Pathol 10:226-236
    • (1929) Br J Exp Pathol , vol.10 , pp. 226-236
    • Fleming, A.1
  • 24
    • 54949084693 scopus 로고    scopus 로고
    • The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum
    • García-Rico RO, Fierro F, Mauriz E, Gómez A, Fernández-Bodega MA, Martín JF (2008) The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum. Microbiology 154:3567-3578
    • (2008) Microbiology , vol.154 , pp. 3567-3578
    • García-Rico, R.O.1    Fierro, F.2    Mauriz, E.3    Gómez, A.4    Fernández-Bodega, M.A.5    Martín, J.F.6
  • 27
    • 0034691228 scopus 로고    scopus 로고
    • Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G
    • DOI 10.1002/(SICI)1097-0290(20000620)68:6<602::AID-BIT3>3.0.CO;2-2
    • van Gulik WM, de Laat WT, Vinke JL, Heijnen JJ (2000) Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G. Biotechnol Bioeng 20:602-618 (Pubitemid 30341439)
    • (2000) Biotechnology and Bioengineering , vol.68 , Issue.6 , pp. 602-618
    • Van Gulik, W.M.1    De Laat, W.T.A.M.2    Vinke, J.L.3    Heijnen, J.J.4
  • 29
    • 79955587715 scopus 로고    scopus 로고
    • Versatile enzyme expression and characterization system for Aspergillus nidulans, with the Penicillium brevicompactum polyketide synthase gene from the mycophenolic acid gene cluster as a test case
    • Hansen BG, Salomonsen B, Nielsen MT, Nielsen JB, Hansen NB, Nielsen KF, Regueira TB, Nielsen J, Patil KR, Mortensen UH (2011) Versatile enzyme expression and characterization system for Aspergillus nidulans, with the Penicillium brevicompactum polyketide synthase gene from the mycophenolic acid gene cluster as a test case. Appl Environ Microbiol 77(9):3044-3051
    • (2011) Appl Environ Microbiol , vol.77 , Issue.9 , pp. 3044-3051
    • Hansen, B.G.1    Salomonsen, B.2    Nielsen, M.T.3    Nielsen, J.B.4    Hansen, N.B.5    Nielsen, K.F.6    Regueira, T.B.7    Nielsen, J.8    Patil, K.R.9    Mortensen, U.H.10
  • 32
    • 40949097281 scopus 로고    scopus 로고
    • Eighty years after its discovery, Fleming's Penicillium strain discloses the secret of its sex
    • DOI 10.1128/EC.00430-07
    • Hoff B, Pöggeler S, Kück U (2008) Eighty years after its discovery, Fleming's Penicillium strain discloses the secret of its sex. Eukaryot Cell 7:465-470 (Pubitemid 351959674)
    • (2008) Eukaryotic Cell , vol.7 , Issue.3 , pp. 465-470
    • Hoff, B.1    Poggeler, S.2    Kuck, U.3
  • 33
    • 77955346444 scopus 로고    scopus 로고
    • Two components of a velvet-like complex control hyphal morphogenesis, conidiophore development, and penicillinbiosynthesis in Penicillium chrysogenum
    • Hoff B, Kamerewerd J, Sigl C, Mitterbauer R, Zadra I, Kürnsteiner H, Kück U (2010) Two components of a velvet-like complex control hyphal morphogenesis, conidiophore development, and penicillinbiosynthesis in Penicillium chrysogenum. Eukaryot Cell 9:1236-1250
    • (2010) Eukaryot Cell , vol.9 , pp. 1236-1250
    • Hoff, B.1    Kamerewerd, J.2    Sigl, C.3    Mitterbauer, R.4    Zadra, I.5    Kürnsteiner, H.6    Kück, U.7
  • 34
    • 33846949654 scopus 로고    scopus 로고
    • Cloning, sequencing and expression analysis of the first cellulase gene encoding cellobiohydrolase 1 from a cold-Adaptive Penicillium chrysogenum FS010
    • Hou Y, Wang T, Long H, Zhu H (2007) Cloning, sequencing and expression analysis of the first cellulase gene encoding cellobiohydrolase 1 from a cold-Adaptive Penicillium chrysogenum FS010. Acta Biochim Biophys Sin (Shanghai) 39:101-107
    • (2007) Acta Biochim Biophys Sin (Shanghai) , vol.39 , pp. 101-107
    • Hou, Y.1    Wang, T.2    Long, H.3    Zhu, H.4
  • 35
    • 77953172467 scopus 로고    scopus 로고
    • Proteome analysis of the penicillin producer Penicillium chrysogenum: Characterization of protein changes during the industrial strain improvement
