New fluoro derivatives of the pyrazolo[5,1- c ][1,2,4]benzotriazine 5-oxide system: Evaluation of fluorine binding properties in the benzodiazepine site on γ-aminobutyrric acid type A (GABAA) receptor. design, synthesis, biological, and molecular modeling investigation

Journal of Medicinal Chemistry

Volumn 53, Issue 21, 2010, Pages 7532-7548

  Guerrini, Gabriella ^a   Ciciani, Giovanna ^a   Bruni, Fabrizio ^a   Selleri, Silvia ^a   Guarino, Chiara ^a   Melani, Fabrizio ^a   Montali, Marina ^b   Daniele, Simona ^b   Martini, Claudia ^b   Ghelardini, Carla ^a   Norcini, Monica ^a   Ciattini, Samuele ^a   Costanzo, Annarella ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXYBENZYLOXYCARBONYL) 8 TRIFLUOROMETHYLPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 (2 THIENYLMETHOXYCARBONYL) 8 TRIFLUOROMETHYLPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 3 IODO 8 DIFLUOROMETHOXYPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; DIAZEPAM; FLUORINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CONVULSION; DRUG DESIGN; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR MODEL; MOTOR COORDINATION; MOUSE; MUSCLE RELAXATION; NONHUMAN; SLEEP TIME;

ANIMALS; ANTI-ANXIETY AGENTS; BINDING SITES; CATTLE; CEREBRAL CORTEX; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG INVERSE AGONISM; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 78149261500     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1001887     Document Type: Article

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