A metabolome study of the steady-state relation between central metabolism, amino acid biosynthesis and penicillin production in Penicillium chrysogenum

Metabolic Engineering

Volumn 10, Issue 1, 2008, Pages 10-23

  Nasution, Uly ^a   van Gulik, Walter M ^a   Ras, Cor ^a   Proell, Angela ^a   Heijnen, Joseph J ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Amino acids; Central metabolism; Chemostat; Metabolic flux analysis; Metabolome; Penicillin biosynthesis; Penicillium chrysogenum

Indexed keywords

ACETIC ACID; AMINO ACIDS; BIOSYNTHESIS; GLUCOSE; GROWTH KINETICS; METABOLISM; REDOX REACTIONS;

METABOLIC FLUX ANALYSIS; METABOLOME; PENICILLIUM CHRYSOGENUM; PHENYLACETIC ACIDS; REDOX COFACTORS;

FUNGI;

ADENOSINE TRIPHOSPHATE; ALCOHOL; ALPHA AMINO ACID; AMINO ACID; CARBON; CYSTEINE; GLUCOSE; PENICILLIN G; PHENYLACETIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TREHALOSE; VALINE;

AMINO ACID SYNTHESIS; ARTICLE; ENERGY METABOLISM; GENE CLUSTER; GENE MUTATION; GROWTH RATE; INHIBITION KINETICS; METABOLOMICS; NONHUMAN; OXIDATION REDUCTION REACTION; PENICILLIUM CHRYSOGENUM; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; STEADY STATE; STRAIN IDENTIFICATION;

ACETYL-COA C-ACYLTRANSFERASE; ADENINE NUCLEOTIDES; ALGORITHMS; AMINO ACIDS; CITRIC ACID CYCLE; CULTURE MEDIA; ETHANOL; GLYCOLYSIS; METABOLISM; MULTIGENE FAMILY; OXIDOREDUCTASES; PENICILLINS; PENICILLIUM CHRYSOGENUM; PEPTIDE SYNTHASES;

PENICILLIUM CHRYSOGENUM;

EID: 37349079028     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2007.07.001     Document Type: Article

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