    • Jami MS, Barreiro C, García-Estrada C, Martín JF (2010a) Proteome analysis of the penicillin producer Penicillium chrysogenum: Characterization of protein changes during the industrial strain improvement. Mol Cell Proteomics 9:1182-1198
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1182-1198
    • Jami, M.S.1    Barreiro, C.2    García-Estrada, C.3    Martín, J.F.4
  • 36
    • 78650081816 scopus 로고    scopus 로고
    • The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology
    • Jami MS, García-Estrada C, Barreiro C, Cuadrado AA, Salehi-Najafabadi Z, Martín JF (2010b) The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology. Mol Cell Proteomics 9:2729-2744
    • (2010) Mol Cell Proteomics , vol.9 , pp. 2729-2744
    • Jami, M.S.1    García-Estrada, C.2    Barreiro, C.3    Cuadrado, A.A.4    Salehi-Najafabadi, Z.5    Martín, J.F.6
  • 37
    • 71449104845 scopus 로고    scopus 로고
    • Evidence for Dicer-dependent RNA interference in the industrial penicillin producer Penicillium chrysogenum
    • Janus D, Hoff B, Kück U (2009) Evidence for Dicer-dependent RNA interference in the industrial penicillin producer Penicillium chrysogenum. Microbiology 155:3946-3956
    • (2009) Microbiology , vol.155 , pp. 3946-3956
    • Janus, D.1    Hoff, B.2    Kück, U.3
  • 38
    • 0028904797 scopus 로고
    • Analysis of penicillin V biosynthesis during fed-batch cultivations with a high-yielding strain of Penicillium chrysogenum
    • Jørgensen H, Nielsen J, Villadsen J, Møllgaard H (1995) Analysis of penicillin V biosynthesis during fed-batch cultivations with a high-yielding strain of Penicillium chrysogenum. Appl Microbiol Biotechnol 43:123-130
    • (1995) Appl Microbiol Biotechnol , vol.43 , pp. 123-130
    • Jørgensen, H.1    Nielsen, J.2    Villadsen, J.3    Møllgaard, H.4
  • 39
    • 0029995755 scopus 로고    scopus 로고
    • δ(L-α-Aminoadipyl)-L-cysteinyl-D-valin synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans
    • DOI 10.1007/s004380050312
    • Kennedy J, Turner G (1996) Delta-(L-Alpha-Aminoadipyl)-L-cysteinyl-D- valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans. Mol Gen Genet 253:189-197 (Pubitemid 26420004)
    • (1996) Molecular and General Genetics , vol.253 , Issue.1-2 , pp. 189-197
    • Kennedy, J.1    Turner, G.2
  • 40
    • 12844252572 scopus 로고    scopus 로고
    • Overproduction of a single protein, Pc-Pex11p, results in 2-fold enhanced penicillin production by Penicillium chrysogenum
    • DOI 10.1016/j.fgb.2004.10.010, PII S108718450400177X
    • Kiel JA, van der Klei IJ, van den Berg MA, Bovenberg RA, Veenhuis M (2005) Overproduction of a single protein, Pc-Pex11p, results in 2-fold enhanced penicillin production by Penicillium chrysogenum. Fungal Genet Biol 42:154-164 (Pubitemid 40163993)
    • (2005) Fungal Genetics and Biology , vol.42 , Issue.2 , pp. 154-164
    • Kiel, J.A.K.W.1    Van Der Klei, I.J.2    Van Den Berg, M.A.3    Bovenberg, R.A.L.4    Veenhuis, M.5
  • 41
    • 33748565936 scopus 로고    scopus 로고
    • PEX genes in fungal genomes: Common, rare or redundant
    • DOI 10.1111/j.1600-0854.2006.00479.x
    • Kiel JA, Veenhuis M, van der Klei IJ (2006) PEX genes in fungal genomes: Common, rare or redundant. Traffic 7:1291-1303 (Pubitemid 44364168)
    • (2006) Traffic , vol.7 , Issue.10 , pp. 1291-1303
    • Kiel, J.A.K.W.1    Veenhuis, M.2    Van Der Klei, I.J.3
  • 45
    • 79952574775 scopus 로고    scopus 로고
    • Aminoacyl-coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum
    • Koetsier MJ, Jekel PA, Wijma HJ, Bovenberg RA, Janssen DB (2011) Aminoacyl-coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum. FEBS Lett 585:893-898
    • (2011) FEBS Lett , vol.585 , pp. 893-898
