Analysis of mutations in the creA gene involved in carbon catabolite depression in Aspergillus nidulans

Canadian Journal of Microbiology

Volumn 42, Issue 9, 1996, Pages 950-959

  Shroff, Robert A ^a   Lockington, Robin A ^a   Kelly, Joan M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Carbon catabolite repression; CREA; MIG1; Transcriptional repressor; Zinc figer protein

Indexed keywords

ALLELE; ARTICLE; ASPERGILLUS NIDULANS; CATABOLITE REPRESSION; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ASPERGILLUS; EMERICELLA NIDULANS;

EID: 0029857068     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/m96-122     Document Type: Article

References (35)

1. Arst, H.N., and Bailey, C.R. 1977. The regulation of carbon metabolism in Aspergillus nidulans. In Genetics and physiology of Aspergillus. Edited by J.E. Smith and J.A. Pateman. Academic Press Inc., New York. pp. 131-146.
2. Arst, H.N., and Cove, D.J. 1973. Nitrogen metabolite repression in Aspergillus nidulans. Mol. Gen. Genet. 126: 111-141.
3. Arst, H.N., Tollervey, D., Dowzer, C.E.A., and Kelly, J.M. 1990. An inversion truncating the creA gene of Aspergillus nidulans results in carbon catabolite derepression. Mol. Microbiol. 4: 851-854.
4. Bailey, C.R., and Arst, H.N. 1975. Carbon catabolite repression in Aspergillus nidulans. Eur. J. Biochem. 51: 573-577.
5. Baird, P.N., Santos, A., Groves, N., Jadresic, L., and Cowell, J.K. 1992. Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome. Hum. Mol. Genet. 1: 301-305.
6. Caddick, M.X. 1994. Nitrogen metabolite repression. Prog. Ind. Microbiol. 29: 323-346.
7. Cove, D.J. 1966. The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochim. Biophys. Acta, 113: 51-56.
8. Creaser, E.H., Porter, R.L., Britt, K.A., Pateman, J.A., and Doy, C.H. 1985. Purification and preliminary characterization of alcohol dehydrogenase from Aspergillus nidulans. Biochem. J. 225: 449-454.
9. Cubero, B., and Scazzocchio, C. 1994. Two different adjacent and divergent zinc finger binding sites are necessary for CREA-mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans. EMBO J. 13: 407-415.
10. Dowzer, C.E.A. 1991. The cloning and preliminary characterization of the creA gene from Aspergillus nidulans. Ph.D. thesis, University of Adelaide, Adelaide, Australia.
11. Dowzer, C.E.A., and Kelly, J.M. 1989. Cloning of the creA gene from Aspergillus nidulans: a gene involved in carbon catabolite repression. Curr. Genet. 15: 457-459.
12. Dowzer, C.E.A., and Kelly, J.M. 1991. Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans. Mol. Cell. Biol. 11: 5701-5709.
13. Drysdale, M.R., Kolze, S.E., and Kelly, J.M. 1993. The Aspergillus niger carbon catabolite repressor gene, creA. Gene, 130: 241-245.
14. Gurr, S.J., Unkles, S.E., and Kinghorn, J.R. 1987. In Gene structure in eukaryotic microbes. Edited by J.R. Kinghorn. IRL Press, Oxford, U.K. pp. 93-139.
15. Hynes, M.J. 1975. Studies on the role of the areA gene in the regulation of nitrogen catabolism in Aspergillus nidulans. Aust. J. Biol. Sci. 28: 301-313.
16. Hynes, M.J., and Kelly, J.M. 1977. Pleitropic mutants of Aspergillus nidulans altered in carbon metabolism. Mol. Gen. Genet. 108: 107-116.
17. Hynes, M.J., Corrick, C.M., and King, J.A. 1983. Isolation of genomic clones containing the amdS gene of Aspergillus nidulans. Mol. Cell. Biol. 3: 1430-1439.
18. Kelly, J.M. 1980. Pleiotropic mutants of Aspergillus nidulans affected in carbon metabolism. Ph.D. thesis, La Trobe University, Melbourne, Australia.
19. Kulmberg, P., Mathieu, M., Dowzer, C.E.A., Kelly, J., and Felenbok, B. 1993. Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol. Microbiol. 7: 847-857.
20. Little, M., Holmes, G., Bickmore, W., van Heyningen, V., Hastie, N., and Wainwright, B. 1995. DNA binding capacity of the WT1 protein is abolished by Denys-Drash syndrome WT1 point mutations. Hum. Mol. Genet. 4: 351-358.
21. Lockington, R.A., Sealy-Lewis, H.M., Scazzochio, C., and Davies, R.W. 1985. Cloning and characterization of the ethanol utilization regulon in Aspergillus nidulans. Gene, 33: 137-149.
22. Lundin, M., Nehlin, J.O., and Ronne, H. 1994. Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1. Mol. Cell. Giol. 14: 1979-1985.
23. Mathieu, M., and Felenbok, B. 1994. The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR-specific transactivator. EMBO. J. 13: 402-4027.
24. Nehlin, J.O., and Ronne, H. 1990. Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO. J. 9: 2891-2898.
25. Nehlin, J.O., Carlberg, M., and Ronne, H. 1991. Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response. EMBO. J. 10: 3373-3377.
26. Pavletich, N.P., and Pabo, C.O. 1991. Zinc finger - DNA recognition: crystal structure of a Ziv268-DNA complex at 2.1 Å. Science (Washington, D.C.), 252: 809-817.
27. Pelletier, J., Breuning, W., Kashtan, C.E., Mauer, S.M., Manivel, J.C., Striegel, J.E., Houghton, D.C., Junien, C., Habib, R., Fouser, L., Fine, R.N., Silverman, B.L., Haber, D.A., and Houseman, D. 1991. Germline mutations in the Wilms' Tumour suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell, 67: 437-447.
28. Perez-Estaeban, B., Orejas, M., Gomez Pardo, E., and Penalva, M. 1993. Molecular characterization of a fungal secondary metabolism promoter: transcription of the Aspergillus nidulans isopenicillin N synthetase gene is modulated by upstream negative elements. Mol. Microbiol. 9: 881-895.
29. Rienert, W.R., Patel, V.B., and Giles, N.H. 1981. Genetics regulation of the qa gene cluster of Neurospora crassa: inducation of qa messenger ribonucleic acid and dependency on qa-1 function. Mol. Cell. Biol. 1: 829-835.
30. Sakai, A., Shimizu, Y., and Hishinuma, F. 1988. Isolation and characterization of mutants which show an oversecretion phenotype in Saccharomyces cervisiae. Genetics, 119: 499-506.
31. Sakai, A., Shimizu, Y., Kandou, S., Chibazakura, T., and Hishinuma, F. 1990. Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae. Mol. Cell. Biol. 10: 4130-4138.
32. Suzuki, M., Gerstein, M., and Yagi, N. 1994. Stereochemical basis of DNA recognition by Zn fingers. Nucleic Acids Res. 22: 3397-3405.
33. Trietel, M.A., and Carlson, M. 1995. Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proc. Natl. Acad. Sci. U.S.A. 92: 3132-3136.
34. Tzamarias, D., and Struhl, K. 1995. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes Dev. 9: 821-831.
35. Vallier, L.G., and Carlson, M. 1994. Synergistic release from glucose repression by mig1 and ssn mutations in Saccharomyces cerevisiae. Genetics, 137: 49-54.