Development of ligands at γ-aminobutyrric acid type A (GABA A) receptor subtype as new agents for pain relief

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7441-7452

  Guerrini, Gabriella ^a   Ciciani, Giovanna ^a   Bruni, Fabrizio ^a   Selleri, Silvia ^a   Martini, Claudia ^b   Daniele, Simona ^c   Ghelardini, Carla ^a   Di Cesare Mannelli, Lorenzo ^a   Costanzo, Annarella ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Antihyperalgesic effect; Anxiolytic like effect; Binding affinity; GABA A receptors; Pyrazolo 51 c 1,2,4 benzotriazine system

Indexed keywords

1,2,4 BENZOTRIAZINE DERIVATIVE; 3 IODO 8 (2 METHOXYBENZYLAMINO)PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (2 PHENYLETHYLAMINO)PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (4 CHLOROBENZYLAMINO)PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 IODO 8 [BENZYL(METHYL)AMINO]PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 IODO 8 BENZYLAMINOPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE; 3 IODO 8 BENZYLAMINOPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 METHYL 8 (2 METHOXYBENZYLAMINO)PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 METHYL 8 (2 METHOXYBENZYLOXY)PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 METHYL 8 (2 METHYL 2 PHENYLETHOXY)PYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 METHYL 8 BENZYLAMINOPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE; 3 METHYL 8 BENZYLAMINOPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 METHYL 8 BENZYLOXYPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE; 3 METHYL 8 BENZYLOXYPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANXIETY DISORDER; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONTROLLED STUDY; CONVULSION; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HYPERALGESIA; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NEUROPATHY; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; CATTLE; HYPERALGESIA; MALE; MICE; PAIN; PENTYLENETETRAZOLE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SEIZURES; STREPTOZOCIN; TRIAZINES;

ANIMALIA;

EID: 82255186585     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.047     Document Type: Article

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