    • Koetsier, M.J.1    Jekel, P.A.2    Wijma, H.J.3    Bovenberg, R.A.4    Janssen, D.B.5
  • 46
    • 77954720757 scopus 로고    scopus 로고
    • Application of the Saccharomyces cerevisiae FLP/FRT recombination system in filamentous fungi for marker recycling and construction of knockout strains devoid of heterologous genes
    • Kopke K, Hoff B, Kück U (2010) Application of the Saccharomyces cerevisiae FLP/FRT recombination system in filamentous fungi for marker recycling and construction of knockout strains devoid of heterologous genes. Appl Environ Microbiol 76:4664-4674
    • (2010) Appl Environ Microbiol , vol.76 , pp. 4664-4674
    • Kopke, K.1    Hoff, B.2    Kück, U.3
  • 47
    • 0034723253 scopus 로고    scopus 로고
    • A novel heptameric sequence (TTAGTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum
    • DOI 10.1074/jbc.275.4.2423
    • Kosalková K, Marcos AT, Fierro F, Hernando-Rico V, Gutiérrez S, Martín JF (2000) A novel heptameric sequence (TTAGTAA) is the binding site for a protein required for high level expression of pcbAB, the first gene of the penicillin biosynthesis in Penicillium chrysogenum. J Biol Chem 275:2423-2430 (Pubitemid 30082002)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.4 , pp. 2423-2430
    • Kosalkova, K.1    Marcos, A.T.2    Fierro, F.3    Hernando-Rico, V.4    Gutierrez, S.5    Martin, J.F.6
  • 48
    • 58549084975 scopus 로고    scopus 로고
    • The global regulator LaeA controls penicillin biosynthesis pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum
    • Kosalková K, García-Estrada C, Ullán RV, Godio RP, Feltrer R, Teijeira F, Mauriz E, Martín JF (2009) The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum. Biochimie 91:214-225
    • (2009) Biochimie , vol.91 , pp. 214-225
    • Kosalková, K.1    García-Estrada, C.2    Ullán, R.V.3    Godio, R.P.4    Feltrer, R.5    Teijeira, F.6    Mauriz, E.7    Martín, J.F.8
  • 49
    • 0033059655 scopus 로고    scopus 로고
    • Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages
    • Laich F, Fierro F, Cardoza RE, Martin JF (1999) Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages. Appl Environ Microbiol 65:1236-1240
    • (1999) Appl Environ Microbiol , vol.65 , pp. 1236-1240
    • Laich, F.1    Fierro, F.2    Cardoza, R.E.3    Martin, J.F.4
  • 50
    • 0036193358 scopus 로고    scopus 로고
    • Production of penicillin by fungi growing on food products: Identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum
    • DOI 10.1128/AEM.68.3.1211-1219.2002
    • Laich F, Fierro F, Martín JF (2002) Production of penicillin by fungi growing on food products: Identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum. Appl Environ Microbiol 68:1211-1219 (Pubitemid 34205360)
    • (2002) Applied and Environmental Microbiology , vol.68 , Issue.3 , pp. 1211-1219
    • Laich, F.1    Fierro, F.2    Martin, J.F.3
  • 51
    • 33645581640 scopus 로고    scopus 로고
    • Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an arylcapping enzyme that supplies phenylacetic acid to the isopenicillin N-Acyltransferase
    • Lamas-Maceiras M, Vaca I, Rodríguez E, Casqueiro J, Martín JF (2006) Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an arylcapping enzyme that supplies phenylacetic acid to the isopenicillin N-Acyltransferase. Biochem J 395:147-155
    • (2006) Biochem J , vol.395 , pp. 147-155
    • Lamas-Maceiras, M.1    Vaca, I.2    Rodríguez, E.3    Casqueiro, J.4    Martín, J.F.5
  • 52
    • 0010392177 scopus 로고
    • The Panlabs penicillin strain improvement program
    • Z. Vanek and Z. Hostalek, Editors Butterworths, Boston
    • Lein J (1986) The Panlabs penicillin strain improvement program. In: Z. Vanek and Z. Hostalek, Editors, Overproduction of microbial metabolites, Butterworths, Boston pp. 105-139.
