A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41153-41162

  Wu, Wei ^a,b   Sun, Xiao Hong ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B-LINEAGE CELLS; BIOCHEMICAL MECHANISMS; BIOLOGICAL EFFECTS; BIOLOGICAL SIGNIFICANCE; C TERMINUS; DIFFERENT DOMAINS; DOMINANT-NEGATIVE MUTANTS; E3 LIGASE; GENES ENCODING; HIGH AFFINITY; INDUCED DEGRADATION; JANUS KINASE; KINASE DOMAINS; NOTCH SIGNALING; S-PHASE; UBIQUITINATION;

DEGRADATION; ENZYMES; GENES; SIGNALING;

BIODEGRADATION;

ANKYRIN; ANKYRIN REPEAT SOCS BOX CONTAINING PROTEIN 2; ARGININE; CULLIN; JANUS KINASE 3; MUTANT PROTEIN; NOTCH RECEPTOR; PROTEIN ASB2; PROTEIN CULLIN1; PROTEIN CULLIN5; S PHASE KINASE ASSOCIATED PROTEIN 2; TRYPTOPHAN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UBIQUITINATION;

AMINO ACID SUBSTITUTION; ANIMALS; CULLIN PROTEINS; HUMANS; JANUS KINASE 3; MICE; MUTATION, MISSENSE; NIH 3T3 CELLS; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECEPTORS, NOTCH; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; UBIQUITIN; UBIQUITINATION;

EID: 82355171881     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.273755     Document Type: Article

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