Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-thienylmethoxycarbonyl) derivative: An anxioselective agent in rodents

Journal of Medicinal Chemistry

Volumn 45, Issue 26, 2002, Pages 5710-5720

  Costanzo, Annarella ^a   Guerrini, Gabriella ^a   Ciciani, Giovanna ^a   Bruni, Fabrizio ^a   Costagli, Camilla ^a   Selleri, Silvia ^a   Besnard, François ^b   Costa, Barbara ^c   Martini, Claudia ^c   Malmberg Aiello, Petra ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SANOFI   (France)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 THIENYLMETHOXYCARBONYL) 8 CHLOROPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 CHLOROPYRAZOLO[5,1 C][1,2,4]BENZOTRIAZINE 5 OXIDE 3 ESTER DERIVATIVE; BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; DIAZEPAM; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONFLICT; CONTROLLED STUDY; CONVULSION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROCONVULSIVE THERAPY; HYDROGEN BOND; LIPOPHILICITY; LONG TERM MEMORY; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; RECEPTOR AFFINITY; SHORT TERM MEMORY; SOMNOLENCE; STEREOSPECIFICITY; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; AVOIDANCE LEARNING; CELL LINE; CEREBRAL CORTEX; CYCLIC N-OXIDES; DRUG INTERACTIONS; ETHANOL; EXPLORATORY BEHAVIOR; GABA AGENTS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; LIGANDS; MEMORY; MICE; MOTOR SKILLS; NEUROMUSCULAR AGENTS; RATS; RECEPTORS, GABA-A; SEIZURES; SLEEP; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 0037137587     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020944u     Document Type: Article

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