    • (1986) Overproduction of microbial metabolites , pp. 105-139
    • Lein, J.1
  • 53
    • 0026673332 scopus 로고
    • Regulation of alpha-Aminoadipate reductase from Penicillium chrysogenum in relation to the flux from alpha-Aminoadipate into penicillin biosynthesis
    • Lu Y, Mach RL, Affenzeller K, Kubicek CP (1992) Regulation of alpha-Aminoadipate reductase from Penicillium chrysogenum in relation to the flux from alpha-Aminoadipate into penicillin biosynthesis. Can J Microbiol 38:758-763
    • (1992) Can J Microbiol , vol.38 , pp. 758-763
    • Lu, Y.1    Mach, R.L.2    Affenzeller, K.3    Kubicek, C.P.4
  • 60
    • 37349079028 scopus 로고    scopus 로고
    • A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum
    • DOI 10.1016/j.ymben.2007.07.001, PII S1096717607000432
    • Nasution U, van Gulik WM, Ras C, Proell A, Heijnen JJ (2008) A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum. Metab Eng 10:10-23 (Pubitemid 350298909)
    • (2008) Metabolic Engineering , vol.10 , Issue.1 , pp. 10-23
    • Nasution, U.1    Van Gulik, W.M.2    Ras, C.3    Proell, A.4    Heijnen, J.J.5
  • 61
    • 0030716357 scopus 로고    scopus 로고
    • Analysis of a commercially improved Penicillium chrysogenum strain series: Involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster
    • DOI 10.1038/sj.jim.2900411
    • Newbert RW, Barton B, Greaves P, Harper J, Turner G (1997) Analysis of a commercially improved Penicillium chrysogenum strain series: Involvement of recombinogenic regions in amplification and deletion of the penicillin biosynthesis gene cluster. J Ind Microbiol Biotechnol 19:18-27 (Pubitemid 27467128)
    • (1997) Journal of Industrial Microbiology and Biotechnology , vol.19 , Issue.1 , pp. 18-27
    • Newbert, R.W.1    Barton, B.2    Greaves, P.3    Harper, J.4    Turner, G.5
  • 63
    • 77954752108 scopus 로고    scopus 로고
    • Penicillium chrysogenum Pex14/17p-A novel component of the peroxisomal membrane that is important for penicillin production
    • Opalinski L, Kiel JA, Homan TG, Veenhuis M, van der Klei IJ (2010) Penicillium chrysogenum Pex14/17p-A novel component of the peroxisomal membrane that is important for penicillin production. FEBS J 277:3203-3218
    • (2010) FEBS J , vol.277 , pp. 3203-3218
    • Opalinski, L.1    Kiel, J.A.2    Homan, T.G.3    Veenhuis, M.4    Van Der Klei, I.J.5
  • 64
    • 38549095522 scopus 로고    scopus 로고
    • Yeast-like cell formation and glutathione metabolism in autolysing cultures of Penicillium chrysogenum
    • DOI 10.1556/ABiol.58.2007.4.10
    • Pócsi I, Molnár Z, Pusztahelyi T, Varecza Z, Emri T (2007) Yeast-like cell formation and glutathione metabolism in autolysing cultures of Penicillium chrysogenum. Acta Biol Hung 58:431-440 (Pubitemid 351160507)
    • (2007) Acta Biologica Hungarica , vol.58 , Issue.4 , pp. 431-440
    • Pocsi, I.1    Molnar, Zs.2    Pusztahelyi, T.3    Varecza, Z.4    Emri, T.5
  • 65
    • 0010388919 scopus 로고
    • Industrial strain improvement and the Panlabs penicillin club
    • Kleinkauf H, von Döhren H (eds). Public, Czech Republic
    • Rowlands RT (1991) Industrial strain improvement and the Panlabs penicillin club. In: Kleinkauf H, von Döhren H (eds) 50 years of penicillin applications: History and trends. Public, Czech Republic, pp 258-266
    • (1991) 50 Years of Penicillin Applications: History and Trends , pp. 258-266
    • Rowlands, R.T.1
  • 67
    • 0034836582 scopus 로고    scopus 로고
    • Reduced function of a phenylacetate-oxidizing cytochrome P450 caused strong genetic improvement in early phylogeny of penicillin-producing strains
    • DOI 10.1128/JB.183.19.5465-5471.2001
    • Rodríguez-Sáiz M, Barredo JL, Moreno MA, Fernández-Cañón JM, Peñalva MA, Díez B (2001) Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains. J Bacteriol 183:5465-5471 (Pubitemid 32880573)
    • (2001) Journal of Bacteriology , vol.183 , Issue.19 , pp. 5465-5471
    • Rodriguez-Saiz, M.1    Barredo, J.L.2    Moreno, M.A.3    Fernandez-Canon, J.M.4    Penalva, M.A.5    Diez, B.6
  • 68
    • 57849149449 scopus 로고    scopus 로고
    • Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae
    • Sakai K, Kinoshita H, Shimizu T, Nihira T (2008) Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae. J Biosci Bioeng 106:466-472
    • (2008) J Biosci Bioeng , vol.106 , pp. 466-472
    • Sakai, K.1    Kinoshita, H.2    Shimizu, T.3    Nihira, T.4
  • 69
    • 40849085085 scopus 로고    scopus 로고
    • Quantitative analysis of metabolites in complex biological samples using ion-pair reversed-phase liquid chromatography-isotope dilution tandem mass spectrometry
    • Seifar RM, Zhao Z, van Dam J, van Winden W, van Gulik W, Heijnen JJ (2008) Quantitative analysis of metabolites in complex biological samples using ion-pair reversed-phase liquid chromatography-isotope dilution tandem mass spectrometry. J Chromatogr A 1187:103-110
    • (2008) J Chromatogr A , vol.1187 , pp. 103-110
    • Seifar, R.M.1    Zhao, Z.2    Van Dam, J.3    Van Winden, W.4    Van Gulik, W.5    Heijnen, J.J.6
  • 70
    • 64549153538 scopus 로고    scopus 로고
    • Simultaneous quantification of free nucleotides in complex biological samples using ion pair reversed phase liquid chromatography isotope dilution tandem mass spectrometry
    • Seifar RM, Ras C, van Dam JC, van Gulik WM, Heijnen JJ, van Winden WA (2009) Simultaneous quantification of free nucleotides in complex biological samples using ion pair reversed phase liquid chromatography isotope dilution tandem mass spectrometry. Anal Biochem 388:213-219
    • (2009) Anal Biochem , vol.388 , pp. 213-219
    • Seifar, R.M.1    Ras, C.2    Van Dam, J.C.3    Van Gulik, W.M.4    Heijnen, J.J.5    Van Winden, W.A.6
  • 71
    • 0029857068 scopus 로고    scopus 로고
    • Analysis of mutations in the creA gene involved in carbon catabolite depression in Aspergillus nidulans
    • Shroff RA, Lockington RA, Kelly JM (1996) Analysis of mutations in the creA gene involved in carbon catabolite repression in Aspergillus nidulans. Can J Microbiol 42:950-959 (Pubitemid 26356245)
    • (1996) Canadian Journal of Microbiology , vol.42 , Issue.9 , pp. 950-959
    • Shroff, R.A.1    Lockington, R.A.2    Kelly, J.M.3
  • 72
    • 0031214324 scopus 로고    scopus 로고
    • Null alleles of creA, the regulator of carbon catabolite repression in Aspergillus nidulans
    • DOI 10.1006/fgbi.1997.0989
    • Shroff RA, O'Connor SM, Hynes MJ, Lockington RA, Kelly JM (1997) Null alleles of creA, the regulator of carbon catabolite repression in Aspergillus nidulans. Fungal Genet Biol 22:28-38 (Pubitemid 27491343)
    • (1997) Fungal Genetics and Biology , vol.22 , Issue.1 , pp. 28-38
    • Shroff, R.A.1    O'Connor, S.M.2    Hynes, M.J.3    Lockington, R.A.4    Kelly, J.M.5
  • 74
    • 79551502989 scopus 로고    scopus 로고
    • Among developmental regulators StuA but not BrlA is essential for penicillin V production in Penicillium chrysogenum
    • Sigl C, Haas H, Specht T, Pfaller K, Kürnsteiner H, Zadra I (2011) Among developmental regulators, StuA but not BrlA is essential for penicillin V production in Penicillium chrysogenum. Appl Environ Microbiol 77:972-982
    • (2011) Appl Environ Microbiol , vol.77 , pp. 972-982
    • Sigl, C.1    Haas, H.2    Specht, T.3    Pfaller, K.4    Kürnsteiner, H.5    Zadra, I.6
  • 75
    • 0018734405 scopus 로고
    • Recurrent mutation and selection for increased penicillin titre in Aspergillus nidulans
    • Simpson IN, Caten CE (1979) Recurrent mutation and selection for increased penicillin titre in Aspergillus nidulans. J Gen Microbiol 113:209-217 (Pubitemid 10236570)
    • (1979) Journal of General Microbiology , vol.113 , Issue.2 , pp. 209-217
    • Simpson, I.N.1    Caten, C.E.2
  • 76
    • 73949102329 scopus 로고    scopus 로고
    • Sequence analysis and gene amplification study of the penicillin biosynthesis gene cluster from different strains of Penicillium chrysogenum
    • Smidák R, Kralovicová M, Sevciková B, Jakubcová M, Kormanec J, Timko J, Turna J (2010a) Sequence analysis and gene amplification study of the penicillin biosynthesis gene cluster from different strains of Penicillium chrysogenum. Biologia 65:1e6
    • (2010) Biologia , vol.65
    • Smidák, R.1    Kralovicová, M.2    Sevciková, B.3    Jakubcová, M.4    Kormanec, J.5    Timko, J.6    Turna, J.7
  • 77
    • 77952654996 scopus 로고    scopus 로고
    • Core promoters of the penicillin biosynthesis genes and quantitative RT-PCR analysis of these genes in high and low production strain of Penicillium chrysogenum
    • Smidák R, Jopcík M, Kralovicová M, Gajdosíková J, Kormanec J, Timko J, Turna J (2010b) Core promoters of the penicillin biosynthesis genes and quantitative RT-PCR analysis of these genes in high and low production strain of Penicillium chrysogenum. Folia Microbiol (Praha) 55:126-132
    • (2010) Folia Microbiol (Praha) , vol.55 , pp. 126-132
    • Smidák, R.1    Jopcík, M.2    Kralovicová, M.3    Gajdosíková, J.4    Kormanec, J.5    Timko, J.6    Turna, J.7
  • 78
    • 0024565442 scopus 로고
    • Amplification of the isopenicillin N synthetase gene in a strain of Penicillium chrysogenum producing high levels of penicillin
    • DOI 10.1007/BF00334395
    • Smith DJ, Bull JH, Edwards J, Turner G (1989) Amplification of the isopenicillin N synthetase gene in a strain of Penicillium chrysogenum producing high levels of penicillin. Mol Gen Genet 216:492-497 (Pubitemid 19117843)
    • (1989) Molecular and General Genetics , vol.216 , Issue.2-3 , pp. 492-497
    • Smith, D.J.1    Bull, J.H.2    Edwards, J.3    Turner, G.4
  • 79
    • 64049104778 scopus 로고    scopus 로고
    • Construction of an hdfA Penicillium chrysogenum strain impaired in nonhomologous end-joining and analysis of its potential for functional analysis studies
    • Snoek IS, van der Krogt ZA, Touw H, Kerkman R, Pronk JT, Bovenberg RA, van den Berg MA, Daran JM (2009) Construction of an hdfA Penicillium chrysogenum strain impaired in nonhomologous end-joining and analysis of its potential for functional analysis studies. Fungal Genet Biol 46:418-426
    • (2009) Fungal Genet Biol , vol.46 , pp. 418-426
    • Snoek, I.S.1    Van Der Krogt, Z.A.2    Touw, H.3    Kerkman, R.4    Pronk, J.T.5    Bovenberg, R.A.6    Van Den Berg, M.A.7    Daran, J.M.8
  • 80
    • 52649133438 scopus 로고    scopus 로고
    • Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster
    • Spröte P, Hynes MJ, Hortschansky P, Shelest E, Scharf DH, Wolke SM, Brakhage AA (2008) Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster. Mol Microbiol 70:445-461
    • (2008) Mol Microbiol , vol.70 , pp. 445-461
    • Spröte, P.1    Hynes, M.J.2    Hortschansky, P.3    Shelest, E.4    Scharf, D.H.5    Wolke, S.M.6    Brakhage, A.A.7
  • 81
    • 61949235019 scopus 로고    scopus 로고
    • Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans
    • Spröte P, Brakhage AA, Hynes MJ (2009) Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans. Eukaryot Cell 8:421-423
    • (2009) Eukaryot Cell , vol.8 , pp. 421-423
    • Spröte, P.1    Brakhage, A.A.2    Hynes, M.J.3
  • 83
    • 0035916383 scopus 로고    scopus 로고
    • Quantitative analysis of Penicillium chrysogenum Wis54-1255 transformants overexpressing the penicillin biosynthetic genes
    • Theilgaard H, van den Berg M, Mulder C, Bovenberg R, Nielsen J (2001) Quantitative analysis of Penicillium chrysogenum Wis54-1255 transformants overexpressing the penicillin biosynthetic genes. Biotechnol Bioeng 72:379-388
    • (2001) Biotechnol Bioeng , vol.72 , pp. 379-388
    • Theilgaard, H.1    Van Den Berg, M.2    Mulder, C.3    Bovenberg, R.4    Nielsen, J.5
  • 84
    • 77958567501 scopus 로고    scopus 로고
    • Functional characterization of penicillin production strains
    • Van den Berg MA (2010) Functional characterization of penicillin production strains. Fungal Biol Rev 24:73-78
    • (2010) Fungal Biol Rev , vol.24 , pp. 73-78
    • Van Den Berg, M.A.1
  • 86
    • 34547417000 scopus 로고    scopus 로고
    • Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255
    • DOI 10.1016/j.fgb.2007.03.008, PII S1087184507000667
    • Van den Berg MA, Westerlaken I, Leeflang C, Kerkman R, Bovenberg RAL (2007) Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255. Fungal Genet Biol 44:830-844 (Pubitemid 47176942)
    • (2007) Fungal Genetics and Biology , vol.44 , Issue.9 , pp. 830-844
    • Van Den Berg, M.A.1    Westerlaken, I.2    Leeflang, C.3    Kerkman, R.4    Bovenberg, R.A.L.5
  • 89
    • 34447095636 scopus 로고    scopus 로고
    • Molecular cloning and functional identification of a novel phenylacetyl-CoA ligase gene from Penicillium chrysogenum
    • DOI 10.1016/j.bbrc.2007.06.074, PII S0006291X07013216
    • Wang FQ, Liu J, Dai M, Ren ZH, Su CY, He JG (2007) Molecular cloning and functional identification of a novel phenylacetyl-CoA ligase gene from Penicillium chrysogenum. Biochem Biophys Res Commun 360:453-458 (Pubitemid 47030364)
    • (2007) Biochemical and Biophysical Research Communications , vol.360 , Issue.2 , pp. 453-458
    • Wang, F.-Q.1    Liu, J.2    Dai, M.3    Ren, Z.-H.4    Su, C.-Y.5    He, J.-G.6
  • 90
    • 0036353126 scopus 로고    scopus 로고
    • Ds-like restless deletion derivatives occur in tolypocladium inflatum and two foreign hosts, Neurospora crassa and Penicillium chrysogenum
    • DOI 10.1006/fgbi.2001.1323
    • Windhofer F, Hauck K, Catcheside DE, Kück U, Kempken F (2002) Ds-like restless deletion derivatives occur in Tolypocladium inflatum and two foreign hosts, Neurospora crassa and Penicillium chrysogenum. Fungal Genet Biol 35:171-182 (Pubitemid 34948414)
    • (2002) Fungal Genetics and Biology , vol.35 , Issue.2 , pp. 171-182
    • Windhofer, F.1    Hauck, K.2    Catcheside, D.E.A.3    Kuck, U.4    Kempken, F.5
  • 91
    • 77956313512 scopus 로고    scopus 로고
    • High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei
    • Woo PC, Tam EW, Chong KT, Cai JJ, Tung ET, Ngan AH, Lau SK, Yuen KY (2010) High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei. FEBS J 277:3750-3758
    • (2010) FEBS J , vol.277 , pp. 3750-3758
    • Woo, P.C.1    Tam, E.W.2    Chong, K.T.3    Cai, J.J.4    Tung, E.T.5    Ngan, A.H.6    Lau, S.K.7    Yuen, K.Y.8
  • 93
    • 70350304250 scopus 로고    scopus 로고
    • Purification and characterization of the cold-Active alkaline protease from marine cold-Adaptive Penicillium chrysogenum FS010
    • Zhu HY, Tian Y, Hou YH, Wang TH (2009) Purification and characterization of the cold-Active alkaline protease from marine cold-Adaptive Penicillium chrysogenum FS010. Mol Biol Rep 36:2169-2174
    • (2009) Mol Biol Rep , vol.36 , pp. 2169-2174
    • Zhu, H.Y.1    Tian, Y.2    Hou, Y.H.3    Wang, T.H.4


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